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1 late that replicates in the amoeboflagellate Naegleria.
2 cillaene, and difficidin) in the presence of Naegleria.
6 tubulin during mitosis, and we now show that Naegleria amoebae express a second mitotic alpha- and tw
8 ike nearly all other known eukaryotic cells, Naegleria amoebae lack interphase microtubules; this sug
11 t origin for these processes and establishes Naegleria as a natural model system for studying microtu
12 o build distinct microtubule networks: while Naegleria builds flagella from conserved tubulins during
13 y, and molecular perturbations, we show that Naegleria encodes conserved actin nucleators and builds
16 Population dynamics tracking revealed that Naegleria enriched Bacillus populations, leading to a po
18 other known pathogenic free-living amoebas (Naegleria fowleri and Acanthamoeba species), drug discov
27 amoebic meningoencephalitis (PAM) induced by Naegleria fowleri is extremely lethal, with mortality ra
33 amoeba species, Balamuthia mandrillaris, and Naegleria fowleri, are known to cause infections of the
34 litis (PAM), caused by the free-living ameba Naegleria fowleri, has historically been associated with
35 ubulin homologs of the "brain-eating amoeba" Naegleria fowleri, making them potential drug targets.
37 genus comprises the notorious human pathogen Naegleria fowleri, the causative agent of the rare but f
43 P1 CKK domain (HsCKK) with a CKK domain from Naegleria gruberi (NgCKK), which lacks minus-end specifi
44 different eukaryotic lineages: the discoban Naegleria gruberi and the amoebozoan slime mold Dictyost
47 nase I of the single-celled amoeboflagellate Naegleria gruberi is the only eukaryotic thiaminase I to
48 The genome sequence of the amoeboflagellate Naegleria gruberi reported by Fritz-Laylin et al. reveal
51 d the activity of the mouse TET1 (mTET1) and Naegleria gruberi TET (nTET) oxygenases with DNA substra
52 of a TET-like (5m)C oxygenase (NgTET1) from Naegleria gruberi, a single-celled protist evolutionaril
53 and TET1 from mouse and their homologue from Naegleria gruberi, the full-length protein NgTET1, are d
57 NiV), and show its unique adaptations to its Naegleria host using fluorescence in situ hybridization,
60 les of selected pathogenic and nonpathogenic Naegleria in vitro using an untargeted metabolomics appr
62 ed for infection of Willaertia magna but not Naegleria lovaniensis, suggesting that Cas2 promotes inf
64 Ectocarpus, Emiliania, Euglena, Micromonas, Naegleria, Nephroselmis, Paramecium, Pavlova, Phaeodacty
65 ments, we find that the SynCom together with Naegleria provided significantly greater suppression of
66 h as Clostridium, Cryptococcus, Candida, and Naegleria, reported in one or more of the wetlands asses
67 sexually, many amoebae (e.g., Acanthamoeba, Naegleria) reproduce asexually and therefore, according
68 f the 15,727 protein-coding genes encoded by Naegleria's 41 Mb nuclear genome indicates a capacity fo
69 quantitative light microscopy, we find that Naegleria's mitotic spindle is a distinctive barrel-like
72 Notably, NiV infection was lethal to all Naegleria species tested, including the human pathogen N
74 entify previously unknown Ggamma subunits in Naegleria, suggesting that the trimeric version was alre
76 dy biochemically and structurally one of the Naegleria Tet-like proteins (NgTet1), which shares signi
78 ted during only one process, suggesting that Naegleria uses distinct component pools to specialize it