ライフサイエンスコーパス: ODN

1 ODNs shorter than 21 nt and with the adenosine adjacent

2 ODNs targeting the lagging-strand template blocked the t

3 like receptor 2 ([TLR-2] zymosan) and TLR-9 (ODN M362) each caused a similar increase in CCR9(+) MPP

4 There were more deaths after ODN (4 vs. 0), but this did not reach statistical signif

5 ars (99.2% vs 91.4%, P=0.01) was worse after ODN.

6 ice with a CpG oligonucleotide TLR9 agonist (ODN 1585) enhances expansion of IL-22-producing CD3-NK1.

7 ly modulated to be responsive to alternative ODN triggering sequences and that encapsulating macrocyc

8 central glucoprivation was suppressed by an ODN agonist.

9 of glucose was blunted by coinjection of an ODN antagonist.

10 Finally, in rats treated with an ODN to prevent high salt-induced up-regulation of brain

11 P-LDN compared with HA-LDN (OR 3 [1,10]) and ODN (OR 5 [2, 15]).

12 endozepines, are secreted by astroglia, and ODN is a potent anorexigenic factor.

13 significantly at 6 weeks in both the LDN and ODN groups.

14 TLR9-antagonist ODNs likewise promoted T cell activation, which has impo

15 Stopping AS-ODN was associated with the reappearance of hyperalgesia

16 ic pain, antisense oligodeoxynucleotides (AS-ODNs) or mismatch ODNs (MM-ODNs) for PKCepsilon were adm

17 patient spleens, suggest that collaborative ODN and IL-15 signaling may promote in vivo B-CLL growth

18 tion of negative controls (non-complementary ODN) were clearly discriminated by the sensor.

19 free alginate strands carrying complementary ODNs.

20 nds led to specific binding to complementary-ODN-carrying alginate gels in vitro and to injected gels

21 Induction of IDO by a GpC-containing ODN could also be demonstrated in human dendritic cells,

22 Control-ODN or iCpG-ODN did not alter CLP-induced cardiac dysfun

23 eated with CpG-ODN, control CpG-ODN (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 hour prior to c

24 Coupling ODNs to alginate strands led to specific binding to comp

25 CpG ODN enhanced expression of class I MHC and the costimula

26 CpG ODN was also co-encapsulated with p-Trp2 as an adjuvant.

27 able hapten analogue and a Th1 adjuvant (CpG ODN).

28 e a normal response to both anti-IgM and CpG ODN 1826.

29 The controlled release of anti-PD1 and CpG ODN by CpG DNA-based "nano-cocoons" can induce considera

30 with PspA plus a combination of pFL and CpG ODN elicited elevated levels of PspA-specific secretory-

31 given PspA plus a combination of pFL and CpG ODN showed protective immunity against nasal S. pneumoni

32 serving as a DC enhancement factor, and CpG ODN, serving as a DC activating factor, into sponge-like

33 veal that DEC-205 directly binds class B CpG ODN and enhances their uptake.

34 entify an important receptor for class B CpG ODN and reveal a unique function for DEC-205.

35 preferentially binds a specific class B CpG ODN that has been selected for human clinical trials.

36 nstitutively active ARF6 mutant enhanced CpG ODN-induced cytokine production.

37 by a variety of cells, is a receptor for CpG ODN.

38 How CpG ODN are captured and delivered to the intracellular rece

39 6 by dominant mutants and siRNA impaired CpG ODN-mediated responses, whereas cells expressing the con

40 receptor 1 (MRC1; CD206) is involved in CpG ODN uptake and trafficking in wild-derived MOLF/Ei perit

41 th CpG ODN but not GpC ODN had increased CpG ODN uptake due to CpG ODN-induced ARF6 activity.

42 The capacity of prophylactic intranasal CpG ODN to enhance survival does not require adaptive immuni

43 ed cytidyl guanosyl dinucleotide motifs (CpG ODN) are TLR9 ligands with attractive immunostimulatory

44 ablish that intranasal administration of CpG ODN 1 day prior to lethal pulmonary exposure to Y. pesti

45 nt studies indicate that the delivery of CpG ODN directly into the tumor bed reduces the immunosuppre

46 , indicating that intranasal delivery of CpG ODN has systemic impacts.

47 we evaluated the therapeutic profile of CpG ODN in a triple transgenic mouse model, Tg-SwDI, with ab

48 quired for downstream ARF6 regulation of CpG ODN uptake.

49 Peripheral administration of CpG ODN, both before and after the development of CAA, negat

50 iphile-CpG, an albumin-binding analog of CpG ODN, following systemic administration 3days after tumor

51 nformation for potential clinical use of CpG ODN.

52 ing by regulating the cellular uptake of CpG ODN.

53 the potential clinical applicability of CpG ODN.

54 CpG oligodeoxynucleotide (CpG ODN) cellular uptake into endosomes, the rate-limiting s

55 ants [Bordetella pertussis toxin (PT) or CpG ODN or a squalene-based oil-in-water nanoemulsion (NE)],

56 Additional studies showed that CpG ODN uptake was increased in ARF6-activated cells but imp

57 To identify the gene responsible for the CpG ODN defect, we have performed genome-wide linkage analys

58 All of these CpG ODN-mediated impacts, including the increased pulmonary

59 llele, R892W, which is hyporesponsive to CpG ODN and acts as a dominant-negative in a cellular model

60 e strain, MOLF/Ei, are hyporesponsive to CpG ODN but are fully responsive to bacterial DNA, thus impl

61 ODN had increased CpG ODN uptake due to CpG ODN-induced ARF6 activity.

62 When CpG ODN are used as an adjuvant, mice deficient in DEC-205 h

63 insight into a novel mechanism by which CpG ODN contribute to tumor regression, and they support int

64 Furthermore, cells pretreated with CpG ODN but not GpC ODN had increased CpG ODN uptake due to

65 Indeed, intranasal prophylaxis with CpG ODN provides significant protection against subcutaneous

66 nding and defective co-localization with CpG ODN.

67 Both CpG and non-CpG ODNs directly costimulate mouse and human CD4(+) T cells

68 antibody and CpG oligodeoxynucleotides (CpG ODNs) has been demonstrated to prevent cancer relapse ut

69 -motif containing oligodeoxynucleotides (CpG ODNs) is preceded by agonist endocytosis and delivery in

70 CpG-ODN attenuation of angiogenesis, however, remains TLR9-d

71 CpG-ODN induced a more robust inflammatory response than did

72 CpG-ODN pre-treated endothelial cells enhance macrophage mig

73 CpG-ODN prevented CLP-induced cardiac dysfunction, as eviden

74 CpG-ODN prevents CLP-induced cardiac dysfunction, in part th

75 CpG-ODN significantly attenuated CLP-induced myocardial apop

76 CpG-ODN-induced intraocular inflammation was abrogated in TL

77 bition of ERK by U0126 in vivo abolished CpG-ODN attenuation of CLP-induced cardiac dysfunction.

78 Addition of the adjuvants CpG-ODN or Poly(I:C) preferentially amplified Teffs over Tre

79 By 6 hours after CpG-ODN administration, TLR9 mRNA was increased in the corne

80 synergy between accessory cytokines and CpG-ODN in NK cells.

81 In contrast, LPS, MPLA, and CpG-ODN, but not poly(I:C), improved the host response to a

82 study, we report the development of anti-CpG-ODN antibodies in 21 of 37 patients who received CpG 790

83 These data show that topically applied CpG-ODN induces intraocular inflammation owing to TLR9 activ

84 d CpG-ODN with different CpG motifs, but CpG-ODN with GACGTT or AACGTT had better activity to this TL

85 Regulation of angiogenesis by CpG-ODN is pervasive and tissue non-specific.

86 Activation of these two TLRs by CpG-ODN occurred inside the cells and was modulated by UNC93

87 mice were treated with CpG-ODN, control CpG-ODN (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 ho

88 ew and alternative signaling pathway for CpG-ODN in murine NK cells.

89 Furthermore, CpG-ODN stimulation in the presence of accessory cytokines i

90 The impaired CpG-ODN-induced TNF-alpha production is GNP concentration- a

91 itment of peripheral cells to the CNS in CpG-ODN-inoculated mice.

92 d with protective TLR ligands, including CpG-ODN, showed reduced plasma cytokines during P. aeruginos

93 rol CpG-ODN (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 hour prior to cecal ligation and punctu

94 Fluorescein isothiocyanate-CpG-ODN rapidly penetrated the cornea and ocular media to re

95 peutic compounds evaluated in the model, CpG-ODN reduced body weight loss (to <6% on days 3-7 after c

96 otide containing unmethylated CpG motif (CpG-ODN) and alanyl-glutamine in vivo and in vitro.

97 s the endocytosis and internalization of CpG-ODN by mouse bone marrow-derived macrophages and directl

98 a molecular basis for the activities of CpG-ODN in fish.

99 and TLR21 are the cellular receptors of CpG-ODN in mammals and chickens, respectively.

100 mediate the antimicrobial activities of CpG-ODN.

101 and respond to CpG oligodeoxynucleotide (CpG-ODN) by producing IFN-gamma and GM-CSF.

102 hosphate-guanosine oligodeoxynucleotide (CpG-ODN) to induce neuroinflammation after intracerebroventr

103 stimulation by CpG-oligodeoxynucleotide (CpG-ODN) was integrated into microbiome-gene expression asso

104 the effect of CpG oligodeoxynucleotide (CpG-ODN), the TLR9 ligand, on polymicrobial sepsis-induced c

105 nt in binding CpG oligodeoxynucleotides (CpG-ODN), the microbial DNA mimetic sensed by toll-like rece

106 osphate-guanosine oligodeoxynucleotides (CpG-ODN), to investigate the role of TLR9 in vascular pathop

107 ith CXCL13-coupled CpG oligonucleotides (CpG-ODN) can block cancer metastasis by inhibiting CD20(Low)

108 ing GM-CSF in combination with P(I:C) or CpG-ODN induced the complete regression of solid tumors (</=

109 Vaccine formulations of peptide+CpG-ODN or Poly(I:C) induced selective production of proinfl

110 zebTLR9 broadly recognized CpG-ODN with different CpG motifs, but CpG-ODN with GACGTT o

111 Further, we noted that synthetic CpG-ODN requires backbone phosphorothioate but not TLR9 acti

112 In vitro experiments demonstrated that CpG-ODN promotes an association between TLR9 and Ras, result

113 We demonstrate that CpG-ODN stimulates inflammation yet inhibits angiogenesis.

114 echanistic investigations suggested that CpG-ODN upregulates low surface levels of 4-1BBL on tBregs t

115 The CpG-ODN binding function of DEC-205 is conserved between mou

116 Consistent with cytokine inhibition, the CpG-ODN-induced phosphorylation of NF-kappaB and JNK as well

117 This CpG-ODN chaperone complex-promoted innate immunity confers i

118 afish TLRs are functional, responding to CpG-ODN but not to other TLR ligands.

119 LR signaling pathways was also linked to CpG-ODN responsive fibroblasts, OTU1341 (Prevotella), and Sh

120 dividuals with fibroblasts responsive to CpG-ODN stimulation.

121 st, zebTLR21 responded preferentially to CpG-ODN with GTCGTT motifs.

122 stored corneal inflammatory responses to CpG-ODN.

123 s IL-15 and IL-18) was required, whereas CpG-ODN or accessory cytokines alone did not induce IFN-gamm

124 reflecting endotoxin tolerance, whereas CpG-ODN-primed mice showed augmented cytokine production.

125 of Listeria monocytogenes compared with CpG-ODN treatment alone.

126 Male C57BL/6 mice were treated with CpG-ODN, control CpG-ODN (control-ODN), or inhibitory CpG-OD

127 Additionally, CpG-ODNs induce an M1 macrophage phenotype that restricts an

128 The effects mediated by CpG-ODNs can therefore modulate both endothelial cells and m

129 CpG-oligodeoxynucleotides (CpG-ODNs) are potent immune stimuli currently under investig

130 tion of TLR9 (CpG oligodeoxynucleotides; CpG-ODNs) signal in macrophages.

131 odies cross-reacted with other synthetic CpG-ODNs but not with the DNA of mixed bacterial vaccine and

132 The CpG-ODNs that activate both zebTLR9 and zebTLR21 were more p

133 fected TLR9 translocation in response to CpG-ODNs and to phagosomes.

134 Unlike CpG-ODNs, the effects of GpC-ODN required TLR7/TRIF-mediated

135 ongoing and planned clinical trials with CpG-ODNs.

136 Administration of decoy ODNs comprising the NRSF DNA-binding sequence (neuron re

137 tegy may furnish a general method to develop ODN-responsive protein-binders.

138 We performed 4286 DNs: 2759 open DN (ODNs), 1190 hand-assisted (HA) laparoscopic DNs (LDNs),

139 -(Ph)ImdC):ORN(G) was reduced only 3.8-fold, ODN(CF3-(Ph)ImdC) appears to be a DNA-selective probe.

140 These findings establish poly-G ODN as a novel type of cancer immunotherapy.

141 Mechanistically, poly-G ODN directly induced the phosphorylation of Lck (an esse

142 The antitumor activity of poly-G ODN was mediated through CD8 T cells in a TLR9-independe

143 e, cells pretreated with CpG ODN but not GpC ODN had increased CpG ODN uptake due to CpG ODN-induced

144 Unlike CpG-ODNs, the effects of GpC-ODN required TLR7/TRIF-mediated but not TLR9/MyD88-media

145 In this study, we show that a synthetic GpC-ODN conferred highly suppressive activity on mouse splen

146 NA (dsDNA) donors with central heterologies, ODNs generated short conversion tracts with Gaussian-lik

147 N (control-ODN), or inhibitory CpG-ODN (iCpG-ODN) 1 hour prior to cecal ligation and puncture (CLP)-i

148 Control-ODN or iCpG-ODN did not alter CLP-induced cardiac dysfunction.

149 since the quantum yield of ODN(CF3-(Ph)ImdC):ODN(G) was reduced 17-fold vs that of a single strand, w

150 The high yield of Gh in ODNs underscores the importance of further study on this

151 When incorporated in ODNs, this fluorescent deoxyuridine analog exhibits rema

152 INH-ODN 2088 is a prototypic member of this class of INH-ODN

153 ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888, TLR7-induced TNF-alpha release and TLR7- and

154 dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888,

155 toimmune MRL/Mp-lpr/lpr mice, G-modified INH-ODN 24888 was significantly more efficient than unmodifi

156 is a prototypic member of this class of INH-ODN and acts as a TLR7 and TLR9 antagonist.

157 nucleotides (inhibitory oligonucleotide [INH-ODN]) are characterized by a phosphorothioate backbone a

158 Surprisingly, INH-ODN 2088 stimulated B cells to proliferate when used in

159 ificantly more efficient than unmodified INH-ODN 2088.

160 inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888, TLR7-induced TNF-alpha relea

161 more efficiently impaired by G-modified INH-ODNs.

162 ignificantly more impaired by G-modified INH-ODNs.

163 G modification allows the development of INH-ODNs with superior inhibitory potency for inflammatory d

164 ications for the study of these "inhibitory" ODNs in inflammatory diseases.

165 sufficiently stable to be incorporated into ODNs.

166 minoethyl phosphotriester modifications into ODNs.

167 and WM-239A cells with fluorescently labeled ODNs shows significant cytoplasmic fluorescence when vie

168 A fluorescently labeled 16-mer ODN modified with two TP linkages shows efficient cellul

169 Fluorescently labeled 23-mer ODNs modified with four cationic or hydrophobic Z phosph

170 The minimal ODNs that activate human TLR9 comprise 2 CG dinucleotide

171 oligodeoxynucleotides (AS-ODNs) or mismatch ODNs (MM-ODNs) for PKCepsilon were administered intrathe

172 xynucleotides (AS-ODNs) or mismatch ODNs (MM-ODNs) for PKCepsilon were administered intrathecally.

173 a slight destabilization when a TP-modified ODN is hybridized to its complementary RNA.

174 the subcellular distribution of TP-modified ODNs is highly dependent on cell type; a significant nuc

175 ontaining cationic or hydrophobic Z modified ODNs indicate that the backbone-phosphotriester modifica

176 is to use overexpression dominant-negative (ODN) phenotypes to identify mutant proteins that disrupt

177 N) or short-incision open donor nephrectomy (ODN).

178 ransplantation after open donor nephrectomy (ODN).

179 th open procurement (open donor nephrectomy [ODN]) for children.

180 In vivo, decoy NRSE ODN treatment restored theta rhythm and altered the init

181 processing product the octadecaneuropeptide (ODN), collectively named endozepines, are secreted by as

182 A small molecule, odanacatib (ODN), which is a cathepsin K (Ctsk) inhibitor, was inves

183 dy, a small molecular inhibitor (odanacatib [ODN]) is explored to inhibit the function of CTSK in a b

184 The application of ODN decreased the number of osteoclasts, macrophages, an

185 modeling showed that the negative effect of ODN on graft survival was reduced when adjusted for acut

186 vs that of a single strand, whereas that of ODN(CF3-(Ph)ImdC):ORN(G) was reduced only 3.8-fold, ODN(

187 Furthermore, since the quantum yield of ODN(CF3-(Ph)ImdC):ODN(G) was reduced 17-fold vs that of

188 genic strains with varying concentrations of ODNs, no gene editing events were detected.

189 ated with the association or dissociation of ODNs were measured as change in resistance.

190 cross-links are produced upon irradiation of ODNs containing 1 at 350 nm.

191 ence, length, and dimerization properties of ODNs modulate their activation of TLR9.

192 pression and augmented oligodeoxynucleotide (ODN) sequestration and PLT clumping upon addition of bac

193 matically characterize oligodeoxynucleotide (ODN)-mediated PGE using Cas9 and its nickase variants in

194 anide ISA 720 plus CpG oligodeoxynucleotide (ODN) and was observed in both inbred and outbred strains

195 adjuvants alum and CpG oligodeoxynucleotide (ODN) generated heroin "immunoantagonism", reducing heroi

196 B-CLL exposure to CpG oligodeoxynucleotide (ODN) raised questions about a central role for TLR-9.

197 sphate-guanidine (CpG) oligodeoxynucleotide (ODN), a toll-like receptor 9 (TLR9) agonist, confers pro

198 Gh yield increased in oligodeoxynucleotide (ODN) contexts or at reduced pH.

199 preparation of labeled oligodeoxynucleotide (ODN) probes based on MS2 and cyclin D1 (a known breast c

200 rast, the TLR9 ligand [oligodeoxynucleotide (ODN)1826] stimulated sFlt-1 secretion from macrophages a

201 re SMDHs with multiple oligodeoxynucleotide (ODN) strands.

202 Selective oligodeoxynucleotide (ODN)-mediated down-regulation of brain Galphai(2) protei

203 Mammalian telomeric oligodeoxynucleotide (ODN) significantly inhibited all features of TLR ligand-

204 ut a TLR9 agonist (CpG oligodeoxynucleotide [ODN] 2006) for 2 d and then assessed for phenotype, endo

205 cked by synthetic CpG oligodeoxynucleotides (ODN).

206 Oligodeoxynucleotides (ODNs) complementary to the (CTG)(45) . (CAG)(45) lagging

207 sis of mixed-backbone oligodeoxynucleotides (ODNs) consisting of methylborane phosphine and phosphate

208 Application of CpG oligodeoxynucleotides (ODNs) resulted in neutrophil and macrophage infiltration

209 ne-phosphate-guanine) oligodeoxynucleotides (ODNs) leads to cognitive improvements and CAA reduction,

210 ne-phosphate-guanine) oligodeoxynucleotides (ODNs), can reduce amyloid and tau pathologies without ca

211 ific incorporation in oligodeoxynucleotides (ODNs) of an emissive deoxyuridine analog electronically

212 be incorporated into oligodeoxynucleotides (ODNs) by chemical DNA synthesis and thus very little is

213 and incorporated into oligodeoxynucleotides (ODNs).

214 Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif TTAGGG bl

215 Short synthetic oligodeoxynucleotides (ODNs) rich in CpG or GpG motifs have been considered as

216 Indeed, short U3 oligodeoxynucleotides (ODNs) based on these RNA sequences ably inhibited prolif

217 ls were modified with oligodeoxynucleotides (ODNs) that provide a target for drug payloads in the for

218 ts showed that CpG oligodeoxyribonucleotide (ODN) induces very low levels of anti-CPS IgM antibodies,

219 of mixed backbone oligodeoxyribonucleotides (ODNs) having 1,2,3-triazolylphosphonate (TP) as well as

220 f phosphotriester oligodeoxyribonucleotides (ODNs) that are stable to the conditions used for their p

221 Synthetic oligodeoxyribonucleotides (ODNs) containing CpG (unmethylated deoxycytidylyl-deoxyg

222 C) that undergoes an input oligonucleotide (ODN)-selective structural transformation from a stem-loo

223 Immunostimulatory CpG oligonucleotides (ODN) activate cells that express TLR9 and have been show

224 Synthetic CpG oligonucleotides (ODN) have potent immunostimulatory properties exploited

225 of polyguanosine (poly-G) oligonucleotides (ODN) has such an effect, boosting antitumor immunity and

226 onds (fNDs) to deliver CpG oligonucleotides (ODNs) for sustained immunostimulation is reported.

227 ucleases (TALENs) with DNA oligonucleotides (ODNs).

228 We show that oligonucleotides (ODNs) designed to anneal to the lagging strand generate

229 e randomized in a 2:1 ratio to LDN (n=56) or ODN (n=28).

230 nic effects of centrally injected glucose or ODN agonist were suppressed by blockade of the melanocor

231 Pam2-ODN also extended survival of pneumonia in NSG mice engr

232 Pam2-ODN had no discernible effect on replication rate, total

233 Pam2-ODN prevented death due to pneumonia caused by Pseudomon

234 ceptor 2/6 (TLR 2/6) and TLR9 agonists (Pam2-ODN) induces protective mucosal defenses in mice against

235 As Pam2-ODN-induced protection persists despite depletion of sev

236 lity assays show that methylborane phosphine ODNs are highly resistant to 5' and 3' exonucleases.

237 motifs of B-class and C-class phosphodiester ODNs to identify the sequence properties that govern TLR

238 type, right LDN (OR=1.58, P<0.01) and right ODN (OR=1.38, P=0.02) demonstrated an association with i

239 ain Galphai(2) proteins, but not a scrambled ODN, abolished the renal sympathoinhibitory response and

240 In scrambled ODN-treated rats, chronic changes in dietary sodium inta

241 anic substrates and homo- or mixed-sequenced ODNs.

242 SMDHs bearing up to six ODNs were successfully prepared through the coupling of

243 The present novel molecularly imprinted ss-ODN biosensor could greatly benefit in terms of cost-eff

244 single-stranded oligodeoxyribonucleotide (ss-ODN) biosensor was fabricated and characterised in this

245 The resulting ss-ODN imprinted PoPD/ITO electrode was characterised using

246 i.e., Deltai as a function of the target ss-ODN concentration was studied.

247 near Delta current response to the target ss-ODN concentration within the range of 0.01-300 fM.

248 The template ss-ODN was washed out of the ss-ODN/poly(o-phenylenediamine

249 The template ss-ODN was washed out of the ss-ODN/poly(o-phenylenediamine)(PoPD)/ITO electrode using s

250 Using ss-ODN as the template and o-phenylenediamine as the functi

251 The biosensor using ss-ODN imprinted PoPD/ITO as the working electrode showed a

252 is inhibition in vivo, we administered ssDNA-ODNs and poly I:C, alone or in combination, via the intr

253 immune activation can be modulated by ssDNA-ODNs and provide evidence of dampening proinflammatory c

254 atopoietic cells was also inhibited by ssDNA-ODNs.

255 o cells was reduced in the presence of ssDNA-ODNs, preventing TLR3 engagement from occurring.

256 single-stranded DNA oligonucleotides (ssDNA-ODNs) on TLR3 activation.

257 s were reduced in the groups receiving ssDNA-ODNs or both substances.

258 events were inhibited in cultures with ssDNA-ODNs.

259 study, we demonstrate that such suppressive ODN abrogate activation of cytosolic nucleic acid-sensin

260 c cells and macrophages with the suppressive ODN-A151 abrogated type I IFN, TNF-alpha, and ISG induct

261 nd unveil novel applications for suppressive ODNs in the treatment of infectious and autoimmune disea

262 ings reveal a new route by which suppressive ODNs modulate the immune system and unveil novel applica

263 turally derived pathogenic DNA and synthetic ODNs.

264 ddition of different concentration of target ODNs in presence of relevant buffer.

265 The target ODNs specific to Homo sapiens Breast and ovarian cancer

266 Host-derived telomeric ODN suppress B-cell activation and antibody production d

267 Our results demonstrated that ODN can inhibit endodontic disease development, bone ero

268 hroism spectroscopy, which demonstrates that ODN is a more sensitive assessment of protein stability

269 mal protease, we were surprised to find that ODN can suppress the bacterium-induced immune response a

270 cal and immunofluorescent staining show that ODN treatment dramatically decreased F4/80+ macrophages

271 rocomputed tomography (micro-CT) showed that ODN treatment had significant bone protection effects at

272 Collectively, our results suggest that ODN-mediated PGE utilizes synthesis-dependent strand ann

273 olarization of distinct Th subsets, and that ODNs differentially affect human naive and memory T cell

274 Cytokine profiling revealed that ODNs promote polarization of distinct Th subsets, and th

275 Acute rejection was higher in the ODN group, compared with LDN (40.6% vs. 24.3% P=0.007).

276 and corresponding cytokine expression in the ODN-treated disease group.

277 rs 4, 5, and 9 also largely decreased in the ODN-treated disease group.

278 nylenediamine as the functional monomer, the ODN biosensor was fabricated by an electropolymerisation

279 ately 70%) occur by the incorporation of the ODN during replication within the lagging strand.

280 ted poly-thymidine tail at the 3' end of the ODN.

281 We conclude that the ODN(CF3-(Ph)ImdC) probe, exhibiting emission sensitivity

282 etween the stimulatory CpG motifs within the ODN fine-tunes the activation of B cells.

283 remove base labile protecting groups and the ODNs from the solid support.

284 Moreover, the ODNs were physically incorporated into the genome only i

285 epending on the relative strandedness of the ODNs and the nick.

286 Among potentially therapeutic ODNs, this study identifies GpC-rich sequences as novel

287 After synthesis these ODNs were found to be stable to the condition required t

288 ular uptake measurements indicate that these ODNs are efficiently taken up by cells even when the str

289 A robust response to ODN+IL-15 was positively linked to presence of chromosom

290 mal memory B cells proliferate vigorously to ODN+IL-15, a cytokine found in stromal cells of bone mar

291 esults demonstrate that triazolylphosphonate ODNs are versatile additions to the oligonucleotide chem

292 , through proof-of-concept experiments using ODN-modified nanopores, we show that functionalized nano

293 Interestingly, single-nick-induced PGE using ODN donors produced conversion tracts biased either most

294 DN group (median [range], 59 [6-136]) versus ODN group (90 [35-312] mg; P=0.001).

295 LT clumping upon addition of bacterial/viral ODNs.

296 nce was observed for the G-matched duplex vs ODN(CF3-(Ph)ImdC), while for A-mismatched duplex, only a

297 ly conserved charged residues, combined with ODN screening to eliminate partially unfolded proteins,

298 tes of graft failure at 1 year compared with ODN (P = 0.002).

299 For the entire cohort compared with ODN, LDN was not associated with early allograft loss (o

300 oupling of arylenethynylene macrocycles with ODNs, which were used to mediate the assembly of gold na