ライフサイエンスコーパス: P2X receptor

1 ion by activating ligand-gated ion channels (P2X receptors).

2 expression and/or subunit composition of the P2X receptor.

3 portant role in the agonist operation of the P2X receptor.

4 for how ATP binding triggers activation of a P2X receptor.

5 stimulation enhances MAPK activation through P2X receptors.

6 s were attenuated by PPADS, an antagonist to P2X receptors.

7 sed to contribute to the ATP binding site of P2X receptors.

8 rlying inflammation-induced sensitization of P2X receptors.

9 tic agents, there are no structures of human P2X receptors.

10 s308) have been implicated in ATP binding to P2X receptors.

11 nown that sympathetic nerves have purinergic P2X receptors.

12 transients that represent Ca2+ entry through P2X receptors.

13 contribute to the properties of heteromeric P2X receptors.

14 rminal varicosities acting at postjunctional P2X receptors.

15 ng sites for transition metals that modulate P2X receptors.

16 he concurrent activation of both GABA(A) and P2X receptors.

17 nal vanilloid receptor-1 (VR1) receptors and P2X receptors.

18 abilities of extracellular agonists to gate P2X receptors.

19 e cross-desensitization with the heteromeric P2X receptors.

20 methyleneATP, suggesting a specific role for P2X receptors.

21 c mediator by binding to membrane nucleotide P2X receptors.

22 forms the intrinsic transmembrane channel of P2X receptors.

23 on is thought to be a hallmark of purinergic P2X receptors.

24 lso trimers but are unrelated in sequence to P2X receptors.

25 ed functional redundancy among Dictyostelium P2X receptors.

26 (2-) and ATP(4-) differs between subtypes of P2X receptors.

27 nteric neurons, which involves nicotinic and P2X receptors.

28 are weak sequence similarity with vertebrate P2X receptors.

29 nt Ca2+ entering smooth muscle cells through P2X receptors activated by ATP released from sympathetic

30 Ts to influx of Ca2+ through post-junctional P2X receptors activated by ATP.

31 P2X receptors, activated by extracellular ATP, may be im

32 armacological studies show that both P2Y and P2X receptor activation by exogenous and endogenous ATP

33 P2X receptor activation causes excitation of visceral af

34 This work demonstrates that P2X receptor activation enhances inhibitory neurotransmi

35 P2X receptor activation protects in heart failure models

36 +)/calmodulin protein kinase II (CaMKII) and P2X receptor activation, we studied the effects of elect

37 rred a beneficial effect, likely via cardiac P2X receptor activation.

38 Inhibition of P2X receptor activity suppresses HIV-1 fusion and replic

39 We found that purinergic P2X receptor activity was significantly enhanced in ente

40 of cardiac contractility in response to the P2X receptor agonist 2-methylthioATP, consistent with ov

41 The P2X receptor agonist alpha,beta-methylene ATP (alpha,bet

42 However, the desensitizing P2X receptor agonist alpha,beta-methylene ATP, and the p

43 Furthermore, microinjections in NTS of the P2X receptor agonist alpha,beta-methyleneadenosine 5'-tr

44 nspiratory neurones were also excited by the P2X receptor agonist alphabeta-methyleneATP, suggesting

45 A P2X receptor agonist had no effect on PDGFRalpha(+) cell

46 data show that alpha, beta-methylene ATP (a P2X receptor agonist), in the concentration of 50 microM

47 Application of the selective P2X receptor agonist, alpha, beta-methylene ATP (100 mic

48 th A-fibres and C-fibres, are insensitive to P2X receptors agonist and mostly express substance P.

49 bres are exclusively C-fibres sensitive to a P2X receptors agonist and rarely express the neuropeptid

50 eurons however, application of the selective P2X; receptor agonist, alpha, beta-methylene ATP (100 mi

51 ion is reduced by up to 60% and responses to P2X receptor agonists are abolished.

52 The activity to evoke cationic currents by P2X receptor agonists in non-neuronal cells showed a ran

53 Intradermal administration of different P2X receptor agonists induced similar levels of nocifens

54 es of Ca2+ transients induced by P2Y but not P2X receptor agonists were larger in WT than in Cx43-nul

55 the intradermal injection of three different P2X receptor agonists, ATP, BzATP or alpha,beta-meATP, i

56 ed under voltage clamp during application of P2X receptor agonists.

57 and ADP) that are not normally effective as P2X receptor agonists.

58 We suggest that ATP4- activates a P2X receptor and becomes trapped on a site, on or near t

59 vements of the transmembrane helices in both P2X receptors and ASICs, and the method will allow preci

60 e a possible regulatory relationship between P2X receptors and ENaC, coexpression studies were perfor

61 ide new insight into the gating mechanism of P2X receptors and establish a versatile strategy applica

62 We investigated this mechanism in P2X receptors and found that the hallmark shift in equil

63 of ATP are mediated through both ionotropic P2X receptors and metabotropic P2Y receptors.

64 P2X receptors and nicotinic acetylcholine receptors (nAC

65 ubunit interfaces in the gating mechanism of P2X receptors and points to a role of the internal pore

66 ve approach to track activation of ATP-gated P2X receptors and potentially other transmitter-gated ca

67 sults support a common site of ATP action at P2X receptors and suggest that non-conserved residues al

68 hen sequester the Ca(2+) that enters through P2X receptors and there is no amplification by local vol

69 currents, altered the voltage dependence of P2X receptors, and enhanced the expression of P2X2 and P

70 min has been widely used as an antagonist at P2X receptors, and its analog 4,4',4'',4'''-[carbonylbis

71 or other Cys-loop receptors interacting with P2X receptors, and this crosstalk is dependent on the pr

72 methylene ATP was abolished by the selective P2X receptor antagonist 2',3'-O-(2,4,6-Trinitrophenyl) a

73 cadmium, and was abolished by the selective P2X receptor antagonist 2',3'-O-(2,4,6-Trinitrophenyl) a

74 onse to muscle stretch was blunted after the P2X receptor antagonist pyridoxal phosphate-6-azophenyl-

75 cholinergic receptor antagonist) and PPADS (P2X receptor antagonist).

76 widely recognized as a potent and selective P2X receptor antagonist, and is currently being used to

77 were left-shifted compared to MA; (iii) the P2X receptor antagonist, pyridoxal-phosphate-6-azophenyl

78 his increased excitability is inhibited by a P2X receptor antagonist.

79 topic discharges was blocked by non-specific P2X receptor antagonists, PPADS or suramin.

80 Purinergic P2X receptors are a family of ligand-gated ion channels

81 Human P2X receptors are a family of seven ATP-gated ion channe

82 P2X receptors are a family of seven ligand-gated ion cha

83 Hence, P2X receptors are a natural conduit allowing cell-type-s

84 However, studies in amoeba suggest that P2X receptors are also present intracellularly and invol

85 P2X receptors are ATP-gated cation channels composed of

86 P2X receptors are ATP-gated cation channels that are wid

87 P2X receptors are ATP-gated ion channels in the plasma m

88 P2X receptors are ATP-gated ion channels made up of thre

89 rs are G-protein-coupled, whereas ionotropic P2X receptors are ATP-gated ion channels.

90 P2X receptors are cation-selective channels activated by

91 P2X receptors are cation-selective ion channels gated by

92 P2X receptors are commonly known as plasma membrane cati

93 e from liver, these studies evaluate whether P2X receptors are expressed by hepatocytes and contribut

94 These results suggest that GABAA and P2X receptors are expressed on DRG cell bodies and slow

95 We propose that, while P2X receptors are fast ligand-gated cation channels, the

96 ATP-gated P2X receptors are formed by the association of three sub

97 P2X receptors are highly expressed throughout the nervou

98 P2X receptors are ligand gated ion channels activated by

99 P2X receptors are ligand-gated cation channels that tran

100 ng I(ATPCl), suggesting that neither P2Y nor P2X receptors are likely to be involved in I(ATPCl) acti

101 P2X receptors are membrane cation channels gated by extr

102 P2X receptors are membrane ion channels activated by the

103 P2X receptors are membrane ion channels gated by extrace

104 Because P2X receptors are not related to other ion channel prote

105 The P2X receptors are oligomeric ligand-gated ion channels o

106 P2X receptors are simple polypeptide channels that media

107 Although P2X receptors are suggested to play a role in synaptic n

108 Together, these results suggested that P2X receptors are the major purinergic receptor subfamil

109 P2X receptors are trimeric adenosine-5'-triphosphate (AT

110 P2X receptors are trimeric ATP-activated ion channels pe

111 P2X receptors are trimeric ATP-gated cation channels par

112 P2X receptors are trimeric cation channels that open in

113 P2X receptors are trimeric cation channels with widespre

114 P2X receptors are trimeric membrane proteins that functi

115 P2X receptors are trimeric membrane proteins.

116 P2X receptors are trimeric, non-selective cation channel

117 These results suggest that P2X receptors are useful targets for inflammatory pain t

118 P2X receptors are widely distributed in the nervous syst

119 Purinergic P2X receptors are widely distributed in the nervous syst

120 ATP-gated P2X receptors are widely expressed in the nervous system

121 Vanilloid (VR1) and purinergic (P2X) receptors are found in cranial afferent neurons in

122 ion channels activated by extracellular ATP (P2X receptors) are widely distributed in the nervous sys

123 the Entpd2-knockout animals desensitize the P2X receptors associated with nerve fibers, thereby depr

124 in diameter were measured before and during P2X receptor blockade with NF279 or A1 receptor blockade

125 channel (VDCC) inhibitor, diltiazem and with P2X receptor blockade.

126 at P2XA receptors and decreased currents at P2XD receptors, but increased the currents at P2XB and P

127 pinal cord, we showed that the activation of P2X receptors by alpha,beta-methylene-ATP (alphabetam-AT

128 ucture of the pore changes during opening in P2X receptors by measuring the modification of introduce

129 We previously reported the modulation of P2X receptors by phospholipids in DRG neurons and inject

130 likely that regulation of the properties of P2X receptors by this subunit is more widespread.

131 s responsible for the differential gating of P2X receptors by various agonists.

132 both the gating and permeation properties of P2X receptors can be tuned.

133 Here we show that purinergic P2X receptors can bring significant contribution to the

134 A flickery P2X receptor channel was observed in three patches with

135 P2X receptor channels are ATP-activated cation channels

136 P2X receptor channels open in response to the binding of

137 tle is known about the structure of trimeric P2X receptor channels, a family of channels that are act

138 r understanding ion permeation and gating in P2X receptor channels, as well as more broadly for using

139 lectivity, the prevailing view of purinergic P2X receptor channels, transient receptor potential V1 (

140 dentify the pore-forming and gate regions in P2X receptor channels, we introduced cysteine residues t

141 ngements of the TM helices during opening of P2X receptor channels.

142 P2X receptors, co-localized with NMDA receptors in the e

143 ude that varying proportions of two distinct P2X receptors coexist on the cell bodies of individual g

144 Inhibition of P2X receptors completely blocks the RTX toxin-induced he

145 The extracellular domains of all seven P2X receptors contain 10 conserved cysteines, which coul

146 The results indicate that trimeric P2X receptors containing only two intact binding sites c

147 Ca(2+) homeostasis through the activation of P2X receptors could cause the dysfunction and apoptosis

148 tion to their modulatory role, the family of P2X receptors could have a previously undescribed functi

149 P2X receptors define a protein family unlike other neuro

150 ATP-gated P2X receptors display ion permeability increases within

151 ith HIV-1 in the presence of an inhibitor of P2X receptors effectively inhibited HIV-1 infection thro

152 smission to cardiac vagal neurons indicating P2X receptors enhance glutamatergic release to cardiac v

153 sine 5'-triphosphate (100 microM) indicating P2X receptors enhance the release of inhibitory neurotra

154 esponse, and (2) activation of ATP-sensitive P2X receptors enhances the pressor response seen when mu

155 These findings suggest that P2X receptors, especially P2X(7) receptors, contribute t

156 ATP activation of P2X receptors excited presynaptic GABA neurons to increa

157 ception by characterising the profile of the P2X receptors expressed by physiologically identified re

158 from damaged or inflamed tissues can act at P2X receptors expressed on primary afferent neurones.

159 The aim of this study was to characterize P2X receptor expression within sympathetic postganglioni

160 y provide the first evidence indicating that P2X receptors facilitate glutamatergic synaptic transmis

161 Based on pharmacological properties, the P2X receptor family can be subdivided into those homo-ol

162 ghlights the importance of ATP activation of P2X receptors for a normal response to hypo-osmotic shoc

163 P2X receptors for ATP have a wide range of physiological

164 tors for adenosine in addition to ionotropic P2X receptors for ATP.

165 ting this site is fundamentally important to P2X receptor function.

166 P2X receptors function by opening a transmembrane pore i

167 Ionotrophic purinergic (P2X) receptors function as receptor-gated cation channel

168 conformational rearrangements that underlie P2X receptor gating and provide a foundation for the dev

169 receptors of conserved residues in mammalian P2X receptors has established the paradigm that three ly

170 The study of P2X receptors has long been handicapped by a poverty of

171 P2X receptors have a molecular architecture distinct fro

172 Presynaptic ATP P2X receptors have been proposed to play a role in modul

173 Purinergic P2X receptors have been reported to be present in region

174 ing used to discriminate between subtypes of P2X receptors in a variety of tissues.

175 To test further the role of postsynaptic P2X receptors in afferent signalling, we used AF-353, a

176 udies revealed a heterogeneous population of P2X receptors in approximately 70% of neurons.

177 Despite the importance of P2X receptors in cellular physiology, the three-dimensio

178 The determination of the atomic structure of P2X receptors in closed and open (ATP-bound) states by X

179 rasubunit interactions between TM helices of P2X receptors in membranes using both computational and

180 udy was to determine the role of presynaptic P2X receptors in modulating excitatory and inhibitory sy

181 ATP-gated P2X receptors in nociceptive sensory neurons participate

182 d by the identification of distantly related P2X receptors in simple eukaryotes.

183 Thus, we explored roles for P2Y and P2X receptors in stably increasing [Ca(2+)](i) in human

184 receptors are distinct from other ATP-gated P2X receptors in that they are potently inhibited by sub

185 a family of ATP-gated ion channels known as P2X receptors in the renal collecting duct.

186 ls and may influence the phenotype of native P2X receptors in those cells in which it is expressed.

187 An activation of P2X receptors in turn leads to down-regulation of postsy

188 eceptor (P2X7R) differ strikingly from other P2X receptors in two main ways: high concentrations of A

189 r ATP in the initiation of pain by acting on P2X receptors, in particular P2X3, expressed on nocicept

190 cates that the extended family of functional P2X receptors includes six homomeric channels composed o

191 understanding of the molecular properties of P2X receptors, including how this understanding is infor

192 We further uncover that several P2X receptors, including those able to desensitize, are

193 n of pH-sensitive RTN neurons: activation of P2X receptors indirectly inhibited RTN firing by increas

194 from astrocytes facilitates a recruitment of P2X receptors into excitatory synapses by Ca(2+)-depende

195 t preclinical research programs are studying P2X receptor involvement in pain, inflammation, osteopor

196 ate and its derivatives are also ligands for P2X receptor ion channels.

197 Among P2X receptors, ion currents through homomeric P2X4 recep

198 The ectodomain of the P2X receptor is formed mainly from two- or three-strande

199 The agonist binding site of ATP-gated P2X receptors is distinct from other ATP-binding protein

200 Activation of P2X receptors is implicated in dental pain, and receptor

201 Sensitization of purinergic P2X receptors is one of the mechanisms responsible for e

202 Our understanding of the ATP-gated P2X receptors is progressing rapidly, and the pharmacolo

203 ue to the P2X(7) receptor; also unique among P2X receptors is the long intracellular C terminus of th

204 urons but the subunit composition of enteric P2X receptors is unknown.

205 ssion but the subunit composition of enteric P2X receptors is unknown.

206 own but rather reveal that the open pore of P2X receptors is wide enough to allow the permeation of

207 Activation of the P2X receptor leads to the opening of a non-specific cati

208 ossible functional consequences of increased P2X receptor levels, whole-cell patch-clamp recordings w

209 Intralumenal release of the endogenous P2X receptor ligand adenosine triphosphate did not diffe

210 e for the reversal potentials of GABA(A) and P2X receptors, little or no current is observed, consist

211 this issue of Neuron show that postsynaptic P2X receptors may be activated by ATP released from astr

212 Our results suggest that altered function of P2X receptors may be an important contributor to pathoge

213 Our results suggest that P2X receptors may provide a therapeutic target and that

214 X4 receptor and another yet-to-be-identified P2X receptor mediate this current.

215 Here we show that P2X receptors mediate the entry of photoswitches into RG

216 , such as occurs in injurious conditions, on P2X receptor-mediated ATP responses in primary sensory d

217 signaling that sustains Ca(2+) signaling via P2X receptor-mediated Ca(2+) influx and maintains functi

218 Tetrodotoxin-resistant P2X receptor-mediated events are readily observed at LH

219 Fast P2X receptor-mediated excitatory postsynaptic current (E

220 acellular signaling molecule at cell-surface P2X receptors, mediating a variety of important physiolo

221 c neuronal populations suggesting that other P2X receptors might contribute to cellular responses typ

222 ur data provide the first direct measures of P2X receptor mobility and show that P2X2 receptors are m

223 s reversibly inhibited by the antagonists of P2X receptors NF023 (8,8'-[carbonylbis(imino-3,1-phenyle

224 rvation of structure-function relations with P2X receptors of higher organisms.

225 However, recent data show that P2X receptors often underlie neuromodulatory responses o

226 ent not involving the RBC, inhibition of the P2x receptor on the platelets (an ATP receptor) resulted

227 agal neurons is dependent upon activation of P2X receptors on glutamatergic presynaptic terminals.

228 ndings demonstrate a new functional role for P2X receptors on intracellular organelles, in this case

229 Characterization of P2X receptors on neurons of guinea-pig superior cervical

230 tanding of the other physiological roles for P2X receptors on primary afferent neurones.

231 These data indicate that P2X receptors on sensory and sympathetic ganglion neuron

232 by skeletal muscle during stretch stimulates P2X receptors on the sympathetic nerves and increases th

233 method will allow precise optical control of P2X receptors or ASICs in intact tissues.

234 , whereas the rapid desensitization of other P2X receptors (P2X(3)) may mask the detection of competi

235 The lymphocytic ionotropic purinergic P2X receptors (P2X1R-P2X7R, or P2XRs) sense ATP released

236 (2+) channel (L-type) families, ligand-gated P2X receptors (P2X2 and P2X4), tandem P domain K(+) chan

237 Expression of P2X receptor (P2XR) subtypes was assessed by immunoblott

238 P2X receptors (P2XR) function as ATP-gated nonselective

239 The P2X receptors (P2XRs) are a family of ligand-gated chann

240 P2X receptors (P2XRs) are ATP-activated calcium-permeabl

241 P2X receptors (P2XRs) are ligand-gated ion channels acti

242 ned the expression and function of ATP-gated P2X receptors (P2XRs) in the SCN neurons of slices isola

243 We assessed the effects of P2X receptors (P2XRs) on neuronal excitability from preh

244 eadily rescued by overexpression of P2XA and P2XD receptors, partially rescued by P2XB and P2XE recep

245 P2X receptors participate in intestinal neurotransmissio

246 The ionic pore of the P2X receptor passes through the central axis of six tran

247 sults indicate that alphabetam-ATP-sensitive P2X receptors play a significant role in modulating exci

248 to increased levels of plasma membrane-bound P2X receptor protein, suggesting that ENaC modulates pro

249 l activity by a light-gated, ATP-insensitive P2X receptor, providing an original tool devoid of endog

250 ach that allows precise determination of rat P2X receptor quaternary assembly.

251 reaction showed the presence of mRNA for all P2X receptors, raising the possibility of multiple subun

252 in response to distension and its action on P2X receptors resulting in activating both motor and sen

253 The P2X receptor selective agonist, alpha, beta-methylene AT

254 Thus, activation of VR1 and P2X receptors selectively facilitated presynaptic glutam

255 Structural studies of P2X receptors show a novel U shaped ATP orientation foll

256 in real time of photoactivatable GFP-tagged P2X receptors showed that they are highly mobile.

257 gous to previously identified sites in other P2X receptors shown to be important for functional poten

258 effect through the activation of purinergic P2X receptor signaling in breast cancer cells evidenced

259 e investigated whether extracellular ATP and P2X receptors signaling tuned TCR signaling at the alpha

260 These approaches should lead to P2X receptors soon taking their place alongside other io

261 We show that Ca2+ flashes occur through P2X receptor stimulation and ryanodine receptor-mediated

262 P2X receptor stimulation by alpha,beta-methylene ATP enh

263 The degree of inhibition depended on the P2X receptor subtype present.

264 ion, the specific physiological role of each P2X receptor subtype remains largely unknown.

265 P2X receptor subtype-selective antagonists are promising

266 The seven P2X receptor subtypes are implicated in physiological pr

267 P2X receptor subtypes can be distinguished by their sens

268 4) and P2X(7) are the predominant purinergic P2X receptor subtypes expressed on immune and neural cel

269 with the amount of ionic charge conducted by P2X receptor subtypes.

270 be a function of respective selectivity for P2X receptor subtypes.

271 and good selectivity versus the other human P2X receptor subtypes.

272 Seven P2X receptor subunits (P2X(1-7)) are widely distributed

273 Further, P2X receptor subunits are present as multimeric, membran

274 Our data argue that ATP acts by binding to P2X receptors that form a molecular complex with ASICs;

275 functions have not been as widely studied as P2X receptors, the effects that they mediate indicate th

276 Among all P2X receptors, the P2X7 receptor (P2X7R) is a well-defin

277 Unlike vertebrate P2X receptors, these proteins are not expressed on the s

278 We genetically engineered rat P2X receptors to carry calcium sensors near the channel

279 ATP acts at P2X receptors to contribute to fast excitatory postsynap

280 fluorescent dyes likewise penetrate through P2X receptors to label a subset of RGCs in the degenerat

281 es ATP responses by promoting trafficking of P2X receptors to the membrane and may play a key role in

282 To determine the role of P2X receptors under injurious conditions, we examined AT

283 may play a key role in the sensitization of P2X receptors under injurious conditions.

284 Thus, P2X receptor upregulation could account for neuronal hyp

285 A large conductance P2X receptor was observed in 19 out of 98 patches with a

286 Here the gating mechanism of a P2X receptor was studied by normal mode analysis and mol

287 alcium/caesium permeability (P(Ca)/P(Cs)) of P2X receptors was 12.3 as estimated from the reversal po

288 sstalk, whereas the ion channel pores of the P2X receptors were fully functional and unaltered by the

289 /or P2Y4 receptors, whereas P2Y6, P2Y11, and P2X receptors were not involved.

290 c nodose C-fibre neurones express functional P2X receptors, whereas lung specific jugular C-fibres do

291 oxic effect of HlyA is strongly amplified by P2X receptors, which are activated by extracellular ATP

292 transiently activated all cloned isoforms of P2X receptors, which in some cases irreversibly inhibite

293 en implicated in ATP release, and of various P2X receptors, which serve as ATP-gated Ca(2+) channels,

294 P) induces pain via activation of ionotropic P2X receptors while adenosine mediates analgesia via act

295 itors of HIV-1 fusion were those that target P2X receptors, while P2Y-selective receptor antagonists

296 oswitch compounds require permeation through P2X receptors, whose gene expression is upregulated in t

297 rect evidence for the presence of functional P2X receptors with a phenotype resembling the P2X1 recep

298 al the existence of two classes of homomeric P2X receptors with differential sensitivity to MgATP(2-)

299 at NCTs are generated by Ca2+ influx through P2X receptors without a detectable contribution from L-t

300 hibited the Na+ currents (presumably through P2X receptors) without altering I(ATPCl), suggesting tha