ライフサイエンスコーパス: P2X(3) receptor

1 ensory neurons express messenger RNA for the P2X3 receptor.

2 latability of potential analgesics targeting P2X3 receptors.

3 responsible for the potency drop in primate P2X3 receptors.

4 express TRPV1, bradykinin B2, and purinergic P2X3 receptors.

5 phenomena are normalized by the blockade of P2X3 receptors.

6 ors, and enhanced the expression of P2X2 and P2X3 receptors.

7 ochemically stained with an antibody against P2X3 receptors.

8 p, 11, was also very potent at both P2X1 and P2X3 receptors.

9 e, 10, was 28-fold selective for P2X1 versus P2X3 receptors.

10 with activation of the rapidly desensitising P2X3 receptors.

11 tivation of nociceptive fibres which possess P2X3 receptors.

12 .03) but was significantly higher (0.07) for P2X3 receptors.

13 s formed heteromeric channels with the human P2X(3) receptor.

14 ptors and weakly express mRNA for P2X(1) and P2X(3) receptors.

15 In contrast, the expression of the P2X3 receptor, a marker for non-peptidergic nerve fibers

16 ATP in a manner dependent on P2Y1, P2Y2, and P2X3 receptor activation.

17 ndogenously active CaMKII up-regulates basal P2X3 receptor activity in dorsal root ganglion neurons.

18 a(2+)](i) and protein secretion, whereas the P2X(3) receptor agonist alpha,beta methylene ATP signifi

19 Antagonism of P2X3 receptors also reduces arterial pressure and basal

20 s of 5 mM at the P2X2 receptor, 89 mM at the P2X3 receptor and 15 mM at both the P2X2/3 heteromeric r

21 s probably due to co-expression of homomeric P2X3 receptors and heteromeric receptors comprising P2X3

22 ocked by PPADS (30 microm) and the selective P2X(3) receptor antagonist A-317491 (3 microm), suggesti

23 by 1 microM A-317491, a potent and selective P2X3 receptor antagonist.

24 C-fibers), which was inhibited by TRPV4 and P2X3 receptor antagonists.

25 In the trigeminal ganglion, P2X(3) receptors are often co-expressed with the nocicep

26 P2X(3) receptors are selectively expressed on small-diam

27 Preclinical studies suggest that P2X3 receptors are expressed by airway vagal afferent ne

28 agonist, A-317491, all indicate that ATP and P2X3 receptors are more likely to be involved in chronic

29 We conclude that P2X3 receptors are present on both myelinated and unmyel

30 These data support the identification of the P2X3 receptor as a potential new target for the control

31 In contrast, deletion of the P2X3 receptor causes enhanced thermal hyperalgesia in ch

32 m to prevent excessive ATP signaling through P2X3 receptor channels.

33 Pirt and P2X3 receptor co-localize in bladder nerve fibres and he

34 To determine whether ATP and P2X3 receptors contribute to bone-cancer pain in a mouse

35 To examine P2X(3) receptor contributions to colon mechanosensation

36 P2X3 receptors could mediate sensitisation of the cough

37 P2X3 receptors desensitize within 100 ms of channel acti

38 Mice with genetic deletion of P2X2 and P2X3 receptors (double knockout mice) lack responses to

39 al assays at recombinant rat P2X1, P2X2, and P2X3 receptors expressed in Xenopus oocytes (ion flux st

40 We verified P2X3 receptor expression in human carotid bodies and obs

41 d purinergic receptor sensitivity and raised P2X3 receptor expression in the urothelium.

42 ckout mice lacking expression of P2X2 and/or P2X3 receptors failed to show increases in apical surfac

43 o the high affinity (< 1 nM) of desensitized P2X3 receptors for agonist.

44 pha6beta4*) nAChRs and P2X2 receptors and/or P2X3 receptors have not been fully characterized.

45 showed weak antagonistic activity at the rat P2X3 receptor (IC50 58.3 +/- 0.1 microM), while at recom

46 P2X(3) receptor immunostaining was present on subpopulat

47 In mice, we examined the role of P2X(3) receptors in colon mechanosensitivity and intraco

48 ifferential roles for peripheral and central P2X(3) receptors in colon mechanosensory transduction an

49 Released ATP activates P2X(3) receptors in the beta-cell plasma membrane, resul

50 report X-ray crystal structures of the human P2X3 receptor in apo/resting, agonist-bound/open-pore, a

51 ATP currents that are mediated by homomeric P2X3 receptors in dorsal root ganglion (DRG) neurons iso

52 ncy was confirmed by comparing rat and human P2X3 receptors in HEK293 cells.

53 we studied the presence and distribution of P2X3 receptors in human dental pulp, and their co-locali

54 Interestingly, native P2X3 receptors in rat and monkey DRGs show similar agoni

55 rical stimulation enhances the expression of P2X3 receptors in the membrane and that the enhancement

56 P2X(3) receptor inhibitors A-317491 and TNP-ATP signific

57 The interaction with P2X3 receptors is less pronounced for the alpha6beta4bet

58 substitutions at equivalent positions in the P2X3 receptor (Lys63 and Lys299) also prevented channel

59 P2X3 receptors may contribute to detection of distention

60 Our data indicate that ATP and P2X3 receptors may play a role in nociception, rather th

61 These results support the theory that P2X3 receptors mediate a form of nociception, but also s

62 The results support the view that P2X(3) receptor-mediated mechanisms contribute to both n

63 We therefore studied the effects of PGE2 on P2X3 receptor-mediated ATP currents in DRG neurons disso

64 TNFalpha in turn potentiates the P2X3 receptor-mediated responses and increases the excit

65 sis, unbinding of [32P]ATP from desensitized P2X3 receptors mirrored the rate of recovery from desens

66 n the supposed ATP binding site of the human P2X3 receptor on the agonistic effect of nucleotide anal

67 studies demonstrate increased expression of P2X3 receptors on CGRP-ir ENFs during tumor growth and s

68 identify whether changes in the labeling of P2X3 receptors on epidermal nerve fibers (ENFs) occurred

69 a transmitter, ATP, that activates P2X2 and P2X3 receptors on gustatory afferent fibers.

70 These reports indicate that P2X3 receptors on sensory nerves may be tonically activa

71 ssumption has been that eliminating P2X2 and P2X3 receptors only removes postsynaptic targets but tha

72 e largely abolished in mice lacking P2X2 and P2X3 receptors [P2X2 and P2X3 double knock-out (DKO) mic

73 lues of 11 and 25 nM at recombinant P2X1 and P2X3 receptors, respectively.

74 rgic, placodal in origin, expresses P2X2 and P2X3 receptors, responds to alpha,beta-methylene ATP, an

75 P2X3 receptors seem to have a key role in mediation of c

76 Coexpression of alpha6beta4 nAChRs with P2X3 receptors shifts the ATP dose-response relation to

77 sed individually and together with P2X(2) or P2X(3) receptor subunits in HEK 293 cells.

78 uggesting that modulation of sEPSCs involves P2X(3) receptor subunits.

79 Antagonists of P2X3 receptors such as AF-219 are a promising new group

80 nusual subtype of ATP-gated ion channel, the P2X3 receptor, that rapidly desensitizes (<100 msec) and

81 In 1995 the P2X3 receptor was found to be expressed at high levels i

82 l evidence showed that immunostaining of the P2X3 receptors was more intense in both IB4-positive (C-

83 Western blot data showed that P2X3 receptors were significantly upregulated in doral r

84 P2X3 receptors with an equivalent mutation (P320C) were