ライフサイエンスコーパス: Ogen

1 sdrC), all with binding affinity for fibrin(ogen).

2 orresponding to the alphaC regions of fibrin(ogen).

3 synthetic B-knobs that bind to human fibrin(ogen).

4 rophils to fibrin gel and immobilized fibrin(ogen).

5 -383 sequence in the gammaC-domain of fibrin(ogen).

6 ne expression in Plg(o) mice required fibrin(ogen).

7 viously to be a surface receptor for plasmin(ogen).

8 of bacteria to human fibronectin and fibrin(ogen).

9 a clot composed of both platelets and fibrin(ogen).

10 2 (FGF-2) binds with high affinity to fibrin(ogen).

11 gated the possible binding of IL-1 to fibrin(ogen).

12 action is enhanced by the presence of fibrin(ogen).

13 assessed and related to the extent of fibrin(ogen).

14 I, thrombin activity, and cleavage of fibrin(ogen).

15 roduction and macrophage adhesion via fibrin(ogen).

16 entified by Western blot analysis as plasmin(ogen).

17 rs measuring low levels of functional fibrin(ogen).

18 verall streptococcal ability to bind plasmin(ogen).

19 ulation of cellular interactions with fibrin(ogen).

20 inogen-deficient mice is dependent on fibrin(ogen).

21 amma'-fibrin(ogen) than gammaA/gammaA-fibrin(ogen).

22 cruitment of host proteases, such as plasmin(ogen).

23 of beta-amyloid (Abeta) peptide with fibrin(ogen).

24 nts of CD44 binding to hyaluronan and fibrin(ogen).

25 oprotein that binds to hyaluronan and fibrin(ogen).

26 due-extended C-terminus, which binds plasmin(ogen).

27 s versus two of seven [P = .01]; 125I-fibrin(ogen), 170 +/- 76 versus 48 +/- 6 x 10(6) molecules/cm2

28 el glutathione conjugate of harderoporphyrin(ogen) (2,7,12,18-tetramethyl-3-vinylporphyrin-8,13,17-tr

29 IIIa, can covalently incorporate into fibrin(ogen) a physiologically active peptide, thymosin beta(4)

30 of both of these serine proteases is fibrin(ogen), a logical extension of this hypothesis is that lo

31 PAI-1 expression also correlated with fibrin(ogen) accumulation (R=0.77, P<0.001), and fibrin(ogen) a

32 ociate elevated PAI-1 expression with fibrin(ogen) accumulation and increased cell proliferation.

33 ) accumulation (R=0.77, P<0.001), and fibrin(ogen) accumulation correlated strongly with proliferatio

34 define the biological significance of fibrin(ogen)-alpha(M)beta(2) interaction in vivo, gene-targeted

35 dies suggest that therapies targeting fibrin(ogen)-alpha(M)beta(2) interactions may be useful in prev

36 ndent apo(a)-binding sites within the fibrin(ogen) alphaC domains which contribute to an alternative

37 fibronectin binds exclusively to the fibrin(ogen) alphaC domains.

38 Because the fibrin(ogen) alphaC-domains bind plasminogen and tissue-type pl

39 * following chemical cross-linking of fibrin(ogen) alphaC389-402 peptides to FXIII-A(2)*; and (3) car

40 the hypothesis that disruption of the fibrin(ogen)-alphaMbeta2 interaction in Fibgamma(390-396A) mice

41 Fibrin(ogen)-alphaMbeta2 interaction inhibited iNOS induction i

42 tissue can proceed in the absence of fibrin(ogen) and all of its proteolytic derivatives.

43 Both receptors promote degradation of fibrin(ogen) and also confer adhesive properties on cells becau

44 These findings indicate that host fibrin(ogen) and bacterial ClfA are dual determinants of virule

45 IL-1beta binds with high affinity to fibrin(ogen) and demonstrates increased activity in the bound f

46 s, even though these peptides bind to fibrin(ogen) and enhance turbidity, the delay in lysis is mainl

47 on at physiological concentrations of fibrin(ogen) and factor XIII was significant with molar incorpo

48 he presence of substantial amounts of fibrin(ogen) and fibrin degradation products within intimal les

49 tory role for the hemostatic factors plasmin(ogen) and fibrin(ogen) in cellular plasticity within adu

50 osition of radiolabeled platelets and fibrin(ogen) and immunohistochemical analysis of perfused arter

51 bind to the lysine binding sites of plasmin(ogen) and is only a kinetically slow plasmin inhibitor.

52 In this paper, the role of fibrin(ogen) and its degradation products in the growth and spo

53 xplore the interactions of polyP with fibrin(ogen) and its effect on fibrin structure and fibrinolysi

54 we studied binding of alpha(2)-AP to fibrin(ogen) and its fragments by an enzyme-linked immunosorben

55 affinity-based assays, we found that fibrin(ogen) and its heparin-binding domain bind several GFs fr

56 s lack endothelium but have extensive fibrin(ogen) and platelet deposition, we hypothesized that Mac-

57 FBA-tb bound human plasmin(ogen) and protected FBA-tb-bound plasmin from regulation

58 This accumulated Abeta can bind to fibrin(ogen) and render fibrin clots more resistant to degradat

59 the first time, a unique link between fibrin(ogen) and the development of inflammation-driven maligna

60 t physiological ionic conditions only fibrin(ogen) and the E(1) fragment bind heparin, indicating tha

61 predominant gammaA/gammaA isoform of fibrin(ogen) and the gammaA/gamma' variant with an extended gam

62 In addition, we demonstrate that plasmin(ogen) and thrombin induce a significant increase in secr

63 t." Confocal microscopy revealed that fibrin(ogen) and thrombospondin colocalized as "cap," a single

64 ase ancistron increased the amount of fibrin(ogen) and thrombospondin on the surface of the PS-positi

65 venance and putative neurotoxicity of fibrin(ogen), and its potential impact on clinical disability.

66 the mechanisms by which blood cells, fibrin(ogen), and platelet-fibrin interactions modulate clot co

67 ins include binding of host laminin, plasmin(ogen), and regulators of complement activation.

68 ly determine whether fibrin(ogen) or plasmin(ogen) are determinants of the metastatic potential of ci

69 nteractions of endothelial cells with fibrin(ogen) are implicated in inflammation, angiogenesis, and

70 effects on fibrin clots, implicating fibrin(ogen) as a potential critical factor in this disease.

71 identify the gamma370-381 sequence of fibrin(ogen) as the binding site for alpha(IIb)beta3 involved i

72 r cytoskeletal motility proteins) and fibrin(ogen) (as the substrate bridging platelets for contracti

73 echanistic links between the thrombin/fibrin(ogen) axis and obesity-associated pathologies are incomp

74 t one mechanism by which the platelet-fibrin(ogen) axis contributes to metastatic potential is by imp

75 vel 45-kDa protein displaying strong plasmin(ogen) binding activity from the streptococcal surface.

76 pes and showed significantly greater plasmin(ogen) binding affinity compared with previously reported

77 (3) The micromolar-effective thrombin-fibrin(ogen) binding may initiate a partial alphaC repulsion.

78 We have shown previously that fibrin(ogen) binding potentiates the capacity of fibroblast gro

79 The plasmin(ogen) binding property of group A streptococci is incrim

80 creases the tensile strength of CD44s-fibrin(ogen) binding, which is in stark contrast to CD44v-fibri

81 We have shown previously that fibrin(ogen) binds fibroblast growth factor 2 (FGF-2) and poten

82 Additionally, upon activation plasmin(ogen) bound to PGK cleaved the central complement protei

83 agments and NDSK corresponding to the fibrin(ogen) central E region, using laser tweezers-based force

84 sites involved in fibrin binding and plasmin(ogen) cleavage, respectively.

85 ain protein prior to perfusion over a fibrin(ogen)-coated surface.

86 ts were added before perfusion over a fibrin(ogen)-coated surface.

87 hesion and closeness of apposition to fibrin(ogen)-containing surfaces.

88 These studies demonstrate that plasmin(ogen) contributes to favorable arterial remodeling and a

89 These data show that the fibrin(ogen)-covered cap, predominantly formed as a result of f

90 ther, these results indicate that the fibrin(ogen) D region and the C-terminal subdomain of the alpha

91 aused by deficiency of hepatic uroporphyrin- ogen decarboxylase activity.

92 Fibrin(ogen) deficiency (Fg-/-) was shown previously to be comp

93 versed when the animals are also made fibrin(ogen) deficient.

94 nockout mice were crossed to generate fibrin(ogen)-deficient apo(a) transgenic mice and control mice.

95 demonstrate that coagulation-impaired fibrin(ogen)-deficient mice, in comparison with genetically mat

96 However, adhesion was suppressed in fibrin(ogen)-deficient mice, suggesting that fibrin formation s

97 rsiniosis with a phenotype similar to fibrin(ogen)-deficient mice, whereas factor XI-deficient mice s

98 rsiniosis with a phenotype resembling fibrin(ogen)-deficient mice.

99 Interactions between CgA and plasmin(ogen) define a previously unrecognized autocrine/paracri

100 Although surface-bound plasmin(ogen) degraded fibrin, no direct evidence for a role in

101 linking TF to metastasis is through a fibrin(ogen)-dependent and platelet-dependent restriction in na

102 l accumulation of IL-6 and MCP-1 in a fibrin(ogen)-dependent manner.

103 enicity, inhibiting both platelet and fibrin(ogen) deposition (580 versus 194 plateletsx10(6)/cm2; P<

104 Fibrin(ogen) deposition (x10(12) molecules/cm(2) of carotid art

105 addition, these mice showed decreased fibrin(ogen) deposition and expression of proinflammatory media

106 Progressive MS cases with severe fibrin(ogen) deposition have significantly reduced neuronal den

107 erved that cerebral infarct sizes and fibrin(ogen) deposition in chimeric mice with only platelet VWF

108 n was noted in Plg-/- mice and sparse fibrin(ogen) deposition in control mice on days 1 and 3 after i

109 y had focal sterile inflammation with fibrin(ogen) deposition in the liver and elevated plasma thromb

110 Fibrin(ogen) deposition is neurotoxic in animal models of MS, b

111 s activation of synovial fibroblasts, fibrin(ogen) deposition may promote the recruitment (via chemok

112 Fibrin(ogen) deposition occurs during corneal wound repair afte

113 The amount of fibrin(ogen) deposition on the collagen/vWF spots was approxima

114 We tested the hypothesis that hepatic fibrin(ogen) deposition reduces severity of APAP-induced liver

115 essel wall of apo(a) transgenic mice, fibrin(ogen) deposition was found to be essentially colocalized

116 Exuberant corneal fibrin(ogen) deposition was noted in Plg-/- mice and sparse fib

117 Motor cortical fibrin(ogen) deposition was significantly over-represented in M

118 s platelet and (125)I-labeled porcine fibrin(ogen) deposition, and the incidence of macroscopic mural

119 damage was correlated with increased fibrin(ogen) deposition, suggesting that this protein might pla

120 intracerebral thrombosis [assessed by fibrin(ogen) deposition] and postischemic inflammation (phospho

121 Residual 111In-platelet and 125I-fibrin(ogen) depositions were lower in the heparin-treated grou

122 Fibrin(ogen) deposits resolved in control mice but persisted in

123 More abundant fibrin(ogen) deposits were also found in brain and lungs.

124 After Stx2/LPS, intraglomerular fibrin(ogen) deposits were detected earlier in TM(LeD/LeD) than

125 s is mediated through interaction of fibrin-(ogen) deposits with the apolipoprotein(a) (apo(a)) moiet

126 tiple sclerosis lesions together with fibrin(ogen) deposits.

127 e interaction of alpha(2)-AP with the fibrin(ogen)-derived D(1), D-D, and E(3) fragments, and the rec

128 The results indicate that fibrin(ogen) does not contribute to development of APAP-induced

129 Increased ICAM-1 expression was fibrin(ogen) dose-dependent and was demonstrated by ELISA, flow

130 The beta chain 15-42 sequence of the fibrin(ogen) E region was implicated in heparin binding; whethe

131 hesion, and microthrombi formation on fibrin(ogen), extracellular matrix, and collagen at high shear

132 le myosin II, red blood cells (RBCs), fibrin(ogen), factor XIIIa (FXIIIa), and thrombin on the kineti

133 ibers, and (2) through inhibition of plasmin(ogen)-fibrin binding.

134 tion why pathogenic microbes utilize plasmin(ogen) for immune evasion and tissue penetration.

135 Herein, we review aspects of fibrin(ogen) formation, structure, stability, and function, foc

136 mulations of the structural models of fibrin(ogen) fragment D complexed with synthetic peptides GPRP

137 herichia coli a number of recombinant fibrin(ogen) fragments containing the beta15-42 region or the V

138 nteraction between apo(a) and various fibrin(ogen) fragments representing the whole fibrin(ogen) mole

139 Purified plasmin(ogen) from diabetic subjects had impaired fibrinolytic a

140 inogen (Fib) and show that removal of fibrin(ogen) from the extracellular environment alleviates the

141 Plasma-purified plasmin(ogen) functional activity was evaluated by chromogenic,

142 Thus, plasmin(ogen) functions in limiting progressive fibrosis in the

143 f a 30-kDa C-terminal fragment of the fibrin(ogen) gamma chain complexed with the peptide Gly-Pro-Arg

144 related conformational changes in the fibrin(ogen) gamma-modules.

145 ne levels, proteinuria, deposition of fibrin(ogen), glomerular endothelial damage, hemolysis, leukocy

146 tified a key residue on the alphaC of fibrin(ogen) (Glu396) involved in binding activated factor XIII

147 in the accumulation of the harderoporphyrin(ogen)-glutathione conjugate observed in the expression s

148 ses with high levels of extracellular fibrin(ogen) had significantly upregulated PAI-1 expression in

149 r of the normal fibrinolytic role of plasmin(ogen) has been a major research focus.

150 Hepatic fibrin(ogen) has been noted to occur after acetaminophen (APAP)

151 ntrol of blood loss following injury, fibrin(ogen) has been proposed to play an important role in tis

152 unctional features of factor XIII and fibrin(ogen) have been elucidated by protein and gene analysis,

153 sue plasminogen activator (tPA) and plasmin (ogen) have been implicated in this death.

154 ons bound both strongly and weakly to fibrin(ogen) have been localized, and some aspects of their rol

155 physiologic functions of extravasated fibrin(ogen) have led to the discovery, reported here, that fib

156 scanning via anti-GPIbalpha and anti-fibrin(ogen) immunofluorescence.

157 vascular plasma perfusion deficit and fibrin(ogen) immunoreactivity in a rat model of focal cerebral

158 Therefore, batroxobin binds fibrin(ogen) in a manner distinct from thrombin, which may cont

159 Herein, we investigate roles for fibrin(ogen) in an in vivo model of mycobacterial granuloma for

160 To determine the importance of fibrin(ogen) in arthritis, gene-targeted mice either deficient

161 To directly examine the role of fibrin(ogen) in atherogenesis, Fib-deficient mice were crossed

162 Chemokine production was induced by fibrin(ogen) in cell culture supernatants >100-fold as compared

163 hemostatic factors plasmin(ogen) and fibrin(ogen) in cellular plasticity within adult tissues of the

164 ht the increasingly important role of fibrin(ogen) in health and disease.

165 urrent in-vivo studies on the role of fibrin(ogen) in hemostasis and thrombosis.

166 To investigate the role of plasmin(ogen) in mammary tumor development and progression, plas

167 tigate the extent and distribution of fibrin(ogen) in progressive MS cortex and elucidate its relatio

168 udies indicated an important role for fibrin(ogen) in sustained adhesion and survival of tumor cells

169 Here, we characterize the role of plasmin(ogen) in the complement cascade.

170 es, suggesting an additional role for fibrin(ogen) in the growth of established adenomas.

171 The presence of immunoreactive fibrin(ogen) in the liver and intravascular thrombi is consiste

172 To further define the role of fibrin(ogen) in thrombus formation and stabilization, platelet

173 or dissemination through at least one fibrin(ogen)-independent mechanism.

174 blastic cells, no significant data on fibrin(ogen)-induced gene expression by fibroblasts have been p

175 Our data suggest that extravascular fibrin(ogen) induces macrophage chemokine expression, thereby p

176 cterize a novel mechanism whereby the fibrin(ogen)-integrin-alphaMbeta2 interaction reduces biliary f

177 -glycosylation of CD44, whereas CD44s-fibrin(ogen) interaction has an absolute requirement for N-, bu

178 nent importance of the bacterial ClfA-fibrin(ogen) interaction in determining host survival.

179 inhibitory factor (which blocks CD11b-fibrin(ogen) interaction).

180 n, although it has no effect on CD44s-fibrin(ogen) interaction.

181 ular requirements of CD44-HA and CD44-fibrin(ogen) interactions at the single-molecule level.

182 ogen) mediated by the 5-residue FGF-2-fibrin(ogen) interactive site is required for augmented angioge

183 matory demyelination include entry of fibrin(ogen) into the central nervous system (CNS), which is no

184 The authors concluded that fibrin(ogen) is a critical determinant of the metastatic potent

185 To test directly whether fibrin(ogen) is a key binding site for apolipoprotein(a) [apo(a

186 studies definitively demonstrate that fibrin(ogen) is a physiologically relevant ligand for alpha(M)b

187 he data provide direct evidence that plasmin(ogen) is a tumor progression factor in PymT-induced mamm

188 Plasmin(ogen) is an extracellular serine protease implicated in

189 ized that Mac-1-dependent adhesion to fibrin(ogen) is an important determinant of leukocyte recruitme

190 Thus, fibrin(ogen) is an important, but context-dependent, determinan

191 Fibrin(ogen) is central to hemostasis and thrombosis and also c

192 pha(M)beta(2), integrin engagement of fibrin(ogen) is critical to leukocyte function and innate immun

193 we provide unequivocal evidence that fibrin(ogen) is extensively deposited in progressive MS motor c

194 that the only heparin-binding site in fibrin(ogen) is formed by NH(2)-terminal portions of the beta c

195 However, fibrin (ogen) is important for appropriate cellular migration an

196 ally relevant heparin-binding site of fibrin(ogen) is located in its E region.

197 lpha(M)beta(2)-mediated engagement of fibrin(ogen) is mechanistically coupled to local inflammatory p

198 ent position in gamma-chains of human fibrin(ogen) is occupied by a lysine (gamma338), but in chicken

199 olecular interaction between CD44 and fibrin(ogen) is predominantly mediated by the chondroitin sulfa

200 XIII, indicating that the presence of fibrin(ogen) is required to confer sufficient stability at the

201 Although fibrin and/or fibrinogen (fibrin(ogen)) is abundantly present in inflamed tissues and joi

202 Angiostatin, a fragment of plasmin(ogen), is a ligand and an antagonist for integrin alpha(

203 In contrast, batroxobin binds both fibrin(ogen) isoforms with similar high affinity (Kd values of

204 gamma338), but in chicken and lamprey fibrin(ogen), it is an arginine, just as occurs in beta chains.

205 As such, fibrin(ogen) lies at the nexus of vascular injury and repair.

206 cules loosely bound to the surface of fibrin(ogen) matrix are not able to consolidate their grip on t

207 rculating leukocytes to the insoluble fibrin(ogen) matrix is mediated by integrins and occurs in the

208 iple ligands, but local engagement of fibrin(ogen) may be particularly important for leukocyte functi

209 of concept that targeting thrombin or fibrin(ogen) may limit pathologies in obese patients.

210 demonstrate that binding of FGF-2 to fibrin(ogen) mediated by the 5-residue FGF-2-fibrin(ogen) inter

211 d ICAM-1 may participate in multistep fibrin(ogen)-mediated melanoma cell adhesion within the circula

212 3), ICAM-1, and CD11b/CD18 (Mac-1) in fibrin(ogen)-mediated melanoma-PMN aggregations was explored.

213 ogen) to investigate whether abnormal fibrin(ogen) might contribute to the pathogenesis of CTEPH.

214 gen) fragments representing the whole fibrin(ogen) molecule except the alphaC regions.

215 l coiled-coil connectors of the human fibrin(ogen) molecule using biomolecular simulations of their f

216 ain that together encompass the whole fibrin(ogen) molecule.

217 egion of a gamma chain of an adjacent fibrin(ogen) molecule.

218 ether encompass practically the whole fibrin(ogen) molecule.

219 Individual fluorescently labeled fibrin(ogen) molecules and their assembly to make a clot were o

220 n and cross-links the gamma chains of fibrin(ogen) more efficiently than the Aalpha chains.

221 etalloproteinase-3 and degradation of fibrin(ogen), nidogen, and perlecan in the adventitia of descen

222 and the presence of anterior chamber fibrin(ogen) occurred in plasminogen-deficient mice but not in

223 n acute lesions tPA co-localized with fibrin(ogen) on large diameter axons also stained with SMI-32,

224 we explored the hypothesis that host fibrin(ogen), on balance, supports Staphylococcus aureus infect

225 The batroxobin-binding sites on fibrin(ogen) only partially overlap with those of thrombin beca

226 To directly determine whether fibrin(ogen) or plasmin(ogen) are determinants of the metastati

227 g of alpha(IIb)beta(3) to immobilized fibrin(ogen), per se, triggers interaction of the integrin with

228 CD44 and fibrin(ogen) play critical roles in the hematogenous disseminat

229 These results suggest that plasmin(ogen) plays a role in the turnover of extracellular matr

230 Hence, our results suggest fibrin(ogen) plays an important role in spontaneous metastasis,

231 ylococcal aureus, we demonstrate that fibrin(ogen) plays little role in controlling peritoneal number

232 d in T2D, and we recently showed that fibrin(ogen) polymerisation during blood clotting can be affect

233 escence colocalized with staining for fibrin(ogen) present in the extravascular compartment of tumors

234 Rather, fibrin(ogen) primarily limits the growth of these intracellular

235 espite confirming a prior report that fibrin(ogen) promotes the peritoneal clearance of the extracell

236 Our results suggest that fibrin(ogen) provides one of the major sites to which apo(a) bi

237 ar, failure to effectively remove the fibrin(ogen) provisional matrix.

238 -linking, and binding to the platelet fibrin(ogen) receptor.

239 s was unimpeded by the absence of the fibrin(ogen) receptors, alphaMbeta2 and ICAM-1, the myeloid cel

240 rsus CD44 variant (CD44v) isoforms in fibrin(ogen) recognition have yet to be delineated.

241 te alone or in conjunction with other fibrin(ogen) region(s) can support clot retraction.

242 d that the betaN-domains are the only fibrin(ogen) regions involved in the interaction with VE-cadher

243 nding; whether heparin binds to other fibrin(ogen) regions remains to be clarified.

244 al fragments corresponding to various fibrin(ogen) regions, and tested the interactions between them

245 To test if the other fibrin(ogen) regions/domains are involved in this interaction a

246 Thus, plasmin(ogen) regulates both complement and coagulation, the two

247 laques contain substantial amounts of fibrin(ogen)-related antigen, and more recently, MMPs have been

248 e studies suggest that one target of plasmin(ogen) relevant to tumor progression in vivo is intravasc

249 the interaction of apo(a) with intact fibrin(ogen) remained unclear.

250 In mice depleted of fibrin(ogen), remyelination of myelinated axons is accelerated

251 re of human synovial fibroblasts with fibrin(ogen) results in the up-regulation of ICAM-1 as well as

252 hat FGF-2 bound to surface-associated fibrin(ogen) retained activity.

253 Fibrin(ogen) retention was normal in Bernard-Soulier syndrome a

254 Without fibrin(ogen) retention, their ability to be incorporated in agg

255 ransglutaminases are also involved in fibrin(ogen) retention.

256 f platelet glycoprotein GPIbalpha and fibrin(ogen) revealed a critical TF concentration (EC50) of 3.6

257 Immunoblotting analysis of plasmin(ogen) revealed increased levels of lysine-plasminogen in

258 tions performed in a prior study with fibrin(ogen)'s gamma' peptide and IIa.

259 the alpha(M)beta(2)-binding motif on fibrin(ogen) severely compromised the inflammatory response in

260 Fibrin(ogen) stimulation of ICAM-1 could be suppressed by pyrro

261 ed lysis may be due to alterations in fibrin(ogen) structure affecting accessibility to plasmin cleav

262 egrins but rather associated with the fibrin(ogen) substrate.

263 ctive mechanisms, we demonstrate that fibrin(ogen) suppresses anemia, reduces hemorrhagic pathology,

264 n rapidly bound, covering >90% of the fibrin(ogen) surface area, whereas the intact tri-A domain prot

265 to rapidly bind, covering 100% of the fibrin(ogen) surface area.

266 en utilize the plasminogen activator-plasmin(ogen) system to facilitate tissue invasion without produ

267 ffin cells express components of the plasmin(ogen) system, including tissue plasminogen activator, wh

268 eparin and heparan sulfate bound more fibrin(ogen) than did other proteoglycans; however, heparin bou

269 finity interaction with gammaA/gamma'-fibrin(ogen) than gammaA/gammaA-fibrin(ogen).

270 rminus contains the binding site for plasmin(ogen), the key component necessary for the rapid and eff

271 o mediating high affinity binding to plasmin(ogen), the streptokinase beta-domain is required for non

272 ide interaction of apo(a) with intact fibrin(ogen) through another alternative mechanism, which depen

273 the enhancement requires binding of plasmin(ogen) to cellular receptors.

274 Binding of fibrin(ogen) to heparin agarose was saturable as well as inhibi

275 itis, but the precise contribution of fibrin(ogen) to inflammatory events that cause debilitating joi

276 lts indicate that the contribution of fibrin(ogen) to intimal mass and local cell adhesion, migration

277 c, genomic, and functional studies on fibrin(ogen) to investigate whether abnormal fibrin(ogen) might

278 arthritis, and one mechanism linking fibrin(ogen) to joint disease is coupled to alphaMbeta2-mediate

279 tablished the overall utility of host fibrin(ogen) to S. aureus virulence.

280 Vitronectin-enhanced fibrin(ogen) turnover by Mac-1 may operate as a salvage pathway

281 moglobin (Hb) on platelet adhesion to fibrin(ogen) under conditions of different hydrodynamic forces.

282 hesion to subendothelial matrices via fibrin(ogen), von Willebrand factor, and vitronectin.

283 The extent and distribution of fibrin(ogen) was assessed and related to measures of demyelinat

284 n during the observational period and fibrin(ogen) was detected immunohistochemically.

285 Binding of VEGF to fibrin(ogen) was independent of FGF-2, indicating that there ar

286 pe (WT) A1A2A3 protein, collagen, and fibrin(ogen) was inhibited (32-75%) by anti-vimentin antibody u

287 Fibrin(ogen) was not essential for leukocyte trafficking to joi

288 In this model, fibrin(ogen) was not required for cell recruitment, cytokine re

289 Fibrin(ogen) was observed in blood vessels positive for amyloid

290 The surface fibrin(ogen) was strongly decreased in the presence of a fibrin

291 Levels of ICAM-1 induced by fibrin(ogen) were comparable to those that could be induced by

292 polymeric fibrin and surface-adsorbed fibrin(ogen), while no binding was observed with fibrinogen in

293 and GPR binding to D domains of other fibrin(ogen) will lead to the formation of the trimer and bring

294 s revealed a significant increase in plasmin(ogen) with age.

295 2 from P1 may regulate interaction of fibrin(ogen) with leukocytes during the inflammatory response.

296 tissue transglutaminase cross-linked fibrin(ogen) with mainly alpha-gamma cross-links.