ライフサイエンスコーパス: P-selectin glycoprotein ligand-1

1 by pretreatment of monocytes with Ab against P-selectin glycoprotein ligand 1.

2 ted when the bacterium engaged its receptor, P-selectin glycoprotein ligand 1.

3 C(high) monocytes to the CNS is regulated by P-selectin glycoprotein ligand-1.

4 ockade of P-selectin or its leukocyte ligand P-selectin glycoprotein ligand-1.

5 d by monoclonal antibodies to L-selectin and P-selectin glycoprotein ligand-1.

6 ce deficient in the major P-selectin ligand, P-selectin glycoprotein ligand-1.

7 K562 cells transfected with P-selectin glycoprotein ligand-1, a ligand for P-selecti

8 f initial treatment with the soluble form of P-selectin glycoprotein ligand-1, a soluble ligand for P

9 As reported previously, P-selectin glycoprotein ligand 1 and a distinct 130-kDa

10 d and rejected grafts express high levels of P-selectin glycoprotein ligand 1 and glycosylated CD43.

11 edominant E-selectin ligands on NK cells are P-selectin glycoprotein ligand-1 and protease-resistant

12 heres (MSs) were conjugated with recombinant P-selectin glycoprotein ligand-1 and systemically inject

13 uding CD43, CD44, CD45, CD93, CD162 (PSGL-1; P-selectin glycoprotein ligand 1), and the surface-attac

14 E-selectin-mediated migration of Tc1 cells, P-selectin glycoprotein ligand-1 appears to be the sole

15 These results indicate that P-selectin and P-selectin glycoprotein ligand-1 are not required for le

16 thesis of E- and P-selectin ligands, such as P-selectin glycoprotein ligand 1, are unknown.

17 at utilizes sialyl Lewis x (sLe(x))-modified P-selectin glycoprotein ligand 1 as a receptor for infec

18 or with a supporting role for the P-selectin/P-selectin glycoprotein ligand 1 axis, followed by (2) f

19 ltransferases, C2GnT (Core2 transferase), or P-selectin glycoprotein ligand-1 between HL60var and typ

20 irectly shown to contribute to high-affinity P-selectin glycoprotein ligand-1 binding by P-selectin.

21 played on O-linked glycans, akin to those on P-selectin glycoprotein ligand-1, but distinct from the

22 e reduced tethering to the L-selectin ligand P-selectin glycoprotein ligand-1, but rolling velocity o

23 ectin-bearing microspheres or neutrophils on P-selectin glycoprotein ligand-1 by force decreased bond

24 To address whether the glycosylation of P-selectin glycoprotein ligand-1 by ppGalNAcT-1 is impor

25 tethering of these microspheres or cells to P-selectin glycoprotein ligand-1 by three transport mech

26 trafficking, and P-selectin and its ligand, P-selectin glycoprotein ligand-1, can modulate hemostasi

27 on an array of protein scaffolds, including P-selectin glycoprotein ligand-1, CD43, and CD44 (render

28 ther administration of a soluble recombinant P-selectin glycoprotein ligand-1 chimera (rPSGL-Ig) in c

29 significantly higher numbers of recombinant P-selectin glycoprotein ligand-1-conjugated MSs adhered

30 m-diameter microspheres with the recombinant P-selectin glycoprotein ligand-1 construct 19.ek.Fc.

31 O treatment reduced intragraft expression of P-selectin glycoprotein ligand-1, CX(3)CL1, CCL19, CCL20

32 pus was induced in female wild-type (WT) and P-selectin glycoprotein ligand-1 deficient (Psgl-1(-/-))

33 neutrophils roll over FLIPRs in a P-selectin/P-selectin glycoprotein ligand-1-dependent manner, retri

34 Mice lacking P-selectin or P-selectin glycoprotein ligand-1 did not have a prothrom

35 /hematopoietic cell E-/L-selectin ligand and P-selectin glycoprotein ligand-1) from hematopoietic cel

36 og of the naturally occurring binding ligand P-selectin glycoprotein ligand 1 fused to a human fragme

37 which contained two E-selectin ligands, the P-selectin glycoprotein ligand-1 glycoform "CLA," and CD

38 ty regulates thrombosis in a P-selectin- and P-selectin glycoprotein ligand-1-independent manner and

39 f infection and is mediated by chemokine- or P-selectin glycoprotein ligand-1-induced inside-out sign

40 D49d and CD49e, as well as to P-selectin and P-selectin glycoprotein ligand 1, inhibited basophil rol

41 vealed that CLP-2 homing involves P-selectin/P-selectin glycoprotein ligand 1 interactions, pertussis

42 ycoprotein ligand-1, but rolling velocity on P-selectin glycoprotein ligand-1 is not affected.

43 P-selectin glycoprotein ligand-1 is the best characteriz

44 n-associated antigen-1 activation that links P-selectin glycoprotein ligand-1 ligation to integrin ac

45 tern to LNs, neutrophils used L-selectin and P-selectin glycoprotein ligand-1, macrophage-1 Ag and LF

46 P-selectin glycoprotein ligand-1-mediated rolling of mou

47 eefold increase in O-linked glycosylation of P-selectin glycoprotein ligand-1 on the surface of leuko

48 rvival times of P-selectin dissociating from P-selectin glycoprotein ligand 1 or from an antibody in

49 ls through engagement of the selectin ligand P-selectin glycoprotein ligand-1 or the chemokine recept

50 urements of L- and P-selectin complexed with P-selectin glycoprotein ligand-1 or their respective ant

51 P-selectin glycoprotein ligand-1 plays an important role

52 teraction between P-selectin and its ligand (P-selectin glycoprotein ligand-1) plays a role in adenos

53 pendent of the mucin-like molecules CD43 and P-selectin glycoprotein ligand-1, previously implicated

54 ECA-452-reactive and nonreactive isoforms of P-selectin glycoprotein ligand 1 (PSGL-1) and can tether

55 Surface P-selectin glycoprotein ligand 1 (PSGL-1) and LFA-1 were

56 The receptor-ligand pair P-selectin and P-selectin glycoprotein ligand 1 (PSGL-1) are critically

57 Platelet GP Ibalpha and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1) are membrane m

58 P-Selectin and P-selectin glycoprotein ligand 1 (PSGL-1) are vascular a

59 ocytophilum are linked to bacterial usage of P-selectin glycoprotein ligand 1 (PSGL-1) as a receptor

60 d with neutrophil activation, rolling ligand P-selectin glycoprotein ligand 1 (PSGL-1) expression, as

61 P-selectin glycoprotein ligand 1 (PSGL-1) is a mucin-lik

62 P-selectin glycoprotein ligand 1 (PSGL-1) is a sialomuci

63 residues in the leukocyte adhesion molecule P-selectin glycoprotein ligand 1 (PSGL-1) is required fo

64 P-selectin glycoprotein ligand 1 (PSGL-1) is the main P-

65 cule 1 failed to ameliorate ileitis, whereas P-selectin glycoprotein ligand 1 (PSGL-1) neutralization

66 ding of P-selectin on activated platelets to P-selectin glycoprotein ligand 1 (PSGL-1) on the microvi

67 However, mice lacking P-selectin glycoprotein ligand 1 (PSGL-1) or P-selectin,

68 nine, and interleukin 15, adhesion molecules P-selectin glycoprotein ligand 1 (PSGL-1), intercellular

69 e many candidate ligands for selectins, only P-selectin glycoprotein ligand 1 (PSGL-1), which also ac

70 Here we show that BACE1 acts on the P-selectin glycoprotein ligand 1 (PSGL-1), which mediate

71 ce probe to test the leukocyte adhesion bond P-selectin glycoprotein ligand 1 (PSGL-1)-P-selectin, we

72 tion of endothelial P-selectin and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1).

73 ss dependent upon ligation of L-selectin and P-selectin glycoprotein ligand 1 (PSGL-1).

74 d lamina propria (LP) up-regulate functional P-selectin glycoprotein ligand 1 (PSGL-1).

75 iated antigen 1 (LFA-1) integrins, CD44, and P-selectin glycoprotein ligand 1 (PSGL-1).

76 and leukocyte surface glycoproteins CD45 and P-selectin glycoprotein ligand 1 (PSGL-1).

77 tion of endothelial P-selectin and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1).

78 P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and int

79 mic endothelial cells and lost expression of P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and L-s

80 tion of T cells marked by down-regulation of P-selectin glycoprotein ligand 1 (PSGL-1; also known as

81 king antibodies against either P-selectin or P-selectin glycoprotein ligand-1 (PSGL-1) alone inhibite

82 selectin ligands are expressed on human HCs, P-selectin glycoprotein ligand-1 (PSGL-1) and a speciali

83 to human neutrophils requires expression of P-selectin glycoprotein ligand-1 (PSGL-1) and alpha1-3-f

84 CLA epitope on T cells has been described on P-selectin glycoprotein ligand-1 (PSGL-1) and associated

85 etween oligosaccharides from human leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) and from zona

86 P-selectin glycoprotein ligand-1 (PSGL-1) and its glycos

87 P-selectin glycoprotein ligand-1 (PSGL-1) and L-selectin

88 antigen-1, and CXCR4 but lower expression of P-selectin glycoprotein ligand-1 (PSGL-1) and of L-selec

89 eshold shear to support leukocyte rolling on P-selectin glycoprotein ligand-1 (PSGL-1) and other vasc

90 Bacterial recognition of P-selectin glycoprotein ligand-1 (PSGL-1) and the alpha2

91 lection fluorescence/epi intensity, and that P-selectin glycoprotein ligand-1 (PSGL-1) and the integr

92 Previous studies identified P-selectin glycoprotein ligand-1 (PSGL-1) as the essenti

93 face expression of CXCR2 and less pronounced P-selectin glycoprotein ligand-1 (PSGL-1) begin to incre

94 P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-s

95 glycosulfopeptide binding site (2-GSP-6) on P-selectin glycoprotein ligand-1 (PSGL-1) but not for a

96 E-selectin binding to P-selectin glycoprotein ligand-1 (PSGL-1) can activate t

97 the off-rate of P-selectin interacting with P-selectin glycoprotein ligand-1 (PSGL-1) decreased with

98 ed antigen (CLA), a specialized glycoform of P-selectin glycoprotein ligand-1 (PSGL-1) defined by mon

99 this study, we show that mice deficient for P-selectin glycoprotein ligand-1 (PSGL-1) develop a more

100 L-selectin interacts with the dimeric mucin P-selectin glycoprotein ligand-1 (PSGL-1) expressed on l

101 n a shear field via bonding of L-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) followed by a

102 (X) (sialyl-Lewis-X) epitope is expressed in P-selectin glycoprotein ligand-1 (PSGL-1) from neutrophi

103 P-selectin glycoprotein ligand-1 (PSGL-1) has long been

104 lectin-ligand at the N terminus of leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) in humans and

105 blockade of P- and E-selectins by a soluble P-selectin glycoprotein ligand-1 (PSGL-1) in rat models

106 The role of P-selectin glycoprotein ligand-1 (Psgl-1) in this proces

107 erminus as an extension of membrane-anchored P-selectin glycoprotein ligand-1 (PSGL-1) inhibited inte

108 inhibited by anti-P-selectin aptamer or anti-P-selectin glycoprotein ligand-1 (PSGL-1) inhibitory ant

109 P-selectin glycoprotein ligand-1 (PSGL-1) is a dimeric m

110 P-selectin glycoprotein ligand-1 (PSGL-1) is a disulfide

111 P-selectin glycoprotein ligand-1 (PSGL-1) is a disulfide

112 P-selectin glycoprotein ligand-1 (PSGL-1) is a high-affi

113 P-selectin glycoprotein ligand-1 (PSGL-1) is a homodimer

114 P-selectin glycoprotein ligand-1 (PSGL-1) is a large (24

115 P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin on

116 P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin-lik

117 P-selectin glycoprotein ligand-1 (PSGL-1) is a mucin-lik

118 P-selectin glycoprotein ligand-1 (PSGL-1) is a muclin-li

119 P-selectin glycoprotein ligand-1 (PSGL-1) is constitutiv

120 Leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) is expressed a

121 Further analyses indicate that P-selectin glycoprotein ligand-1 (PSGL-1) is expressed i

122 we found that the E-selectin-binding form of P-selectin glycoprotein ligand-1 (PSGL-1) is expressed o

123 P-selectin glycoprotein ligand-1 (PSGL-1) is present on

124 uggested that glycosylation and sulfation of P-selectin glycoprotein ligand-1 (PSGL-1) is required fo

125 Dissociation of bonds between L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) loaded at a co

126 re mediated through binding of P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) located on the

127 P-selectin monoclonal antibody (mAb) or anti-P-selectin glycoprotein ligand-1 (PSGL-1) mAb would redu

128 prevention of platelet-leukocyte binding via P-selectin glycoprotein ligand-1 (PSGL-1) may be benefic

129 Interactions between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) mediate the ea

130 P-selectin glycoprotein ligand-1 (PSGL-1) mediates rolli

131 P-selectin glycoprotein ligand-1 (PSGL-1) mediates the c

132 P-selectin glycoprotein ligand-1 (PSGL-1) mediates the i

133 P-selectin glycoprotein ligand-1 (PSGL-1) modified by al

134 Here, we demonstrate that a subset of P-selectin glycoprotein ligand-1 (PSGL-1) molecules is c

135 while P-selectin interacts exclusively with P-selectin glycoprotein ligand-1 (PSGL-1) on leukocytes.

136 we focused on adhesion dynamics that involve P-selectin glycoprotein ligand-1 (PSGL-1) on MM cells an

137 dhesion receptor L-selectin forms bonds with P-selectin glycoprotein ligand-1 (PSGL-1) on other leuko

138 ated platelets through a mechanism involving P-selectin glycoprotein ligand-1 (PSGL-1) on the microve

139 Containing most of the L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) on their tips,

140 d P- and L-selectin to their natural ligand, P-selectin glycoprotein ligand-1 (PSGL-1) over the predi

141 P-selectin glycoprotein ligand-1 (PSGL-1) serves as the

142 In inflamed venules, leukocytes use P-selectin glycoprotein ligand-1 (PSGL-1) to roll on P-s

143 Leukocytes use the cell-surface mucin P-selectin glycoprotein ligand-1 (PSGL-1) to tether to a

144 Under shear stress, leukocytes use P-selectin glycoprotein ligand-1 (PSGL-1) to tether to a

145 bond formation rates on their common ligand P-selectin glycoprotein ligand-1 (PSGL-1) under shear fl

146 ics of selectins (P-, L-, and E-selectin) to P-selectin glycoprotein ligand-1 (PSGL-1) via computatio

147 P-selectin glycoprotein ligand-1 (PSGL-1) was identified

148 an in vitro flow model and a blocking mAb to P-selectin glycoprotein ligand-1 (PSGL-1) were used to d

149 ts on sialyl Lewis X expression displayed by P-selectin glycoprotein ligand-1 (PSGL-1) with sialylate

150 We tested the hypothesis that deficiency of P-selectin glycoprotein ligand-1 (Psgl-1) would improve

151 P-selectin glycoprotein ligand-1 (PSGL-1), a dimeric muc

152 P-selectin glycoprotein ligand-1 (PSGL-1), a heavily gly

153 is an inducible carbohydrate modification of P-selectin glycoprotein ligand-1 (PSGL-1), a known surfa

154 P-selectin binds to the N-terminal region of P-selectin glycoprotein ligand-1 (PSGL-1), a mucin on le

155 L-selectin bind to the N-terminal region of P-selectin glycoprotein ligand-1 (PSGL-1), a mucin on le

156 A candidate ligand for L-selectin is P-selectin glycoprotein ligand-1 (PSGL-1), a mucinlike p

157 A mouse homolog of P-selectin glycoprotein ligand-1 (PSGL-1), a P-selectin

158 enge increase on blood or BAL eosinophils of P-selectin glycoprotein ligand-1 (PSGL-1), a receptor fo

159 P-selectin glycoprotein ligand-1 (PSGL-1), a sialomucin

160 id adhesion of beads coated with recombinant P-selectin glycoprotein ligand-1 (PSGL-1), an E-selectin

161 we showed that E-selectin ligand-1 (ESL-1), P-selectin glycoprotein ligand-1 (PSGL-1), and CD44 enco

162 neutrophils roll on P- or E-selectin, engage P-selectin glycoprotein ligand-1 (PSGL-1), and signal ex

163 ophils is linked to neutrophil expression of P-selectin glycoprotein ligand-1 (PSGL-1), as well as si

164 electin binding to its physiological ligand, P-selectin glycoprotein ligand-1 (PSGL-1), both in cell

165 P-selectin glycoprotein ligand-1 (PSGL-1), CD43, and CD4

166 Current evidence suggests that P-selectin glycoprotein ligand-1 (PSGL-1), E-selectin li

167 Ethanol (0.3% by volume) had no effect on P-selectin glycoprotein ligand-1 (PSGL-1), L-selectin, o

168 and its leukocyte ligand, a homodimer termed P-selectin glycoprotein ligand-1 (PSGL-1), mediate the e

169 gated the function of the adhesion molecule, P-selectin glycoprotein ligand-1 (PSGL-1), that is upreg

170 We hypothesize that P-selectin glycoprotein ligand-1 (PSGL-1), the common li

171 do not generate microthrombi in mice lacking P-selectin glycoprotein ligand-1 (PSGL-1), the leukocyte

172 P-selectin glycoprotein ligand-1 (PSGL-1), the primary l

173 pressing PMPs bridge leukocytes that express P-selectin glycoprotein ligand-1 (PSGL-1), thereby allow

174 lities of selectins and the selectin ligand, P-selectin glycoprotein ligand-1 (PSGL-1), to support te

175 e predominant leukocyte L-selectin ligand is P-selectin glycoprotein ligand-1 (PSGL-1), which display

176 P-selectin blockade is completely absent in P-selectin glycoprotein ligand-1 (PSGL-1)-/- mice or wil

177 intravascular neutrophils through P-selectin/P-selectin glycoprotein ligand-1 (PSGL-1)-mediated bindi

178 rate determinant differentially expressed on P-selectin glycoprotein ligand-1 (PSGL-1).

179 ctin binds to the N-terminal region of human P-selectin glycoprotein ligand-1 (PSGL-1).

180 o severely impaired binding of P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1).

181 recognition of L-selectin may be mediated by P-selectin glycoprotein ligand-1 (PSGL-1).

182 ligand for P-selectin on human leukocytes is P-selectin glycoprotein ligand-1 (PSGL-1).

183 sion of leukocytes through interactions with P-selectin glycoprotein ligand-1 (PSGL-1).

184 ropod, the "nucleopod," which is capped with P-selectin glycoprotein ligand-1 (PSGL-1).

185 hat cleaves mucin type glycoproteins such as P-selectin glycoprotein ligand-1 (PSGL-1).

186 uman leukocyte cell surface selectin-ligand, P-selectin glycoprotein ligand-1 (PSGL-1).

187 ed to a leukocyte cell-surface glycoprotein, P-selectin Glycoprotein Ligand-1 (PSGL-1).

188 rophage adherence promoted signaling through P-selectin glycoprotein ligand-1 (PSGL-1)/Akt/mTOR that

189 minus of the leukocyte cell-surface molecule P-selectin glycoprotein ligand-1 (PSGL-1, CD162) are imp

190 ar adhesion molecule-1 (ICAM-1, CD54), CD44, P-selectin glycoprotein ligand-1 (PSGL-1, CD162), cytoki

191 gulant microparticles in human blood through P-selectin glycoprotein ligand-1 (PSGL-1; encoded by the

192 inistration of a recombinant soluble form of P-selectin glycoprotein ligand-1 (PSGL-1; the recombinan

193 on in vivo and on P-selectin in vitro, where P-selectin-glycoprotein-ligand-1 (PSGL-1) is found in di

194 eously express functional rolling machinery (P-selectin glycoprotein ligand-1 [PSGL-1] and Sialyl-Lew

195 5 (a leukocyte adhesion blocking mAb against P-selectin glycoprotein ligand-1; PSGL-1).

196 to mouse neutrophils, this was dependent on P-selectin glycoprotein ligand 1 (PSGL1), alpha(L)beta(2

197 erized by a Bcl6-dependent downregulation of P-selectin glycoprotein ligand 1 (PSGL1, a CCL19- and CC

198 ced synthesis of C2-O-sLe(x) associated with P-selectin glycoprotein ligand-1, reduced cell tethering

199 d the lifetimes of P-selectin complexes with P-selectin glycoprotein ligand-1, revealing both catch a

200 teraction with its leukocyte ligand, PSGL-1 (P-selectin glycoprotein ligand 1), the interaction with

201 cking molecules, including CCR9, L selectin, P selectin glycoprotein ligand-1, the integrin subunits

202 singly, however, donor T cells deficient for P-selectin glycoprotein ligand 1, the most well describe

203 y use multiple P-selectin ligands apart from P-selectin glycoprotein ligand 1 to interact with P-sele

204 nd that eosinophils and neutrophils both use P-selectin glycoprotein ligand-1 to form stable conjugat

205 trafficking is dependent upon the binding of P-selectin glycoprotein ligand-1 to P- and E-selectin on

206 amed endothelium in vivo and cooperates with P-selectin glycoprotein ligand-1 to recruit neutrophils

207 t caNFATc1 enhances expression of functional P-selectin glycoprotein ligand-1, up-regulates Fas ligan

208 Tregs, forming the Sialyl Lewis X moiety on P-selectin glycoprotein ligand-1, would improve their tr