ライフサイエンスコーパス: Nfe2l2

1 nd the transcription factor Nrf2 (encoded by Nfe2l2).

2 rythroid-derived 2 like 2 [also called NRF2 (NFE2L2)].

3 the master antioxidant transcription factor NFE2L2.

4 n of the oxidative stress targets TXNRD1 and NFE2L2.

5 , and mutations in EP300 (16%), FBXW7 (15%), NFE2L2 (4%), TP53 (5%) and ERBB2 (6%).

6 ar factor-erythroid 2-related factor 2 (Nrf2/NFE2L2), a redox-sensitive transcription factor plays a

7 Nuclear factor, erythroid 2-like 2 (NFE2L2), a transcription factor also known as NF-E2-rela

8 We showed that activation of NFE2L2, a frequent event in lung squamous cancers, confe

9 This was accompanied by nuclear Nfe2l2 accumulation and led us to identify abundant Nfe2

10 r nuclear factor-erythroid-derived 2-like 2 (NFE2L2 alias NRF-2).

11 r nuclear factor-erythroid derived 2-like 2 (nfe2l2, also known as Nrf2) in the nucleus.

12 monstrate that BTG2 is a binding partner for NFE2L2 and increases its transcriptional activity.

13 equires the antioxidant transcription factor NFE2L2 and is associated with up-regulation of the expre

14 Significantly altered pathways included NFE2L2 and KEAP1 in 34%, squamous differentiation genes

15 ed with the discovery of SOX2 amplification, NFE2L2 and KEAP1 mutations, PI3K pathway changes, FGFR1

16 trees targeted oncogenes, including PIK3CA, NFE2L2 and MTOR, among others.

17 nt of lung injury and for SNPs in IL8, MBL2, NFE2L2 and NAMPT with severity in ALI outcomes.

18 accumulation and led us to identify abundant Nfe2l2 and other mitochondrial biogenesis transcription

19 demonstrated an interaction between hepatic Nfe2l2 and PGC-1alpha in WT mice that was greatly reduce

20 cantly mutated genes, including TP53, CDH10, NFE2L2 and PTEN.

21 ytes, revealing decreased mRNA expression of NFE2L2 and several NFE2L2 target genes.

22 the transcription factor Nrf2 (also known as Nfe2l2) and its repressor protein Keap1.

23 NF-E2-related factor 2 (NRF2; also called NFE2L2) and related NRF family members regulate antioxid

24 redicted activators (HNF1, HNF4, FOXA, GATA, NFE2L2) and two predicted repressors (GFI1, ZFP161) and

25 itors of phosphoinositide 3-kinase (PI3K) as NFE2L2 antagonists.

26 designated 50 tumor-associated genes as the NFE2L2-associated molecular signature (NAMS).

27 everal transcriptional regulators, including NFE2L2, ATF4, Srebf1 and Rictor were identified as poten

28 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to deoxyribonucleic acid-regulatory sequ

29 EAP1 ubiquitin ligase or its substrate NRF2 (NFE2L2) commonly occur in human cancer, resulting in con

30 and validated for the first time that human NFE2L2 could be targeted by miR153/miR27a/miR142-5p/miR1

31 ation of antioxidant gene expression is also NFE2L2-dependent.

32 e, implicating PGC-1alpha in facilitation of Nfe2l2 DNA binding.

33 Co-transfections with an Nfe2l2 expression vector and a luciferase reporter const

34 8 (PAX8)-nuclear factor, erythroid 2 like 2 (NFE2L2) fusion in thyroid carcinoma.

35 hen developed a risk scoring system based on NFE2L2 gene expression profiling and designated 50 tumor

36 n of a master regulator of cellular defence, NFE2L2, has little effect, suggesting redundancy in the

37 ulator of nuclear factor erythroid 2-like 2 (NFE2L2; hereafter NRF2), which is the master transcripti

38 a novel role for BTG2 as a co-activator for NFE2L2 in up-regulating cellular antioxidant defenses.

39 ncer region provide additional evidence that Nfe2l2 is involved in the regulation of Ucp1 by cAMP-med

40 stress-regulated transcription factor NRF2 (NFE2L2) is a prominent feature of many types of cancer,

41 Transcription factor NRF2, encoded by NFE2L2, is the master regulator of defense against stres

42 The NFE2L2-KEAP1 and MLL pathways are recurrently mutated in

43 Somatic mutations of NFE2L2 leading to NRF2 accumulation promote cell surviva

44 epithelial cells, leading to increased Nrf2 (NFE2L2) levels and subsequent Nrf2-dependent expression

45 We hypothesized that NFE2L2-mediated gene expression would reflect cancer sev

46 d a meta-analysis of microarray data for 240 NFE2L2-mediated genes that were enriched in tumor tissue

47 ndrial antioxidant enzyme expression through Nfe2l2-mediated SOD-2 expression in sepsis.

48 Nfe2l2(-/-) mice compared with WT mice, showed more live

49 Nfe2l2(-/-) mice in sepsis also generated higher hepatic

50 in Nfe2l2-silenced cells and post-sepsis in Nfe2l2(-/-) mice.

51 Moreover, NFE2L2 mutations correlate with the allele status of a n

52 fect on different components of the CUL3 and NFE2L2 (NRF2) pathway was assessed in affected individua

53 ling by the antioxidant transcription factor NFE2L2 (NRF2) through the antioxidant response element i

54 ested the idea that HO-1, acting through the Nfe2l2 (Nrf2) transcription factor, links anti-inflammat

55 ion revealed consensus binding sites for the Nfe2l2 (Nrf2) transcription factor.

56 ha (Hnf4a) and Hnf1a, as well as Nr3c1 (Gr), Nfe2l2 (Nrf2), peroxisome proliferator-activated recepto

57 enic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate pancreatic and lung cancer init

58 Loss of KEAP1, a negative regulator of NFE2L2/NRF2, modulated the response to BRAF, MEK, EGFR,

59 and IL1Ra promoters, which for IL10 included Nfe2l2, nuclear respiratory factor (NRF)-2 (Gabpa), and

60 decreased NRF2 protein levels and sensitized NFE2L2 or KEAP1-mutant cells to radiation.

61 ther the nuclear factor, erythroid 2-like 2 (NFE2L2 or NRF2), which is sensitive to oxidative stress,

62 AD-related genes (C4a/C4b, Cd74, Ctss, Gfap, Nfe2l2, Phyhd1, S100b, Tf, Tgfbr2, and Vim) was increase

63 immunoprecipitation demonstrated diminished Nfe2l2 protein binding to the antioxidant response eleme

64 ntioxidant response element (ARE) of several NFE2L2-responsive genes.

65 In cells, Hmox1 or Nfe2l2 RNA silencing prevented IL-10 and IL-1Ra up-regul

66 wer ventilator-free days (VFDs), and SNPs in NFE2L2 (rs6721961) and NAMPT (rs61330082) were nominally

67 nding factors, we find that TP53, EP300, and NFE2L2 show higher mutational frequencies in Asian patie

68 ation, and HO-1 induction failed post-LPS in Nfe2l2-silenced cells and post-sepsis in Nfe2l2(-/-) mic

69 ), SOX17 and FOXA2 (endometrial cancer), and NFE2L2, SOX2, and TP63 (squamous cell lung cancer).

70 reased mRNA expression of NFE2L2 and several NFE2L2 target genes.

71 w that the ability of BTG2 to associate with NFE2L2, to protect cells against oxidative stress, and t

72 The NRF2 (also known as NFE2L2) transcription factor is a critical regulator of

73 nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) transcription factor resulting from accumulated

74 hnRNP K protein was bound to antioxidant NFE2L2 transcripts encoding Nrf2 antioxidant transcripti

75 These transcripts and Nrf2 (Nfe2l2) were increased by systemic application of tunica

76 es are regulated by the transcription factor Nfe2l2, which is also increased in expression at 3 weeks