ライフサイエンスコーパス: Nocardia

1 lity patterns vary with different species of Nocardia.

2 s; Burkholderia, 1.06 per 100 patient-years; Nocardia, 0.81 per 100 patient-years; Serratia, 0.98 per

3 ess of PCR amplification of a portion of the Nocardia 16S rRNA gene and subsequent restriction endonu

4 tion of N. veterana from the related species Nocardia africana and N. nova because of the very high d

5 r the identification of clinical isolates of Nocardia and for the detection of new or unusual species

6 m the Corynebacterium genus, 1 each from the Nocardia and Rhodococcus genera).

7 hiolactone antibiotic produced by species of Nocardia and Streptomyces, is an inhibitor of the beta-k

8 o the genera Mycobacterium, Corynebacterium, Nocardia and Streptomyces.

9 lowed the recognition of many new species of Nocardia and to date have been the most precise methods

10 d to Staphylococcus, Burkholderia, Serratia, Nocardia, and Aspergillus.

11 order Corynebacterineae (e.g., mycobacteria, nocardia, and rhodococci) share a glycolipid-rich cell w

12 presentative Mycobacterium, Corynebacterium, Nocardia, and Rhodococcus species.

13 tative isolates of the drug pattern types of Nocardia asteroides (except for N. asteroides drug patte

14 Nocardia asteroides accounts for most transplant-related

15 l and included all the isolates belonging to Nocardia asteroides complex antibiogram type IV.

16 dent with the unofficial species designation Nocardia asteroides complex antimicrobial susceptibility

17 or the in vitro susceptibility testing of 26 Nocardia asteroides complex isolates to the following an

18 patterns were seen with Gordona bronchialis, Nocardia asteroides complex type VI, Nocardia otitidisca

19 st clinically significant species within the Nocardia asteroides complex.

20 , DNA-DNA hybridization results confirm that Nocardia asteroides drug pattern type VI, which has long

21 The interactions of Nocardia asteroides GUH-2 with pulmonary epithelial cell

22 The adherence of Nocardia asteroides in the murine brain and lungs was de

23 Nocardia asteroides was isolated after prolonged culture

24 ia thailandica is a rare pathogen related to Nocardia asteroides, Nocardia neocaledoniensis, and Noca

25 xonomic history; this is especially true for Nocardia asteroides, the type species of the genus and p

26 ion of the murine lung by log-phase cells of Nocardia asteroides.

27 subsequent clearance of the infectious agent Nocardia asteroides.

28 irectly test this, mice were inoculated with Nocardia asteroides.

29 ii pneumonia, infection with Cryptococcus or Nocardia, bacterial pneumonia, viral pneumonia, and Kapo

30 Here we describe the first reported case of Nocardia beijingensis infection in the United States, ma

31 r most transplant-related nocardiosis, while Nocardia brasiliensis rarely causes infection in organ t

32 h microdilution testing on single strains of Nocardia brasiliensis, Nocardia cyriacigeorgica, Nocardi

33 a asteroides, Nocardia neocaledoniensis, and Nocardia caishijiensis that, since its original descript

34 Coexpression of Nocardia Car and PPTase in E. coli gave a reductase with

35 bating purified recombinant Car with CoA and Nocardia cell-free extracts indicated that post-translat

36 retrospective molecular screening of recent Nocardia clinical isolates at our New York City medical

37 The type strains of three Nocardia species, Nocardia concava, Nocardia ignorata, and Nocardia yamana

38 Whole cells of Nocardia corallina B-276 catalyse the stereoselective ep

39 Nocardia corallina B-276 possesses a constitutive multi-

40 lkanes) by the alkene-utilizing actinomycete Nocardia corallina B276 was investigated.

41 lase system was purified to homogeneity from Nocardia corallina B276, a bacterium phylogenetically un

42 (AMO) from Rhodococcus rhodochrous (formerly Nocardia corallina) B-276 is a three-component enzyme sy

43 tinomycete Rhodococcus rhodochrous (formerly Nocardia corallina) B276.

44 tients enrolled in the trial, 55 (11%) had a Nocardia corneal ulcer.

45 Nocardia cyriacigeorgica has recently been described as

46 Nocardia cyriacigeorgica is recognized as an emerging pa

47 We describe an outbreak of Nocardia cyriacigeorgica soft-tissue infections attribut

48 on single strains of Nocardia brasiliensis, Nocardia cyriacigeorgica, Nocardia farcinica, Nocardia n

49 ports of sulfonamide failure in treatment of nocardia disease.

50 tion of 2 isolates, Enterococcus faecium and Nocardia exalbida, all the other 725 (99.7%) gram-positi

51 Nocardia farcinica is the most clinically significant sp

52 ochemical and structural characterization of Nocardia farcinica Lys monooxygenase (NbtG), which has s

53 Although Nocardia farcinica surgical site infection outbreaks hav

54 Nocardia farcinica was more frequently associated with b

55 ing the IcmFs from Geobacillus kaustophilus, Nocardia farcinica, and Burkholderia xenovorans.

56 Mycobacterium genomes, Rhodococcus sp. RHA1, Nocardia farcinica, and Saccharopolyspora erythraea.

57 didatus Pelagibacter ubique, actinobacterium Nocardia farcinica, chlorobi species Chloroherpeton thal

58 rdia brasiliensis, Nocardia cyriacigeorgica, Nocardia farcinica, Nocardia nova, and Nocardia wallacei

59 , we report crystal structures of RIFMO from Nocardia farcinica, the determination of the oligomeric

60 oxazole and the lack of quality controls for Nocardia for these agents.

61 ent susceptibilities of clinical isolates of Nocardia from six major laboratories in the United State

62 olates could not be characterized beyond the Nocardia genus level.

63 A gene sequencing and phenotypic analysis as Nocardia higoensis, an opportunistic organism isolated o

64 of three Nocardia species, Nocardia concava, Nocardia ignorata, and Nocardia yamanashiensis, which al

65 introduced as a new environmental species of Nocardia in 2004.

66 GM-CSF production was induced by Nocardia in vitro, suggesting a causative role for anti-

67 this study was to identify risk factors for Nocardia infection after SOT and to describe the present

68 immunocompromised patients with disseminated Nocardia infection, our patient responded favorably to p

69 -dose cotrimoxazole was not found to prevent Nocardia infection.

70 wise unexplained disseminated/extrapulmonary Nocardia infections, anti-GM-CSF autoantibodies should b

71 atment with trimethoprim-sulfamethoxazole in Nocardia infections.

72 ermediates, a carboxylic acid reductase from Nocardia iowensis and an alcohol dehydrogenase from Leif

73 bility testing (AST) of clinical isolates of Nocardia is recommended to detect resistance to commonly

74 The gold standard result for each Nocardia isolate was established by a consensus of the r

75 all antimicrobial agents tested against all Nocardia isolates by all methods, the BACTEC radiometric

76 describe here a novel method for identifying Nocardia isolates by using sequence analysis of a portio

77 atories have allowed us to define a group of Nocardia isolates from clinical samples which resemble t

78 and precise method for the identification of Nocardia isolates than 16S rRNA gene sequencing.

79 Nocardia isolates that share the property of in vitro am

80 the importance of accurate identification of Nocardia isolates to the species level by integrated use

81 No single method could identify all Nocardia isolates to the species level; therefore, a com

82 16S rRNA gene sequences of 102 Nocardia isolates were analyzed using the Integrated Dat

83 A standardized study protocol, 150 Nocardia isolates, and NIH and OSU Nocardia MALDI-TOF MS

84 Patients with non-Nocardia keratitis and those having no topical antibioti

85 performed for subgroups of patients with non-Nocardia keratitis and those with no topical antibiotic

86 r 299 cultures submitted to the Mycobacteria/Nocardia Laboratory at the University of Texas Health Ce

87 Reference Laboratories and the Mycobacteria/Nocardia Laboratory at the University of Texas Health Sc

88 ation, and score interpretation, using three Nocardia libraries, the Bruker, National Institutes of H

89 Oerskovia spp. are gram-positive, Nocardia-like bacilli which inhabit the soil and rarely

90 ocol, 150 Nocardia isolates, and NIH and OSU Nocardia MALDI-TOF MS libraries were distributed to thre

91 Finally, supplementation of the Bruker Nocardia MALDI-TOF MS library with both the OSU and NIH

92 and may coexist with bacterial (Legionella, Nocardia), mycobacterial, and fungal (Aspergillus, Histo

93 Cells of the Corynebacterium-Nocardia-Mycobacterium group of bacteria are surrounded

94 Nocardia neocaledoniensis was introduced as a new enviro

95 are pathogen related to Nocardia asteroides, Nocardia neocaledoniensis, and Nocardia caishijiensis th

96 nocompromised patients were characterized as Nocardia nova by biochemical and susceptibility testing

97 device infection and bacteremia caused by a Nocardia nova complex isolate.

98 Moreover, for all Nocardia nova isolates tested, ampicillin susceptibility

99 We describe the first case of Nocardia nova spondylodiscitis accompanied by a psoas ab

100 ttern was identical to that obtained for the Nocardia nova type strain.

101 A variant RFLP pattern for Nocardia nova was also observed.

102 Patterns typical of Nocardia nova were obtained with REA of an amplified por

103 ocardia cyriacigeorgica, Nocardia farcinica, Nocardia nova, and Nocardia wallacei.

104 ulcers that were central, deep or large, non-Nocardia, or classically invasive Pseudomonas aeruginosa

105 NotI from Nocardia otitidis-caviarum (recognition sequence 5'-GCGG

106 hialis, Nocardia asteroides complex type VI, Nocardia otitidiscaviarum, Nocardia transvalensis, and S

107 Molecular investigation of two Nocardia patient isolates showed unusual restriction fra

108 Nocardia phosphopantetheine transferase (PPTase) express

109 When incubated with [(3)H]acetyl-CoA and Nocardia PPTase, the labeled acetylphosphopantetheine mo

110 ncreasing in vitro sulfonamide resistance in Nocardia prompted us to investigate the findings.

111 A total of 85 strains of Nocardia representing five species were used in the stud

112 Of the nocardioforms examined, Nocardia, Rhodococcus, and Mycobacteria spp. all produce

113 , natural products isolated from a strain of Nocardia, showed growth inhibition against three human t

114 The protein sequence of the Nocardia sp NAD(P)-dependent cholesterol dehydrogenase r

115 n = 3), Mycobacterium avium complex (n = 2), Nocardia sp. (n = 1), Aspergillus sp. (n = 1), or pulmon

116 lator that was originally misidentified as a Nocardia sp. due, in part, to its partially acid-fast st

117 y 50-fold lower than that of purified native Nocardia sp. enzyme.

118 An aryl aldehyde oxidoreductase from Nocardia sp. strain NRRL 5646 was purified 196-fold by a

119 polymorphism (RFLP) patterns were found for Nocardia sp. type strains (except for the N. asteroides

120 sed as a quality control organism for AST of Nocardia sp., and the use of a disk diffusion test for s

121 udomonas aeruginosa (109 cases [22.7%]), and Nocardia species (55 cases [11.5%]).

122 hniques for the identification of pathogenic Nocardia species and for the recognition of novel specie

123 Nocardia species are a complex group of organisms consid

124 orithms for the phenotypic identification of Nocardia species are limited in practice, the true preva

125 All isolates were identified as Nocardia species by the use of standard methods.

126 Nocardia species cause infections in both immunocompromi

127 A study was performed to evaluate Nocardia species identification obtained by partial 16S

128 Infection with Nocardia species is an increasingly recognized complicat

129 evaluation of 297 mycobacteria isolates, 148 Nocardia species isolates, and 61 other aerobic actinomy

130 as sequenced from 40 clinical isolates of 12 Nocardia species previously identified by 16S rRNA gene

131 Molecular methods for identification of Nocardia species provide more accurate and rapid results

132 ight mass spectrometry for identification of Nocardia species remains challenging.

133 Sequencing of Nocardia species revealed that members of the group were

134 to devise a method for the identification of Nocardia species that is more technically simple, accura

135 ble with identification of Mycobacterium and Nocardia species using matrix-assisted laser desorption

136 ecA1 gene of 30 type or reference strains of Nocardia species was amplified using secA1-specific prim

137 Molecular diagnosis of Nocardia species was performed using multilocus sequence

138 1 patient had a positive result by culture (Nocardia species) but negative result by qPCR.

139 162 Mycobacterium species and subspecies, 53 Nocardia species, and 13 genera (totaling 43 species) of

140 lococcus aureus, certain gram-negative rods, Nocardia species, and fungi.

141 g isolates, including Mycobacterium species, Nocardia species, and other aerobic actinomycetes) showe

142 The type strains of three Nocardia species, Nocardia concava, Nocardia ignorata, a

143 olates encompassing the 8 medically relevant Nocardia species.

144 bcutaneous tissue infections than were other Nocardia species.

145 biotic susceptibility of clinically isolated Nocardia species.

146 es in bacterial corneal ulcers not caused by Nocardia species.

147 g thiolactomycin (TLM), which is produced by Nocardia spp.

148 eproducible method for the identification of Nocardia spp.

149 rapid identification of clinically relevant Nocardia spp. and to implement MALDI-TOF MS libraries de

150 Nocardia spp. are common environmental organisms that, t

151 n many species and that many taxa within the Nocardia spp. are unnamed at present.

152 y for the identification of mycobacteria and Nocardia spp. has also been reported in a limited scope.

153 cal workup of pericardial fluid for possible Nocardia spp. is described in an effort to improve the t

154 This multicenter study analyzed Nocardia spp., including extraction, spectral acquisitio

155 equence typing sequence data for determining Nocardia strain relatedness in an outbreak.

156 ative role for anti-GM-CSF autoantibodies in Nocardia susceptibility and dissemination.

157 including a wound culture that contained two Nocardia taxa that were indistinguishable morphologicall

158 lates that distinguished them from all other Nocardia taxa, but did not differentiate the four taxa w

159 vely, and differentiated them from all other Nocardia taxa.

160 rt a case of pulmonary nocardiosis caused by Nocardia thailandica in a 66-year-old solid organ transp

161 Nocardia thailandica is a rare pathogen related to Nocar

162 Five clinical isolates of Nocardia that showed ambiguous bases within the variable

163 olymorphism (RFLP) identification schema for Nocardia that used an amplified 439-bp segment (amplicon

164 rRNA gene sequences of different species of Nocardia, those laboratories employing molecular methods

165 Identification of clinical isolates of Nocardia to the species level is important for defining

166 Identification of Nocardia to the species level is useful for predicting a

167 are grouped together by some authors in the Nocardia transvalensis complex.

168 complex type VI, Nocardia otitidiscaviarum, Nocardia transvalensis, and Streptomyces spp.

169 However, the sequences of Nocardia transvalensis, N. otitidiscaviarum, and N. nova

170 ythritol and ribitol and were grouped within Nocardia transvalensis.

171 A regression model including a Nocardia-treatment arm interaction found corticosteroid

172 dentified by treatment for scar size for non-Nocardia ulcers (-0.06 mm, 95% CI, -0.21 to 0.10, P = .4

173 n BSCVA at 12 months among patients with non-Nocardia ulcers (-0.10 logMAR, 95% CI, -0.19 to -0.02, P

174 ifference was observed in 12-month BSCVA for Nocardia ulcers (0.18 logMAR, 95% CI, -0.04 to 0.41, P =

175 provement in visual acuity compared with non-Nocardia ulcers (0.21 logarithm of the minimal angle of

176 ith larger mean scar size at 12 months among Nocardia ulcers (0.47 mm, 95% CI, 0.06-0.88, P = .02) an

177 presentation visual acuity compared with non-Nocardia ulcers (median Snellen visual acuity, 20/45, co

178 Nocardia ulcers had approximately 2 lines less of improv

179 Patients with Nocardia ulcers had better presentation visual acuity co

180 Nocardia ulcers responded well to treatment.

181 verall improvement in visual acuity than non-Nocardia ulcers, but had better presentation acuity.

182 In Nocardia ulcers, corticosteroids were associated with an

183 tter starting visual acuity in patients with Nocardia ulcers.

184 transferase was cloned from a sublibrary of Nocardia uniformis DNA.

185 c gene cluster for the nocardicin A producer Nocardia uniformis subsp. tsuyamanensis ATCC 21806 was r

186 tam antibiotics produced by the actinomycete Nocardia uniformis subsp. tsuyamanensis ATCC 21806.

187 c beta-lactam isolated from the actinomycete Nocardia uniformis that shows moderate antibiotic activi

188 c beta-lactam isolated from the actinomycete Nocardia uniformis, which shows moderate activity agains

189 Nocardia veterana is a newly described species named aft

190 al samples which resemble the type strain of Nocardia veterana.

191 characteristics of the proposed new species Nocardia wallacei (N. asteroides drug pattern IV) and N.

192 gica, Nocardia farcinica, Nocardia nova, and Nocardia wallacei.

193 GM-CSF-mediated cellular activation by Nocardia was assessed by staining for intracellular cyto

194 Nocardia was cultured from all affected sites.

195 Linezolid also covers Nocardia well and could be a second line agent.

196 s, Gordonia, and Tsukamurella and 10 taxa of Nocardia were studied.

197 rovide background on the current taxonomy of Nocardia, with a focus on clinically relevant species, a

198 es, Nocardia concava, Nocardia ignorata, and Nocardia yamanashiensis, which also showed ambiguous bas