ライフサイエンスコーパス: P-selectin

1 ligand by using a ridged channel coated with P selectin.

2 a-granule proteins von Willebrand factor and P-selectin.

3 d binding affinity to that between SNX17 and P-selectin.

4 Th17, but not Th2 and regulatory T cells on P-selectin.

5 on of STXBP5 increased exocytosis of vWF and P-selectin.

6 t, and Tregs showed reduced capacity to bind P-selectin.

7 te adhesion molecules such as E-selectin and P-selectin.

8 of the WPB cargos von Willebrand factor and P-selectin.

9 tes expressed on leukocytes to endothelial E/P-selectin.

10 on is also dependent upon E-selectin but not P-selectin.

11 platelet-derived versus endothelial-derived P-selectin.

12 that it efficiently binds E- and L- but not P-selectin.

13 based microparticles of iron oxide targeting P-selectin.

14 lso decreased the upregulation of ICAM-1 and P-selectin.

15 We focused on Efb interaction with P-selectin.

16 us 24.4 +/- 13.3 ng/mL, P < 0.0001), soluble p-selectin (14.2 +/- 4.05 versus 33.2 +/- 15.2 ng/mL, P

17 (rho = 0.79), and expression levels of both P-selectin (37.4% +/- 14.7 [standard deviation] of vesse

18 Platelet count and P-selectin (a ubiquitous cargo of alpha-granules) were n

19 atelets to lymphocytes was blocked with anti-P-selectin Abs, and when this occurred we observed highe

20 1 (PAR1) thrombin receptor (TRAP-stimulated P-selectin, activated GPIIb-IIIa, and CD42b), independen

21 ERM domain bound to the sorting motif of the P-selectin adhesion protein, revealing both the architec

22 Both deletion and overexpression of P-selectin affected the survival of LSCs.

23 as IL-6, monocyte chemotactic protein-1, and P-selectin, after renal ischemia/reperfusion, exacerbati

24 a1-integrin correlated with eosinophil-bound P-selectin among all subjects with asthma even though ac

25 challenge, variation in VWFpp, VWFpp/Ag, and P-selectin among time-points was less than that among su

26 gher than in control ileum (5.1% +/- 3.7 for P-selectin and 4.8% +/- 2.3 for E-selectin).

27 Blood was assayed by flow cytometry for P-selectin and activated beta1-integrin on eosinophils a

28 dimer, prothrombin fragment 1+2, and soluble P-selectin and also for clotting factor VIII and the thr

29 and genetic data show an association between P-selectin and DR in the Jackson Heart Study.

30 further investigate the relationship between P-selectin and DR, we examined the association between P

31 Whereas antagonists to P-selectin and glycoprotein IIb/IIIa had no effects on L

32 neutrophil interactions using antagonists to P-selectin and glycoprotein IIb/IIIa or a small peptide

33 l beta(2) integrin-dependent slow rolling on P-selectin and ICAM-1.

34 molecular imaging, expression of endothelial P-selectin and intravascular recruitment of CX(3)CR-1-po

35 ligands modulate leukocyte trafficking, and P-selectin and its ligand, P-selectin glycoprotein ligan

36 via lumi-aggregometry and FACS analysis for P-selectin and LAMP-1 exposure.

37 gher plasma levels of PTX3 and its mediators P-selectin and matrix metalloproteinase-1 than normotens

38 endothelial cells constitutively synthesize P-selectin and mobilize it to the plasma membrane to med

39 ys followed by immunoblotting, we identified P-selectin and multimerin-1 as novel Efb interaction par

40 The interaction of both P-selectin and multimerin-1 with Efb is independent of f

41 The presence of P-selectin and normal levels of VPS33B and VPS16B in Nbe

42 Similarly, both P-selectin and proinflammatory cytokine levels were mark

43 late basal and inducible expression of human P-selectin and reveal human-specific differences in P-se

44 Baseline plasma levels of soluble P-selectin and soluble CD40 ligand and serum TxB2 were s

45 plasma inflammatory biomarkers, and carotid P-selectin and vascular cell adhesion molecule-1 express

46 minutes) mobilized Weibel-Palade body (WPB) P-selectin and VWF onto EC and vessel wall surfaces and

47 irculation of healthy individuals are CD41(+)P-selectin(+)and that distinct binding of patient plasma

48 stischemic detection by targeting the early (P-selectin) and late (E-selectin) endothelial ischemic r

49 y higher platelets activation marker; CD62P (P-selectins) and higher mean fluorescent intensity (MFI)

50 Glycoprotein Ib (GPIb) shedding, exposure of P-selectin, and activated integrin alphaIIbbeta3 upon ac

51 ersed by shedding of endothelial E-selectin, P-selectin, and alphavbeta3 integrin, and leukocyte CD44

52 cute endothelium activation measured by VWF, P-selectin, and angiopoietin-2 release.

53 actor-alpha, monocyte chemotactic protein-1, P-selectin, and E-selectin in DBD compared with LD and D

54 surface expression of activated GPIIb/IIIa, P-selectin, and GPIb was measured with and without low a

55 M-1), vascular adhesion molecule-1 (VCAM-1), P-selectin, and L-selectin, function to facilitate leuko

56 The findings in humans suggest that PTX3, P-selectin, and matrix metalloproteinase-1 may be novel

57 ure protein (VWF:Ag) and propeptide (VWFpp), P-selectin, and platelet factor 4.

58 surface CD42b, unstimulated platelet surface P-selectin, and platelet forward light scatter (FSC) wer

59 f vascular cell adhesion molecule-1 (VCAM 1) P-selectin, and platelet glycoprotein-1balpha (GPIbalpha

60 e shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rollin

61 activating peptide (TRAP)-stimulated percent P-selectin- and activated glycoprotein (GP)IIb-IIIa-posi

62 and FUT7 activity regulates thrombosis in a P-selectin- and P-selectin glycoprotein ligand-1-indepen

63 on and is caused by blockade of L-selectin-, P-selectin-, and CXCL12-mediated leukocyte trafficking.

64 ring recombinant human PSGL-1 (MB(YSPSL)) or P-selectin antibody (MB(Ab)) were prepared.

65 g with neutrophils and was inhibited by anti-P-selectin aptamer or anti-P-selectin glycoprotein ligan

66 aise important questions about why VWFpp and P-selectin are associated specifically with different im

67 ha-TNFR1 signaling and the adhesion molecule P-selectin are central mediators of these monocyte-CEC a

68 we expressed the entire ectodomain of mouse P-selectin as a monomer (sP-selectin) or as a disulfide-

69 mouse model, we identified brain endothelial P-selectin as a potential biomarker for transient ischae

70 P-selectin in metastasis, and they identify P-selectin as an attractive therapeutic target for preve

71 affinity of fCS oligosaccharides for L- and P-selectins as determined by microarray binding of fCS o

72 tudies revealed that heparin inhibits L- and P-selectin, as well as the chemokine CXCL12, leading to

73 are the major source of the eosinophil-bound P-selectin associated with beta1-integrin activation.

74 tethers formed by bonding between sLe(x) and p-selectin at the CEC surface, the initial mechanical st

75 Activated platelets that expressed P-selectin attached to vascular endothelium and macropha

76 d extravasation of tumor cells with platelet P-selectin being implicated in these processes.

77 iated in the presence of PRN694 show reduced P-selectin binding and impaired migration to CXCL11 and

78 Efb-N interaction with P-selectin inhibited P-selectin binding to its physiological ligand, P-select

79 ine responses by activated platelets through P-selectin binding, we found that interaction of monocyt

80 obulin variable domain was also required for P-selectin binding.

81 s enhanced by recombinant E-selectin but not P-selectin; both processes were neutralized by E-selecti

82 recognition involved multiple receptors with P-selectin (CD62P) playing the central role.

83 In summary, P-selectin, cellular or soluble, through binding to PSGL

84 tumor necrosis factor-alpha, E selectin, and P selectin, compared with controls.

85 events diabetes-induced increases in soluble P-selectin concentrations and limits the impact of the d

86 P-selectin correlated with and predicted greater area of

87 TF ELISA, soluble P-selectin, d-dimer, FVIII, and C-reactive protein were

88 t performed in the hindlimb in wild-type and P-selectin-deficient (P(-/-)) mice 45 to 360 min after b

89 ncreased blood pressure, an effect absent in P-selectin-deficient mice.

90 ngineered to overproduce soluble P-selectin (P-selectin(DeltaCT/DeltaCT) mice).

91 significantly enhanced, indicating that the P-selectin(DeltaCT/DeltaCT) neutrophils were primed for

92 in-induced PNA formation was solely platelet P-selectin dependent.

93 plasticity consisted of rapid and selective P-selectin-dependent binding of PMPs to a CCR6(+)HLA-DR(

94 mRNA during contact hypersensitivity reduced P-selectin-dependent inflammation in Selp(KI) (/-) mice.

95 let-leukocyte complexes in vivo and platelet/P-selectin-dependent polymorphonuclear cell migration in

96 However, TNF-alpha did not further reduce P-selectin-dependent rolling velocities.

97 ules of St3gal6-null mice, we found impaired P-selectin-dependent, but not E-selectin-dependent leuko

98 abeling with GSAO, together with exposure of P-selectin, distinguishes necrotic from apoptotic platel

99 nd endothelial cells induces shedding of the P-selectin ectodomain into the circulation.

100 se experiments define a novel VEGF-miR-1-Mpl-P-selectin effector pathway in lung Th2 inflammation and

101 uced reactive oxygen species (ROS) regulated P-selectin exposure upon agonist stimulation and the lig

102 ed alphaIIbbeta3 integrin activation but not P-selectin exposure, Ca(2+) mobilization, beta3-talin1 i

103 sis of platelet surface-bound fibrinogen and P-selectin exposure.

104 ulating platelet-monocyte aggregates (PMAs), p-selectin expression (P-SEL), and integrin alphaIIbbeta

105 -terminal CGHC motif of PDI is important for P-selectin expression and ATP secretion through a non-al

106 L5 also increased P-selectin expression and glycoprotein (GP)IIb/IIIa acti

107 ; P < .01 vs L1-injected mice) and increased P-selectin expression and GPIIb/IIIa activation in plate

108 p-regulation of circulating platelet surface P-selectin expression and the formation of platelet-leuk

109 Compound 6b also inhibited platelet P-selectin expression and thus may diminish atherosclero

110 emonstrated the ability for Abeta to enhance p-selectin expression at the CEC surface and induce cyto

111 indicated the ability for Abeta to increase p-selectin expression at the cell surface and promote ac

112 rdized meal enhanced U46619-induced platelet P-selectin expression by 23% after placebo; this respons

113 P-selectin expression by the endothelium may enhance VTE

114 gnificant reductions in stimulated (ex vivo) P-selectin expression compared with the placebo group (P

115 atelet integrin alphaIIbbeta3 activation and P-selectin expression in a Toll-like receptor 2 (TLR2)-d

116 poxia and low NO bioavailability upregulated P-selectin expression in endothelial cells in an additiv

117 L5 but not L1 induced tissue factor and P-selectin expression in human aortic ECs (P < .01), the

118 ive in vivo quantification and monitoring of P-selectin expression in inflammation in murine IBD.

119 reated mice and correlated well with ex vivo P-selectin expression levels (rho = 0.69; P = .04).

120 NK inhibition reduced fibrinogen binding and P-selectin expression of d12 platelet-like particles (PL

121 induced integrin alpha2bbeta3 activation and P-selectin expression that are partially corrected by in

122 ntima) and endothelial activation (increased P-selectin expression).

123 C3a and C5a generation, endothelial P-selectin expression, and adhesion of human primary and

124 agonists failed to prevent histamine-induced P-selectin expression, and exogenous S1P did not increas

125 ADP-stimulated platelet fibrinogen binding, P-selectin expression, and platelet aggregation were low

126 In contrast, SFLLRN-mediated P-selectin expression, ATP secretion, phosphorylation of

127 ts was abolished by PP2, and AYPGKF-mediated P-selectin expression, integrin alpha(IIb)beta(3) activa

128 and reduced cerebral infarct, demyelination, P-selectin expression, neutrophil infiltration, and micr

129 We found (1) no significant changes for P-selectin expression, PAC-1 binding, delta-granule cont

130 pression, and exogenous S1P did not increase P-selectin expression, suggesting that S1P cell surface

131 ontreated mice detected a 2-fold increase in P-selectin expression, VCAM-1 expression, and platelet a

132 latelet aggregation, fibrinogen binding, and P-selectin expression, whereas the GSK3 inhibitor CHIR99

133 The induced P-selectin expression, which reflects platelet degranula

134 phosphoprotein platelet reactivity index and P-selectin expression.

135 also significantly decreased agonist-induced P-selectin expression.

136 a nonsignificant trend toward an increase in P-selectin expression.

137 appaBbeta degradation mediated apoptosis and P-selectin expression.

138 s and suppressed cellular growth and induced P-selectin expression.

139 ent manner, concurrent with the induction of P-selectin expression.

140 Excess of P-selectin extracellular domain significantly impaired E

141 Our results demonstrated that P-selectin, fibrinogen, platelet factor 4 and vascular e

142 bitor 1, monocyte chemoattractant protein-1, P-selectin, fibrinogen, receptor activator of nuclear fa

143 own to require 6-O-sulfate to inhibit L- and P-selectin function, and in this study we observed that

144 tin and reveal human-specific differences in P-selectin function.

145 and DR, we examined the association between P-selectin genotype and DR.

146 ent myocardial ischemia by using recombinant P-selectin glycoprotein ligand (PSGL)-1 as a targeting l

147 We demonstrate Th17 cells express CD44, P-selectin glycoprotein ligand (PSGL)-1, and CD43.

148 d with neutrophil activation, rolling ligand P-selectin glycoprotein ligand 1 (PSGL-1) expression, as

149 and leukocyte surface glycoproteins CD45 and P-selectin glycoprotein ligand 1 (PSGL-1).

150 d and rejected grafts express high levels of P-selectin glycoprotein ligand 1 and glycosylated CD43.

151 og of the naturally occurring binding ligand P-selectin glycoprotein ligand 1 fused to a human fragme

152 ted when the bacterium engaged its receptor, P-selectin glycoprotein ligand 1.

153 P-selectin glycoprotein ligand-1 (PSGL-1) and its glycos

154 antigen-1, and CXCR4 but lower expression of P-selectin glycoprotein ligand-1 (PSGL-1) and of L-selec

155 face expression of CXCR2 and less pronounced P-selectin glycoprotein ligand-1 (PSGL-1) begin to incre

156 this study, we show that mice deficient for P-selectin glycoprotein ligand-1 (PSGL-1) develop a more

157 P-selectin glycoprotein ligand-1 (PSGL-1) has long been

158 lectin-ligand at the N terminus of leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) in humans and

159 erminus as an extension of membrane-anchored P-selectin glycoprotein ligand-1 (PSGL-1) inhibited inte

160 inhibited by anti-P-selectin aptamer or anti-P-selectin glycoprotein ligand-1 (PSGL-1) inhibitory ant

161 P-selectin glycoprotein ligand-1 (PSGL-1) mediates the c

162 Here, we demonstrate that a subset of P-selectin glycoprotein ligand-1 (PSGL-1) molecules is c

163 we focused on adhesion dynamics that involve P-selectin glycoprotein ligand-1 (PSGL-1) on MM cells an

164 dhesion receptor L-selectin forms bonds with P-selectin glycoprotein ligand-1 (PSGL-1) on other leuko

165 ics of selectins (P-, L-, and E-selectin) to P-selectin glycoprotein ligand-1 (PSGL-1) via computatio

166 P-selectin glycoprotein ligand-1 (PSGL-1) was identified

167 enge increase on blood or BAL eosinophils of P-selectin glycoprotein ligand-1 (PSGL-1), a receptor fo

168 electin binding to its physiological ligand, P-selectin glycoprotein ligand-1 (PSGL-1), both in cell

169 P-selectin glycoprotein ligand-1 (PSGL-1), CD43, and CD4

170 gated the function of the adhesion molecule, P-selectin glycoprotein ligand-1 (PSGL-1), that is upreg

171 ropod, the "nucleopod," which is capped with P-selectin glycoprotein ligand-1 (PSGL-1).

172 minus of the leukocyte cell-surface molecule P-selectin glycoprotein ligand-1 (PSGL-1, CD162) are imp

173 ar adhesion molecule-1 (ICAM-1, CD54), CD44, P-selectin glycoprotein ligand-1 (PSGL-1, CD162), cytoki

174 eously express functional rolling machinery (P-selectin glycoprotein ligand-1 [PSGL-1] and Sialyl-Lew

175 pus was induced in female wild-type (WT) and P-selectin glycoprotein ligand-1 deficient (Psgl-1(-/-))

176 Mice lacking P-selectin or P-selectin glycoprotein ligand-1 did not have a prothrom

177 P-selectin glycoprotein ligand-1 plays an important role

178 /hematopoietic cell E-/L-selectin ligand and P-selectin glycoprotein ligand-1) from hematopoietic cel

179 trafficking, and P-selectin and its ligand, P-selectin glycoprotein ligand-1, can modulate hemostasi

180 on an array of protein scaffolds, including P-selectin glycoprotein ligand-1, CD43, and CD44 (render

181 tern to LNs, neutrophils used L-selectin and P-selectin glycoprotein ligand-1, macrophage-1 Ag and LF

182 pendent of the mucin-like molecules CD43 and P-selectin glycoprotein ligand-1, previously implicated

183 ced synthesis of C2-O-sLe(x) associated with P-selectin glycoprotein ligand-1, reduced cell tethering

184 Tregs, forming the Sialyl Lewis X moiety on P-selectin glycoprotein ligand-1, would improve their tr

185 ty regulates thrombosis in a P-selectin- and P-selectin glycoprotein ligand-1-independent manner and

186 f infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out sign

187 C(high) monocytes to the CNS is regulated by P-selectin glycoprotein ligand-1.

188 t in E-selectin ligand-1 (ESL-1), or in both P-selectin glycoprotein-1 (PSGL-1) and ESL-1, to explore

189 Soluble P-selectin has been identified as a biomarker of cancer-

190 Moreover, NETosis was also promoted by P-selectin-immunoglobulin fusion protein but not by cont

191 Microbubble attachment to P-selectin-immunoglobulin G fusion protein in flow chamb

192 Inhibition of P-selectin in 20 and 40 weeks atherosclerotic mice resul

193 The up-regulation of P-selectin in endothelial cells and platelets contribute

194 n and indirectly inhibited the expression of P-selectin in lung endothelium.

195 clarify the roles of platelets, NK cells and P-selectin in metastasis, and they identify P-selectin a

196 ase pathways to upregulate the expression of P-selectin in platelets, while inducing reactive oxygen

197 tin is just as important as platelet-derived P-selectin in promoting lung metastasis and also plays a

198 Higher basal P-selectin in Selp(KI) (/) (KI) mice compensated for thi

199 e sRBC adhesion, we found a central role for P-selectin in sRBC adhesion.

200 expression, leukocytes rolled more slowly on P-selectin in trauma-stimulated venules of Selp(KI) (/)

201 ifferences in expression of human and murine P-selectin in vivo.

202 ace activated glycoprotein (GP) IIb-IIIa and P-selectin in WAS/XLT patients were proportional to plat

203 plication increased plasma levels of soluble P-selectin in wild-type but not in MC-deficient mice.

204 uch as intercellular adhesion molecule-2 and P-selectin, in breast cancer cells and HUVECs, and antib

205 Expression of the venular adhesion molecule P-selectin increased in endothelial cells from day 1 to

206 s but not conventional CD4(+) T cells became P-selectin independent, and Tregs showed reduced capacit

207 Considering that P-selectin induces prothrombotic and proinflammatory sig

208 uals with AERD and had no effect on platelet P-selectin induction.

209 Efb-N interaction with P-selectin inhibited P-selectin binding to its physiolog

210 filtration-related adhesion molecules (e.g., P-selectin, intercellular adhesion molecule 1, and vascu

211 leading to monocyte adherence, implying that P-selectin is a putative therapeutic target to prevent m

212 P-selectin is an adhesion molecule involved in interacti

213 The platelet alpha-granule membrane protein P-selectin is expressed at 48% of wild-type levels and e

214 nally, it was shown that endothelial-derived P-selectin is just as important as platelet-derived P-se

215 dual targeting properties, as we found that P-selectin is not only expressed on tumor endothelium bu

216 monocyte-platelet interactions via PSGL-1 or P-selectin is not sufficient to prevent platelet-mediate

217 ding by activated platelets, suggesting that P-selectin is the main receptor for Efb on the surface o

218 l-Palade bodies, with membrane expression of P-selectin known to bind C3b and trigger the AP, and the

219 Placebo-adjusted changes in soluble P-selectin level were -9.5% (p = 0.25) and -22.0% (p < 0

220 sma calpain activities and increased soluble P-selectin level.

221 , and other traditional risk factors, higher P-selectin levels were associated with any DR (odds rati

222 Our data demonstrate that TIM-1 is a major P-selectin ligand with a specialized role in T cell traf

223 pmel T cells upregulate expression of CD44, P-selectin ligand, and granzyme B.

224 munoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand.

225 E- and P-selectin ligands (E- and P-ligs) guide effector memory

226 bility, which was restored by injecting anti-P-selectin mAb to prevent neutrophil rolling and arrest.

227 nd platelets activation (CD41, CD42 & CD62P (P- selectins)) markers.

228 l changes in the endothelial layer through a P-selectin/matrix metalloproteinase-1 pathway.

229 Our data suggest that antagonism of P-selectin may ameliorate accumulation of macrophages in

230 Future molecular MRI targeting P-selectin may be used to improve diagnosis, follow-up o

231 Plasma VWFpp and P-selectin may be useful as surrogates of functional and

232 argeting lymphocyte CD4 (MBCD4), endothelial P-selectin (MBPSel), or isotype control antibody (MBIso)

233 Endothelial E- and P-selectins mediate lymphocyte trafficking in inflammato

234 tibody but was not induced by platelets from P-selectin(-/-) mice.

235 lecular magnetic resonance imaging targeting P-selectin might aid in the diagnosis of transient ischa

236 mRNA in tissues but only slightly increased P-selectin mRNA after injection of TNF-alpha or LPS.

237 Blunted up-regulation of P-selectin mRNA during contact hypersensitivity reduced

238 ncrease P-selectin mRNA in mice but decrease P-selectin mRNA in humans.

239 interleukin 1beta, and LPS markedly increase P-selectin mRNA in mice but decrease P-selectin mRNA in

240 ressed more P-selectin on platelets and more P-selectin mRNA in tissues but only slightly increased P

241 Immunohistochemical staining for ICAM-1, P-selectin, nitrotyrosine, and poly(ADP)ribose showed a

242 sue neutrophil infiltration in wild type and P-selectin-null mice but not in E-selectin-null mice.

243 Leukocyte adhesion to P-selectin on activated platelets and endothelial cells

244 ophil histone citrullination and presence of P-selectin on circulating neutrophils were elevated.

245 (/) (KI) mice constitutively expressed more P-selectin on platelets and more P-selectin mRNA in tiss

246 control the induction of ligands for E- and P-selectin on Th cell subsets remains poorly understood.

247 RT(-/-) platelets displayed no difference in P-selectin or alphaIIbbeta3 activation upon stimulation

248 addressin, E-, L-selectin and Mac-1 but not P-selectin or LFA-1.

249 Mice lacking P-selectin or P-selectin glycoprotein ligand-1 did not h

250 soluble CD40 ligand (p < 0.001) and soluble P-selectin (p < 0.001), serum TxB2 (p = 0.030), mean pla

251 Blockade of P-selectin (P-sel)/PSGL-1 interactions holds significant

252 from mice engineered to overproduce soluble P-selectin (P-selectin(DeltaCT/DeltaCT) mice).

253 ebrand factor with a supporting role for the P-selectin/P-selectin glycoprotein ligand 1 axis, follow

254 adhere to intravascular neutrophils through P-selectin/P-selectin glycoprotein ligand-1 (PSGL-1)-med

255 ocytes and neutrophils roll over FLIPRs in a P-selectin/P-selectin glycoprotein ligand-1-dependent ma

256 Covariate data including P-selectin plasma levels and genotypes were collected in

257 nd strongly correlated with plasma levels of P-selectin, platelet factor 4, and platelet basic protei

258 Correlations indicated that P-selectin-positive platelets complexed to eosinophils a

259 two additional receptor-ligand interactions, P-selectin &PSGL-1 and Notch &DLL1.

260 receptor) was expressed at all CNS barriers, P-selectin (PSGL-1-receptor) was mainly detected at the

261 Because of the importance of P-selectin-PSGL-1 binding in the interaction between pla

262 y an immunoregulatory role via inhibition of P-selectin-PSGL-1-dependent formation of platelet-leukoc

263 The P-selectin/PSGL-1 binding is strengthened at acidic pH,

264 Willebrand factor, soluble CD40 ligand, and P-selectin), pulmonary inflammation and oxidative stress

265 et activation markers such as plasma soluble P-selectin, soluble CD40 ligand, and serum thromboxane B

266 was determined by quantification of soluble P-selectin (sP-selectin) and glycoprotein VI (sGPVI).

267 Plasma soluble P-selectin (sP-selectin) is elevated threefold to fourfo

268 lular adhesion molecule-1 (sICAM-1), soluble P-selectin (sP-selectin), systolic blood pressure (SBP),

269 membrane-labeled mouse neutrophils rolled on P-selectin substrate at 10 dyn/cm(2).

270 lls and undergo a step-wise peeling from the P-selectin substrate enabled by the failure of PSGL-1 pa

271 fectors expressing high levels of binding to P-selectin, T-bet, and Blimp-1, and that more of them se

272 Deshpande et al (1) have shown that P-selectin-targeted microbubbles (MBs) can be used to mo

273 By encapsulating BYL719 into P-selectin-targeted nanoparticles, we achieve specific a

274 an additional 30 mice with colitis by using P-selectin-targeted US imaging, by measuring bowel wall

275 tracellular adhesion molecule-1, E-selectin, P-selectin, TAT (thrombin/antithrombin complex), tumor n

276 ycoprotein ligand-1 (PSGL-1), a receptor for P-selectin that causes activation of beta(1) -integrins.

277 esent study, we found that binding of E- and P-selectin to neutrophils and L-selectin binding to lymp

278 d platelet granule release, translocation of P-selectin to the cell surface, and a consequent increas

279 In vivo binding specificity of MB(P-selectin) to P-selectin was tested in mice with trinit

280 igher levels of vWF in the plasma, increased P-selectin translocation, and more platelet-endothelial

281 ble cluster of differentiation 40 ligand and p-selectin (two markers of platelet activation), and zon

282 rties of these modified cells to L-, E-, and P-selectin under hydrodynamic shear were compared with b

283 targeting the endothelial adhesion molecule P-selectin unmasks the pathological events that take pla

284 comes were assessed: ADP-stimulated platelet P-selectin, unstimulated platelet fibrinogen binding, an

285 key role for SK-1 in histamine-induced rapid P-selectin up-regulation and associated leukocyte rollin

286 , but not SK-2, attenuated histamine-induced P-selectin up-regulation and neutrophil rolling in vitro

287 Rapid P-selectin up-regulation by endothelial cells is a key p

288 is dissociated from alpha-granule secretion (P-selectin up-regulation) and occurs more gradually, wit

289 Antibody blockade of adhesion molecules P-selectin, von Willebrand factor (VWF), E-selectin, vas

290 opag treatment, whereas a slight increase in P-selectin was observed.

291 ivo binding specificity of MB(P-selectin) to P-selectin was tested in mice with trinitrobenzenesulfon

292 Platelet activation (P-selectin) was measured by flow cytometry.

293 hereas vascular cell adhesion molecule-1 and P-selectin were not required, deficiency of E-selectin i

294 Binding affinity and specificity of MB(P-selectin) were tested in cell culture experiments unde

295 b, an antibody against the adhesion molecule P-selectin, were evaluated in patients with sickle cell

296 s was rescued by depleting the gene encoding P-selectin, which is upregulated in Alox15-deficient ani

297 ular calcium and endothelial presentation of P-selectin, which supports monocyte binding.

298 urine (m)IgG1 and mIgG2a induced endothelial P-selectin, which was required for monocyte adhesion to

299 because they bind all selectins (L-, E-, and P-selectin) with high affinity under hydrodynamic shear

300 is a recombinant monoclonal antibody against P-selectin, with potential anti-inflammatory, antithromb