ライフサイエンスコーパス: OT

1 OT and VP act on the kidneys controlling the excretion o

2 OT binds strongly to plasma proteins, but a reduction/al

3 OT coadministered with a mu-opioid receptor antagonist,

4 OT COV in a stable phantom was less than 2.8% across all

5 OT enhanced blood perfusion units in the first postopera

6 OT is a mature, confocal microscopy-based implementation

7 OT selectively, and differentially, altered fMRI respons

8 OT-II mice expressing a transgenic T cell receptor (TCR)

9 ember of the 4-oxalocrotonate tautomerase (4-OT) family, was pro-immunogenic in mice when fused to a

10 SAR1376, and perhaps other members of the 4-OT protein family, represent very small domains which ca

11 Importantly, an acute OT treatment of Magel2-deficient pups has a curative eff

12 Additionally, OT neurons discriminate the types and magnitudes of flui

13 monstrate that the peripherally administered OT is entering the CSF.

14 tion, we tested the benefit of administering OT under simultaneously induced opioid antagonism during

15 pioid systems and suggest that administering OT under opioid antagonism may boost the therapeutic eff

16 which revealed that naive neonatal and adult OT-I cells expand equally well in neonatal and adult hos

17 sing a system of reverse micelles of Aerosol OT (AOT) in n-octane.

18 Langmuir phospholipid monolayers and Aerosol-OT (AOT) reverse micelles.

19 Although OT can be detected in various physiological fluids (bloo

20 uronally differentiated SH-SY5Y cells to AM, OT and PT triggered upregulation of p53 gene expression,

21 lable, however, on the coding of odors among OT neurons in behaving animals.

22 the effects of systemic administration of an OT receptor (OTR) antagonist L-368,899 on social behavio

23 modulation of OT, as coadministration of an OT receptor antagonist prevented MTII-induced partner pr

24 To examine whether an OT receptor polymorphism (rs53576) interacts with SES, p

25 ent stress effects on social affiliation and OT signaling dependent on odor context with particularly

26 AVP and OT signaling predominantly occur within a circuit of int

27 Importantly, AVP and OT signaling within the SBNN has been shown to different

28 n part to age and sex differences in AVP and OT synthesis within the SBNN.

29 ever, a thorough characterization of AVP and OT-immunoreactive (ir) fibers and cell bodies across age

30 We therefore quantified AVP- and OT-ir fibers and cell bodies in 22 subregions of the for

31 In this study, using Jurkat cells and OT-I TCR transgenic primary murine CTLs, we show that th

32 that both the alteration in OT delivery and OT receptor expression may cause behavioral abnormalitie

33 cally determined pathways of OT delivery and OT signaling, which orchestrate activity of the mesolimb

34 u-opioid and kappa-opioid receptor genes and OT genes at the OT-releasing sites in the human brain.

35 s well as the interaction between the MC and OT systems during this process.

36 s -0.3 (IQR = -0.7; 0.3) for the PI-mono and OT groups respectively, P = .28), the proportion with sy

37 e impairment (13% and 18% in the PI-mono and OT groups respectively; P = .41), or any of the neuroima

38 sed Oxt messenger RNA, total OT neurons, and OT/c-fos colocalizations in female mice but not male mic

39 long-lasting increases in OT production and OT/c-fos cells in the medioventral bed nucleus of the st

40 and Ser20, seen in cells treated with PT and OT.

41 n implicated in mediating natural reward and OT-synthesizing neurons project to the ventral tegmental

42 MNCs and the consequent secretion of VP and OT.

43 Data acquired with our small-animal OT system were highly repeatable and reproducible across

44 We used a commercial small-animal OT system.

45 erapy (PI-mono group) or ongoing triple ART (OT group) in the PIVOT trial.

46 As OT is a peptide, delivery by the intranasal (IN) route i

47 that mesenchymal stem cells (MSCs) attenuate OT and OIH in rats and mice based on the understanding t

48 ype p53-response element markedly attenuated OT-induced THTR1, PDHB and OGDH gene expression suggesti

49 pecific, MHC class II-restricted alpha/beta (OT-II) T cells reflected CD36-dependent DC function.

50 We then describe associations between OT-pathway genes with psychopathologies involving social

51 ts demonstrated that the interaction between OT and serotonin (5-HT) is critical for several aspects

52 However, the underlying mechanism between OT and 5-HT remains unclear.

53 tation in vivo and in vitro assessed by BMDC OT-I cocultivation assays.

54 e anti-inflammatory properties and that both OT and chronic pain are associated with neuroinflammatio

55 s) of the disconnected Ipc units, and causes OT VRFs to shift away from that location.

56 Surprisingly, however, CCR7(-/-) OT-I cells entered the T cell zones after infection, but

57 IINFEKL by wild-type and Dok-1/2(-/-) CD8(+) OT-I cells showed that the absence of Dok-1 and Dok-2 sl

58 inhibitors in mice increased in vivo CD8(+) OT-I CTL function and the clearance of murine gamma-herp

59 ed early activation dynamics of CD8 T cells (OT-1 and TRP1 transnuclear (TN)) and investigated the ex

60 it is unclear whether peripheral and central OT releases match and synergize.

61 othalamic OT neurons and potentiated central OT release.

62 rum disorders and that targeting the central OT system may yield novel treatments to address these sy

63 Consecutive OT patients with positive serum serology and positive we

64 ve shown increased cerebrospinal fluid (CSF) OT levels following IN administration, this does not une

65 labeled (d5-deuterated) from endogenous (d0) OT.

66 We administered d5 OT (80 IU) to six nonhuman primates via IN and IV routes

67 ) and after (t=10, 20, 30, 45 and 60 min) d5 OT dosing.

68 Peripheral administration of d5 OT did not lead to increased d0, endogenous OT in the CS

69 Moreover, CCR7-deficient OT-I cells failed to expand robustly when compared with

70 ere assigned to study groups: 1) test: DGG + OT; or 2) control group: DGG alone.

71 An early OT treatment in this critical period could be a novel th

72 pen-tubular capillary electrochromatography (OT-CEC).

73 oncentrations of administered and endogenous OT before (t=0) and after (t=10, 20, 30, 45 and 60 min)

74 OT did not lead to increased d0, endogenous OT in the CSF.

75 es not lead to central release of endogenous OT.

76 could lead to central release of endogenous OT.

77 Remarkably, established OT and OIH were significantly reversed by either intrave

78 s by an electron transfer-oxygen rebound (ET-OT) mechanism leading to aryl 1-methyl-1-phenylethyl sul

79 by an electron transfer-oxygen transfer (ET-OT) mechanism as supported by the observation of product

80 Evoked OT release from these OT neurons suppresses nociception

81 ochemistry for OT and c-fos cells to examine OT neuron activity immediately after defeat (n = 6-9) an

82 demonstrate CSF penetrance of d5, exogenous OT delivered by IN and IV administration.

83 OT receptor (OXTR), the structural gene for OT (OXT/neurophysin-I), and CD38.

84 We used immunohistochemistry for OT and c-fos cells to examine OT neuron activity immedia

85 Thus, unlike the static pattern observed for OT, AVP innervation of the forebrain SBNN appears to und

86 Compared to measuring free OT, measuring total OT can have advantages in e.g. bioma

87 ce, adoptive transfer with CD4(+) cells from OT-II mice restored effects of OVA on lymphocytes, eosin

88 Further, OT enhances connectivity between nodes of the brain's re

89 However, OT can also be anxiogenic.

90 ndations to improve the reliability of human OT studies in the future.

91 MTII also selectively activated hypothalamic OT neurons and potentiated central OT release.

92 out mice after postnatal day 3, an identical OT increase was not observed.

93 al OT supplementation may be advantageous in OT drug development.

94 PIP2 appears to influence AHPs in OT neurons by reducing Ca(2+) influx during spiking.

95 re, we speculate that both the alteration in OT delivery and OT receptor expression may cause behavio

96 These results suggest that changes in OT-sensitive networks contribute to sex differences in b

97 tively reduced whole cell Ca(2+) currents in OT neurons while leaving VP neurons unaffected.

98 VP, we observed no age or sex differences in OT-ir fiber fractional areas or cell bodies in any of th

99 ial defeat induces long-lasting increases in OT production and OT/c-fos cells in the medioventral bed

100 122 did not inhibit either ImAHP or IsAHP in OT neurons, consistent with wortmannin's effects not bei

101 t PIP2 modulates both the ImAHP and IsAHP in OT neurons, most likely by controlling Ca(2+) entry thro

102 stigated whether this phenomenon occurred in OT and VP neurons of the SON.

103 , batf3(-/-) chimeras had a 75% reduction in OT-I cross-priming capacity in vivo.

104 a(2+) ]i increase induced by spike trains in OT neurons, but had no effect on AHPs evoked by uncaging

105 nalogue (diC8 -PIP2 ) into neurons, which in OT neurons not only prevented wortmannin's inhibitory ef

106 we used arterial spin labeling to measure IN-OT-induced changes in resting regional cerebral blood fl

107 ntral actions and therapeutic efficacy of IN-OT may be marred by the absence of data regarding its te

108 after onset of treatment onset (40 IU of IN-OT or placebo).

109 first visualization and quantification of IN-OT-induced changes in rCBF in the living human brain una

110 and the potential of intranasal oxytocin (IN-OT) to treat social impairment in individuals with neuro

111 oretical and mechanistic models regarding IN-OT effects on typical and atypical social behavior and g

112 n recognition on rCBF maps indicated that IN-OT-induced changes were sustained over the entire posttr

113 osure to a third episode of defeat increased OT/c-fos colocalizations in the paraventricular nucleus

114 A NO donor inhibited OT II T cell receptor recognition of OT II specific tetr

115 Intranasal OT failed to reverse stress-induced social withdrawal in

116 Intranasal OT largely reversed the effects of stress on behavior in

117 Intranasal OT was administered to naive and stressed mice tested in

118 Intranasal OT, which reduces social approach in female mice but not

119 In contrast, intranasal OT increased social interaction in stressed male mice an

120 estigate to what extent the human intranasal OT literature lends support to the hypothesis that intra

121 bility that most of the published intranasal OT findings do not represent true effects.

122 ds support to the hypothesis that intranasal OT consistently influences a wide spectrum of social beh

123 Thus, the remarkable reports that intranasal OT influences a large number of human social behaviors s

124 Our conclusion is that intranasal OT studies are generally underpowered and that there is

125 ings suggest a mechanism by which intranasal OT may bolster social motivation-one that could, in futu

126 Therefore, longitudinal OT studies may be performed with high confidence when ou

127 to be a common complication of longstanding OT in the adult.

128 Magnocellular OT neurons of these nuclei innervate numerous forebrain

129 th collateral projections onto magnocellular OT neurons and neurons of deep layers of the spinal cord

130 As applied to plant material, OT is very fast and nondestructive, yielding richly mine

131 However, tools for measuring OT are still not fully developed.

132 activation of these inflammatory mediators, OT led to increases in the expression of cyclooxygenase-

133 The analysis of TCR-transgenic mice (OT-I and Marilyn) confirmed that abnormal T cell selecti

134 re was significantly accelerated in cMy-mOVA-OT-II compared to cMy-mOVA mice.

135 7 cytokine profile was increased in cMy-mOVA-OT-II mice after TAC.

136 The resulting cMy-mOVA-OT-II mice did not display signs of spontaneous autoimmu

137 were induced in response to TAC in cMy-mOVA-OT-II mice, yet more CD3(+) T cells infiltrated their my

138 strong glutamatergic connections in the NAc, OT, and ERC; moderate strength connections in the centra

139 t this OT treatment partly restores a normal OT system.

140 id not activate G proteins in the absence of OT.

141 into the circulation and from absorption of OT in mother's milk into the blood via intestinal permea

142 cular mechanism underlying the absorption of OT remains unclear.

143 reases throughout a session, the activity of OT neurons is enhanced earlier relative to the behaviora

144 s suggests that peripheral administration of OT does not lead to central release of endogenous OT.

145 Daily administration of OT in the first postnatal week was sufficient to prevent

146 ated or not by a postnatal administration of OT, and determined the effect of this treatment on the b

147 ) platform for measuring the total amount of OT in human plasma/serum.

148 t to achieving greater CSF concentrations of OT.

149 s been suggested that peripheral delivery of OT could lead to central release of endogenous OT.

150 We found that the development of OT and OIH was effectively prevented by either intraveno

151 l animal model to explore the development of OT-based pharmacological strategies for treating patient

152 eases the gain and spatial discrimination of OT units specifically for the locations represented by t

153 antagonist, nolasiban, reduced the effect of OT on NF-kappaB and p38 kinase activation in both myomet

154 The effects of OT are context dependent, and it has been proposed that

155 ls to inhibit the proinflammatory effects of OT in human amnion; atosiban alone activates nuclear fac

156 e neural mechanisms mediating the effects of OT in macaque monkeys, we investigated whether OT would

157 tractions and the proinflammatory effects of OT without the biased agonist effects.

158 inalis (BNST) mediates anxiogenic effects of OT.

159 the neural circuits mediating the effects of OT.

160 gonism may boost the therapeutic efficacy of OT for enhancing social cognition.

161 however, direct neuroanatomical evidence of OT regulation of DA neurons within the VTA is sparse.

162 The family of OT-like molecules affects both peripheral tissues implic

163 dies provide evidence for the involvement of OT-pathway genes in human social functions but also sugg

164 and slow AHP currents (ImAHP and IsAHP ) of OT, but not VP neurons with high affinity.

165 focused and confined interaction kinetics of OT-1 CTL with target cells and increased apoptosis induc

166 be mediated, in part, through modulation of OT, as coadministration of an OT receptor antagonist pre

167 Numbers of OT-II cells in flight mice treated with OVA were signifi

168 y and ontogenetically determined pathways of OT delivery and OT signaling, which orchestrate activity

169 Moreover, the pathways of OT delivery to brain regions involved in specific behavi

170 Our findings identify a new population of OT neurons that modulates nociception in a two tier proc

171 tion task, we report that the firing rate of OT neurons robustly and flexibly encodes the valence of

172 However, this cross-reactivity of OT-1 CD8(+) T cells with MOG peptide in the CNS did not

173 hibited OT II T cell receptor recognition of OT II specific tetramers, thus serving as a direct measu

174 h significant consequences on the release of OT and VP, measured by radioimmunoassay.

175 two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhib

176 ision (repeatability and reproducibility) of OT has yet to be determined.

177 etimes bewildering, evidence for the role of OT in influencing a vast array of complex social cogniti

178 nd clinical evidence relevant to the role of OT in schizophrenia with particular emphasis on its puta

179 ch suggests that the proinflammatory role of OT should be taken into account when developing tocolyti

180 tures such as granuloma are typical signs of OT, atypical features can delay the diagnosis.

181 phabetaTCR(+) cells isolated from spleens of OT-I Rag1(-/-) mice were induced to express gut-homing r

182 and long-lasting effects of social defeat on OT neurons in male and female California mice.

183 ated process with RAGE and suggest that oral OT supplementation may be advantageous in OT drug develo

184 their surface, hydrogen (HT-BDD) or oxygen (OT-BDD).

185 e antagonists - amprolium (AM), oxythiamine (OT) or pyrithiamine (PT).

186 Oxytocin (OT) has become a focus in investigations of autism spect

187 Oxytocin (OT) has been implicated in mediating natural reward and

188 Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic par

189 Oxytocin (OT) is a neuropeptide, which can be seen to be one of th

190 Oxytocin (OT) is a nonapeptide that, in addition to its role as a

191 Oxytocin (OT) is a potential treatment for multiple neuropsychiatr

192 Oxytocin (OT) is considered to be a stress-buffering hormone, damp

193 Oxytocin (OT) is increasingly studied for its therapeutic potentia

194 Oxytocin (OT), a nonapeptide signaling molecule originating from a

195 ABSTRACT: Oxytocin (OT)- and vasopressin (VP)-secreting magnocellular neuron

196 secretion of vasopressin (VP) and oxytocin (OT) by the neurohypophysis.

197 europeptides vasopressin (AVP) and oxytocin (OT) have been implicated in the regulation of numerous s

198 in infancy and preschool, assayed oxytocin (OT) and vasopressin (AVP), and measured coparenting and

199 mice, to characterize the central oxytocin (OT) system of these mutant mice, and to test the curativ

200 Over the last decade, oxytocin (OT) has received focus in numerous studies associating i

201 research suggest that the hormone oxytocin (OT) may be important for metabolic regulation.

202 Importantly, hypothalamic oxytocin (OT) signaling increased coincident with stress in a neut

203 th medium and slow AHP currents in oxytocin (OT) neurons of the supraoptic nucleus.

204 ocioemotional behaviors, including oxytocin (OT) and dopamine.

205 The neuropeptide oxytocin (OT) is a key regulator of social and emotional behaviors

206 The neuropeptide oxytocin (OT) is associated with a plethora of social behaviors, a

207 e toward improving the efficacy of oxytocin (OT) in treating social dysfunction, we tested the benefi

208 e of the most established roles of oxytocin (OT) is in inducing uterine contractions and labor.

209 Plasma oxytocin (OT) originates from secretion from the pituitary gland i

210 The oxytocin (OT) system is known to be implicated in the regulation o

211 d a subset of approximately 30 parvocellular OT neurons, with collateral projections onto magnocellul

212 The PVN also harbors parvocellular OT cells that project to the brainstem and spinal cord,

213 to test the curative effect of a peripheral OT treatment just after birth.

214 To phenotype OT-receptor (OTR) expressing neurons originating within

215 Compared with placebo, OT significantly reduced [(11)C]DASB binding potential i

216 In adult mice, plasma OT was also increased in a RAGE-dependent manner after o

217 Here, we report that plasma OT concentrations increased within 10 min after oral del

218 L-368,899 prevented OT activation of G proteins and did not activate G prote

219 Using a Q-OT-MS, 22 compounds were tentatively identified, 16 of w

220 rid quadrupole-orbitrap mass spectrometer (Q-OT-MS).

221 y (nucleus accumbens; amygdala) that receive OT projections and contribute to social motivation, and

222 rvate numerous forebrain regions and release OT into the blood from the posterior pituitary.

223 Adoptive transfer of TH2-skewed OT-II wild-type CD4(+) T cells reversed IgE and TH2 cyto

224 vivo using adoptive transfer of OVA-specific OT-II cells into wild-type recipients show that DRD3 def

225 ic and TCR-transgenic OVA(257-264)-specific (OT-I) CD8(+) T cells into influenza-infected hosts, whic

226 r activity and (2) indirectly by stimulating OT release from SON neurons into the periphery.

227 cal lesions were placed in the optic tectum (OT) and in the nucleus isthmi pars parvocellularis (Ipc)

228 parvocellularis (Ipc) from the optic tectum (OT) in barn owls by reversibly blocking excitatory trans

229 contrast-based saliency in the optic tectum (OT) of barn owls.

230 ogical levels of 5-HT modification, and that OT does not act directly on the 5-HT1AR.

231 VA323-339 In this study, we demonstrate that OT-II.Ncf1(m1J) CD4 T cells displayed a severe reduction

232 Mass spectrometry evaluated that OT was absorbed intact.

233 d health and adding to growing evidence that OT relates to human obesity risk.

234 We also found that OT administration selectively reduced functional couplin

235 These data highlight that OT is transmitted via a receptor-mediated process with R

236 TR expression by VTA neurons implicates that OT regulation of reward circuitry is more complex than a

237 ext dependent, and it has been proposed that OT increases the salience of both positive and negative

238 -motivated instrumental task, we report that OT neurons modulate their firing rate during initiation

239 Our study reveals that OT plays a crucial role in setting social behaviors duri

240 bo-controlled crossover design, we show that OT administration in ASD increases activity in brain reg

241 contractions, our recent studies showed that OT can also activate proinflammatory pathways in both hu

242 s of gene and metabolic networks showed that OT triggers cell apoptosis through the p53-dependent int

243 avior of Magel2-deficient mice, analyzed the OT system of mutant mice treated or not by a postnatal a

244 pa-opioid receptor genes and OT genes at the OT-releasing sites in the human brain.

245 upport a regulatory relationship between the OT and opioid systems and suggest that administering OT

246 After describing the OT-signaling pathway, we review research on the three ge

247 cell responses, our laboratory generated the OT-II.Ncf1(m1J) mouse, possessing superoxide-deficient T

248 enes most extensively studied in humans: the OT receptor (OXTR), the structural gene for OT (OXT/neur

249 A lesion in the OT caused a severe impairment in orientation discriminat

250 49 (16.8%) participants in the OT group and 65 (22.0%) in the PI-mono group had grade 3

251 icipants (Kaplan-Meier estimate 0.7%) in the OT group and six (2.1%) in the PI-mono group: difference

252 -down leads to topographic missorting in the OT through the upregulation of Nrp1.

253 and corrects the axon-sorting defect in the OT.

254 s, showing that central manipulations of the OT system affect behavioral phenotypes related to social

255 atomical and functional modifications of the OT system and show that these defects change from birth

256 Thus, we report that an alteration of the OT system around birth has long-term consequences on beh

257 onses in the intermediate/deep layers of the OT were recorded from lightly anesthetized owls confront

258 detected antigen recognition motility of the OT-1 CD8(+) T cells within the CNS leading to a selectiv

259 IL-12/IL-12R pathway and the novelty of the OT-II.Ncf1(m1J) mouse model to determine the role of red

260 unt when developing tocolytics targeting the OT/oxytocin receptor (OTR) system.

261 We predict that the OT is an essential region whereby odor valence is encode

262 nical and clinical research suggest that the OT system may play a role in regulating the expression o

263 The data support the proposal that the OT transmits a space-specific signal that is required to

264 Using the OT-I RIP-mOVA model, we found that Nur77 deficiency did

265 Here we address whether the OT encodes natural reinforcers and serves as a substrate

266 eus accumbens or distributed also within the OT.

267 tudy evaluates the effects of ozone therapy (OT) on the early healing period of deepithelialized ging

268 ed (1:1) to maintain ongoing triple therapy (OT) or to switch to a strategy of physician-selected rit

269 Evoked OT release from these OT neurons suppresses nociception and promotes analgesia

270 We show that this OT treatment partly restores a normal OT system.

271 Thus, OT may serve as a treatment for psychiatric disorders, m

272 collaborative coparenting and was linked to OT, whereas a stronger caudate-dACC connectivity was ass

273 0, we randomly allocated 587 participants to OT (291) or PI-mono (296).

274 ddress human social functions in relation to OT-pathway genes, including parenting, empathy, and usin

275 s commonly associated with opioid tolerance (OT) and opioid-induced hyperalgesia (OIH), which limit e

276 Optoacoustic tomography (OT) is now widely used in preclinical imaging; however,

277 resent our exploration of optical topometry (OT) for the analysis of plant organ surfaces.

278 obust nanoLC-MS) was used to determine total OT plasma/serum levels to startlingly high concentration

279 mpared to measuring free OT, measuring total OT can have advantages in e.g. biomarker studies.

280 this bond, enabling ample detection of total OT.

281 s, defeat increased Oxt messenger RNA, total OT neurons, and OT/c-fos colocalizations in female mice

282 pography is seen clearly in the optic tract (OT) and in the optic radiations.

283 anced effector functions in both transferred OT-1 and endogenous cytotoxic T lymphocytes (CTLs).

284 remained on the ground received transferred OT-II cells and cognate peptide stimulation with ovalbum

285 ptive transfer of T-cell receptor transgenic OT-II CD4 T cells to track an in vivo antigen-specific i

286 o CD4(+) T cells (T cell receptor transgenic OT-II) was measured via a [(3)H]-thymidine incorporation

287 Using transgenic OT-II mice we demonstrated that this impairment in T-cel

288 determined that murine ovalbumin-transgenic (OT-1) CD8(+) T cells recognize the myelin peptide myelin

289 ls from ROCK2-sufficient OVA TCR transgenic (OT-II) mice or saline i.v. 48 h before challenge with ae

290 egrin knock-in (KI) mice and TCR-transgenic (OT-II) KI mice, in which the integrin/kindlin connection

291 dearth of effective way to prevent or treat OT and OIH is a major medical challenge.

292 's nucleus accumbens and olfactory tubercle (OT) suggests the distributed involvement of neurons with

293 The olfactory tubercle (OT), a ventral striatum structure that receives monosyna

294 Using optical tweezers (OT) and steered molecular dynamic simulations (SMD), we

295 Optical tweezers (OTs) measure the force-dependent time-resolved extension

296 expand robustly when compared with wild-type OT-I cells and were preferentially skewed toward a short

297 ed and very distinct compared with wild-type OT-I cells.

298 estingly, CCR7(-/-), CD2-CCR7, and wild-type OT-I memory cells responded equally well to rechallenge

299 In monogamous prairie voles, OT and dopamine interact to promote partner preference f

300 in macaque monkeys, we investigated whether OT would modulate functional magnetic resonance imaging