ライフサイエンスコーパス: OEC

1 OEC cultures were successfully generated from a similar

2 OECs attenuated immune cell infiltration, reduced second

3 OECs demonstrate a TLR-response profile similar to that

4 OECs from T1D participants are TLR-hyper-responsive, due

5 OECs have a unique response to P. gingivalis LPS, where

6 OECs may be used for further phenotypic, genetic, and fu

7 OECs proliferated in injection sites, cell tracts, and l

8 OECs showed a dramatic ability to rapidly change shape,

9 OECs transplanted into transected peripheral nerve have

10 OECs, but not FBs, intermingled with astrocytes, facilit

11 more (NS) and nvAMD 32-times more (P < 0.05) OECs on expansion of clusters than did non-AMD/low-risk

12 peared to be expressed in GFAP(-)/RALDH 1(-) OECs as well as in unidentified structures in the LP.

13 by ligand lability, with the Mn(IV)(3)CaO(4) OEC model being unreactive.

14 he applied cell suspension consisted of >98% OECs, 2) that the majority of the cells expressed the tr

15 rall improvement in locomotor function after OEC transplantation, measured using the Basso, Beattie,

16 nd share many properties in common, although OECs appear to be a better candidate for transplantation

17 An OEC population was isolated and expanded from the blood

18 Site-selective deposition of an OEC, guided by the activity maps, improves the overall p

19 The lack of an OEC-specific marker, however, has limited the investigat

20 re can be applied to human studies, where an OEC can be analyzed in light of an individual's entire g

21 orescent protein-labeled fibroblast (FB) and OEC transplants acutely after a complete low-thoracic sp

22 pha1 was expressed in immature OSN axons and OECs of the nerve layer, as well as mitral and tufted ce

23 atically reduced, exhibiting fewer axons and OECs.

24 ignaling network that exists in human OM and OECs.

25 referentially extend into the cell tract and OECs failed to support bridging of corticospinal axons.

26 SN axon bundles were enlarged and associated OECs increased, indicating impaired migration of OECs an

27 nstrated that immune suppression can augment OEC contact-mediated protection of axons and neurons dur

28 ively links the OER activity of the Ni-based OECs with the generation of those sites on the surface o

29 tain catalytically active phases in Ni-based OECs, in addition to the key role of the Fe impurities.

30 d to a deprotonation process of the Ni-based OECs, leading to the formation of the negatively charged

31 aracterization of two Fe-containing Ni-based OECs, namely nickel borate (Ni(Fe)-B(i)) and nickel oxyh

32 y of solar-driven devices utilizing Ni-based OECs.

33 reduces interface recombination at the BiVO4/OEC junction while creating a more favorable Helmholtz l

34 lvaging ischemic murine limbs, whereas bolus OEC delivery was ineffective in preventing toe necrosis

35 neration of negatively charged sites in both OECs (NiOO(-)), which can be described as adsorbed "acti

36 The OER activity of both OECs is strongly pH dependent, which can be attributed t

37 sorption spectroscopy results show that both OECs are chemically similar, and that the borate anions

38 Since the ammonia-bound OEC is active, the ammonia-binding Mn site is not a subs

39 We found that, as in the case of bulbar OEC preparations, the mucosal cells also restored direct

40 rose from a CD14+ subpopulation of PBMCs but OECs developed exclusively from the CD14- fraction.

41 osis of the primary olfactory axon debris by OECs was first detected at E14.5.

42 While the repertoire of TLRs expressed by OECs is similar to that expressed by macrophages (M), th

43 However, it is unclear when phagocytosis by OECs first commences.

44 We investigated the onset of phagocytosis by OECs in the developing mouse olfactory system by utilizi

45 modelling (reduction) of HS 6-O-sulfation by OECs, compared with SCs, to suppress boundary formation.

46 ing two different oxygen evolution catalyst (OEC) layers, FeOOH and NiOOH, which reduces interface re

47 hotoanode with an oxygen evolution catalyst (OEC) to increase the photocurrent and reduce the onset p

48 kinetic profile of the O2 evolving catalyst (OEC).

49 Ni-based oxygen evolution catalysts (OECs) are cost-effective and very active materials that

50 ection model and olfactory ensheathing cell (OEC) or fibroblast (FB; control) transplantation as a re

51 Olfactory ensheathing cell (OEC) transplantation is a candidate cellular treatment a

52 eficial therapy, olfactory ensheathing cell (OEC) transplantation, results in functional improvements

53 In this study, human oral cancer cells (OEC-M1) were encapsulated in 3D agarose scaffold and cul

54 n with cultured olfactory ensheathing cells (OEC) into the lesion cavity 6 weeks after contusion inju

55 rd migration of outgrowth endothelial cells (OECs) have been delineated, and a material incorporating

56 ure of 50% p75+ olfactory ensheathing cells (OECs) and fibroblasts derived from the outer layers of t

57 Olfactory ensheathing cells (OECs) are known to enhance axonal regeneration and to pr

58 Olfactory ensheathing cells (OECs) are the glia of the primary olfactory nerve and ar

59 Transplants of olfactory ensheathing cells (OECs) cultured from the olfactory bulb are able to induc

60 Wnt-5a, whereas olfactory ensheathing cells (OECs) express Wnt-4.

61 Olfactory ensheathing cells (OECs) have been reported to migrate long distances and t

62 Olfactory ensheathing cells (OECs) have neuro-restorative properties in animal models

63 GFAP(+)/p75(-) olfactory ensheathing cells (OECs) in the underlying lamina propria (LP).

64 infected human olfactory ensheathing cells (OECs) in vitro and measured bacterial invasion and the c

65 nsplantation of olfactory ensheathing cells (OECs) into injured spinal cord results in improved funct

66 Olfactory ensheathing cells (OECs) prepared from the olfactory bulbs of adult transge

67 flux pathway in olfactory ensheathing cells (OECs) was performed using Indo-1 calcium microfluorometr

68 ons (OSNs), and olfactory ensheathing cells (OECs), but was excluded from mature OSNs.

69 (SCs), but not olfactory ensheathing cells (OECs), form a boundary with astrocytes, due to a SC-spec

70 al culturing of olfactory ensheathing cells (OECs), which can be used to understand how OECs interact

71 cells (SCs) and olfactory ensheathing cells (OECs).

72 donor rats [GFP-olfactory ensheathing cells (OECs)] into a region of spinal cord demyelination and fo

73 bicans-infected human oral epithelial cells (OECs) and in tongue tissue from mice with OPC.

74 riodontium, including oral epithelial cells (OECs), express innate immune receptors, including TLRs.

75 atalyst found in the oxygen evolving center (OEC) in photosystem II, nanostructured manganese oxide s

76 e a structure of the oxygen-evolving center (OEC).

77 luble model of a cobalt-phosphate/borate (Co-OEC) water splitting catalyst.

78 the growing cobaltate clusters comprising Co-OEC.

79 ) solutions in weakly basic electrolytes (Co-OEC).

80 ity is oxidized to produce the well-known Co-OEC heterogeneous cobaltate catalyst, which is an active

81 n isotopologues produced by (18)O-labeled Co-OEC in H2(16)O reveals that water splitting catalysis pr

82 Steady-state electrodeposition of Co-OEC exhibits a Tafel slope approximately equal to 2.3 x

83 The edge site chemistry of Co-OEC has been probed by using a dinuclear cobalt complex.

84 s are consistent with the OER activity of Co-OEC in Bi and Pi.

85 orce microscopy reveal that nucleation of Co-OEC is progressive and reaches a saturation surface cove

86 n oxygens bound to dicobalt edge sites of Co-OEC.

87 is also confirmed by DEMS experiments of Co-OEC.

88 These complementary studies on Co-OEC and the dicobalt edge site mimic allow for a direct

89 em and the high-valent active site of the Co-OEC, with specific emphasis on the manifestation of a do

90 oxidic cobalt oxygen-evolving catalysts (Co-OECs).

91 of anions in the self-repair mechanism of Co-OECs.

92 The Co-OECs are active when residing at two oxidation levels ab

93 e properties of the oxygen-evolving complex (OEC) and the structure of the Mn(4)Ca cluster in Photosy

94 he active site of the O(2)-evolving complex (OEC) as expected.

95 hin and outside the oxygen-evolving complex (OEC) have been examined.

96 is the case for the oxygen evolving complex (OEC) in photosystem II (PSII), where we have studied whe

97 o S(3) steps of the oxygen-evolving complex (OEC) in photosystem II (PSII).

98 The oxygen-evolving complex (OEC) in the membrane-bound protein complex photosystem I

99 sible models of the oxygen-evolving complex (OEC) in the S0-S4 states.

100 down turnover of the O(2)-evolving complex (OEC) is a plausible approach to gain mechanistic informa

101 nd S2 states of the oxygen-evolving complex (OEC) of photosystem II (PS II).

102 water oxidation at the O2-evolving complex (OEC) of photosystem II (PSII) is a complex process invol

103 ctural model of the oxygen-evolving complex (OEC) of photosystem II (PSII) is introduced.

104 5)Ca cluster of the oxygen-evolving complex (OEC) of Photosystem II (PSII) poised in the S(2) state w

105 binding site of the oxygen evolving complex (OEC) of photosystem II (PSII) to the paramagnetic Mn clu

106 ation catalyst, the oxygen-evolving complex (OEC) of photosystem II (PSII).

107 ent S states of the oxygen evolving complex (OEC) of photosystem II (PSII).

108 e Mn4Ca site in the oxygen evolving complex (OEC) of photosystem II (PSII).

109 otif present in the oxygen-evolving complex (OEC) of photosystem II and in water-oxidizing Mn/Ca laye

110 The oxygen-evolving complex (OEC) of photosystem II contains a Mn(4)CaO(n) catalytic

111 etic organisms, the oxygen-evolving complex (OEC) of photosystem II generates dioxygen from water usi

112 ry synthesis of the oxygen-evolving complex (OEC) of photosystem II has been the objective of synthet

113 hough the {CaMn4O5} oxygen evolving complex (OEC) of photosystem II is a major paradigm for water oxi

114 lly relevant to the oxygen-evolving complex (OEC) of photosystem II were prepared and characterized.

115 d reactivity of the oxygen-evolving complex (OEC) of photosystem II, a low-symmetry Mn4CaOn cluster.

116 ional models of the oxygen evolving complex (OEC) of photosystem II, we report the synthesis of site-

117 laser pulse on the oxygen-evolving complex (OEC) of photosystem II.

118 n this process, the oxygen-evolving complex (OEC) of PSII cycles through five states, S0 to S4, in wh

119 ere assigned to the oxygen-evolving complex (OEC) tetramanganese cluster (Em = 0.2 V vs NHE), quinone

120 takes place in the oxygen-evolving complex (OEC) that is comprised of a tetranuclear manganese clust

121 anganese-containing oxygen evolving complex (OEC) to the oxidized primary electron-donor chlorophyll

122 s binding site in the O(2)-evolving complex (OEC) under continuous illumination.

123 occurs at the PSII oxygen-evolving complex (OEC), which contains a tetranuclear manganese (Mn) clust

124 on reactions at the oxygen-evolving complex (OEC), which is composed of four manganese ions and one c

125 equivalents at the oxygen-evolving complex (OEC).

126 equivalents at the oxygen-evolving complex (OEC).

127 anganese-containing oxygen evolving complex (OEC).

128 e manganese-containing O 2-evolving complex (OEC).

129 4)Ca cluster of the oxygen-evolving complex (OEC).

130 CaO5 cluster in the oxygen-evolving complex (OEC).

131 tosystem II (PS II) oxygen-evolving complex (OEC): a multiprotein assembly embedded in the thylakoid

132 mbrane-protruding oxygen-evolving complexes (OECs) associated with photosystem II (PSII) on spinach (

133 In conclusion, OEC transplantation exerts considerable beneficial effec

134 se structural model of the asymmetric-cubane OEC unit.

135 e used floating liquid marbles to co-culture OECs with Schwann cells and astrocytes which formed natu

136 he injured olfactory pathway and of cultured OECs identified 102 genes that were subsequently functio

137 rous simultaneous oxygen equilibrium curves (OECs) can be obtained under truly identical conditions f

138 ate that from early in embryonic development OECs are the primary phagocytic cells of the primary olf

139 ike myelinated axons were derived from donor OECs.

140 Direct injection of an EPC/OEC combination was minimally effective in improving lim

141 However, because excess OEC material can hinder light absorption and decrease ph

142 between the number of OEC clusters, expanded OECs and levels of KDR was demonstrated.

143 GFP-expressing OECs survived in the lesion and distributed longitudinal

144 e large axon fascicles, but are negative for OEC markers.

145 tes give optimal improvement if targeted for OEC deposition, and whether sites catalysing water oxida

146 des persisted for at least 8 weeks after GFP-OEC transplantation.

147 monstrated enhanced conduction along the GFP-OEC-remyelinated axons.

148 in addition to forming myelin, engrafted GFP-OECs provide an environment that supports the developmen

149 nd accordingly suggest a reassessment in how OEC activities of different catalysts are compared and r

150 This protocol can be used to determine how OECs and other cell types associate and interact while f

151 (OECs), which can be used to understand how OECs interact with other cells in three dimensions.

152 Human OECs killed >90% of the B. pseudomallei in a CPS I-indep

153 timicrobial program to be described in human OECs and establishes the extensive transcriptional defen

154 -hyper-inflammatory phenotype, primary human OECs from individuals with T1D and diabetes-free individ

155 to play two ostensibly antagonistic roles in OEC activity: as a promulgator of catalyst activity by e

156 To interrogate the role of the IL-17R in OECs, we generated mice with conditional deletion of IL-

157 a network of signaling pathways activated in OECs following infection involving a novel group of 378

158 ess this issue, cell populations enriched in OECs were isolated from the olfactory bulbs of adult gre

159 tive siRNA-mediated knockdown of 16 genes in OECs (ADAMTS1, BM385941, FZD1, GFRA1, LEPRE1, NCAM1, NID

160 that endogenous expression of these genes in OECs supports neurite extension of DRG neurons.

161 Expression of VEGF receptor-2 (KDR) in OECs after expansion was determined by Western blot.

162 ice which express red fluorescent protein in OECs.

163 d with OECs, and siRNA reduction of Sulfs in OECs was, in itself, sufficient to induce boundary forma

164 perty is effective in abrogating TLR-induced OEC hyperactivity.

165 rated significantly higher number of initial OEC clusters and expansion potential of OECs in patients

166 ential hydrogen bond network, which involves OEC peptide CO groups.

167 The data justify OECs as a cellular substrate to develop and optimize min

168 One month later, OECs formed an apparent migrating cell tract continuousl

169 T lesion paradigm to examine whether mucosal OEC preparations can provide a similar repair to those f

170 ing by a self-assembled nickel-borate (NiBi) OEC.

171 strocytes, we demonstrated that SCs, but not OECs, secrete a heat labile factor(s) that inhibits olig

172 d conditions; and observed for appearance of OEC clusters and growth characteristics on expansion.

173 This study evaluated the effect of OEC transplantation on microsurgically repaired sciatic

174 ogic approach, (i) to assess the efficacy of OEC transplantation on locomotor recovery after traumati

175 To understand mechanisms of OEC migration and axonal guidance, we injected lamina pr

176 risk dry AMD had a 5.6-fold higher number of OEC clusters per 20 mL blood, and subjects with nvAMD ha

177 ignificant correlation between the number of OEC clusters, expanded OECs and levels of KDR was demons

178 To date, studies of OEC behaviour in a multicellular environment have been h

179 e mucosal cell cultures contained only 5% of OECs and a conversely much larger proportion of fibrobla

180 es from mucosal samples yielded around 5% of OECs compared with the 50% obtained from samples culture

181 The aberrant TLR-activation of OECs in T1D has the potential to contribute to excessive

182 functionally characterized in cocultures of OECs and primary dorsal root ganglion (DRG) neurons.

183 lly, material deployment of a combination of OECs with another cell population commonly isolated from

184 ttle is known of the detailed integration of OECs at the transplantation site in peripheral nerve.

185 Isolation of OECs involves concurrent isolation of other cell types,

186 increased, indicating impaired migration of OECs and OSN axons.

187 tial OEC clusters and expansion potential of OECs in patients at risk for or already affected by nvAM

188 These results suggest that presentation of OECs at the time of nerve injury enhances regeneration a

189 concept that the regenerative properties of OECs are profoundly influenced by the cells with which t

190 to the regeneration-promoting properties of OECs.

191 To delineate the TLR responses of OECs derived from T1D participants and to determine effe

192 Immunosuppression enhanced survival of OECs and FBs, but only OEC transplantation promoted scaf

193 Notably, the "bridging" tract of OECs formed within 1 h of cell injection, raising the po

194 Transplantation of OECs is being trialled for repair of the paralysed spina

195 microsurgical repair and transplantation of OECs or injection of medium without cells.

196 enhanced survival of OECs and FBs, but only OEC transplantation promoted scaffold formation in the l

197 to freely associate and interact to produce OEC spheroids with uniform shapes and sizes.

198 Progeny OECs might take on the parental or a non-parental morpho

199 axonal guidance, we injected lamina propria OECs 1 mm rostral and caudal to C4 SCI sites.

200 ulting in the disordered arrangement of PSII-OEC particles.

201 3 reaction center protein (CP43) in the PSII-OEC extrinsic domains of grana membranes under condition

202 techniques are required to produce purified OECs.

203 ide analysis of HS in SC-conditioned and rat OEC-conditioned media showed that SCs secrete more highl

204 Reporter TOPGAL mice demonstrated that some OECs located in the inner olfactory nerve layer can resp

205 connective tissue growth factor (CTGF) than OECs.

206 hat SCs secrete more highly sulfated HS than OECs.

207 Our findings indicate that OECs survive longer than FBs post-transplantation, prese

208 ll tracts, and lesion sites, indicating that OECs can also accumulate through cell proliferation.

209 Additionally, we show that OECs limit immune-cell activation and infiltration, wher

210 Collectively, these data suggest that OECs have neuroprotective and immunomodulatory mechanism

211 The OEC is a Mn4CaO5 cluster, and its sequentially oxidized

212 The OEC is successively oxidized by the absorption of 4 quan

213 e tyrosine between those of P680(*+) and the OEC.

214 sis of amino acid residues in and around the OEC has identified residue 87 in the D1 subunit as the o

215 gen bonds to water form a network around the OEC; this network is predicted to involve multiple pepti

216 orable Helmholtz layer potential drop at the OEC/electrolyte junction.

217 is study, we have used NH 2OH to destroy the OEC, which would release any tightly bound bicarbonate i

218 atory cap" model of PS II, which follows the OEC-33 kDa-23 kDa-17 kDa binding order, as these results

219 The relevance of these cubanes for the OEC and synthetic oxides is discussed.

220 the X-ray absorption data with those for the OEC reveal 1 to possess structural parameters that make

221 Observed Em values, especially for the OEC, may be influenced by protein-lipid interactions and

222 lectrons are sequentially extracted from the OEC in four light-driven charge-separation events.

223 essential for the relay of protons from the OEC to the lumen, are affected.

224 Under illumination, the OEC cycles through five intermediate S-states (S0 to S4)

225 ctural changes of the Mn4CaO5 cluster in the OEC during the S state transitions using x-ray absorptio

226 te-containing, internal water cluster in the OEC hydrogen-bonded network.

227 roposals that one function of calcium in the OEC is to modulate the reduction potential of the cluste

228 o the geometry of the Mn4CaO5 cluster in the OEC obtained from a polarized XAS model and the 1.9-A hi

229 nding site is close to the Mn cluster in the OEC of PSII.

230 Conduction velocity in the OEC transplant group was increased in comparison to the

231 r behavior was significantly improved in the OEC transplantation group.

232 larities with the bound water network in the OEC.

233 t OH(-)-induced release from its site in the OEC.

234 ly observed Mn oxidation states found in the OEC.

235 gainst tightly bound bicarbonate ions in the OEC.

236 er by facilitating retention of Cl(-) in the OEC.

237 those of other Mn(IV) species, including the OEC S(2) state.

238 mber of manipulations which may increase the OEC content and the effectiveness of mucosal preparation

239 en ammonia/ammonium is incorporated into the OEC hydrogen bond network.

240 ore amino acid residues that reside near the OEC active site on the D1 and CP43 intrinsic subunits of

241 ith more structurally accurate models of the OEC ([MMn3O4]) suggest a general relationship between th

242 The sequentially oxidized forms of the OEC are referred to as the S(n) states.

243 Although the basic structures of the OEC are the same for T. elongatus PSII and spinach PSII,

244 n reported to prevent the advancement of the OEC beyond the S(2)Yz(*) intermediate state.

245 AgO4 cluster that models the topology of the OEC by displaying both a cubane motif and a "dangler" tr

246 tions as a barrier against inhibition of the OEC by OH(-).

247 PS II that was depleted of the OEC did not give the peak at 0.2 V.

248 Although the structure of the OEC has remained conserved over eons of evolution, signi

249 bly inhibited the S1 to S2 transition of the OEC in PSII.

250 re elucidation of both the structures of the OEC in the different S-states and the binding of the two

251 t a range of DFT optimized structures of the OEC may all be considered consistent with experimental E

252 Molecular models of the OEC Mn3CaO4Mn catalytic cluster are constructed by expli

253 genome-wide transcriptomic profiling of the OEC response by RNA-Seq revealed a network of signaling

254 ctivity as well as the Cl(-) affinity of the OEC that decreases with an increasing pH.

255 s study we address whether the purity of the OEC transplant affects their ability to remyelinate.

256 ssue is the most suitable composition of the OEC transplant.

257 Q-band CW ENDOR from the S(2) state of the OEC was obtained following multihour (17)O exchange, whi

258 (III)-Mn(IV) state is a protein model of the OEC's S(2) state.

259 rly useful to establish the structure of the OEC, consistently with high-resolution spectroscopic dat

260 rt recent proposals for the mechanism of the OEC, involving oxido migration between distinct position

261 an oxyl radical ligand in the center of the OEC.

262 1) signals from the D1-His332 ligand of the OEC.

263 e trimanganese-calcium-cubane subsite of the OEC.

264 ase in the rate of catalytic turnover of the OEC.

265 ed in the formation and stabilization of the OEC.

266 S(1) is the dark-adapted state of the OEC.

267 1-Asp(170) in the coordination of Mn4 of the OEC.

268 bind and oxidize the first manganese of the OEC.

269 ween Mn atoms in the S2 and S3 states of the OEC.

270 acceptor side and at the Mn4CaO5 core of the OEC.

271 ded invaluable structural information on the OEC and show that it comprises a [Mn(3)CaO(4)] distorted

272 the absence of structural information on the OEC has hampered these efforts.

273 nce of the additional negative charge on the OEC of the mutant.

274 accumulation of oxidizing equivalents on the OEC.

275 ukaryotic PSII play a role in protecting the OEC against OH(-) inhibition.

276 The data strongly suggest that the OEC contains a cubane-like Mn3CaO4 cluster linked to a f

277 is consistent with the observation that the OEC is functional only with one of these two metals.

278 2 as the protonation sites, analogous to the OEC in PS-II of the natural water oxidation system; the

279 rbonate is bound sufficiently tightly to the OEC that it cannot readily exchange with bicarbonate in

280 te ion does not bind reversibly close to the OEC, but it remains possible that bicarbonate is bound s

281 where and when substrate water binds to the OEC.

282 ation, a key transformation pertinent to the OEC.

283 G MSPs are defective in Cl(-) binding to the OEC.

284 increase in hydrogen bond strength when the OEC is oxidized.

285 a product of the reaction of NH 2OH with the OEC, is detected in good yield.

286 ate water-binding sites and modes within the OEC.

287 The OECs survived and integrated into the repaired nerves as

288 Floating liquid marbles allow the OECs to freely associate and interact to produce OEC sph

289 eration of those sites on the surface of the OECs.

290 Thus, OECs do not appear to exhibit significant migratory prop

291 Thus, OECs dominantly control IL-17R-dependent responses to OP

292 ive sprouting and that SCARB2 contributes to OEC-mediated neuronal repair.

293 ctivity of bridging oxidos is fundamental to OEC function.

294 ges were often present in close proximity to OECs but they contributed only a minor role to clearing

295 These results indicate that transplanted OECs extensively integrate into transected peripheral ne

296 ed axons were myelinated by the transplanted OECs and nodes of Ranvier were formed.

297 copy for GFP indicated that the transplanted OECs formed peripheral type myelin.

298 Thus, transplanted OECs derived from the adult olfactory bulb can survive a

299 As probes, we used OEC peptide carbonyl frequencies, the substrate-based in

300 provide evidence for the advantages of using OECs, and not mature SCs, for transplant-mediated repair

301 gnificantly lower level by SCs compared with OECs, and siRNA reduction of Sulfs in OECs was, in itsel