ライフサイエンスコーパス: Na Ca exchanger

1 blockers of the angiotensin receptor and the Na-Ca exchanger.

2 nd mitochondrial calcium release through the Na/Ca exchanger.

3 distribution is identical to that of the PM Na/Ca exchanger.

4 of ankyrin-B, a binding partner for EHD3 and Na/Ca exchanger.

5 pendent and is attenuated by blockers of the Na+-Ca+ exchanger.

6 lization and post-translational stability of Na/Ca exchanger 1 in neonatal mouse cardiomyocytes.

7 7943, which inhibits the reverse mode of the Na/Ca exchanger, abolished the cardiotonic effects of ou

8 Na/Ca exchanger activity is important for calcium extrus

9 ivation of I(CaL) combined with extrusion by Na-Ca exchanger and troponin binding.

10 s display reduced expression/localization of Na/Ca exchanger and L-type Ca channel type 1.2 with a pa

11 pha 1 isoform co-immunoprecipitated with the Na/Ca exchanger and vice versa.

12 s Ca(2+) uptake, whereas NCLX (mitochondrial Na/Ca exchanger) and LETM1 (leucine zipper-EF-hand-conta

13 te that atria have fewer sodium pumps, fewer Na+-Ca++ exchangers, and enhanced sensitivity to inotrop

14 transporters, in this case the Na/K ATPase, Na/Ca exchanger, and InsP(3) receptor.

15 y loss of cellular targeting of Na/K ATPase, Na/Ca exchanger, and InsP3 receptor (all ankyrin-binding

16 nd Ca channels, cardiac ryanodine receptors, Na/Ca-exchanger, and SR Ca-ATPase are involved in this r

17 Moreover, using ankyrin-B mutants that lack Na/Ca exchanger binding activity, and primary cardiomyoc

18 Whereas the molecular mechanisms underlying Na/Ca exchanger biophysical properties are widely studie

19 Inhibition of mitochondrial Na/Ca exchanger by CGP37157 ameliorates the metabolic ch

20 We found that a dominance of inward Na-Ca exchanger current (I(NCX)) over Ca-dependent inact

21 ude and SR Ca load associated with increased Na/Ca exchanger expression and enhanced diastolic SR Ca

22 ankyrin-B localization and selective loss of Na/Ca exchanger expression and function.

23 Animal models exhibiting altered Na/Ca exchanger expression display abnormal cardiac phen

24 In humans, elevated Na/Ca exchanger expression/activity is linked with patho

25 ,K-ATPase alpha1, alpha2, alpha3, beta1, and Na+-Ca++ exchangers in all regions.

26 o-localization of the alpha1 isoform and the Na/Ca exchanger in cardiac sarcolemma.

27 ing the specialized membrane localization of Na/Ca exchanger in cardiac tissue are essentially unknow

28 functionally and physically coupled with the Na/Ca exchanger in heart.

29 ) Removal from or decreased concentration of Na/Ca exchangers in the cleft will cause [Ca] to fall to

30 uctural requirements on ankyrin-B for direct Na/Ca exchanger interactions.

31 alpha3, beta1, sodium pump activity, and Na+-Ca++ exchanger levels were 30-50% lower in atria com

32 evidence for a protein pathway required for Na/Ca exchanger localization and stability in primary ca

33 hannel type 1.2 with a parallel reduction in Na/Ca exchanger-mediated membrane current and Cav1.2-med

34 in-B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate

35 and abnormal localization and expression of Na/Ca exchanger, Na/K ATPase, and InsP(3)R in ankyrin-B(

36 The Na-Ca exchanger (NCX) is a critical calcium efflux pathw

37 vestigate the functional distribution of the Na/Ca exchanger (NCX) and Na/K-ATPase between the t-tubu

38 cell function by activation of electrogenic Na/Ca exchanger (NCX) during diastole.

39 The electrogenic Na/Ca exchanger (NCX) mediates bidirectional Ca movement

40 elope (NE) was previously shown to contain a Na/Ca exchanger (NCX) tightly linked to GM1 ganglioside

41 rotein, phospholemman (PLM), and the cardiac Na/Ca exchanger (NCX1) show greater surface membrane loc

42 We have cloned Calx, a gene that encodes a Na-Ca exchanger of Drosophila melanogaster.

43 -ATPase in the heart, through effects on the Na/Ca exchanger, raises the intracellular Ca2+ concentra

44 , which are alpha(beta) heterodimers, and of Na+-Ca++ exchangers, this study aimed to determine the r

45 Ca(2+), due to reduced extrusion through the Na/Ca exchanger, without affecting resting Na(+) and Ca(