ライフサイエンスコーパス: OA

1 OA chondrocytes treated with F4 in the presence of IL-1b

2 OA increased cystogenesis in polycystic kidney rats by 3

3 OA oxygenation increased with further oxidation for all

4 OA synovial fluids (SF) stimulated TLR2 and TLR4 recepto

5 This study included 392 AYA and 5373 OA patients diagnosed with GISTs (207 [52.8%] male AYA p

6 Oleanolic acid (OA), a pentacyclic triterpenoid, has been shown to modul

7 hen cells were exposed to 0.4 mm oleic acid (OA) complexed to BSA.

8 nal groups in stearic acid (SA), oleic acid (OA), and octadecylphosphonic acid (ODP) coatings led to

9 he first time, PhIP-incorporated oleic acid (OA, simulating cooking oil) (PhIP@OA) particles, includi

10 acids (NO2 -FAs), such as nitro oleic acid (OA-NO2 ) and nitro linoleic acid (LNO2 ).

11 sly studied the effects of nitro-oleic acid (OA-NO2) on the human endothelial cell transcriptome.

12 ists (taurolithocholic acid, oleanolic acid [OA], and two synthetic compounds), (2) a novel TGR5 anta

13 hytoplankton to ongoing ocean acidification (OA) are appearing rapidly in the literature.

14 rticularly sensitive to ocean acidification (OA) as their skeleton is made of high-magnesium calcite,

15 Ocean acidification (OA) increasingly threatens marine systems, and is especi

16 ear-term progression of ocean acidification (OA) is projected to bring about sharp changes in the che

17 change drivers, such as ocean acidification (OA), will shape species distributions in the future.

18 ncentrations: so called ocean acidification (OA).

19 ies most susceptible to ocean acidification (OA).

20 the profiles and contents of organic acids (OAs) and beta-carotene in sulfured dried apricots (SDAs)

21 oretinal lymphoma (PVRL) and ocular adnexal (OA)-uveal DLBCL.

22 dy of 392 AYA patients and 5373 older adult (OA) patients in the Surveillance, Epidemiology, and End

23 tion of water-solubility of organic aerosol (OA) by coupling a Particle Into Liquid Sampler (PILS) to

24 erved for all stoves/tests; organic aerosol (OA) enhancement factor ranged from 1.2 to 3.1, decreasin

25 nanoparticles capped with octylamine (AgNPs-OA) is reported for detection of hydrogen peroxide (H2O2

26 nt pen filled with nanoink (10 wt % of AgNPs-OA in chloroform).

27 The PE/AgNPs-OA exhibited a wide linear calibration range from 1.7 mu

28 OA and chondrocytes lacking A2AR develop an 'OA phenotype' with increased expression of Mmp13 and Col

29 noRNA expression levels in murine ageing and OA joints and serum for the first time.

30 nucleolar RNAs (snoRNAs) in joint ageing and OA may provide diagnostic biomarkers and therapeutic tar

31 ical guidelines for anxiety, depression, and OA and was supported by a brief training package.

32 vestigate the levels of TWIST1 in normal and OA cartilage and examine its role in regulating gene exp

33 coral-macroalgal interactions under OA, and OA further suppresses the resilience of coral reefs suff

34 characteristics of AYA (13-39 years old) and OA (>/=40 years old) patients and among AYA patients str

35 For all PVRL and OA-uveal DLBCL, a Cox proportional hazards regression mo

36 p with neurons expressing Octbeta3R, another OA receptor previously implicated in hunger-driven exube

37 fferent adsorption extents (SA approximately OA > ODP) under the same conditions.

38 /US images, scored OA features, and assigned OA/US POM and a BI-RADS category.

39 n accurate diagnosis of occupational asthma (OA) is, generally, important.

40 IgE), which may lead to occupational asthma (OA).

41 aled breath condensate from obese asthmatic (OA) patients, lean asthmatic (LA) patients, and obese no

42 EGFR2 kinase inhibitor Vandetanib attenuates OA progression.

43 systematic evaluation of pleiotropy between OA and BMD, highlight genes with biological relevance to

44 reproducibility) of a new optical biometer (OA-2000, Tomey, Japan) based on swept-source optical coh

45 activation of Notch signaling fully blocked OA induced MSC osteogenic differentiation.

46 ng cues to abalone, which may further buffer OA effects.

47 gnificantly reduced macrophage activation by OA SF (p < 0.01).

48 specific Ab reduced macrophage activation by OA SF, and CD44 is a potentially novel target in OA trea

49 effects of endothelin-1 (ET-1) is induced by OA-NO2 Inasmuch as ET-1 is one of the key regulators of

50 BMP signaling, was significantly induced by OA.

51 rrent (pCO2 370 muatm) or end-of-the-century OA (pCO2 1,100 muatm) scenarios, crossed in an orthogona

52 Through a novel coastal OA observing network, we have uncovered a remarkably per

53 rs and improves understanding of the complex OA sources in the atmosphere.

54 Conclusion OA/US increases the specificity of breast mass assessmen

55 ression of cathepsin B resulted in decreased OA uptake and VLDL secretion.

56 worsening of disease; conversely, diagnosing OA when it is not present may lead to inappropriate remo

57 the currently available tools for diagnosing OA to promote a common nomenclature and procedures to be

58 destabilization of the medial meniscus (DMM) OA-inducing surgery in mice.

59 In primary emissions, OA mass spectral fragments associated with oxygenated sp

60 A specific exosomal miRNA of male and female OA.

61 e, here defined as "metabotype." Twenty-five OA patients, 30 ONA subjects, and 30 mild-to-moderate LA

62 scales, tests, and potential biomarkers for OA are reviewed.

63 but complexation efficiency was greater for OA.

64 rkers) increased (decreased) with MCE; fresh OA from FDGS combustion was especially oxygenated.

65 at autopsy from normal knee joints and from OA-affected joints at the time of total knee arthroplast

66 these neurons receive convergent input from OA neurons and P1 neurons, a population of FruM(+) neuro

67 SP-A (P = .002) was detected in samples from OAs compared with those from control subjects.

68 Furthermore, OA rescues in vitro processing of pri-miR-7, which is ot

69 apparatus-like pattern, which required a 1-h OA treatment.

70 the identification of subjects who may have OA and require further objective testing before excludin

71 e OA, replication cohorts: 17 knee OA, 9 hip OA patients).

72 Increased adiposity in hip OA patients is associated with altered subchondral bone

73 Subchondral bone from over-weight/obese hip OA patients exhibited reduced trabecular thickness, incr

74 y on the architecture and composition of hip OA subchondral bone, and to examine the pathological rol

75 re found between obese and normal-weight hip OA patients.

76 alpha1/alpha2, compared to normal-weight hip OA patients.

77 eight or over-weight/obese patients with hip OA.

78 We investigated how OA affects the impact of a cubozoan predator on their zo

79 Single-species experiments have shown how OA can dramatically affect zooplankton development, phys

80 Human OA articular chondrocytes were examined for miR-146b exp

81 LEF1-mediated MMP13 gene expression in human OA chondrocytes.

82 NA levels and RUNX2 gene expression in human OA chondrocytes.

83 that of MMP and IL-1beta in individual human OA cartilage specimens.

84 1 and MMP13 protein levels, similar to human OA cartilage.

85 re separable as males with a hypermethylated OA neuronal genome exhibited a decrease in aggression wi

86 ing device that fuses laser optical imaging (OA) with grayscale ultrasonography (US) to grayscale US

87 d to be significantly elevated (P < 0.05) in OA patients compared to RA patients.

88 in, leading to greater production of IL-6 in OA patients.

89 ion of c-Fos/AP-1 expression and activity in OA chondrocytes under pathological conditions.

90 oter and may determine RUNX2 availability in OA cartilage for transactivation of genes such as MMP13.

91 In vivo, we examined hepatic cystogenesis in OA-treated polycystic kidney rats and after genetic elim

92 Anti-IgE mAb has positive effects in OA induced by persulfate salts.

93 n that the abnormal MMP13 gene expression in OA chondrocytes is controlled by changes in the DNA meth

94 ter on RUNX2-driven MMP13 gene expression in OA chondrocytes.

95 e-1 (HO-1), one of its main target genes, in OA cartilage from T2DM and non-T2DM patients as well as

96 which have not previously been implicated in OA progression.

97 on was observed between RUNX2 mRNA levels in OA chondrocytes and the percentage methylation of the Cp

98 riptional and post transcriptional levels in OA chondrocytes.

99 flammatory joint diseases, it also occurs in OA and is thus relevant to the prevalent tissue destruct

100 lammatory mediator thought to participate in OA pathogenesis.

101 e identified consistent molecular players in OA progression that replicated across independent datase

102 MiR-146b expression was up-regulated in OA chondrocytes.

103 dea that SnCs might play a causative role in OA, we used the p16-3MR transgenic mouse, which harbors

104 ciled with an apparently destructive role in OA.

105 DHA was associated with lower pain scores in OA patients (beta -0.41; 95% CI-0.69, -0.12; p < 0.005;

106 F, and CD44 is a potentially novel target in OA treatment.

107 .0 months; 95% CI, 14.2-61.8 months) than in OA-uveal DLBCL (96.0 months; 95% CI, 67.3-124.7 months;

108 Decreased levels of SP-A in OAs, which could be due to increased local TNF-alpha lev

109 determine whether SP-A levels are altered in OAs compared with a control group and to determine the i

110 This means that increased OA may indirectly alter the biotic conditions by modifyi

111 (DMM) surgery at 12-week-old mice to induce OA in adult Runx2 (Agc1CreER) mice, in which Runx2 was s

112 tional knock-down of Vegf attenuates induced OA.

113 could at least partially rescue DMM-induced OA-like defects in adult mice.

114 Knee OA among individuals estimated to be >/=50 y old was als

115 Knee OA is thus more preventable than is commonly assumed, bu

116 placement surgery (discovery cohort: 12 knee OA, replication cohorts: 17 knee OA, 9 hip OA patients).

117 rt: 12 knee OA, replication cohorts: 17 knee OA, 9 hip OA patients).

118 We analyzed long-term trends in knee OA prevalence in the United States using cadaver-derived

119 to explain the approximate doubling of knee OA prevalence that has occurred in the United States sin

120 Overall, knee OA prevalence was found to be 16% among the postindustri

121 ators for the diagnosis of radiographic knee OA.

122 d support the diagnosis of radiographic knee OA.

123 [52.8%] male AYA patients, 2767 [51.5%] male OA patients, 277 [70.7%] white AYA patients, and 3661 [6

124 We investigated genes and pathways that mark OA progression in isolated primary chondrocytes taken fr

125 Furthermore, 12 M females developed milder OA than males as indicated by less cartilage degradation

126 dence of only mild or, in one case, moderate OA.

127 yster reproduction was resilient to moderate OA projected for the near-future.

128 (DMM) used for evaluating disease-modifying OA targets are frequently performed on young adult mice

129 Moreover, OA cartilage from patients with T2DM exhibits a greater

130 Moreover, OA-NO2 is capable of enhancing regulatory T-cell activit

131 e to both traits, and establish a robust new OA genetic risk locus at SMAD3.

132 NO2-OA inhibited TNFalpha-induced NF-kappaB transcriptional

133 NO2-OA reduced TNBC cell growth and viability in vitro, atte

134 ecal pathways are the main routes for 10-NO2-OA excretion in rats, and allowed the identification of

135 Bio-elimination pathways for 10-NO2-OA were evaluated in rats (30 mg/kg.day) and in humans (

136 In particular, 10-nitro oleic acid (10-NO2-OA) potently induces Nrf2-dependent antioxidant gene exp

137 -inflammatory agent 10-nitro-oleic acid (NO2-OA), a component of the Mediterranean diet, reduced p38a

138 -octadec-9-enoic acid (nitro-oleic acid, NO2-OA), were investigated in multiple preclinical models of

139 2-OA in TNBC cells were multifaceted, as NO2-OA (a) inhibited the inhibitor of NF-kappaB subunit kina

140 ng for NF-kappaB signaling inhibition by NO2-OA in TNBC cells were multifaceted, as NO2-OA (a) inhibi

141 steric obstruction of Cys-119/Cys-162 by NO2-OA pretreatment in Langendorff-perfused murine hearts pr

142 Moreover, NO2-OA reduced the dephosphorylation of p38alpha by hematopo

143 ion, and greater MRP1-mediated efflux of NO2-OA-glutathione conjugates.

144 ial MCF-10A and MCF7 cells revealed that NO2-OA more selectively inhibited TNBC function.

145 However, synovial fibroblasts from obese OA patients were found to secrete greater amounts of the

146 n of resistin was higher in overweight/obese OA patients, compared to normal-weight OA patients.

147 detected in the synovial fluid of the obese OA patients.

148 Octopamine (OA), the insect homolog of NE, is known to promote both

149 of tubules to the related amine octopamine (OA), indicating that OA can activate TAR2.

150 ne, which encodes a receptor for octopamine (OA, the invertebrate homologue of norepinephrine), plays

151 ction in dMBD-R2 specifically in octopamine (OA) neurons exhibit courtship toward divergent interspec

152 iring an alpha2A-adrenergic-like octopamine (OA) receptor, OCTR-1, and a 5-HT1A-like serotonin (5-HT)

153 We showed that approximately 88% and 77% of OA are water-soluble in rural Centreville, Alabama and u

154 inction risk under projected acceleration of OA over the next 30 years.

155 med the first systematic overlap analysis of OA and BMD on a genome wide scale.

156 daptation to address the global challenge of OA in productive coastal systems.

157 the curve of 0.82 for the classification of OA and control samples.

158 indicate that the ecological consequences of OA may be greater than predicted from single-species exp

159 containing adenosine prevents development of OA in rats.

160 dations, and algorithms for the diagnosis of OA are proposed for use by both allergists and ophthalmo

161 The diagnosis of OA is usually based on clinical history and signs and sy

162 Missing a diagnosis of OA may lead to continued exposure to a causative agent a

163 The distribution of OA exposure across these early-impact systems, however,

164 We evaluated the effect of OA-NO2 on allergic contact dermatitis (ACD) using an est

165 hose to examine in more detail the effect of OA-NO2 on endothelin signaling in human endothelial cell

166 In this study, we examined effects of OA on cell viability, osteogenic differentiation in MSCs

167 Recent studies have investigated effects of OA on the skeleton of "classical" sea urchins (euechinoi

168 of at least 39, and radiographic evidence of OA of the knee were recruited from December 1, 2010, to

169 Increased TWIST1 expression is a feature of OA-affected cartilage.

170 lts suggest that the distinctive features of OA-MCL are its appearance in older male individuals, adv

171 the whole spectrum of the different forms of OA.

172 Thus, we find no impacts of OA exposure history on CCRA provision of settlement cues

173 lowering agents on reducing the incidence of OA.

174 neurons that mediate a specific influence of OA on aggression, independent of any effect on arousal.

175 tors provides insights for interpretation of OA factors and improves understanding of the complex OA

176 Our results suggest that future levels of OA could mediate temperature-driven shifts in species di

177 aling in a pre-clinical obese mouse model of OA.

178 Future modeling of OA radiative forcing should consider the importance of b

179 ol of gene expression in the pathogenesis of OA.

180 6b may play a role in the pathophysiology of OA.

181 testing before excluding the possibility of OA.

182 ly, we show that in the combined presence of OA and a cubozoan predator, populations of the most abun

183 shows reduced processing in the presence of OA.

184 Given that the only formal record of OA in Dolly is a brief mention of a single joint in a co

185 e of our aged sheep showed clinical signs of OA, and they had radiographic evidence of only mild or,

186 This study on the water-solubility of OA factors provides insights for interpretation of OA fa

187 The water-solubility of OA factors, resolved with Positive Matrix Factorization

188 ntial therapeutic target in the treatment of OA.

189 concerns that cloning had caused early-onset OA in Dolly were unfounded.

190 oid, ciliary body, lacrimal gland, or orbit (OA-uveal lymphoma) were included.

191 ix, which can progress to an osteoarthritic (OA) phenotype.

192 Osteoarthritis (OA) is a common cause of pain and disability and is ofte

193 Osteoarthritis (OA) is a common disease characterized by cartilage degen

194 Osteoarthritis (OA) is a common joint disorder with varying degrees of i

195 Osteoarthritis (OA) is a low-grade chronic inflammatory joint disease.

196 Osteoarthritis (OA) is characterised by progressive destruction of artic

197 Osteoarthritis (OA) is characterized by cartilage destruction and chondr

198 Black patients with advanced osteoarthritis (OA) of the knee are significantly less likely than white

199 sociated with Panx3, such as osteoarthritis (OA).

200 in joint remodelling during osteoarthritis (OA).

201 y is a major risk factor for osteoarthritis (OA) and diminished wound healing.

202 the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilizatio

203 (T2DM) is a risk factor for osteoarthritis (OA).

204 3) represents a key event in osteoarthritis (OA) progression.

205 atrices such as cartilage in osteoarthritis (OA).

206 Knee osteoarthritis (OA) is believed to be highly prevalent today because of

207 lop drug therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries.

208 lt cells) whose diagnoses of osteoarthritis (OA) at 5(1/2) years of age led to considerable scientifi

209 The pathogenesis of osteoarthritis (OA) is poorly understood, and therapeutic approaches are

210 rtant role in development of osteoarthritis (OA).

211 , psoriatic arthritis (PsA), osteoarthritis (OA)) or chronic inflammatory conditions (inflammatory bo

212 in patients consulting with osteoarthritis (OA) improves pain outcomes.

213 A (VEGF) is associated with osteoarthritis (OA), and increased VEGF expression correlates with incre

214 pressed TAR2 is highly selective for TA over OA.

215 reharvest treatment with malic (MA), oxalic (OA), or acetylsalicylic (ASA) acid at three concentratio

216 Less-oxidized oxygenated OA has the lowest water-solubility among all secondary O

217 More-oxidized oxygenated OA is dominantly water-soluble, consistent with this fac

218 PhIP and PhIP@OA did not show significant cytotoxic effects on SHSY5Y,

219 leic acid (OA, simulating cooking oil) (PhIP@OA) particles, including individual particulate PhIP as

220 lly providing an eventual therapy to prevent OA.

221 Stimulation of primary OA osteoblasts with recombinant resistin increased Wnt s

222 Fifty subjects per group with RA, PsA, OA or IBD and 50 healthy controls were included in the s

223 d if at least one knee had both radiographic OA and pain.

224 prevalence and distribution of radiographic-OA similar to that observed in naturally conceived sheep

225 ate TWIST1 as an important factor regulating OA related gene expression.

226 ients aged >/=45 y consulted with a relevant OA-related code, and 4,240 patients were deemed potentia

227 that the majority of this factor represents OA formed through the aqueous-phase reaction of isoprene

228 The same independent readers then reviewed OA/US images, scored OA features, and assigned OA/US POM

229 whether the original concerns about Dolly's OA were justified.

230 In vivo SC OA-NO2 significantly inhibits pathways that lead to infl

231 We found that subcutaneous (SC) OA-NO2 injections administered 18 h prior to sensitizati

232 d for replication in independent large-scale OA datasets, and subsequent meta-analysis with arcOGEN f

233 t readers then reviewed OA/US images, scored OA features, and assigned OA/US POM and a BI-RADS catego

234 lowest water-solubility among all secondary OA factors, which agrees with the hypothesis that this f

235 rate (pH 7.5, pCO2 2260 microatm) and severe OA (pH 7.1, pCO2 5584 microatm; and 6.7, pCO2 18480 micr

236 Exposure at severe OA during gametogenesis caused disruption in oyster repr

237 Our results showed that severe OA-like defects were observed after DMM surgery in Cre-n

238 assemblies of the dog, CF 3.1 and the sheep, OA 3.1, genomes contain 264 and 598 FLIs, respectively.

239 MiRNA microarray analysis showed OA specific exosomal miRNA of male and female OA.

240 llular AMP to adenosine) develop spontaneous OA and chondrocytes lacking A2AR develop an 'OA phenotyp

241 e use of TKR for the management of end-stage OA of the knee.

242 to surgery for black patients with end-stage OA of the knee.

243 ked the effects of F4 in IL-1beta-stimulated OA chondrocytes.

244 ntra-articular anti-VEGF antibodies suppress OA progression, reduce levels of phosphorylated VEGFR2 i

245 factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial me

246 xpression is reduced in T2DM versus non-T2DM OA cartilage (0.57-fold Nrf-2 and 0.34-fold HO-1), and p

247 e likely to undergo surgical management than OA patients.

248 Thus, it can be concluded that OA preharvest treatment could be a natural and useful to

249 Together, our results demonstrate that OA can regulate the processing of pri-miRs by remodeling

250 Finally, we demonstrate that OA induces mature miR-7 production in HeLa cells.

251 (R(2) = 0.86 and Q(2) = 0.83) indicated that OA patients possess a respiratory metabolic profile full

252 This indicates that OA may inhibit the binding of other RRM-containing prote

253 NMR-based metabolomics indicates that OA patients are characterized by a respiratory metabolic

254 lated amine octopamine (OA), indicating that OA can activate TAR2.

255 Based on these results, we propose that OA-NO2 and Nrf2 may alleviate the vasoconstrictive effec

256 n immunoprecipitation analysis revealed that OA-NO2 increased the binding of Nrf2 to an antioxidant r

257 t assays in HeLa cell extracts, we show that OA treatment disrupts pre-miR/protein complexes.

258 Our results suggest that OA is a promising bioactive agent for bone tissue regene

259 These data suggest that OA-NO2 modulates endothelin signaling by increasing Nrf2

260 hese stressors in isolation, suggesting that OA increases the susceptibility of plankton to predation

261 zation of LFABP and apoB, independent of the OA treatment.

262 Nrf2 was found to regulate the OA-NO2-induced transcription of ET-B in human and mouse

263 in their growth in longer duration under the OA condition.

264 Compared with the OA patients, more AYA patients had small-intestine GISTs

265 choice for calculation of IOL power with the OA-2000.

266 readers reviewed US images obtained with the OA/US device, assigned a probability of malignancy (POM)

267 -containing proteins are required within the OA neural circuitry to inhibit interspecies and conspeci

268 D, and from the arcOGEN consortium for three OA phenotypes (hip, ncases=3,498; knee, ncases=3,266; hi

269 Thus, OA-NO2 treatment results in anti-inflammatory effects ca

270 Innate immunity contributes to OA progression, mediated by TLR2 and TLR4.

271 in patients presenting with symptoms due to OA, with those in the intervention group reporting stati

272 n, we demonstrate that addition of hepsin to OA cartilage in explant culture induced significant coll

273 Responses of phytoplankton to OA may depend on the timescale for which they are expose

274 CA have shown strongly negative responses to OA in previous studies, including disruption of settleme

275 ng this surgical technique for translational OA research.

276 P-9, MMP-13 and ADAMTS-4 in IL-1beta-treated OA chondrocytes.

277 o affect coral-macroalgal interactions under OA, and OA further suppresses the resilience of coral re

278 has were increased approximately 2-fold upon OA treatment.

279 to benign and malignant breast masses using OA/US versus US alone.

280 The 5-year survival in PVRL vs OA-uveal DLBCL differed by 17.7%, and overall survival w

281 obese OA patients, compared to normal-weight OA patients.

282 ] white AYA patients, and 3661 [68.1%] white OA patients).

283 men [51.1%] and 23 men [48.9%]) and 349 with OA-uveal DLBCL (192 women [55.0%] and 157 men [45.0%]) h

284 eatment (37 TSSR, 24 SR, 19 OSSR) and 6 with OA.

285 ly replicating evidence for association with OA at rs12901071 (OR 1.08 95% CI 1.05-1.11, Pmeta=3.12 x

286 tices, patients aged >/=45 y consulting with OA received point-of-care anxiety and depression screeni

287 mega-3 PUFAs were negatively correlated with OA and wound size, but positively correlated with adipon

288 6 PUFAs exhibited positive correlations with OA, impaired healing, and inflammatory adipokines.

289 g serum and synovial fluid lipid levels with OA, synovitis, adipokine levels, and wound healing in a

290 dent set of serum samples from patients with OA (n = 188), control individuals (n = 83) and RA (n = 1

291 to analyze serum samples from patients with OA (n = 273), control subjects (n = 76) and patients wit

292 cement (TKR) surgery for black patients with OA of the knee.

293 of chondrocytes isolated from patients with OA undergoing total knee replacement decreased expressio

294 Patients with OA-MCL frequently presented with disseminated lymphoma (

295 The prognosis of patients with OA-MCL might be improved by addition of rituximab to che

296 Medical records of 55 patients with OA-MCL were reviewed; the median length of follow-up was

297 PVRL was 41.4% (SE, 8.6%); among those with OA-uveal DLBCL, 59.1% (SE, 2.8%; Mantel-Cox test, P = .0

298 bands we can confidently diagnose three with OA and OCA2, and one with a PAX6 mutation.

299 hermore, articular chondrocytes treated with OA derived extracellular vesicles had decreased expressi

300 athepsin B knockdown and 24-h treatment with OA resulted in increased CD36 expression alone and addit