ライフサイエンスコーパス: OX40 ligand

1 atory factor 4, and moderate upregulation of OX40 ligand.

2 (also called Ox40l or Cd134l), which encodes OX40 ligand.

3 including CD2, CD11a, CD20, CD25, CD52, and OX40 ligand.

4 In contrast, anti-HLA-DR or anti-OX40 ligand Ab mainly affected beryllium-induced prolife

5 this process is dependent upon expression of OX40 ligand and B7 by the activated NK cells.

6 T cells rapidly up-regulate CD30 through an OX40 ligand and interleukin 4 (IL-4)-dependent mechanism

7 rough combined induction of TSLP, IL-33, and OX40 ligand and that this can lead to susceptibility to

8 les of DCs such as programmed death ligands, OX40 ligand, and inducible T-cell costimulator ligands w

9 C2-associated markers, such as CD141, GATA3, OX40 ligand, and receptor-interacting serine/threonine-p

10 tors, namely, 4-1BB ligand, ICOS ligand, and OX40 ligand, are up-regulated on cultured HDMEC in respo

11 whereas inhibition of degranulation was OX40/OX40 ligand dependent, enhancement of IL-6 was due to TG

12 ell-established day 17 sarcomas with a novel OX40 ligand-Fc fusion protein (OX40L-Fc) resulted in tum

13 more, blocking 4-1BB ligand, ICOS ligand, or OX40 ligand in this model reduces human skin allograft i

14 ss II and costimulatory molecules, including OX40 ligand, in vitro.

15 munity in animal models by blocking the OX40-OX40-ligand interaction or depleting OX40+ T cells.

16 antagonist OX40 reagents, we show that OX40/OX40 ligand interactions can determine the extent of exp

17 ast cells, inhibiting degranulation via OX40/OX40 ligand interactions while promoting IL-6 via TGF-be

18 ll-length monoclonal antibody raised against OX40 ligand is described.

19 In this study, we show that OX40 ligand is selectively induced on IL-2, IL-12, or IL

20 e established that activated B cells express OX40 ligand (L), a member of the tumor necrosis factor/n

21 OX40 ligand, mostly expressed by M2-like monocytes and m

22 in vivo expression of the TNF family protein OX40 ligand on lung dendritic cells that was dependent o

23 y drugs, including PD-1 or PD-L1 antibodies, OX40 ligand, or GITR ligand fusion proteins, produced sy

24 e expression of the T cell survival signals, OX40 ligand (OX40L) and CD30 ligand (CD30L) on CD4(+)CD3

25 ilic CRSwNP demonstrated an up-regulation of OX40 ligand (OX40L) and programmed death ligand 1(PD-L1)

26 particulate matter-treated HBEC upregulated OX40 ligand (OX40L) and the Notch ligand Jagged-1 mRNA a

27 eport that TSLP induced human DCs to express OX40 ligand (OX40L) but not IL-12.

28 We report that OX40 ligand (OX40L) completely inhibited the generation

29 The OX40-OX40 ligand (OX40L) costimulatory pathway is known to in

30 In these studies, we examined the effects of OX40 ligand (OX40L) deficiency on the development of Th2

31 nvolving the costimulatory molecule OX40 and OX40 ligand (OX40L) enhance tumor rejection.

32 in (TSLP) released from epithelial cells and OX40 ligand (OX40L) expressed on dendritic cells (DCs) i

33 lizing Abs were used to test the function of OX40 ligand (OX40L) in Th2 skewing.

34 his study was to determine the role for OX40-OX40 ligand (OX40L) interaction in the innate immune res

35 OX40 ligand (OX40L) is a costimulatory molecule involved

36 In our current study, we have shown that OX40 ligand (OX40L) is a critical in vivo mediator of TS

37 expressed on activated T cells; its ligand, OX40 ligand (OX40L) is expressed on dendritic cells, B c

38 Ox40 ligand (Ox40L) locus genetic variants are associate

39 ibition of IL-12 production and induction of OX40 ligand (OX40L) on DCs.

40 V challenge, we found expression of CD40 and OX40 ligand (OX40L) on lung inflammatory DCs was higher

41 f interactions between OX40 on Th2 cells and OX40 ligand (OX40L) on TSLP-activated DCs using an OX40L

42 Although the impact of blockade of the OX40-OX40 ligand (OX40L) pathway has been well documented in

43 We found that the costimulatory molecule OX40 ligand (OX40L) was critical in driving Th2 response

44 The TNF superfamily members CD70 and OX40 ligand (OX40L) were reported to be important for CD

45 PD-L1, and PD-L2) and the TNF/TNFR families (OX40 ligand (OX40L), CD153, Fas, 4-1BB, and glucocortico

46 Here we showed the OX40 ligand (OX40L)-OX40 axis contributes to the aberran

47 f asthma through 2 distinct pathways: a TSLP-OX40 ligand (OX40L)-T cell axis and a TSLP-mast cell axi

48 -24-RGDOX expressing the immune costimulator OX40 ligand (OX40L).

49 ls (MCs) with regulatory T cells through the OX40 ligand (OX40L):OX40 axis downregulates FcepsilonRI-

50 Here we describe that TNF superfamily member OX40 ligand (OX40L; CD252), which is expressed predomina

51 The OX40 (TNFRSF4)-OX40 ligand (OX40L; TNFSF4) pathway is important for the

52 The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a potential c

53 TN, and IL25 and downstream targets in sDCs (OX40 ligand [OX40L], CCL17, PPP1R14A, CD1E, CD1b, CD80,

54 ediated by memory T cells, blocking the OX40/OX40 ligand pathway alone did not prolong the skin allog

55 wild-type C57BL/6 mice, as blocking the OX40/OX40 ligand pathway in combination with CD28/CD154 block

56 ejection in this model, as blocking the OX40/OX40 ligand pathway, but not the ICOS/ICOS ligand, 4-1BB

57 , we found that CD4(+) T effector cells from OX40 ligand-transgenic (OX40Ltg) mice are highly resista

58 DC) expression of the TNF superfamily member OX40 ligand was dependent on type I IFN signaling in the

59 However, thymic stromal lymphopoietin and OX40 ligand were not required for Th2 priming.