ライフサイエンスコーパス: Nudix hydrolase

1 n reading frame (ylgG) specifying a putative Nudix hydrolase.

2 ties that were not consistent with the known Nudix hydrolases.

3 and suggest a common catalytic mechanism for Nudix hydrolases.

4 mary structure, unique among all other known Nudix hydrolases.

5 unctional, and evolutionary relationships to Nudix hydrolases.

6 Arabidopsis nudix hydrolase 7 (AtNudt7) plays an important role in r

7 Nudix hydrolases act upon a wide variety of substrates,

8 and the purified protein was identified as a Nudix hydrolase active on FAD, adenosine 5'-triphospho-5

9 was a CDP-choline pyrophosphatase, the first Nudix hydrolase active on this substrate.

10 rified and shown to belong to a subfamily of Nudix hydrolases active on ADP-ribose.

11 y characteristic of a family of enzymes, the Nudix hydrolases, active on a variety of nucleoside diph

12 n to be associated with skin infections, the Nudix hydrolase and its associated genes may have a role

13 island-like emm region that included a novel Nudix hydrolase, and, further, this cluster appears to b

14 ther, contain a mutT motif characteristic of nudix hydrolases, and are conserved in all sequenced pox

15 This gene, nudA, encoded for a Nudix hydrolase based on the inferred protein sequence.

16 sent the only virus family shown to encode a Nudix hydrolase-decapping enzyme.

17 mined the crystal structure, at 1.4A, of the Nudix hydrolase DR1025 from the extremely radiation resi

18 four structural superfamilies: MutT-related (Nudix) hydrolases, dUTPase, ITPase (Maf/HAM1) and all-al

19 scribe two alternatives to SVP-the bacterial Nudix hydrolase EcRppH and human HsNudT16.

20 Nudix hydrolases eliminate potentially hazardous materia

21 ide triphosphate pyrophophohydrolases of the Nudix hydrolase family discovered thus far, Orf135 is hi

22 orf186, a new member of the Nudix hydrolase family of genes, has been cloned and exp

23 otection step is catalyzed by members of the Nudix hydrolase family.

24 acterized enzymes, possibly belonging to the NUDIX hydrolase family.

25 The Nudix hydrolase GDP-mannose mannosyl hydrolase (Gmm) con

26 This is the first member of the Nudix hydrolase gene superfamily identified in bacterial

27 All 21 of the Nudix hydrolase genes from the radiation-resistant organ

28 The genome of Bacillus cereus contains 26 Nudix hydrolase genes, second only to its closest relati

29 Four Nudix hydrolase genes, ysa1 from Saccharomyces cerevisia

30 th Mg2+, Zn2+, or Mn2+ and, like most of the Nudix hydrolases, has an alkaline pH optimum between 8.5

31 MutT proteins, belonging to a class of Nudix hydrolases, hydrolyze 8-oxo-G nucleoside triphosph

32 This is the first Nudix hydrolase identified from the Archaea, indicating

33 A new subfamily of the Nudix hydrolases, identified by conserved amino acids up

34 pporting the notion that the function of the Nudix hydrolases is to monitor the concentrations of rea

35 Aps1 is the first nudix hydrolase isolated from S. pombe, and it is the fi

36 each subunit comprised of the ligand-binding Nudix hydrolase-like domain and the DNA-binding winged-h

37 des a decapping protein (ASFV-DP) that has a Nudix hydrolase motif and decapping activity in vitro He

38 decapping activity of D10 is dependent on a Nudix hydrolase motif that is also present in the VACV D

39 SFV) g5R gene encodes a protein containing a Nudix hydrolase motif which in terms of sequence appears

40 vity was abolished by point mutations in the Nudix hydrolase motif.

41 cterization of a human cDNA encoding a novel nudix hydrolase NUDT5 for the hydrolysis of ADP-sugars.

42 In addition to representatives of known Nudix hydrolase subfamilies active on ADP-ribose, NADH,

43 ocida encodes PnhA, which is a member of the Nudix hydrolase subfamily of dinucleoside oligophosphate

44 omogeneity and identified as a member of the Nudix hydrolase subfamily of dinucleoside oligophosphate

45 eness of a human pathogen as a member of the Nudix hydrolase subfamily of dinucleoside oligophosphate

46 ly been identified to encode a member of the Nudix hydrolase subfamily which acts specifically on din

47 oxynucleoside triphosphates or other typical Nudix hydrolase substrates, required a physiological lev

48 udA had hydrolytic activity typical of other Nudix hydrolases, such as Escherichia coli YgdP, in that

49 t Orf1.9 (wcaH) is a bona fide member of the Nudix hydrolase superfamily is discussed.

50 k we have identified a new sub-family of the Nudix hydrolase superfamily recognizable by a specific a

51 e ytkD of Bacillus subtilis, a member of the Nudix hydrolase superfamily, has been cloned and express

52 A pyrophosphohydrolase RppH, a member of the Nudix hydrolase superfamily, triggers this degradation p

53 active at alkaline pH, characteristic of the Nudix hydrolase superfamily.

54 Schizosaccharomyces pombe Aps1 is a nudix hydrolase that catalyzes the hydrolysis of both di

55 hosphatase NUDT9 belongs to a superfamily of Nudix hydrolases that catabolize potentially toxic compo

56 Like other Nudix hydrolases, the enzyme cleaves its substrates to p

57 Typical of members of the Nudix hydrolases, the enzyme has an alkaline pH optimum

58 To elucidate interdependence among the NUDIX hydrolases, we pairwise deplete them generating an

59 l-molecule kinases and IDI is similar to the nudix hydrolases, which act on nucleotide diphosphatecon

60 U" (where U is usually Leu, Val, or Ile) are Nudix hydrolases, which catalyze the hydrolysis of a var

61 sional structure of DR-CoAse, the first of a Nudix hydrolase with this specificity, reveals that this

62 on chromosome I that encodes a hypothetical nudix hydrolase, YA9E.

63 tion of sirtuins and can be modulated by the Nudix hydrolase Ysa1.