ライフサイエンスコーパス: P-cadherin

1 pe along with decreased expression of E- and P-cadherin.

2 rparts also expressed all these mRNAs except P-cadherin.

3 regulate the expression of endogenous E- and P-cadherin.

4 m ZO-1, alpha-, beta-, and gamma-catenin and P-cadherin.

5 d in cells with high levels of junctional E-/P-cadherin.

6 ss E-cadherin, whereas the glomeruli express P-cadherin.

7 not dependent on the cell adhesion molecule P-cadherin.

8 ot restricted to E-cadherin but is shared by P-cadherin.

9 Cs expressed transcripts of N-, VE-, E-, and P-cadherins, alpha-, beta-, gamma-, and p120-catenins, a

10 in resulted in downregulation of both E- and P-cadherin and a scattered fibroblastic phenotype.

11 nvolved in structural integrity (E-cadherin, P-cadherin and beta-catenin) and function (aquaporin 1 a

12 In contrast, animals mutant for both P-cadherin and desmoglein 3 die before weaning.

13 Both P-cadherin and desmoglein 3 expression are restricted to

14 , and ectopic expression of Snail suppressed P-cadherin and nephrin in podocytes.

15 The mutually exclusive expression of P-cadherin and prostatic-specific antigen suggests that

16 a cause-effect relationship between loss of P-cadherin and suppression of the canonical Wnt signalin

17 This effect was mediated by up-regulation of P-cadherin and the beta-catenin downstream target fascin

18 46, and 50), one adherens junction protein (P-cadherin) and eight components of desmosomes (plakophi

19 with the closely related epithelial cadherin P-cadherin), and RPE cells with different levels of junc

20 ice deficient for both a classical cadherin, P-cadherin, and a desmosomal cadherin, desmoglein 3.

21 ssion of other cadherins such as N-cadherin, P-cadherin, and the mesenchymal cadherin-11 is actually

22 ecific and not shared by either protein with P-cadherin, another integral slit diaphragm protein.

23 The adherens junction protein P-cadherin appears loosely distributed within the albino

24 his mechanical regulation is mediated by the P-cadherin/beta-PIX/Cdc42 axis; P-cadherin specifically

25 on reduced cell surface CDH1 and upregulated P-cadherin (CDH3) without affecting CDH2 expression.

26 galectin 3 (LGALS3), fibronectin 1 (FN1) and p-cadherin (CDH3), and cell proliferation (CRIP1, IGFBP3

27 In high but not low E-/P-cadherin cells, ankyrin and fodrin levels varied among

28 zed to apical microvilli, whereas in high E-/P-cadherin cells, Na/K ATPase was on basolateral surface

29 eral membrane domains were taller in high E-/P-cadherin cells.

30 educed KC Par3 function fosters a permissive P-cadherin-dependent niche for MC transformation, invasi

31 meric proteins made of functional E-, N-, or P-cadherin ectodomains fused to the Fc fragment of immun

32 epidermal basal layer responded by elevating P-cadherin, enabling these cells to maintain adherens ju

33 In agreement, low epidermal PAR3 and high P-cadherin expression correlate with human melanoma prog

34 as to determine whether the degree of E- and P-cadherin expression in melanomas correlates with the i

35 let radiation significantly decreased E- and P-cadherin expression in the human epidermal melanocytes

36 ssion in the human epidermal melanocytes and P-cadherin expression in the WM 35 melanoma cell line (p

37 P-cadherin expression is localized to the myoepithelial

38 Increased P-cadherin expression levels are correlated with tumor a

39 nalysis, we localized and quantitated E- and P-cadherin expression on melanoma cell lines derived fro

40 This indicates that E- and P-cadherin expression patterns evolved differently betwe

41 , as well as Rho-dependent morphogenesis and P-cadherin expression.

42 uamous epithelial cell with increased E- and P-cadherin expression.

43 nd typical adherens junction proteins (e.g., P-cadherin, FAT, and catenins).

44 adherins is selective since cell adhesion to P-cadherin-Fc through alphaEbeta7 requires >100-fold mor

45 Although values for P-cadherin fluorescence were less, the trend of decreasi

46 Furthermore, the loss of P-cadherin from the myoepithelium has uncovered a novel

47 Recently, mutations in the P-cadherin gene (CDH3) have been shown to cause two inhe

48 suppressed the expression of the endogenous P-cadherin gene in follicular keratinocytes.

49 ate," or "advanced disease." Melanoma E- and P-cadherin immunofluorescence, as quantified by fluoresc

50 In order to define the role of P-cadherin in hair follicle and limb development, we per

51 Knocking down the expression of P-cadherin in hair follicles in vitro recapitulated the

52 clinical model for studying the functions of P-cadherin in human epithelial biology and pathology.

53 mbrane classical cadherin (E-cadherin and/or P-cadherin in squamous epithelial cells) linked to eithe

54 the early mouse embryo corresponds to Snail2/P-cadherin in the chick, but both Snail factors and Zeb2

55 elopment, we performed expression studies on P-cadherin in the mouse embryo, and demonstrated the pre

56 he expression of E-cadherin, N-cadherin, and P-cadherin in tissues obtained from radical prostatectom

57 To investigate the functions of P-cadherin in vivo, we have mutated the gene encoding th

58 interference to uncover new roles for E- and P-cadherins in epidermal sheet formation in vitro and ma

59 Transfection of E-cadherin and/or P-cadherin into this cell line did not restore the abili

60 P-cadherin is a key component of epithelial adherens jun

61 P-cadherin is a member of the classical cadherin family

62 We conclude that P-cadherin is a newly defined transcriptional target gen

63 Although P-cadherin is expressed at high levels in the placenta,

64 In epithelial cells, P-cadherin is localized to the adherens junction, wherea

65 intact human organ in vitro, and shows that P-cadherin is needed for anagen maintenance by regulatin

66 These studies suggest that loss of P-cadherin leads to a more severe desmoglein 3 mutant ph

67 human melanoma progression, whereas elevated P-cadherin levels are associated with reduced survival o

68 Melanoma cells appear to express E- and P-cadherin levels inversely related to disease progressi

69 found among cells with both low and high E-/P-cadherin levels.

70 P-cadherin may become a useful marker in the diagnosis a

71 These results indicate that P-cadherin-mediated adhesion and/or signals derived from

72 The ability of the P-cadherin mutant female to nurse and maintain her litte

73 The P-cadherin mutant mice develop hyperplasia and dysplasia

74 Although P-cadherin mutant mice have no apparent defect in epithe

75 rin- deficient mice, mice homozygous for the P-cadherin mutation are viable.

76 In cells with low E/P-cadherin, Na/K ATPase localized to apical microvilli,

77 Prostatic cancers were mostly P-cadherin negative, but some tumors had P-cadherin-posi

78 d demonstrated the predominant expression of P-cadherin not only in the hair follicle placode, but al

79 is expressed at high levels in the placenta, P-cadherin-null females are fertile.

80 The virgin P-cadherin-null females display precocious differentiati

81 and that the expression patterns of p63 and P-cadherin overlap in the hair follicle placode and AER,

82 normal urothelium such as keratin 5 (KRT5), P-cadherin (P-Cad), and epidermal growth factor receptor

83 tly P-cadherin negative, but some tumors had P-cadherin-positive areas frequently located close to ej

84 All P-cadherin-positive cells were negative for prostatic-sp

85 rcinoma and aggressive sarcoma; however, how P-cadherin promotes tumor malignancy remains unknown.

86 of-function mutations in CDH3, which encodes P-cadherin, result in hypotrichosis with juvenile macula

87 As in HJMD patients, P-cadherin silencing inhibited hair shaft growth, premat

88 P-cadherin silencing reduced the expression of the anage

89 antagonized the catagen-promoting effects of P-cadherin silencing.

90 iated by the P-cadherin/beta-PIX/Cdc42 axis; P-cadherin specifically activates Cdc42 through beta-PIX

91 d biophysical approaches, we determined that P-cadherin specifically induces polarization and CCM thr

92 GH down-regulated expression of E- and P-cadherins, targets of ZEB2, and inhibited E-cadherin p

93 KC-specific Par3 loss up-regulates surface P-cadherin that is essential to promote MC proliferation

94 Thus, we identify a specific role of P-cadherin through beta-PIX-mediated Cdc42 activation in

95 nied by a switch in cadherin expression from P-cadherin to N-cadherin.

96 in We also show that Snail2 and Zeb2 repress P-cadherin transcription in the primitive streak and the

97 P-cadherin was expressed in epithelial cells of the semi

98 However, neither E-cadherin nor P-cadherin was expressed.

99 We found that deletion of P-cadherin was sufficient for sustained dissemination, b

100 In addition to N-cadherin, E-cadherin (and P-cadherin) was found in adult human RPE in situ.

101 streak stages where it is substituted for by P-cadherin We also show that Snail2 and Zeb2 repress P-c

102 sociated with BLBCs such as FOXC2, CXCL1 and p-cadherin were also repressed in a similar manner.

103 RPE cells with low and high E-/P-cadherin were costained in various combinations with N

104 ressed the slit diaphragm-associated protein P-cadherin, zonula occludens-1, and nephrin, a change co