ライフサイエンスコーパス: P2X(4) receptor

1 lar dynamics study of the closed form of the P2X4 receptor.

2 ding of these antagonists are present in the P2X4 receptor.

3 toma cells stably transfected with the human P2X4 receptor.

4 EK293 cells transfected to express the human P2X4 receptor.

5 g that the 58-kDa protein was a glycosylated P2X(4) receptor.

6 LB fusion with the PM, but not activation of P2X(4) receptors.

7 profile characteristic of the involvement of P2X(4) receptors.

8 revealed a novel physiologic function of the P2X(4) receptor and suggested the importance of N-linked

9 ated current in WT cells, implying that both P2X4 receptor and another yet-to-be-identified P2X recep

10 ion results in the translocation of P2X1 and P2X4 receptors and pannexin-1 hemichannels to the immune

11 P2X4 receptor antagonists have potential as drugs for th

12 aracterizing the biochemical property of the P2X(4) receptor, antibody against cP2X(4)R detected a 44

13 Here, we demonstrate that P2X(4) receptors are expressed in neurons of the spinal

14 P2X4 receptors are ATP-gated cation channels that are wi

15 Thus, our data indicate that P2X4 receptors are dynamically regulated mobile ATP sens

16 These studies provide evidence that P2X4 receptors are functionally important in hepatocyte

17 P2X4 receptors are likely involved because the calcium r

18 However, the nature of how plasma membrane P2X4 receptors are regulated in microglia is not fully u

19 ATP-gated ionotropic P2X4 receptors are up-regulated in activated microglia a

20 r at other sites in the nervous system where P2x4 receptors are widely expressed.

21 This perspective focuses on P2X(4) receptors as a new cardioprotective target in hea

22 cetate (PMA), results in a cation influx via P2X(4) receptors at the site of LB fusion with the plasm

23 mpletely abolished the pH sensitivity of the P2X4 receptor at all agonist concentrations.

24 ic lactone that stabilizes the open state of P2X(4) receptor channels.

25 purification and pulldown assays reveal that P2X4 receptors complex with aminobutyric acid, type A (G

26 The chick P2X4 receptor (cP2X(4)R) mRNA was expressed in the heart

27 2X receptors, ion currents through homomeric P2X4 receptors exhibit intermediate desensitization when

28 To identify P2X4 receptor-expressing cells, we generated BAC transge

29 well-characterized tool with which to study P2X4 receptor-expressing cells.

30 Iba1 protein, a microglial marker, and P2X(4) receptor expression were significantly increased

31 P2X4 receptor expression in the liver, liver histology,

32 Furthermore, increased surface P2X4 receptor expression significantly decreases the fre

33 de that pannexin-1 hemichannels and P2X1 and P2X4 receptors facilitate ATP release and autocrine feed

34 ever, it was not clear whether the lysosomal P2X4 receptors function as channels and how they are act

35 expressing tdTomato under the control of the P2X4 receptor gene (P2rx4).

36 tations of equivalent residues in P2X(2) and P2X(4) receptors have similar effects and if these mutan

37 Cells expressing ATP-gated P2X4 receptors have proven problematic to identify and s

38 313)-Ile(333) ectodomain sequence of the rat P2X(4) receptor in ATP binding and transduction of signa

39 present crystal structures of the zebrafish P2X(4) receptor in its closed, resting state.

40 study a potential physiological role of the P2X(4) receptor in mediating the positive inotropic effe

41 eport the crystal structure of the zebrafish P2X4 receptor in complex with ATP and a new structure of

42 aracterize the electrophysiologic actions of P2X4 receptors in cardiac myocytes and to determine whet

43 cells, consistent with an important role of P2X4 receptors in mediating the ATP current not only in

44 t previously unanticipated roles for ATP and P2X4 receptors in the neural circuitry controlling feedi

45 The crystal structure of a P2X4 receptor, in combination with mutagenesis studies,

46 l and functional data regarding the P2X2 and P2X4 receptors indicate that the central trihelical TM2

47 These results indicate that P2X(4) receptors influence inflammasome signaling involv

48 hibition, mutation, or silencing of P2X1 and P2X4 receptors inhibits Ca(2+) entry, nuclear factors of

49 The data suggest that the native P2X(4) receptor is involved in mediating the P2 agonist-

50 Biochemical evidence showed that the P2X(4) receptor is the major subtype shared by these air

51 ranes and that transfer of the TM regions of P2X(4) receptors is sufficient to convey sensitivity to

52 The P2X4 receptor is a newly identified receptor expressed i

53 e and have shown further that ATP-responsive P2X4 receptor is required for Tbeta4-induced HUVEC migra

54 The P2X4 receptor is unique among family members in its sens

55 Ca(2+) entry through P2X4 receptors is known to trigger downstream signaling

56 We find that plasma membrane P2X4 receptor lateral mobility in resting microglial pro

57 ted morphine-induced migration, suggesting a P2X(4) receptor-mediated effect.

58 in, indicating that these responses were not P2X(4) receptor-mediated.

59 GABA(A) receptors in recombinant system and P2X4 receptor-mediated GABAergic depression in SF-1 GFP-

60 nd clear evidence for functional presynaptic P2X4 receptor-mediated responses in terminals of AgRP-NP

61 ATP decreased cellular glycogen content; and P2X4 receptor messenger RNA increased in glycogen-rich l

62 uantum dot-labeled P2X4 receptors to explore P2X4 receptor mobility in the processes of resting and a

63 1 microM), while at recombinant rat P2X2 and P2X4 receptors no enhancing or antagonistic properties w

64 Genetic deletion of the PSD-95 or P2X4 receptors obliterated ATP-mediated down-regulation

65 ogical evidence for functional expression of P2X4 receptors on AgRP-NPY neuron somata, but instead, w

66 ned in myocytes from both wild-type (WT) and P2X4 receptor-overexpressing transgenic (TG) mice.

67 The P2X4 receptor (P2X4R) is a member of a family of puriner

68 P2X4 receptors (P2X4R) have emerged as potentially impor

69 Of the seven P2X subtypes, P2X4 receptors (P2X4Rs) are richly expressed in the brai

70 Activation of a cardiac myocyte P2X4 receptor protects against heart failure.

71 nd involves increased expression of Iba1 and P2X(4) receptor protein, which imparts a promigratory ph

72 tures of the detergent-solubilized zebrafish P2X4 receptor provide a blueprint for receptor mechanism

73 The recent crystal structure of a P2X4 receptor provides a 3D view of their topology and a

74 es activate NLRP1 inflammasomes, but whether P2X(4) receptors regulate inflammasome signaling is esse

75 tion with zinc, which potentiates P2X(2) and P2X(4) receptor responses, or lowering the pH to 6.8, wh

76 on feeding-related regulation of presynaptic P2X4 receptor responses, and the rationale to explore ex

77 ing ion channel structure with the ATP-gated P2X(4) receptor reveals similarity in pore architecture

78 In the presence of the P2X4 receptor-selective allosteric enhancer ivermectin (

79 conclusion, these data show that epithelial P2X(4) receptors serve as ATP-gated calcium entry channe

80 The P2X(4) receptor subunit (P2X(4)R) is likely to be import

81 In intact heart study, the P2X4 receptor TG mouse exhibited significantly elevated

82 on with no associated heart pathology in the P2X4 receptor TG mouse suggests a novel physiologic role

83 use suggests a novel physiologic role of the P2X4 receptor, that of stimulating the cardiac contracti

84 Furthermore, in P2X4 receptors, this ability to alter ion selectivity ca

85 ncreased responsiveness of the overexpressed P2X4 receptor to endogenous ATP is responsible for the e

86 olecule imaging to track quantum dot-labeled P2X4 receptors to explore P2X4 receptor mobility in the

87 4)R showed that only the glycosylated 58-kDa P2X(4) receptor was expressed on the cell surface, indic

88 The nonglycosylated 44-kDa P2X(4) receptor was resistant to various detergent/aqueo

89 P2X4 receptors were expressed in hepatocytes and Kupffer

90 ia a novel interaction between mu-opioid and P2X(4) receptors, which is dependent upon PI3K/Akt pathw

91 -2,4-disulfonate, with residues from the rat P2X4 receptor, which is insensitive to these antagonists

92 nsistent with overexpression of a functional P2X4 receptor with consequent increase in the receptor-m