ライフサイエンスコーパス: O-antigen

1 an LPS core oligosaccharide plus one unit of O antigen).

2 needed for the biosynthesis of the core and O-antigen).

3 -Ss, which stably expresses S. sonnei form I O antigen.

4 mposed of lipid A, core oligosaccharide, and O antigen.

5 of E. coli K-12 strain MG1655 to express the O antigen.

6 d by vaccine strains containing a homologous O antigen.

7 g to the waaL mutant, despite the absence of O antigen.

8 smooth-rough synthesis of lipopolysaccharide O antigen.

9 illing produce lipopolysaccharide containing O-antigen.

10 f the LPS; thus, LPS from waaL mutants lacks O-antigen.

11 pCZ1) efficiently expressed the heterologous O-antigen.

12 mutant expresses only one repeating unit of O-antigen.

13 flagellar expression, and a band for the LPS O-antigen.

14 id A domain to the core oliogosaccharide and O-antigen.

15 sults in the loss of only a band for the LPS O-antigen.

16 articipate in the synthesis of the bacterial O-antigen.

17 -linked glycoproteins and lipopolysaccharide O-antigen.

18 T16 (pCZ1) mainly expressed the heterologous O-antigen.

19 , since a gtr(BTP) (1) mutant yields a short O-antigen.

20 lity of sera to kill strains with long-chain O-antigen.

21 for forming the repeat unit domains of these O-antigens.

22 , a truncated core LPS mutant with an intact O antigen, a capsule mutant, and a poly-N-acetylglucosam

23 The O antigen, a component of the surface lipopolysaccharide

24 pertussis, but not B. pertussis, produces an O antigen, a factor shown in other models to confer seru

25 particular of the O-acetylation state of the O-antigen, a factor that can play an important role in v

26 es that occur, on average, once per complete O antigen: a multiply O-methylated terminal fucose and 2

27 polymerase mutants) the low molecular weight O-antigen accumulates in the periplasm of the mutant.

28 ults showed that in the absence of opsonins, O antigen allows B. parapertussis to inhibit phagolysoso

29 synthesis, abolished the linkage of both the O antigen and APS to the lipid A core of O-LPS and A-LPS

30 s elicited a strong antibody response to the O antigen and conferred efficient protection against a s

31 In the absence of RfaH, O antigen and core sugars were not synthesized.

32 ella enterica serovar Typhimurium, including O antigen and lipopolysaccharide core sugars.

33 body bound predominantly monovalently to the O antigen and reduced bacterial growth without causing c

34 arental or other strains, the biofilm of the O antigen and the PGA mutants was dramatically reduced,

35 P. gingivalis has dual specificity for both O-antigen and APS repeating units.

36 type Schu S4 and exhibited marked defects in O-antigen and capsular polysaccharide biosynthesis.

37 A2 or FTT1236/FTL0708-genes required for LPS O-antigen and capsule biosynthesis.

38 d transport also prevented the expression of O-antigen and conferred resistance to HGG1.

39 PF4 bound strongest to mutants lacking the O-antigen and core structure of LPS, but still exposing

40 esized different glycoconjugates, by linking O-antigen and core sugars (OAg) of LPS to the nontoxic m

41 have been elucidated, the effect of removing O-antigen and core sugars on the virulence and immunogen

42 l cell envelope components, such as capsule, O-antigen and lipid A, are often essential for the succe

43 The structure of the O-antigen and the core components of the LPS and their p

44 nctional assays suggest that the hydrophilic O-antigen and the core oligosaccharide of the LPS may pa

45 nsferase involved in the biosynthesis of the O-antigen) and ManBcoreproteins (phosphomannomutase invo

46 type IV secretion system, a perosamine-based O antigen, and systems for sequestering metal ions that

47 o include trimeric autotransporter adhesins, O antigens, and type IV pili (T4P).

48 s, due to a defect in the lipopolysaccharide O-antigen, and identify a mutation associated with this

49 Thus, molecules other than O antigen are important in triggering dramatic pseudopod

50 As the core and O-antigen are added, per-lipid area increases and lipid

51 igenically variable lipopolysaccharide (LPS) O antigens as a primary effector.

52 ommon antigen (A band) and the heteropolymer O antigen (B band), which impart serospecificity.

53 nization with an isogenic mutant lacking the O antigen, B. parapertussis Deltawbm, induced antibodies

54 1 bond resulted in significantly higher anti O-antigen bactericidal antibody titers than coupling to

55 assessing responses to vaccines, especially O-antigen-based vaccines, and that the Salmonellagtr rep

56 s S. boydii due to nonfunctional S. flexneri O antigen biosynthesis genes.

57 E. coli harboring the R. terrigena O-antigen biosynthesis genes produced an O-antigen displ

58 In this model, O-antigen biosynthesis is initiated with the addition of

59 , which is required for flagellin glycan and O-antigen biosynthesis, was essential for bacterial viab

60 es because of its roles in peptidoglycan and O-antigen biosynthesis.

61 n glycosylation and lipopolysaccharide (LPS) O-antigen biosynthesis.

62 sis a gene from the lipopolysaccharide (LPS) O-antigen biosynthetic cluster which is involved in flag

63 -antigen polymerase, which is located in the O-antigen biosynthetic locus of Francisella tularensis.

64 These included genes encoding the O-antigen biosynthetic pathway, an intact Type 1 Secreti

65 arming by promoting wettability, the loss of O antigen blocks a regulatory pathway that links surface

66 ies, which were directed not only to the LPS O antigens but also to the LPS core and surface proteins

67 lipopolysaccharide (LPS), which contains the O antigen, but not B. parapertussis Deltawbm LPS drastic

68 wzz, encoding a chain length determinant for O antigen, but not by a mutation in wzyE, encoding an en

69 rain HS206 did not bind substantially to A/B/O antigens by synthetic HBGA binding, hemagglutination,

70 The composition of the O-antigen can be modified by the activity of glycosyltra

71 isaccharide fragments of the polysialic acid O-antigen capsular polysaccharide (CPS) of Neisseria men

72 Our experiments indicate that the Salmonella O-antigen capsule (yihU-yshA and yihV-yihW) is a crucial

73 Thus, the O-antigen capsule genes are bile induced, and the capsul

74 assembly of group 4 polysaccharide capsule (O-antigen capsule).

75 owth in bile resulted in upregulation of the O-antigen capsule-encoding operon in an agfD-independent

76 haride biosynthesis and that the Francisella O antigen, capsule, or both are important for avoiding t

77 ore oligosaccharide branch not linked to the O-antigen causing an increase in overall negative charge

78 e production of preferred lipopolysaccharide O antigen chain lengths is important for the survival of

79 ich encodes the protein that determines long O-antigen chain length and confers resistance to complem

80 lation of 4-aminoarabinose incorporation and O-antigen chain length to respond against the host defen

81 their products are required to determine the O-antigen chain length.

82 ture (OpvAB(OFF)) and a lineage with shorter O-antigen chains (OpvAB(ON)).

83 endorhamnosidase domain and thus may mediate O-antigen cleavage.

84 Another O-antigen cluster gene, rmlB, which is required for flag

85 utants with disruptions in specific ddhD-wzz O-antigen cluster genes produced LPS that was indistingu

86 by itself and other phage that uses the same O-antigen co-receptor.

87 detect and characterize an evolution of the O-antigen composition, in particular of the O-acetylatio

88 The O-antigen concentration of mixed LPS bilayers does not h

89 PS0/10 bilayer simulations show that the LPS O-antigen conformations at a higher concentration of LPS

90 Clinical proof of concept of a 4-valent O antigen conjugate vaccine is ongoing.

91 n technology it is expected that multivalent O antigen conjugate vaccines can be produced at industri

92 s not displaying a polysaccharide capsule or O-antigen-containing lipopolysaccharide, a trait commonl

93 urine model of infection, we determined that O antigen contributes to the ability of B. parapertussis

94 ntly reported the development of a candidate O-antigen-CRM197 glycoconjugate vaccine against S. Typhi

95 In conclusion, an O-antigen-CRM197 glycoconjugate vaccine can induce O-ant

96 train RB50 (O1), 1289 (O2), or RB50Deltawbm (O antigen deficient), our data indicate that these O ant

97 d-type B. parapertussis bacteria but not the O antigen-deficient mutants were found colocalizing with

98 Interestingly, an O antigen-deficient strain of B. parapertussis was not d

99 Opsonization of O-antigen-deficient LVS in serum lacking terminal comple

100 Unlike parental bacteria, O-antigen-deficient LVS is efficiently killed by serum w

101 that infection by this strain may not be A/B/O antigen dependent or that in vitro binding patterns do

102 agolysosomal maturation in a lipid raft- and O antigen-dependent manner.

103 y surface plasmon resonance, but the lack of O antigen did not abolish these interactions.

104 ena O-antigen biosynthesis genes produced an O-antigen displaying reduced reactivity toward antisera

105 gen deficient), our data indicate that these O antigens do not confer cross-protection in vivo.

106 These data indicate that O antigen enables B. parapertussis to efficiently coloni

107 Despite carrying the O-antigen essential inB. melitensisvirulence, the core d

108 ed in loss of several genetic traits such as O antigen expression.

109 plementation of these rough mutants returned O-antigen expression and susceptibility to amoebae.

110 Our study demonstrates that heterologous O-antigen expression is a promising strategy for the dev

111 ationic antimicrobial peptide resistance and O-antigen expression.

112 A quadrivalent vaccine with O antigens from S. sonnei, S. flexneri 2a, S. flexneri 3

113 h the recombinant expression of heterologous O-antigens from Salmonella Choleraesuis in Salmonella Ty

114 We recombineered the S. sonnei form I O-antigen gene cluster into the Ty21a chromosome to crea

115 pCZ1 with the cloned Salmonella Choleraesuis O-antigen gene cluster was introduced into three constru

116 Transcription of genes in the ddhD-wzz O-antigen gene cluster, but not core oligosaccharide gen

117 l, attachment invasion locus gene, and rfbC, O-antigen gene, was increased.

118 se systems coexpressed with S. sonnei form I O-antigen gene.

119 Within the known O-antigen genetic clusters of this strain, nine open rea

120 hanistic barriers for bacteriophage-mediated O-antigen glucosylation in ABC transporter-dependent pat

121 modify the structures of lipopolysaccharide O-antigen glycans, altering the structure of the bacteri

122 Including the O-antigen greatly reduces the flexibility of the OprH lo

123 The structure of the O antigen has been determined, but the roles of specific

124 e products involved in synthesis of core and O-antigen have been elucidated, the effect of removing O

125 tial virulence genes for the biosynthesis of O antigens, hemolysins, and exonucleases as well as othe

126 orresponding to three repeating units of the O-antigen in complex with Sf6TSP were studied computatio

127 Salmonella regulates the proportion of long O-antigen in its LPS to respond to the different conditi

128 units of ECA at the position occupied by the O-antigen in the case of smooth S. sonnei phase I.

129 a decrease in LPS content and defects in the O-antigen incorporation.

130 Additionally, we establish that long O-antigen inhibits growth in bile only in the presence o

131 These data suggest that the O antigen is a critical protective antigen of B. paraper

132 The Rhizobium etli CE3 O antigen is a fixed-length heteropolymer with O methyla

133 The Rhizobium etli CE3 O antigen is a fixed-length heteropolymer.

134 Since the O antigen is a protective antigen for many pathogenic ba

135 ns of many phenotypes and the density of the O antigen is critical for the observed phenotypes.

136 Thus, preventing the production of O-antigen is a pathway for producing resistance to grazi

137 The E coli O-antigen is a promising vaccine target.

138 LVS DeltacapB retains the immunoprotective O antigen, is serum resistant, and is outgrown by parent

139 haride (LPS), composed of lipid A, core, and O-antigen, is a major virulence factor of Salmonella ent

140 gG, although not required for binding to the O-antigen, is required for motility inhibition.

141 ive strains lack both capsule production and O-antigen laddering.

142 ce of a terminal decoration severely affects O-antigen length and transport.

143 GtrC(BTP) (1) is essential for maintaining O-antigen length in isolate D23580, since a gtr(BTP) (1)

144 xamining the role of regulated variations in O-antigen length in the lipopolysaccharide (LPS), a glyc

145 of these decorations is required for normal O-antigen length, transport, or assembly into the final

146 Finally, expression of O-antigen Lewis X and Y epitopes, known to mimic glycoco

147 e recently demonstrated that deletion of the O antigen ligase gene, waaL, from the uropathogenic E. c

148 Inactivation of a putative O-antigen ligase (waaL) at PG1051, which is required for

149 identified a point-mutation in the gene for O-antigen ligase (WaaL) in Escherichia coli that causes

150 (ABC) sugar transport protein (wzt), and the O-antigen ligase (waaL).

151 lysaccharide (LPS) structure by deleting the O-antigen ligase gene (waaL) enhanced proinflammatory cy

152 In these studies, an O-antigen ligase mutant, waaL, was utilized to determine

153 nsposon insertion in the waaL gene, encoding O-antigen ligase, blocked swarming motility on solid sur

154 ted a transposon insertion in waaL, encoding O-antigen ligase, that resulted in a loss of swarming bu

155 ve acetyltransferase gene located within the O-antigen lipopolysaccharide cluster.

156 ylogenetic tree, which revealed that the two O-antigen loci did not associate with a particular linea

157 e data are consistent with the idea that the O-antigen loci of B. bronchiseptica are horizontally tra

158 ntaining either the classical or alternative O-antigen locus, respectively.

159 Well-characterized mutants were used: an O-antigen LPS mutant, a truncated core LPS mutant with a

160 virulence genes, including hrpD6, hpaF, the O-antigen LPS synthesis gene rfbC, and the catalase gene

161 ydrate of the P. aeruginosa PAO1 (O5) B-band O-antigen, ManNAc(3NAc)A, has been shown to be critical

162 Therefore, although O antigen may serve a role in swarming by promoting wett

163 The glucosylated form of the O-antigen mediated enhanced survival in human serum and

164 Strikingly, WarA influences P. aeruginosa O antigen modal distribution and interacts with the LPS

165 mine whether structural changes underlie the O-antigen modal length specification, we have determined

166 O-antigen modification was dependent on a functional ABC

167 prophage encodes a gtrC gene, implicated in O-antigen modification.

168 Our results emphasize that natural O-antigen modifications should be taken into considerati

169 In murine immunization studies, both O-antigen modifications were generally immunodominant.

170 R, and cpxA mRNA in the biofilm cells of the O-antigen mutant compared to that in the biofilm cells o

171 n capsular mutants and to a lesser degree in O-antigen mutants.

172 and in vivo protection against strains with O antigens not expressed by the vaccine strains, whereas

173 polymeric IgA antibody directed against the O antigen (O-Ag) of Salmonella enterica serovar Typhimur

174 Such capsules are known as O-antigen (O-Ag) capsules, due to their high degree of s

175 t binds an immunodominant epitope within the O-antigen (O-Ag) component of lipopolysaccharide.

176 glycosyltransferase with a single subunit of O-antigen (O-ag).

177 ternal repeat units of the O-polysaccharide [O-antigen (OAg)] of Ft LPS.

178 ation patterns associated with Bp and Bm LPS O-antigens (OAgs).

179 results indicate that binding of IgG to the O antigen of C. turicensis causes a direct antimicrobial

180 lin A (SIgA) antibodies directed against the O antigen of lipopolysaccharide (LPS) are the primary de

181 nd wbtI genes essential for synthesis of the O antigen of lipopolysaccharide.

182 rious secondary metabolites as well as K and O antigens of bacterial lipopolysaccharide.

183 hemical synthesis of the complete protective O-antigen of a human-disease-causing pathogenic bacteriu

184 The O-antigen of Salmonella lipopolysaccharide is a major an

185 flagellum filament, to be present in the LPS O-antigen of the A. caviae wild-type strain, and to be a

186 The short O-antigen of the gtr(BTP) (1) mutant was also compensate

187 dy nanovalve with a tetrasaccharide from the O-antigen of the lipopolysaccharide (LPS) of Francisella

188 The B-band O-antigen of the lipopolysaccharide found in the opportu

189 bits motility by specifically binding to the O-antigen of V. cholerae We demonstrate that the bivalen

190 It and similar deoxysugars are added to the O-antigens of bacteria via the action of glycosyltransfe

191 ity of a bioconjugate vaccine containing the O-antigens of four E coli serotypes (ExPEC4V).

192 is an unusual deoxyamino sugar found in the O-antigens of some Gram-negative bacteria and in the S-l

193 d-perosamine are unusual sugars found in the O-antigens of some Gram-negative bacteria such as Escher

194 - d-mannose is an unusual sugar found in the O-antigens of some Gram-negative bacteria such as Vibrio

195 mine is an unusual dideoxysugar found in the O-antigens of some Gram-negative bacteria, including the

196 s one of several dideoxy sugars found in the O-antigens of such infamous Gram-negative bacteria as Vi

197 Full chemical analysis of the O-antigens of these strains identified gtr-dependent glu

198 NAc is an unusual dideoxy sugar found in the O-antigens of various Gram-negative bacteria and in the

199 ical study, we follow the composition of the O-antigen on the outer bacterial membrane with high-reso

200 The WaaL-mediated ligation of O-antigen onto the core region of the lipid A-core block

201 Wild-type and O-antigen or capsular mutants of K. pneumoniae were grow

202 gene, which controls production of very long O-antigen, or other PmrA-activated genes that mediate mo

203 mination with extracellular polysaccharides, O-antigen, or storage compounds.

204 Thus, the O antigen plays a role in the morphology of uptake in th

205 t demonstrated that (as is characteristic of O-antigen polymerase mutants) the low molecular weight O

206 The O-antigen polymerase of gram-negative bacteria has been

207 ssessment) strongly suggested that Wzy is an O-antigen polymerase whose function is to catalyze the a

208 A wzy (O-antigen polymerase) deletion mutant of Ft. live attenu

209 (Wzy) of the gene annotated as the putative O-antigen polymerase, which is located in the O-antigen

210 The surface O-antigen polymers of gram-negative bacteria exhibit a m

211 enuation in its ability to produce very long O-antigen polymers.

212 The O-antigen polysaccharide (O-PS) component of lipopolysac

213 The Escherichia coli serotype O9a O-antigen polysaccharide (O-PS) is a model for glycan bi

214 of lipid A, core oligosaccharide (C-OS), and O-antigen polysaccharide (O-PS).

215 non-repeating core oligosaccharide, and the O-antigen polysaccharide is the most exposed component o

216 n and is modified with sugars mediated by an O-antigen polysaccharide ligase (WaaL) that is associate

217 and hydrolyzes the high-rhamnose, serotype Y O-antigen polysaccharide of the Gram-negative bacterium

218 cross-relaxation rates are obtained from an O-antigen polysaccharide sample.

219 is revealed a 19-gene locus, involved in LPS O-antigen polysaccharide synthesis and conserved among m

220 pid A insertion and core oligosaccharide and O-antigen polysaccharide translocation, respectively.

221 regions: lipid A, core oligosaccharide, and O-antigen polysaccharide.

222 inner core oligosaccharide, and a repeating O-antigen polysaccharide.

223 ructures, only one, the antibody against the O-antigen polysaccharides, showed a relatively efficient

224 Raoultella terrigena ATCC 33257 produces an O-antigen possessing the same disaccharide motif, but it

225 O antigen prevented both complement component C3 deposit

226 study the glucosylation potential of a model O-antigen produced in an ATP-binding cassette (ABC) tran

227 Importantly, O antigen production enables laboratory strains of E. co

228 We demonstrate that O antigen production results in drastic alterations of m

229 e demonstrate that the temperature-sensitive O-antigen production defect in 2192 is due to a mutation

230 time that a temperature-sensitive defect in O-antigen production has been reported.

231 Although O-antigen production is cryptic in Escherichia coli K-12

232 d strains that are disrupted for capsule and O-antigen production.

233 (1) mediates modification of the BTP1 phage O-antigen receptor in lysogenic D23580, and thereby prev

234 In conclusion, the absence of the O antigen reduces the ability of A. pleuropneumoniae to

235 is important for the formation of the short O-antigen region.

236 a mixture of long and very long polymers of O antigen, regulated by two different genes.

237 al Escherichia coli lipopolysaccharide (LPS) O antigen regulator WbdD.

238 showed that the V. fischeri LPS has a single O-antigen repeat composed of yersiniose, 8-epi-legionami

239 eGlcA) to complete the first instance of the O-antigen repeat unit.

240 The O-antigen repeating unit (O-unit) of Escherichia coli O8

241 nas aeruginosa 1244 pilin by adding a single O-antigen repeating unit to the beta carbon of the C-ter

242 o catalyze the addition of newly synthesized O-antigen repeating units to a glycolipid consisting of

243 N) with its ligands comprising two and three O-antigen repeats from Salmonella enterica serovar Typhi

244 Depletion of IgG2 to O-antigen restores the ability of sera to kill strains w

245 sources to implement a combination PCR-based O-antigen screening and sequencing of internal fliC and

246 and 1289, express two antigenically distinct O-antigen serotypes (O1 and O2, respectively).

247 The lack of cross-immunity between O-antigen serotypes appears to contribute to inefficient

248 The Escherichia coli O9a and O8 O-antigen serotypes represent model systems for the ABC

249 nclude the involvement of specific clones or O-antigen serotypes, the presence of certain horizontall

250 valently linked to Shigella flexneri type 2a O-antigen (Sf2E) produced by engineered Escherichia coli

251 We suggest that excessive binding of IgG2 to O-antigen shields the bacterium from other antibodies th

252 omer can lead to shifts in the length of the O antigen side chain.

253 The O-antigen side chain of the lipopolysaccharide is an imm

254 rface proteins augmented the contribution of O-antigen-specific antibodies elicited by vaccine strain

255 gen-CRM197 glycoconjugate vaccine can induce O-antigen-specific antibodies of different isotypes that

256 munologic interference in the development of O-antigen-specific antibody responses when closely relat

257 ed killing is caused by excess production of O-antigen-specific IgG2 antibodies.

258 t LPS sugar compositions and reactivity with O-antigen-specific monoclonal antibodies.

259 As there is significant sharing of O-antigen structure between different Gram-negative bact

260 human blood group B activity because of its O-antigen structure, sharing the human blood group B epi

261 tudies indicate that the unusual V. fischeri O-antigen sugars play a role in the early phases of bact

262 ule structures, and not a lipopolysaccharide O antigen, supported by the fact that they contain genes

263 n pathway and its possible relationship with O-antigen surface sensing, mutations were made in the rc

264 Mutations in three other genes involved in O-antigen synthesis and transport also prevented the exp

265 the AcrAB efflux pump and lipopolysaccharide O-antigen synthesis for bile salt resistance.

266 WbbB, a modular protein participating in LPS O-antigen synthesis in Raoultella terrigena The beta-Kdo

267 s/deletions or point mutations identified in O-antigen synthesis or modification genes, rendering the

268 genotypically serotyped using PCR targeting O-antigen synthesis or modification genes.

269 dent pathways, one of the two most prevalent O-antigen synthesis systems.

270 with an unusual defect in lipopolysaccharide O-antigen synthesis, but loss of FTL_0325 was not.

271 sed on these results and current theories of O-antigen synthesis, specific roles were deduced for eac

272 des a UDP-4,6-GlcNAc dehydratase involved in O-antigen synthesis.

273 ate, glucosylation has only been observed in O-antigens synthesized by Wzy-dependent pathways, one of

274 The O antigen targets B. parapertussis to lipid rafts that a

275 ifferent glycan repeating units: O-LPS (with O-antigen tetrasaccharide repeating units) and A-LPS (wi

276 DS-PAGE revealed stepwise truncations of the O antigen that were consistent with differences in mutan

277 Modifications of the O-antigen that can affect the serotype include those car

278 We identify human monoclonal antibodies to O-antigens that are highly protective in mouse models of

279 core sugar biosynthesis and the ligation of O antigen to the LPS core sugars.

280 p facilitate the transport or linking of the O antigen to the LPS.

281 he impact of coupling Salmonella typhimurium O-antigen to different amino acids of CRM197 protein car

282 WaaL ligates the O-antigen to the core of the LPS; thus, LPS from waaL mu

283 zer-resistant knockout mutant of the wzm ABC O-antigen transporter gene, SynPCC7942_1126.

284 roduce an oligosaccharide core with a single O-antigen unit attached in an RfaH-dependent fashion.

285 vaccine, while a wzy mutant that retains one O-antigen unit is adequate for stimulating the optimal p

286 4P) (5) , two of which are glycosylated with O-antigen units (6) or polymers of D-arabinofuranose (7-

287 onization, and is in contrast to the role of O-antigen variation described for Shigella.

288 It is added to the bacterial O-antigen via a nucleotide-linked version, namely GDP-pe

289 aaP, waaY, and rfaQ), outer core (rfaG), and O-antigen (waaL, wzzE, and wzyE).

290 a model for biosynthesis of the R. etli CE3 O antigen was proposed.

291 In addition, O antigen was required for B. parapertussis to systemica

292 Production of a fully extended O-antigen was also diminished in a Kdo hydrolase mutant,

293 ific antibody responses when closely related O antigens were combined in multivalent vaccines.

294 In contrast, 2192 expresses no LPS O antigen when grown at 37 degrees C.

295 pressed both the homologous and heterologous O-antigens, whereas in the absence of arabinose, SLT16 (

296 tisic acid; while A galU mutant is devoid of O-antigen, which is required for phage adsorption.

297 nduced specific IgG against the heterologous O-antigen, which mediated significant killing of Salmone

298 B. pertussis does not express the O antigen, while B. parapertussis retains it as a domina

299 Escherichia coli strain O157 produces an O-antigen with the repeating tetrasaccharide unit alpha-

300 Finally, the O antigen would be capped by attachment of di- or tri-O-