ライフサイエンスコーパス: OVLT

1 c stimuli produce different responses across OVLT neurons and may represent distinct cellular process

2 Although OVLT neurons are intrinsically osmosensitive and shrink

3 Among OVLT neurones with axons projecting directly to the PVN

4 positive cells in the SFO (42% greater) and OVLT (100% greater).

5 cally as a result of inputs from the SFO and OVLT, which have themselves been activated directly by a

6 te load tended to amplify the FLI in SFO and OVLT.

7 osum of the lamina terminalis-preoptic area (OVLT-POA) continuum.

8 ute to long-term osmosensory transduction by OVLT neurons and might therefore participate in the elev

9 cute and chronic osmosensory transduction by OVLT neurons may be mediated by distinct mechanisms.

10 reflects reduced somal stores of GnRH in DBB/OVLT and MS, suggesting that these subpopulations promot

11 num vasculosum of the lamina terminalis (DBB/OVLT) and medial septum (MS) in adults as compared to ju

12 However, OVLT neurons in CLP rats were hyperpolarized significant

13 oduced a concentration-dependent increase in OVLT cell discharge, lumbar SNA and ABP.

14 hypertonic NaCl evokes a greater increase in OVLT neuronal discharge frequency than equi-osmotic sorb

15 produced significantly greater increases in OVLT discharge and ABP than icv infusion of equi-osmotic

16 at intracerebroventricular infusion or local OVLT injection of hypertonic NaCl increases lumbar sympa

17 Stimulating glutamatergic MnPO/OVLT neurons induced water consumption, whereas stimulat

18 stimulation of glutamatergic neurons in MnPO/OVLT drives voracious water consumption, and that optoge

19 that glutamate and GABA neurons in the MnPO/OVLT reciprocally regulate water consumption.

20 subfornical organ, suggesting that the MnPO/OVLT serves as a key link in regulating drinking respons

21 l recordings demonstrate that 50% (18/36) of OVLT neurons display an increased discharge to both hype

22 Whereas acute hypertonic activation of OVLT neurons critically depends on TRPV1 channels, studi

23 performed to quantify osmotic activation of OVLT-PVN neurones.

24 We found that the intrinsic excitability of OVLT neurons was not affected significantly 18-24 h afte

25 PVN-projecting neurones in the DC and LM of OVLT could participate in behavioural, neuroendocrine, a

26 dorsal cap (DC) and lateral margins (LM) of OVLT.

27 -cell recordings demonstrate the majority of OVLT neurons are responsive to hypertonic NaCl or mannit

28 the DC and LM contained a similar number of OVLT-PVN neurones, the proportion of such neurones that

29 mined the electrophysiological properties of OVLT neurons and magnocellular neurosecretory cells (MNC

30 ly, these novel data suggest that subsets of OVLT neurons respond differently to hypertonic NaCl vers

31 Renin induced Fos-IR in SFO, MnPO, peri-OVLT region, SON and PVN.

32 ipheral origin activates the SFO and/or peri-OVLT region and contributes to sodium appetite.

33 n which OVLT neurones projecting to the PVN (OVLT-PVN) were retrogradely labelled with cholera toxin

34 Second, OVLT microinjection (20 nl) of 1.0 m NaCl significantly

35 Furosemide-induced activation in the SFO, OVLT, SON and PVN does not depend on renal innervation.

36 ults suggest that the activation of the SFO, OVLT, SON and PVN may be via a different mechanism than

37 the number of Fos-positive cells in the SFO, OVLT, SON and PVN, but not in the caudal thoracic spinal

38 ation of the pathway that occurs in the SFO, OVLT, SON, and magnocellular region of the paraventricul

39 erminalis (OVLT), these observations suggest OVLT neurons may sense or respond differently to hyperto

40 organum vasculosum of the lamina terminalis (OVLT) and lateral hypothalamus (LH) of rats with coronar

41 organum vasculosum of the lamina terminalis (OVLT) and median preoptic nucleus (MnPO).

42 organum vasculosum of the lamina terminalis (OVLT) and subfornical organ (SFO) became infected.

43 rgans, organum vasculosum lamina terminalis (OVLT) and subfornical organ (SFO), are potential sites t

44 organum vasculosum of the lamina terminalis (OVLT) and the preoptic area (POA).

45 organum vasculosum of the lamina terminalis (OVLT) are known to regulate fluid/electrolyte homeostasi

46 in the organum vasculosum lamina terminalis (OVLT) region of the preoptic area (POA).

47 organum vasculosum of the lamina terminalis (OVLT) sense changes in extracellular osmolarity and NaCl

48 the vascular organ of the lamina terminalis (OVLT) that contains a subpopulation of gonadotropin rele

49 organum vasculosum of the lamina terminalis (OVLT) were compared between the two developmental stages

50 organum vasculosum of the lamina terminalis (OVLT), a region that has also been implicated in fluid a

51 (VMH), organum vasculosum lamina terminalis (OVLT), CA1 field of the hippocampus, striatum or cortex.

52 organum vasculosum of the lamina terminalis (OVLT), medial preoptic nucleus (MNPO), subfornical organ

53 organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus (MNPO), hypothalamic para

54 (SFO), organum vasculosum lamina terminalis (OVLT), supraoptic nuclei (SON), and magnocellular region

55 (SFO), organum vasculosum lamina terminalis (OVLT), supraoptic nucleus (SON), magnocellular region of

56 organum vasculosm of the lamina terminalis (OVLT), the median preoptic nucleus (MnPO) and/or the sub

57 organum vasculosum of the lamina terminalis (OVLT), these observations suggest OVLT neurons may sense

58 the vascular organ of the lamina terminalis (OVLT).

59 in the organum vasculosum lamina terminalis (OVLT; which drives thirst) and attenuates that of neuros

60 brain organum vasculosum laminae terminalis (OVLT) and hypothalamic paraventricular nucleus (PVN) eac

61 brain organum vasculosum laminae terminalis (OVLT) play a pivotal role in triggering hyperosmotic act

62 y the organum vasculosum laminae terminalis (OVLT), on the midline of the POA, by the presumptive act

63 n the organum vasculosum laminae terminalis (OVLT), which then activates downstream neurons that indu

64 d the organum vasculosum laminae terminalis (OVLT).

65 n the organum vasculosum lateral terminalis (OVLT), DOC pretreatment augmented cFos expression.

66 Notably, we found that OVLT neurons are hyperpolarized and electrically silence

67 le (AV3V), which destroys cell bodies in the OVLT and MnPO, as well as efferent projections from the

68 effects on the properties of neurons in the OVLT and supraoptic nucleus.

69 also increased the number of neurons in the OVLT expressing AngII-induced cFos.

70 by synaptic density were not observed in the OVLT nor on GnRH dendrites in either brain region.

71 ted at 14:00 h and 20:00 h (P < 0.01) in the OVLT-POA of young females.

72 bstantial presence of oxytocin fibers in the OVLT.

73 Injecting TTX into the OVLT completely blocked the lactate-induced response, wh

74 jections of lactate (100 or 500 nl) into the OVLT elicited robust anxiety-like responses in these rat

75 rminate means of neurons projecting into the OVLT from the brain.

76 cannula was implanted into the region of the OVLT, SFO, or an adjacent control site, the median preop

77 These results suggest that the OVLT may be the primary site that detects lactate infusi

78 as efferent projections from the SFO to the OVLT and MnPO, abolishes DOCA-salt hypertension in the r

79 Caudal to the OVLT, l-GnRH-III-positive neurons were also observed dor

80 One is linked to the OVLT, SFO, and anteroventral third ventricular (AV3V) re

81 ossibly relayed directly from the PVN to the OVLT.

82 were delayed relative to projections to the OVLT.

83 fy molecularly defined cell types within the OVLT and MnPO that are activated by fluid imbalance and

84 hyperosmolality activate specifically those OVLT neurones that form a monosynaptic pathway to the PV

85 na terminalis, including organum vasculosum (OVLT) and subfornical organ (SFO), as well as in the mag

86 , PVH, SFO and hippocampus, but not the VMH, OVLT and striatum or cortex.

87 ns were performed in conscious rats in which OVLT neurones projecting to the PVN (OVLT-PVN) were retr