ライフサイエンスコーパス: O6-methylguanine

1 key role in the interaction with the flipped O6-methylguanine.

2 e containing O6-benzylguanine and the other, O6-methylguanine.

3 le-stranded oligodeoxynucleotides containing O6-methylguanine.

4 g-Cpr-null mice correlated with reduced lung O6-methylguanine adduct levels, without decreases in NNK

5 NA alkyltransferase (AGT)-mediated repair of O6-methylguanine adducts.

6 ensitive to alkylating agents that result in O6-methylguanine adducts.

7 lting in a fully functional protein for both O6-methylguanine and apurinic/apyrimidinic (AP) site rep

8 hesis across SOS-independent lesions such as O6-methylguanine and DNA uracil is around 90%, very clos

9 oplatinum(II), as well as base pairs between O6-methylguanine and thymine or cytosine, or between O4-

10 ecognize certain forms of DNA damage such as O6-methylguanine and UV photoproducts, and, therefore, m

11 inhibited the formation of N7-methylguanine, O6-methylguanine, and O6-pyridyloxobutylguanine at a nei

12 (c) bind to oligodeoxynucleotides containing O6-methylguanine; and (d) react with the low molecular w

13 action is the result of MutS recognition of O6-methylguanine base pairs.

14 th LMO1 and MGMT, and thereby able to repair O6-methylguanine DNA adducts induced by MNU, would be pr

15 omain family protein 1A (RASSF1A) (57%), and O6-methylguanine DNA methylatransferase (MGMT) (34%), an

16 The human DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) dealkylate

17 tin structure in the CpG island of the human O6-methylguanine DNA methyltransferase (MGMT) gene.

18 etinoic acid receptor-beta2 (RAR-beta2), and O6-methylguanine DNA methyltransferase (MGMT) genes were

19 O6-methylguanine DNA methyltransferase (MGMT) is a DNA r

20 of the gene encoding the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) might be r

21 ow cells express extremely low levels of the O6-methylguanine DNA methyltransferase (MGMT) protein th

22 The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) removes al

23 O6-Methylguanine DNA methyltransferase (MGMT) removes al

24 O6-Methylguanine DNA methyltransferase (MGMT) repairs th

25 tal carcinogens and the protective effect of O6-methylguanine DNA methyltransferase (MGMT), heterozyg

26 etection of four different proteins, avidin, O6-methylguanine DNA methyltransferase (MGMT), SNAP-tag,

27 complished in mammalian cells by the protein O6-methylguanine DNA methyltransferase (MGMT).

28 uclease protein resulted in the retention of O6-methylguanine DNA methyltransferase activity but loss

29 These results demonstrate that the fusion of O6-methylguanine DNA methyltransferase and apurinic endo

30 tructed a human fusion protein consisting of O6-methylguanine DNA methyltransferase coupled with an a

31 of the apurinic endonuclease portion of the O6-methylguanine DNA methyltransferase-apurinic endonucl

32 t increased levels of the DNA repair protein O6 methylguanine-DNA methyltransferase (MGMT), also refe

33 ructure-function information about the human O6-methylguanine-DNA methyltransferase (EC 2.1.1.63), as

34 Pretreatment leukemia cell O6-methylguanine-DNA methyltransferase (MGMT) activity,

35 ith a vector containing or lacking the human O6-methylguanine-DNA methyltransferase (MGMT) cDNA.

36 The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) confers re

37 h-level expression of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) correlates

38 O6-methylguanine-DNA methyltransferase (MGMT) functions

39 The DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) inhibits t

40 The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is a major

41 The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonl

42 The mechanism whereby the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is silence

43 ed methylation data from a CpG island in the O6-methylguanine-DNA methyltransferase (MGMT) promoter.

44 nation in the disposition of the inactivated O6-methylguanine-DNA methyltransferase (MGMT) protein in

45 The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes mu

46 O6-Methylguanine-DNA methyltransferase (MGMT), a constit

47 O6-methylguanine-DNA methyltransferase (MGMT), a ubiquit

48 O6-Methylguanine-DNA methyltransferase (MGMT), a ubiquit

49 O6-Methylguanine-DNA methyltransferase (MGMT), an enzyme

50 This lesion is repaired by O6-methylguanine-DNA methyltransferase (MGMT), the expre

51 rivatives is countered by the repair protein O6-methylguanine-DNA methyltransferase (MGMT), which rem

52 O6-MeG, a DNA lesion repaired by the protein O6-methylguanine-DNA methyltransferase (MGMT).

53 ese mechanisms may be the high expression of O6-methylguanine-DNA methyltransferase (MGMT).

54 as the P140K mutant of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT*).

55 ariate analysis, the factors age, WHO grade, O6-methylguanine-DNA methyltransferase promoter methylat

56 wed prognostic significance, with WHO grade, O6-methylguanine-DNA methyltransferase status, age, and

57 ctional 39 kDa Escherichia coli Ada protein (O6-methylguanine-DNA methyltransferase) (EC 2.1.1.63), p

58 ges in molecules involved in DNA repair (eg, O6-methylguanine-DNA methyltransferase, DNA topoisomeras

59 DNA repair enzymes, DNA polymerase beta and O6-methylguanine-DNA methyltransferase, have been shown

60 cosylase, Nth protein (endonuclease III) and O6-methylguanine-DNA methyltransferase.

61 ve DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C. 2.1.1.63, M

62 essor gene p16 (CDKN2A), the DNA repair gene O6-methylguanine-DNA-methyltransferase (MGMT) and the pu

63 These include the importance of O6-methylguanine-DNA-methyltransferase (MGMT) in gliobla

64 r of metalloproteinase 3 (TIMP-3), p16INK4a, O6-methylguanine-DNA-methyltransferase (MGMT), death-ass

65 O6-methylguanine-DNA-methyltransferase (MGMT), which rep

66 uced cells in vivo, selection based on P140K O6-methylguanine-DNA-methyltransferase (MGMT[P140K]) gen

67 or radiotherapy alone, with consideration of O6-methylguanine-DNA-methyltransferase gene (MGMT) promo

68 ion-specific PCR and included: p16 (CDKN2A), O6-methylguanine-DNA-methyltransferase, glutathione S-tr

69 ne S-transferase P1, and the DNA repair gene O6-methylguanine-DNA-methyltransferase.

70 udied: 27% (26/95) at p16, 33% (31 of 95) at O6-methylguanine-DNA-methyltransferase; and 18% (17 of 9

71 protein does not transfer methyl groups from O6-methylguanine in [3H]-methylated DNA but reversibly i

72 TMZ produces O6-methylguanine in DNA, which mispairs with thymine dur

73 n the alkyltransferase activity in repairing O6-methylguanine in methylated DNA.

74 over of MGMT protein and increased repair of O6-methylguanine in nitrosomethylurea-treated human bron

75 O6-Methylguanine is removed from DNA via the transfer of

76 Replication in vivo across unrepaired O6-methylguanine (m6dG) lesions by mammalian DNA polymer

77 DNA synthesis in vitro across site-specific O6-methylguanine (m6dG) residues by DNA polymerase beta

78 o form specific and stable complexes with an O6-methylguanine (m6G)-containing oligonucleotide substr

79 ng by Sn1 methylators has been attributed to O6-methylguanine (MeG), we have constructed nicked circu

80 n the course of removing a methyl group from O6-methylguanine (meG)-DNA or O4-methylthymine (meT)-DNA

81 The MutSDelta800 protein binds to O6-methylguanine mismatches but not to intrastrand plati

82 O6-methylguanine mispairs with thymine during replicatio

83 MNU produces carcinogenic O6-methylguanine (O6-meG) adducts, resulting in thymic l

84 nsformation of human fibroblasts and whether O6-methylguanine (O6-MeG) is involved, two populations o

85 We examined the effect of a single O6-methylguanine (O6-MeG) template residue on catalysis

86 Uracil, O6-methylguanine (O6-meG), and 8-oxoguanine (8-oxoG) wer

87 the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methy

88 of the O6 position of guanine in DNA to form O6-methylguanine (O6-meG).

89 t slowly, T opposite the carcinogenic lesion O6-methylguanine (O6MeG) approximately 30-fold more freq

90 e and a monoclonal antibody which recognizes O6-methylguanine (O6MeGua).

91 Ada protein makes critical interactions with O6-methylguanine (O6mG) at the N1- and O6-positions.

92 ts with the 3-position of the mutagenic base O6-methylguanine (O6mG).

93 tosine and 1,N6-ethenoadenine, as well as at O6-methylguanine (O6mG).

94 The effects of substitution of O6-methylguanine on the structure and stability of a hum

95 PvuII is inhibited by O6-methylguanine, positioned within the restriction site

96 AGT repairs O6-methylguanine; PvuII cleaves at its restriction site,

97 We quantified the number of O6-methylguanine residues in methylated DNA by HPLC-MS/M

98 thyltransferase compete for the MNNG-induced O6-methylguanine residues, and MMR-induced cytotoxicity