ライフサイエンスコーパス: P. multocida

1 P. multocida and A. actinomycetemcomitans are among the

2 The ompH gene was distributed among 15 P. multocida serotypes and strain CU.

3 A P. multocida strain that lacked a functional pnhA gene,

4 Although P. multocida lacks the genes for the two earliest steps

5 porin of strain X-73 and is conserved among P. multocida somatic serotypes.

6 90 was similar to that for H. influenzae and P. multocida as well as for other known homologues.

7 ida, i.e., P. multocida subsp. multocida and P. multocida subsp. septica.

8 us 17%, respectively) (P < 0.05, Z test) and P. multocida subsp. multocida more often associated with

9 All strains categorized as P. multocida subsp. multocida displayed either the group

10 All strains identified as P. multocida subsp. septica were positive for alpha-Glu

11 to identify putative OMPs from two available P. multocida genomes: those of avian strain Pm70 and por

12 isons of 1,197 orthologous sequences between P. multocida, Haemophilus influenzae, and Escherichia co

13 the severity of turbinate atrophy induced by P. multocida compared with that occurring in pigs kept i

14 Neuraminidase produced by P. multocida A:3 was purified by a combination of salt f

15 The 965-residue enzyme, called P. multocida chondroitin synthase (pmCS), is 87% identic

16 -weight neuraminidases produced by different P. multocida serotypes are quite similar.

17 y provide reliable means for differentiating P. multocida subsp. multocida from P. multocida subsp. s

18 viously shown to be a major immunogen during P. multocida infection in rabbits.

19 l-negative subspecies of P. multocida, i.e., P. multocida subsp. multocida and P. multocida subsp. se

20 10 ppm or greater, in the absence of either P. multocida or Bordetella bronchiseptica, induced a mil

21 A majority of these genes encoded P. multocida proteins that were involved in either trans

22 g that, upon exposure to a rich environment, P. multocida immediately begins to turn on many energy-i

23 phates, may also play a role in facilitating P. multocida pathogenicity in the host.

24 ubsp. septica; the 16S rDNA is identical for P. multocida subsp. multocida and Pasteurella multocida

25 entiating P. multocida subsp. multocida from P. multocida subsp. septica, particularly in strains tha

26 evel to the hyaluronan synthase, pmHAS, from P. multocida Type A.

27 In summary, the HA synthase from P. multocida, a Gram-negative bacterium, has kinetic opt

28 ces an effective response against homologous P. multocida challenge.

29 ponse to low iron conditions was analyzed in P. multocida using whole-genome microarrays.

30 primary sialic acid cytidylyltransferase in P. multocida.

31 and transport increased 2.1- to 7.7-fold in P. multocida during the first 2 h of growth under iron-l

32 ed the number of putative OMPs identified in P. multocida and allowed these OMPs to be identified wit

33 d to inorganic or organic sources of iron in P. multocida.

34 anisms of iron acquisition and metabolism in P. multocida and other gram-negative bacteria.

35 ified, undergo transcriptional regulation in P. multocida in response to growth in minimal medium and

36 fied by photoaffinity labeling of the native P. multocida HA synthase with azido-UDP sugar analogs.

37 We studied 35 dulcitol-negative P. multocida isolates from infected dog and cat bite wou

38 hat a HA synthase, PmHAS, from Gram-negative P. multocida bacteria polymerizes the HA chain by the ad

39 Toxigenic and nontoxigenic P. multocida isolates cannot be differentiated by morpho

40 On average, 12% of P. multocida genes were differentially expressed under a

41 (REP-PCR) to characterize 20 strains (14 of P. multocida subsp. multocida and 6 of P. multocida subs

42 was also found in a high proportion (36%) of P. multocida strains isolated from non-PDNS cases.

43 14 of P. multocida subsp. multocida and 6 of P. multocida subsp. septica; the 16S rDNA is identical f

44 unction and may contribute to the ability of P. multocida to colonize and persist on vertebrate mucos

45 hesins that are important in the adhesion of P. multocida to fibronectin.

46 etate (PMA) further enhanced the adhesion of P. multocida to TPBM.

47 Cryopreserved aliquots of P. multocida were administered via an endotracheal tube.

48 n is on the cell surface and that binding of P. multocida to fibronectin is almost completely inhibit

49 ace proteoglycan (CD44) decreased binding of P. multocida.

50 on, each group received an i.n. challenge of P. multocida.

51 The exacerbation of P. multocida colonization by ammonia was restricted to t

52 (PMT) and a potassium thiocyanate extract of P. multocida (CN) in combination and (ii) to evaluate th

53 h either exotoxin or thiocyanate extracts of P. multocida induces partial protection in rabbits.

54 LP techniques enable rapid fingerprinting of P. multocida isolates from multiple avian species and en

55 h sera from 62 rabbits from colonies free of P. multocida, was 92%.

56 e gene, nanH, from a fowl cholera isolate of P. multocida.

57 Most isolates of P. multocida produce sialidase activity, which may contr

58 tor of genetic relatedness among isolates of P. multocida.

59 The kinetics of P. multocida colonization were established by testing sa

60 ted by studying the colonization kinetics of P. multocida enhanced by ammonia and comparing them with

61 otype was observed for the limited number of P. multocida isolates.

62 eriod of ammonia exposure, and the number of P. multocida organisms colonizing the upper respiratory

63 of turbinate degeneration and the number of P. multocida organisms isolated from the nasal epitheliu

64 correlation was found between the numbers of P. multocida organisms isolated from the nasal cavity an

65 was used to capture a 37-kDa polypeptide of P. multocida serotype A:12 in an EIA to detect antibodie

66 ined from cell-free membrane preparations of P. multocida.

67 embrane proteins of the membrane proteome of P. multocida were identified.

68 data provide evidence of host specificity of P. multocida clones.

69 ques, we cloned from a toxinogenic strain of P. multocida the entire toxA gene, encoding the 1,285-am

70 mucopolysaccharide of serogroup A strains of P. multocida recognizes an isoform of CD44 expressed on

71 r results demonstrate that unique subsets of P. multocida genes are expressed in response to differen

72 distinction between different subspecies of P. multocida can be made more easily and accurately.

73 ween the two dulcitol-negative subspecies of P. multocida, i.e., P. multocida subsp. multocida and P.

74 ia facilitates the growth and/or survival of P. multocida within the upper respiratory tract of the p

75 da subsp. gallicida but differs from that of P. multocida subsp. septica) isolated from various anato

76 Isolation of a single variant of P. multocida from tissues of pigs with PDNS warrants fur

77 ntrast, ammonia had only a limited effect on P. multocida colonization at the tonsil.

78 Purified P. multocida A:3 neuraminidase was employed to immunize

79 e effectiveness of vaccination with purified P. multocida toxin (PMT) and a potassium thiocyanate ext

80 Exposure to recombinant P. multocida toxin (rPMT) causes phospholipase C-mediate

81 Collectively, these findings indicate that P. multocida adhesion to TPBM is mediated by capsular HA

82 nfluenzae, and Escherichia coli suggest that P. multocida and H. influenzae diverged approximately 27

83 from the B. bronchiseptica alcA gene and the P. multocida toxA gene.

84 oson insertional mutagenesis to identify the P. multocida HA synthase, the enzyme that polymerizes HA

85 ulting antiserum reduced the activity of the P. multocida A:3 enzyme by 40.3%.

86 e apparent Michaelis constants, K(M), of the P. multocida HA synthase for UDP-N-acetylglucosamine and

87 Overall, the P. multocida sequence is not very similar to the other k

88 e it had a low G + C content relative to the P. multocida genome.

89 and acyl-CoA binding affinities, whereas the P. multocida and H. influenzae proteins showed only weak

90 rt 3 patients who developed life-threatening P. multocida respiratory tract infections after providin

91 otype A:12 in an EIA to detect antibodies to P. multocida.

92 s in inducing protective mucosal immunity to P. multocida in rabbits.

93 D were inoculated with 1.4 x 10(8) toxigenic P. multocida organisms given by the intranasal route.

94 detection of B. bronchiseptica and toxigenic P. multocida that can be performed with a single colony

95 for a rapid direct specimen assay, toxigenic P. multocida was recovered efficiently from inoculated s

96 acteriophages from three different toxigenic P. multocida strains had similar but not identical restr

97 ification protocol is specific for toxigenic P. multocida and can detect fewer than 100 bacteria.

98 demonstrated in spent medium from toxigenic P. multocida isolates.

99 results show that PCR detection of toxigenic P. multocida directly from clinical swab specimens shoul

100 R for accurate, rapid detection of toxigenic P. multocida from swabs was investigated.

101 rked effect on the colonization of toxigenic P. multocida in the nasal cavities of pigs, which result

102 found to be 60% less than that of wild-type P. multocida, but the growth rate of ACP13 and its sensi

103 l presentation and the taxonomic group, with P. multocida subsp. septica more often associated with w

104 n curves of sera from rabbits immunized with P. multocida serotype A:3 or A:12 coincided, indicating

105 ined with sera from 56 rabbits infected with P. multocida, was 98%.

106 capability to identify rabbits infected with P. multocida.