ライフサイエンスコーパス: Nieuwkoop

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1 ed Hensen's node and, therefore, acts like a Nieuwkoop Center.

2 essing caps regained their ability to act as Nieuwkoop Centers.

3 Therefore, Wnt is able to induce a bonafide Nieuwkoop Center, while Vg1, Activin and Noggin probably

4 e of the 'transforming' activity proposed by Nieuwkoop in his 'activation and transformation' model f

5 m of the vertebrate gastrula was proposed by Nieuwkoop to be regionalized into forebrain, midbrain, h

6 m of the vertebrate gastrula was proposed by Nieuwkoop to be specified towards an anterior neural fat

7 initiated by the establishment of the dorsal Nieuwkoop blastula organizer, marked by the nuclear accu

8 the organizer is induced by the dorsalizing Nieuwkoop signal, which is secreted by the Nieuwkoop cen

9 Like their oft-used predecessors from Nieuwkoop and Faber, these drawings can be freely downlo

10 marginal zone (PMZ) of the chick embryo has Nieuwkoop centre-like properties: when transplanted to a

11 respond to the embryonic inductive signal in Nieuwkoop recombinants.

12 terizing and mediating an organizer-inducing/Nieuwkoop-center-like activity.

13 in development to reinforce a Wnt-mediated, Nieuwkoop-like signal to induce anterior endoderm, and l

14 obox gene Siamois share the ability to mimic Nieuwkoop organizer signaling activity when ectopically

15 oint of view of the classical experiments of Nieuwkoop that defined an activation and a transformatio

16 We find that vegetal explants, the source of Nieuwkoop signal in recombination assays, express a numb

17 opus development is the mesoderm-forming (or Nieuwkoop) induction, starting three hours after fertili

18 to prove definitively that the YSL possesses Nieuwkoop-center-like activities.

19 represented in the beloved Xenopus resource, Nieuwkoop and Faber's classic Normal Table of Xenopus la

20 In amphibians, the Nieuwkoop center--a primary inducing region--has a centr

21 g Nieuwkoop signal, which is secreted by the Nieuwkoop center.

22 the Spemann organiser, itself induced by the Nieuwkoop centre.

23 tivity of the dorsalizing region, called the Nieuwkoop Center.

24 he Wnt-signaling pathway by establishing the Nieuwkoop center, which in turn leads to specification o

25 that the maternal Wnt pathway generates the Nieuwkoop center in vitro and the organizer in vivo by a

26 in the organizer just as it is needed in the Nieuwkoop center in vitro.

27 To order the steps in the Nieuwkoop Center signaling cascade, we have tested the r

28 We have used these two properties of the Nieuwkoop Center to evaluate the dorsalizing activity of

29 fore gastrulation under the influence of the Nieuwkoop center.

30 ignalling results in the upregulation of the Nieuwkoop centre genes Siamois and Xnr3, and the subsequ

31 rs to define the zebrafish equivalent of the Nieuwkoop centre.

32 These results suggest that formation of the Nieuwkoop organizer is dependent on activation of Siamoi

33 rnal beta-catenin marks the formation of the Nieuwkoop organizer.

34 Nevertheless, the molecular nature of the Nieuwkoop signal remains unclear.

35 astrula organizer specification requires the Nieuwkoop center-like activity mediated by the nieuwkoid

36 Since the Nieuwkoop center and the organizer both produce dorsaliz

37 of inducing the organizer, equivalent to the Nieuwkoop Center of the amphibian embryo, has focused on

38 of the hypoblast is more consistent with the Nieuwkoop model than with the notion of separate organiz

39 g activity, Siamois, is expressed within the Nieuwkoop Center.

40 Among them, Nieuwkoop's activation/transformation hypothesis and Spe

41 orsal and ventral mesoderm in animal-vegetal Nieuwkoop-type recombinants.

42 nd Wnt pathways in a fashion consistent with Nieuwkoop's two-step neural patterning model.

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