ライフサイエンスコーパス: O. formigenes

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1 O. formigenes interacts with colonic epithelium and indu

2 showed even greater sensitivity in detecting O. formigenes and provided support for further division

3 sequences of oxc or frc were able to divide O. formigenes strains into at least two groups, consiste

4 ly aged healthy volunteers were examined for O. formigenes by culture and DNA analysis.

5 the multivariable model, the odds ratio for O. formigenes remained 0.3 (95% confidence interval 0.1

6 he obligate anaerobe Oxalobacter formigenes, O. formigenes formyl coenzyme A transferase (FRC).

7 on of oxalate-degrading enzymes derived from O. formigenes to determine any subsequent increased resi

8 Compared with control medium, O. formigenes CM significantly stimulated oxalate uptake

9 We investigated whether the absence of O. formigenes and the presence of hyperoxaluria are corr

10 d not differ with the presence or absence of O. formigenes colonization.

11 It was hypothesized that the absence of O. formigenes could lead to increased colonic absorption

12 Absence of O. formigenes from the intestinal tract of CF patients a

13 peroxaluria type 1, rectal administration of O. formigenes CM significantly reduced (>32.5%) urinary

14 both detection as well as classification of O. formigenes strains.

15 Detection of O. formigenes in six of these seven patients required DN

16 Detection of O. formigenes in the gastrointestinal tract has attracte

17 We therefore evaluated the effects of O. formigenes culture conditioned medium (CM) on apical

18 To confirm the importance of O. formigenes in regulating hyperoxaluria, laboratory ra

19 urrent kidney stone episodes and the lack of O. formigenes colonization.

20 As expected, the lack of O. formigenes revealed a clear association with prophyla

21 s, and the CF patient with normal numbers of O. formigenes was the only one of the 43 patients who ha

22 The prevalence of O. formigenes, determined by stool culture, was 17% amon

23 s, consistent with the current separation of O. formigenes strains into groups I and II on the basis

24 The difficulties in sustaining O. formigenes colonization underscore the need to identi

25 ns, taken together, support the concept that O. formigenes is important in maintaining oxalate homeos

26 We conclude that O. formigenes-derived bioactive factors stimulate oxalat

27 ultrafiltration of the CM revealed that the O. formigenes-derived factors have molecular masses of 1

28 Treating the O. formigenes CM with heat or pepsin completely abolishe

29 All seven CF patients colonised with O. formigenes had normal urinary oxalate levels, but 19

30 t 19 (53%) of 36 patients not colonised with O. formigenes were hyperoxaluric, with the most severe h

31 (16%) of 43 CF patients were colonised with O. formigenes.

32 these results suggest that colonization with O. formigenes is associated with a 70% reduction in the

33 amples from an individual not colonized with O. formigenes, indicating unique specificity.

34 excretion in hyperoxaluric mice treated with O. formigenes CM reflects the in vivo retention of biolo

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