ライフサイエンスコーパス: P-type ATPase

1 mains of the alpha and beta subunits of this P type ATPase.

2 ence or dysfunction of a copper-transporting P-type ATPase.

3 as functional properties characteristic of a P-type ATPase.

4 s from all known ATPases and appears to be a P-type ATPase.

5 ons in a gene encoding a copper-transporting P-type ATPase.

6 (ATP7B) appears to be a copper-transporting P-type ATPase.

7 gene encoding a putative copper-transporting P-type ATPase.

8 ly higher than reported so far for any other P-type ATPase.

9 s cerevisiae relies on extrusion via Pca1, a P-type ATPase.

10 he ATP7A gene encoding a copper-transporting P-type Atpase.

11 ncludes several residues conserved among all P-type ATPases.

12 rstanding of ion entry in Cu(+)-transporting P-type ATPases.

13 ins include the Drs2p/ATPase II subfamily of P-type ATPases.

14 olved with a large preexisting repertoire of P-type ATPases.

15 ance, much larger than those seen with other P-type ATPases.

16 al orthologous relationships for all 43 rice P-type ATPases.

17 e common angiosperm ancestor had at least 23 P-type ATPases.

18 metallochaperones and to copper-transporting P-type ATPases.

19 functional characteristics similar to other P-type ATPases.

20 ly applies to Na+,K+-ATPase as well as other P-type ATPases.

21 nto the function not only of PSP but also of P-type ATPases.

22 of general importance in regulating diverse P-type ATPases.

23 occlusion transitions remain obscure for all P-type ATPases.

24 bunit (KdpB) belonging to the superfamily of P-type ATPases.

25 M6 in defining the cation binding pocket of P-type ATPases.

26 r of the superfamily of cation-translocating P-type ATPases.

27 t was sensitive to vanadate, an inhibitor of P-type ATPases.

28 t genes encoding similar copper-transporting P-type ATPases.

29 sus sequence for the phosphorylation site of P-type ATPases.

30 ogous with other bacterial, animal and plant P-type ATPases.

31 nisms through transient hydrophobic pores in P-type ATPases.

32 and E(2)P forms similar to the archetypical P-type ATPases.

33 of metal transport and specificity of metal P-type ATPases.

34 N domains opening the cytoplasmic region of P-type ATPases.

35 uncharacterized prokaryotic transition-metal P-type ATPases.

36 ential function of the DRS2/DNF subfamily of P-type ATPases.

37 r to the secretory pathway by docking with 2 P-type ATPases.

38 Pro393 is invariant in all P-type ATPases.

39 G finger binding protein (RFBP) is a Type IV P-type ATPase, a putative phospholipid pump, with conser

40 conserved, uncharacterized type V branch of P-type ATPases, a large family of ion pumps.

41 argeting these important pathways (including P-type ATPases, ABC transporters and K+ channels) and hi

42 ramembrane lipid transport reactions utilize P-type ATPases, ABC transporters, scramblases, and Niema

43 larial activity by directly interfering with P-type ATPase activity.

44 mediate in phosphotransfer reactions, and in P-type ATPases, also members of the HAD family, it serve

45 TPases constitute the least studied group of P-type ATPases, an essential family of ion pumps in all

46 transduction involving the interaction of a P-type ATPase and a nonreceptor tyrosine kinase.

47 Drs2p/Swa3p is a P-type ATPase and a potential aminophospholipid transloc

48 n's disease (WD) is caused by mutations in a P-type ATPase and is associated with copper deposition i

49 st gene of this class, COD1, which encodes a P-type ATPase and is identical to SPF1.

50 Mg(2+)-ATPase, is a member of a subfamily of P-type ATPase and is presumably responsible for aminopho

51 rom Saccharomyces cerevisiae is an essential P-type ATPase and potential aminophospholipid translocas

52 WA3/DRS2, which encodes an integral membrane P-type ATPase and potential aminophospholipid translocas

53 describes a unique transport mechanism for a P-type ATPase and provides insight into how integral mem

54 contained the conserved motifs found in all P-type ATPases and also motifs that are characteristic o

55 contains all 10 of the conserved regions in P-type ATPases and exhibits 55% amino-acid identity to t

56 Ca(2+)-ATPase belongs to the family of P-type ATPases and maintains low concentrations of intra

57 tdEtn) through the action of plasma membrane P-type ATPases and rapidly acylate it to form PtdEtn.

58 ll transmembrane proteins that interact with P-type ATPases and regulate ion transport in cardiac cel

59 ignificant sequence conservation, among PSP, P-type ATPases and response regulators suggests that the

60 stance nodulation division efflux systems, a P-type ATPase, and a two-component regulator were partic

61 trafficking of Atp7a, a copper-transporting P-type ATPase, and peptidylglycine alpha-amidating monoo

62 f the well-characterized cation-transporting P-type ATPases, and it is unknown whether the flippases

63 tions of the aminophospholipid translocating P-type ATPases (APLTs).

64 he activity of the prototypic proton-pumping P-type ATPase Arabidopsis thaliana isoform 2 (AHA2).

65 P-type ATPases are a large family of enzymes that active

66 P-type ATPases are a venerable family of ATP-dependent i

67 Phosphorylation-type (P-type) ATPases are ubiquitous primary transporters that

68 ons in ATP13A2 (PARK9), encoding a lysosomal P-type ATPase, are associated with both Kufor-Rakeb synd

69 the related ALA1 in the type IV subfamily of P-type ATPases as key components of antiviral RNAi.

70 member of a recently described subfamily of P-type ATPases; ATP-dependent aminophospholipid transpor

71 n mammalian cells is the copper-transporting P-type ATPase ATP7A, which mediates copper transport fro

72 used by mutations in the copper-transporting P-type ATPase ATP7B.

73 in the gene encoding the copper-transporting P-type ATPase (ATP7B).

74 on to various domains corresponding to other P-type ATPases, ATP7B includes an N terminus extension (

75 nesium transporter A (MgtA) is a specialized P-type ATPase, believed to import Mg(2+) into the cytopl

76 , the activity of alpha4 is inhibited by the P-type ATPase blocker vanadate but not by compounds that

77 e highly conserved regions characteristic of P-type ATPases but does possess significant homology to

78 transcellular calcium transport, mediated by P-type ATPases, but the cellular basis for this phenomen

79 rest in the post-translational regulation of P-type ATPases by protein kinase-mediated phosphorylatio

80 2+ transport systems of enteric bacteria are P-type ATPases by sequence homology, mediating Mg2+ infl

81 Menkes proteins are distinguished from other P-type ATPases by the presence of six soluble N-terminal

82 a monomer, as has been established for other P-type ATPases, Ca(2+)-ATPase and Na(+),K(+)-ATPase.

83 aureus plasmid pI258 cadCA operon encodes a P-type ATPase, CadA, that confers resistance to Cd(II)/P

84 aureus plasmid pI258 cadCA operon encodes a P-type ATPase, CadA, that confers resistance to the heav

85 the yeast Saccharomyces cerevisiae encodes a P-type ATPase (Ccc2p) required for the export of cytosol

86 PMR1, a P-type ATPase cloned from the yeast Saccharomyces cerevi

87 cognate metal-binding domains (MBDs) of the P-type ATPases CtaA and PacS, which are proposed to dona

88 accharomyces cerevisiae genome contains five P-type ATPases divergent from both of the well-known sub

89 ng and directed mutagenesis with the type IV P-type ATPases Dnf1 and Drs2 from budding yeast, we iden

90 tdEtn requires the action of plasma membrane P-type ATPases Dnf1p and Dnf2p and their requisite beta-

91 identify two members of the P4 subfamily of P-type ATPases, Dnf1p and Dnf2p, that are necessary for

92 Recently, two members of the P4 family of P-type ATPases, Dnf1p and Dnf2p, were shown to be necess

93 within the Spitzenkorper from another Type 4 P-type ATPase, DnfB.

94 mbers of the DRS2/DNF essential subfamily of P-type ATPases does not affect NBD-PS flip, we conclude

95 ) in cells by regulating the expression of a P-type ATPase efflux pump (Bxa1) and an intracellular me

96 ional induction of the Na+/Li+ translocating P-type ATPase encoded by ENA1.

97 by the absence or dysfunction of a putative P-type ATPase encoded on the X chromosome.

98 ysfunction of a putative copper-transporting P-type ATPase encoded on the X chromosome.

99 Here we report the characterization of a P-type ATPase-encoding gene, MgAPT2, in the economically

100 ositions mimic the first mechanistic step of P-type ATPase enzymes by forming a phospho-enzyme interm

101 However, the type IV P-type ATPases evolved the ability to transport specific

102 alpha and beta subunits and a member of the P-type ATPase family of ion pumps.

103 In the secretory pathway, the P-type ATPase family of transporters is found in every c

104 to previously characterized members of this P-type ATPase family.

105 ly homologous member of the cation-transport P-type ATPase family.

106 2, a phospholipid translocase in the type IV P-type ATPase family.

107 culum Ca(2+)-ATPase (SERCA), a member of the P-type ATPases family, transports two calcium ions per h

108 Two of the P-type ATPases (flippases) in yeast, Dnf1 and Dnf2, tran

109 The class 4 P-type ATPases ("flippases") maintain membrane asymmetry

110 maintained by the action of inward-directed P-type ATPases ("flippases").

111 tion by one of the most popular reagents for P-type ATPases (fluorescein 5'-isothiocyanate) has been

112 sion of cnb1Delta salt sensitivity was ENA1 (P-type ATPase gene)-dependent, due in part to transcript

113 A novel P-type ATPase gene, Saccharomyces cerevisiae PMR1 homolo

114 Forty-six P-type ATPase genes were identified in Arabidopsis, the

115 A model for the active site of P type ATPases has been tested by site-directed mutagene

116 The first Zn(II)-translocating P-type ATPase has been identified as the product of o732

117 t been positively identified, a subfamily of P-type ATPases has been proposed to function as transpor

118 The alpha subunit of eukaryotic P-type ATPases has ten experimentally defined transmembr

119 ene product, a putative copper-translocating P-type ATPase, has been shown to be involved in copper r

120 ive members in all five major subfamilies of P-type ATPases: heavy-metal ATPases (P1B), Ca2+-ATPases

121 Heavy-metal P-type ATPases (HMAs) are a subgroup of the P-type ATPas

122 hrough mutations in PMR1, encoding a calcium P-type ATPase homologue that also functions in manganese

123 s to the large family of cation-transporting P-type ATPases, however, the detailed characterization o

124 rst biochemical characterization of a type V P-type ATPase, implicates Cod1p in ER function and ion h

125 ent of the pre-mRNA encoding the chloroplast P-type ATPase in Arabidopsis 1 (PAA1).

126 ese observations indicate a novel role for a P-type ATPase in late Golgi function and suggest a possi

127 they do express ATP7A, a copper transporting P-type ATPase in the trans-Golgi network that is require

128 and ATP synthesis, which the plasma membrane P-type ATPase in turn uses to create more pmf for phloem

129 ATP7A is a P-type ATPase in which diverse mutations lead to X-linke

130 732 amino acids, similar to cation transport P-type ATPases in the Cpx-type family.

131 cting the E1 and E2 conformations adopted by P-type ATPases in their catalytic cycle.

132 opper-transporting ATPases differ from other P-type ATPases in their topology and the sequence of the

133 However, RFBP differs from all other Type IV P-type ATPases in three ways.

134 ows for comparison of the full complement of P-type ATPases in two different plant species.

135 otein with similarity to copper-transporting P-type ATPases, including the human Menkes/Wilson protei

136 In contrast to findings for other P-type ATPases, inhibition of the plasma membrane H(+)-A

137 ATP7B is a P-type ATPase involved in copper transport and homeostas

138 ch are integral membrane cation-transporting P-type ATPases involved in copper trafficking.

139 (1B)-type ATPases are a ubiquitous family of P-type ATPases involved in the transport of transition m

140 Members of the P-type ATPase ion pump superfamily are found in all thre

141 t the substrate of this copper-translocating P-type ATPase is Cu(I) and not Cu(II).

142 The occurrence of a Hr-like domain in a P-type ATPase is unprecedented and suggests new regulato

143 The common core structure of P-type ATPases is retained in the 3D fold of the N-domai

144 A conserved feature of all P-type ATPases is the formation of an acyl-phosphate int

145 The Na,K-ATPase, a member of the P-type ATPases, is composed of two subunits, alpha and b

146 Pmr1, a novel member of the family of P-type ATPases, localizes to the Golgi compartment in ye

147 revisiae Atx1 is Ccc2, a cation transporting P-type ATPase located in secretory vesicles.

148 PIO1 is SPF1, encoding a P-type ATPase located in the endoplasmic reticulum (ER)

149 son proteins, which are copper-translocating P-type ATPases located in the trans-Golgi apparatus and

150 Cu(+)-specific P-type ATPase membrane protein transporters regulate cel

151 nd characterization of the role of ATP11B, a P-type ATPase membrane protein, in cisplatin resistance.

152 six metal-binding domains (MBDs) of the two P-type ATPases (Menkes and Wilson disease proteins), the

153 As in other P-type ATPases, metal binding to transmembrane metal-bin

154 unds had any effect on transport by the MgtB P-type ATPase Mg(2+) transporter or the PhoQ Mg(2+) rece

155 ecular mass of 22.5 kDa, and MgtB, a 102-kDa P-type ATPase Mg2+ transport protein.

156 three transporters mediate Mg2+ uptake: the P-type ATPases MgtA and MgtB, whose expression is transc

157 isease (ATP7A) encodes a copper transporting P-type ATPase (MNK or ATP7A) with six copper-binding dom

158 used by mutations in the copper transporting P-type ATPase, MNK.

159 The kinetics of conformational changes of P-type ATPases necessary for the occlusion or deocclusio

160 a previously uncharacterized gene, PAA2 (for P-type ATPase of Arabidopsis), which is required for eff

161 PAA2/HMA8 (P-type ATPase of Arabidopsis/Heavy-metal-associated 8) i

162 stem of Enterococcus hirae are homologous to P-type ATPases of animals and plants.

163 otosynthetic eukaryotes, Zn(2+)-transporting P-type ATPases of class IB (ZntA) are crucial for cellul

164 ve mutations in the RAN1 copper-transporting P-type ATPase, once again linking copper ions to the eth

165 ent an ancestral link between the F- and the P-type ATPases or perhaps a new class of ATPases.

166 The mechanism for how a P-type ATPase, or any other transporter, can recognize a

167 not affected by inhibitors of the F-, V- or P-type ATPases, or inhibitors of the Type I or Type II b

168 Type 4 P-type ATPases (P(4)-ATPases) catalyze phospholipid tran

169 Drs2p is a resident type 4 P-type ATPase (P4-ATPase) and potential phospholipid tra

170 Drs2p, a yeast type IV P-type ATPase (P4-ATPase), or flippase, couples ATP hydr

171 Phospholipid flippases in the type IV P-type ATPase (P4-ATPases) family establish membrane asy

172 Type-IV P-type ATPases (P4-ATPases) are putative phospholipid tr

173 Drs2p family P-type ATPases (P4-ATPases) are required in multiple ves

174 Type IV P-type ATPases (P4-ATPases) catalyze translocation of ph

175 Type IV P-type ATPases (P4-ATPases) use the energy from ATP to "

176 organisms typically express multiple type IV P-type ATPases (P4-ATPases), which establish plasma memb

177 translocases in the Drs2/Dnf family (type IV P-type ATPases [P4-ATPases]) are downstream targets of K

178 Type II P-type ATPases (PAIIs) constitute a family of conserved

179 dered less active by mutations in a parasite P-type ATPase, PfATP4.

180 ATPase activity, the activity of a different P-type ATPase, plasma membrane Ca-ATPase (PMCA), was not

181 The 'P'-type ATPases play a key role in metal ion transport i

182 In Saccharomyces cerevisiae, the P-type ATPase Pmr1p transports Ca(2+) and Mn(2+) ions in

183 t from that of the well-characterized Ca(2+) P-type ATPase Pmr1p which is neither required for Hmg2p

184 asing attention, not least because PfATP4, a P-type ATPase postulated to be involved in Na(+) regulat

185 2+ sensitivity of pmc1 mutants, which lack a P-type ATPase presumed to transport Ca2+ into the vacuol

186 P-type ATPases pump ions across membranes, generating st

187 Most P-type ATPases pump specific cations or heavy metals acr

188 As in other P-type ATPases, pump function is more effective when the

189 P-type ATPase pumps generate concentration gradients of

190 a conformational study to describe the PMCA P-type ATPase reaction cycle, adding important features

191 We examined the roles of yeast Ccc2, a P-type ATPase related to human ATP7A (Menkes disease pro

192 ATP7B is a P-type ATPase required for copper homeostasis and relate

193 ed to be partially dependent on ENA1/PMR2, a P-type ATPase required for Li+ and Na+ efflux in yeast,

194 encoding a copper chaperone and a Cu efflux P-type ATPase, respectively.

195 The plasma membrane H(+)-ATPase is a P-type ATPase responsible for establishing electrochemic

196 ma membrane H(+)-ATPases form a subfamily of P-type ATPases responsible for pumping protons out of ce

197 Mutations in ATP8B1, a broadly expressed P-type ATPase, result, through unknown mechanisms, in di

198 also acquires mutations in a gene encoding a P-type ATPase (ScPMA1) after exposure to spiroindolones

199 cofilin-1 (CFL-1) is required for actin and P-type ATPase secretory pathway calcium ATPase (SPCA)-de

200 We have obtained a full-length P type ATPase sequence (PfATP4) encoded by Plasmodium fa

201 In striated muscle, the archetype P-type ATPase, SERCA (sarco(endo)plasmic reticulum Ca(2+

202 at the conserved aspartate (Asp(416)) in the P-type ATPase signature sequence and exists in E(1)P and

203 apparently two parallel efflux pumps: one, a P-type ATPase (SilP); the other, a membrane potential-de

204 tically and mechanistically similar to other P-type ATPases, suggesting its use as a model system for

205 binding sequence and is modified relative to P-type ATPases, suggesting that the F. odoratum Ca2+-ATP

206 lcium activation and the structures of other P-type ATPases suggests the presence of conformational h

207 of E. coli catalyzed by either of these two P-type ATPase superfamily members is inhibited by Pb(II)

208 P-type ATPases (HMAs) are a subgroup of the P-type ATPase superfamily that may contribute to metal h

209 ough the action of H+ pumps belonging to the P-type ATPase superfamily.

210 It is a member of the P-type ATPase superfamily.

211 metals are ATP-driven pumps belonging to the P-type ATPase superfamily.

212 ulum (ER) Ca(2+) ATPase 2 (SERCA2) pump is a P-type ATPase tasked with the maintenance of ER Ca(2+) s

213 ATPase of Escherichia coli is a four-subunit P-type ATPase that accumulates K(+) with high affinity a

214 The Na+/K+ pump is a ubiquitous P-type ATPase that binds three cytoplasmic Na+ ions deep

215 chia coli CopA is a copper ion-translocating P-type ATPase that confers copper resistance.

216 ZntA from Escherichia coli is a P-type ATPase that confers resistance to Pb(II), Zn(II),

217 The Na/K pump is a P-type ATPase that exchanges three intracellular Na(+) i

218 from the metallothionein gene family, and a P-type ATPase that is a member of the P1B subfamily of p

219 rotein (MNK; ATP7A) is a copper-transporting P-type ATPase that is defective in the copper deficiency

220 odes the protein ATP13A2, a lysosomal type 5 P-type ATPase that is linked to autosomal recessive fami

221 ATP7B is a P-type ATPase that mediates the efflux of copper.

222 studies indicate that FIC1 is a canalicular P-type ATPase that participates in maintaining the distr

223 ATP7A is a P-type ATPase that regulates cellular copper homeostasis

224 PMR1 codes for a P-type ATPase that regulates intracellular calcium and m

225 H(+)-ATPase is a P-type ATPase that transports protons across membranes u

226 Menkes syndrome and Wilson's disease, encode P-type ATPases that are more similar to bacterial CadA t

227 Menkes syndrome and Wilson's disease, encode P-type ATPases that are more similar to the bacterial Ca

228 revisiae genome contains five genes encoding P-type ATPases that are potential aminophospholipid tran

229 Ca(2+)-(SERCA-) ATPase belong to a family of P-type ATPases that undergo a cycle of conformational ch

230 um Ca2+-ATPase, a structurally characterized P-type ATPase, the residue corresponding to Asp714 is a

231 ssociated gene encodes a copper-transporting P-type ATPase, the WND protein, the subcellular location

232 Similar to other P-type ATPases, the ATPBD includes nucleotide binding (N

233 ECA3 is the first P-type ATPase to be identified in plants that is require

234 l an interdependent relationship between two P-type ATPases to maintain homeostasis of the organelles

235 A domain movements similar to those of other P-type ATPases to place the conserved TGES motif in the

236 The P-type ATPases translocate cations across membranes usin

237 ity of a unique cardiolipin transporter, the P-type ATPase transmembrane lipid pump Atp8b1, a mutant

238 lved in substrate selection suggests a novel P-type ATPase transport pathway at the protein/lipid int

239 P-type ATPases transport a wide array of ions, regulate

240 lude members of the ATP-binding cassette and P-type ATPase transporter families.

241 ction radically different from that of other P-type ATPase transporters.

242 tif, which signals for endocytosis, a Type 4 P-Type ATPase was identified and named DnfA.

243 Mutant strains in which each of the three P-type ATPases was deleted singly were constructed.

244 at a rabbit gene in the type IV subfamily of P-type ATPases was missing a transmembrane helix (transm

245 o distantly related members of the family of P-type ATPases, which are thought to use similar mechani

246 the 3' UTR of ATP11C, a novel member of the P-type ATPases, which consists of 31 exons with alternat

247 Cod1p is a putative ER P-type ATPase whose expression is regulated by the unfol

248 (H(+)-ATPase) found in plants and fungi is a P-type ATPase with a polypeptide sequence, structure, an

249 Thus, the WND protein is a P-type ATPase with an unusual subcellular localization.

250 PARK9 belongs to type 5 P-type ATPase with its putative function as a cation tra

251 PAA2 encodes a copper-transporting P-type ATPase with sequence similarity to PAA1, which fu