ライフサイエンスコーパス: P2X(7) receptor

1 h-promoting agent (acting at P2Y1, P2Y2, and P2X7 receptors).

2 al role in the transcriptional regulation of P2X7 receptor.

3 hought to be characteristic hallmarks of the P2X7 receptor.

4 o cellular responses typically attributed to P2X7 receptor.

5 S) stimulation and ATP signaling through the P2X7 receptor.

6 to be driven by unimpeded activation of the P2X7 receptor.

7 K(+) caused by stimulation of the purinergic P2X7 receptor.

8 a was unimpaired in macrophages deficient in P2X7 receptor.

9 of the extracellular loop of the full-length P2X7 receptor.

10 hly sensitive to that stimulated through the P2X7 receptor.

11 reatment for epilepsy based on targeting the P2X7 receptor.

12 ophages but not from macrophages lacking the P2X7 receptor.

13 esponse to SCI by activation of low-affinity P2X7 receptors.

14 l lines expressing recombinant human and rat P2X7 receptors.

15 ue-G, and KN-62, demonstrating activation of P2X7 receptors.

16 iate between the two widely used agonists at P2X7 receptors.

17 inhibitor Z-VADfmk, and requires functional P2X7 receptors.

18 with DNA fragmentation, and does not require P2X7 receptors.

19 ifferentially regulated by the activation of P2X7 receptors.

20 a(2+) permeability are difficult to apply to P2X7 receptors.

21 asses that selectively target P2X1, P2X3, or P2X7 receptors.

22 human embryonic kidney cells expressing rat P2X7 receptors.

23 hemichannel protein that interacts with the P2X(7) receptor.

24 opper with residues in the ectodomain of the P2X(7) receptor.

25 e discovered to be novel antagonists for the P2X(7) receptor.

26 suramin, consistent with the actions of the P2X(7) receptor.

27 maturation and release of IL-1 beta via the P2X(7) receptor.

28 ATP is responsible for the activation of the P2X(7) receptor.

29 through purinergic receptors, primarily the P2X(7) receptor.

30 ls and that this released ATP autostimulates P2X(7) receptors.

31 ibly bacterial infection through ligation of P2X(7) receptors.

32 ferase-2 (ART2)-mediated ADP ribosylation of P2X(7) receptors.

33 y, we generated a new NOD stock deficient in P2X(7) receptors.

34 ls and human CD4(+) T cells express abundant P2X(7) receptors.

35 BALB/c mice, which express fully functional P2X(7) receptors.

36 ry pain; and the complex actions mediated by P2X(7) receptors.

37 cessing and release via direct activation of P2X(7) receptors.

38 mma disrupts the functionality of purinergic P2X7 receptors, a key step controlling eCB production by

39 Moreover, in vitro blockade of the P2X7 receptor abrogates the levels of these cytokines.

40 Thus, "transient" P2X(7) receptor activation and Ca(2+) overload act as a

41 retinal microvessels to the lethal effect of P2X(7) receptor activation may be a previously unrecogni

42 romotes IL-1 beta maturation and release via P2X(7) receptor activation, millimolar ATP concentration

43 lammasome activation and apoptosis linked to P2X(7) receptor activation.

44 -1 and release of mature IL-1beta induced by P2X(7) receptor activation.

45 e investigated whether LTB4 is produced upon P2X7 receptor activation and examined whether LTB4 modul

46 Evidence also shows that P2X7 receptor activation is linked to elevated expressio

47 These results indicate that P2X7 receptor activation leads to LTB4 formation, which

48 TLR2 agonists required pannexin-1 and P2X7 receptor activation to stimulate IL-1beta release.

49 investigated for dependence upon caspase-1, P2X7 receptor activation, and loss of membrane asymmetry

50 specific TLR agonists and was accelerated by P2X7 receptor activation.

51 reliant on active caspase-1, pannexin-1, and P2X7 receptor activation.

52 response to ATP concentrations that exclude P2X7 receptor activation.

53 astrocytes with properties characteristic of P2X7 receptor activation: the current was amplified in l

54 Likewise, the purinergic P2X7 receptor acts as a direct conduit for Ca(2+)-influx

55 4-benzoyl)benzoyl adenosine 5'-triphosphate (P2X(7) receptor agonist), AG10, AG18, and carbonyl cyani

56 Acini were stimulated with the P2X(7) receptor agonist, (benzoylbenzoyl)adenosine 5' tr

57 usly, the authors demonstrated that BzATP, a P2X(7) receptor agonist, enhanced corneal epithelial mig

58 ll patch clamp studies, exposure to the P2X4/P2X7 receptor agonist 2'3'-O-(4-benzoyl-benzoyl)-adenosi

59 apoptosis in response to treatment with the P2X7 receptor agonist benzoyl-ATP.

60 The P2X7 receptor agonist benzoylbenzoyl-adenosine 5'-tripho

61 receptor agonist ATPgammaS (p<0.001) and the P2X7 receptor agonist BzATP (p<0.001).

62 Acini were stimulated with the P2X7 receptor agonist, (benzoylbenzoyl)adenosine 5' trip

63 ed treatment with lipopolysaccharide and the P2X7 receptor agonist, benzylated ATP, suggesting that n

64 ess functional purinergic receptors and that P2X7 receptor agonists significantly reduce cell numbers

65 P2Y2, P2Y4, P2Y6, and P2Y12, and at P2X4 and P2X7 receptors), an immunosuppressant (acting at P2Y11),

66 ng mechanisms were prevented by knocking out P2X7 receptor and by the use of specific antagonists.

67 iprotein inflammasome complex, including the P2X7 receptor and caspase-1.

68 However, the roles of P2X7 receptor and intracellular K(+) in IL-1beta secreti

69 Furthermore, we demonstrated that P2X7 receptor and NLRP3 transcription were modulated in

70 -induced cell death in oocytes co-expressing P2X7 receptor and pannexin 1.

71 n experiments with HEK cells, which lack the P2X7 receptor and showed strikingly increased response t

72 S. aureus supernatant was independent of the P2X7 receptor and the essential TLR adaptors MyD88 and T

73 ess a low activation threshold allele of the P2X7 receptor and the P2X7 gene maps to a locus associat

74 ry cytokines through mechanisms depending on P2X7 receptors and Px1 HCs.

75 P2X7 receptors and UTP-activated receptors mediated thes

76 g lipin-2 decreases ion currents through the P2X7 receptor, and downstream events that drive IL-1beta

77 ARP cleavage) were blocked by the purinergic P2X(7) receptor antagonist oxidized ATP.

78 he centrally available, potent, and specific P2X7 receptor antagonist JNJ-47965567 (30 mg/kg) signifi

79 The selective P2X7 receptor antagonist JNJ-47965567 partly replicated

80 y 10-100 nM) and selective (> or = 100-fold) P2X(7) receptor antagonists against the other P2 recepto

81 ally restored by coinstillation of P2X(1) or P2X(7) receptor antagonists or of caffeine with LPS.

82 Other P2X7 receptor antagonists, however, had no effect on LT

83 N'-aryl acyl hydrazides were identified as P2X7 receptor antagonists.

84 y revealed positive immunoreactivity of anti-P2X7 receptor antibodies on non-neuronal cells.

85 ular constituent immunoreactive for specific P2X7 receptor antiserum in the kainate-induced seizure a

86 P2X(7) receptors are ATP-gated cation channels; their ac

87 P2X(7) receptors are distinct from other ATP-gated P2X r

88 P2X7 receptors are ATP-gated ion channels that contribut

89 P2X7 receptors are involved not only in physiological fu

90 P2X7 receptors are nonselective cation channels gated by

91 pressing a rat P2X7 receptor indicating that P2X7 receptors are not involved in stimulation of ATP re

92 TP injection or conditioning lesion, whereas P2X7 receptors are not.

93 ATP-gated P2X7 receptors are prominently expressed in inflammatory

94 pore-forming properties of human and rodent P2X7 receptors are sensitive to perturbations of cholest

95 ive stress in ALS microglia and identify the P2X7 receptor as a promising target for the development

96 P2X7 receptors associate with cholesterol-rich lipid raf

97 The function of P2X(7) receptors (ATP-gated ion channels) in innate immu

98 The P2X7 receptor binds extracellular ATP to mediate numerou

99 r gadolinium chloride, or siRNA silencing of P2X(7) receptors blocks calcium entry and inhibits T-cel

100 nistration of an inhibitor of the purinergic P2X7 receptor blocks the anxiety caused by HFD.

101 f pannexin-1-hemichannel (PNX1) coupled with P2X7-receptor blocks the infection-induced eATP release

102 of fluorescent dyes in many cells expressing P2X7 receptors, but controversy persists as to whether s

103 Activation of the P2X(7) receptor by extracellular nucleotides modulates m

104 , in SOD1-G93A microglia, the stimulation of P2X7 receptor by 2'-3'-O-(benzoyl-benzoyl) ATP enhanced

105 Short-term stimulation of the P2X(7) receptor can raise Ca(2+) in rat retinal ganglion

106 lts demonstrate that the open channel of the P2X7 receptor can allow passage of molecules with sizes

107 itionally, it has been demonstrated that the P2X7 receptor can induce PLA2 activation and arachidonic

108 We further show that activation of P2X7 receptors can lead to the release of tumor necrosis

109 Activation of P2X(7) receptors caused large pores to form and apoptosi

110 The ATP-gated P2X7 receptor channel (P2X7R) operates as a cytolytic an

111 de during activation by endogenous ATP-gated P2X7 receptor channels, the exogenous bacterial ionophor

112 cto-ribosylation reactions known to activate P2X(7) receptor/channels in other cell types.

113 her than upregulate the number of functional P2X(7) receptor/channels, diabetes appears to facilitate

114 P2X7 receptors colocalized with anti-caspase-3 antibody

115 C57BL/6 mice that express poorly functional P2X(7) receptors, compared to control BALB/c mice, which

116 we present crystal structures of a mammalian P2X7 receptor complexed with five structurally-unrelated

117 Considering that extracellular ATP through P2X7 receptor constitutes a neuron-to-microglia alarm si

118 dings suggest that P2X receptors, especially P2X(7) receptors, contribute to ATP- and BzATP-induced C

119 rs controlling proliferation, while P2X5 and P2X7 receptors control early differentiation, terminal d

120 cing T-cell activation through the ATP-gated P2x7 receptor controlling Ca2(+) influx.

121 Patch clamp analysis of P2X7 receptor currents carried by Na(+) and N-methyl-D-g

122 eptic mice displayed enhanced agonist-evoked P2X7 receptor currents, and synaptosomes from these anim

123 In P2X7 receptor deficient mice (P2rx7-/-), the social inte

124 fficient to induce motor neuron death by the P2X7 receptor-dependent activation of the Fas pathway.

125 TLR agonists induced P2X7 receptor-dependent IL-1beta release in both monocyt

126 ion by means of its fimbriae in a purinergic P2X7 receptor-dependent manner.

127 The generation of prothrombotic MPs required P2X7 receptor-dependent production of ROS leading to inc

128 e data suggest that PDI regulates a critical P2X7 receptor-dependent signaling pathway that generates

129 tracellular calcium induced by activation of P2X(7) receptors directly increases DG lipase activity w

130 c receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P2rx7) induced activation (dec

131 blocking effect of antagonists to P2X(4) and P2X(7) receptors expressed by microglial cells in neurop

132 These results were relevant in vivo since P2X7 receptor expression was upregulated in a P. gingiva

133 nglion cells are known to express ionotropic P2X(7) receptors for ATP.

134 tative measures of the Ca(2+) current of the P2X7 receptor for the first time, and suggest that the c

135 P2X7 receptors form large ion channels when activated by

136 study, we investigate the effect of loss of P2X7 receptor function on retinal structure and function

137 Lack of P2X7 receptor function reduced phagocytosis at all ages

138 nalgesic tolerance, without affecting normal P2X7 receptor function.

139 no and carboxyl termini in the regulation of P2X7 receptor gating.

140 TCR activation up-regulates P2X(7) receptor gene expression.

141 PS followed by ATP-induced activation of the P2X(7) receptor; GFP also was released under these condi

142 Our in vitro findings revealed that P2X7 receptor has a dual role, being critical not only f

143 Overall, we conclude that the P2X7 receptor has a role in periodontal immunopathogenes

144 he present study suggests that targeting the P2X7 receptor has anticonvulsant and possibly disease-mo

145 The P2X7 receptor has since been shown to play a leading rol

146 lly relevant strategy by which to antagonize P2X7 receptors has yet, to the best of our knowledge, be

147 ular ATP signaling, particularly through the P2X7 receptor, has considerable translational potential,

148 sue, followed by activation of high-affinity P2X7 receptors, has previously been implicated in second

149 idely distributed in the nervous system, and P2X7 receptors have roles in neuropathic pain and in the

150 ey (HEK) cells stably transfected with human P2X(7) receptors (HEK-P2X(7)) to investigate the mechani

151 pothesized that the ATP-activated macrophage P2X7 receptors implicated in nucleotide-mediated macroph

152 usion, we demonstrated the importance of the P2X(7) receptor in ATP induced cell death of HEK-P2X(7)

153 ) gene were used to evaluate the role of the P2X(7) receptor in nucleotide-evoked fluid secretion.

154 oal here was to characterize the role of the P2X(7) receptor in the repair of in vivo corneal epithel

155 Our recent studies have shown that P2X(7) receptors in neurons and astrocytes activate NLRP

156 These results suggest an important role of P2X(7) receptors in neuropathic pain and therefore a pot

157 P2X(7) receptors in turn activate alpha(1D)-AR to increa

158 We expressed the rat P2X7 receptor in human embryonic kidney cells and measur

159 ent study shows that loss of function of the P2X7 receptor in mice induces retinal changes representi

160 element in the transcriptional regulation of P2X7 receptor in the nervous system.

161 The importance in vivo of P2X7 receptors in control of virulent Mycobacterium tube

162 study demonstrated functional expression of P2X7 receptors in non-neuronal but not in small diameter

163 In the present study, the expression of P2X7 receptors in non-neuronal cells and neurons isolate

164 showed that prolonged agonist activation of P2X7 receptors in non-neuronal cells did not lead to cyt

165 Modulation of P2X7 receptors in non-neuronal cells might have impact o

166 In addition, the released ATP activates P2X7 receptors in satellite cells that enwrap each DRG n

167 le for P2X2 and P2Y1, but not P2X1, P2X3, or P2X7, receptors in injury-induced ERK activation.

168 ophages; however, only monocytes also showed P2X7 receptor-independent release of mature IL-1beta.

169 K293 cells and HEK293 cells expressing a rat P2X7 receptor indicating that P2X7 receptors are not inv

170 lytic cleavage of IL-1F6 was noted following P2X(7) receptor-induced release.

171 In addition, the sustained activation of P2X7 receptors inhibited cell-to-cell electrotonic trans

172 The P2X(7) receptor inhibitor A438079 had no effect on ATP-s

173 tivation, each of which was inhibited by the P2X(7) receptor inhibitors Brilliant Blue G or A 438079.

174 le translational potential, given that novel P2X7-receptor inhibitors are already available for clini

175 es through mediation of integrin beta(3) and P2X7 receptor interactions in primed cells.

176 Mice deficient in the P2X(7) receptor (involved in IL-1 release) or caspase-1

177 ase and autocrine, positive feedback through P2X(7) receptors is required for the effective activatio

178 The P2X7 receptor is a non-selective cation channel activate

179 The P2X7 receptor is a trimeric channel with three binding s

180 The P2X7 receptor is an ATP-gated ion channel known for its

181 The P2X7 receptor is an ATP-sensitive ligand-gated cation ch

182 The P2X7 receptor is an ionotropic receptor predominantly ex

183 well as wild-type mice, suggesting that the P2X7 receptor is not required for control of pulmonary M

184 The P2X7 receptor is unique in having an intracellular carbo

185 In our study, we show that the ATP-gated P2X7 receptor is upregulated in experimental epilepsy an

186 exin channels and blocking activation of the P2X(7) receptor, is neuroprotective for stretched neuron

187 unctional studies, our data suggest that the P2X7 receptor itself constitutes a lipid-composition dep

188 xogenous LTB4, and macrophages obtained from P2X7 receptor knockout mice eliminated L. amazonensis wh

189 at hyperoxia induces K(+) efflux through the P2X7 receptor, leading to inflammasome activation and se

190 indings suggest a noxious mechanism by which P2X7 receptor leads to enhanced oxidative stress in ALS

191 Activation of the P2X7 receptor leads to opening of the characteristic dye

192 ptosomes from these animals showed increased P2X7 receptor levels and altered calcium responses.

193 tivation by mithramycin A reduced endogenous P2X7 receptor levels in primary cultures of cortical neu

194 P2X7 receptor levels were increased in hippocampal subfi

195 Gln have >85% loss of 'pore' function of the P2X7 receptor measured by ATP-induced ethidium uptake.

196 infection inhibits extracellular-ATP (eATP)/P2X7-receptor mediated cell death in gingival epithelial

197 lagellin proceeds normally in the absence of P2X7 receptor-mediated cytoplasmic K(+) perturbations.

198 ctivation of the NLRP3 inflammasome utilizes P2X7 receptor-mediated potassium efflux.

199 The P2X7 receptor mediates extracellular ATP signaling impli

200 AM or by low or no extracellular Ca(2+); and P2X(7) receptor mRNA and protein were expressed in RPE c

201 conserved in the ectodomain of all mammalian P2X(7) receptors, none of which is homologous to previou

202 Neither inhibitors of P2X(7) receptors nor removal of extracellular Mg(2+) or

203 one (compound 35), were found to have robust P2X7 receptor occupancy at low doses in rat with ED50 va

204 Stimulation of the P2X7 receptor of NOD mice resulted in more pronounced sh

205 the agonist-gated Ca(2+) flux of recombinant P2X7 receptors of dog, guinea pig, human, monkey, mouse,

206 ted intraocular pressure, and stimulation of P2X(7) receptors on retinal ganglion cells can be lethal

207 3cr1-deficient MPs express increased surface P2X7 receptor (P2RX7), which stimulates IL-1beta maturat

208 The ATP-gated P2X(7) receptor (P2X(7)R) is a promising therapeutic tar

209 P2X(7) receptors (P2X(7)Rs) are ATP-gated ion channels t

210 Increased P2X7 receptor (P2X7R) activity is a cardinal feature of

211 The P2X7 receptor (P2X7R) belongs to the P2X family of ATP-g

212 n1 (Panx1) channel and purinergic ionotropic P2X7 receptor (P2X7R) blockers.

213 Agonist properties of the P2X7 receptor (P2X7R) differ strikingly from other P2X r

214 the pore of the monovalent cation-selective P2X7 receptor (P2X7R) expands to accommodate large molec

215 Here, we demonstrate that stimulation of the P2X7 receptor (P2X7R) for ATP alkalinizes lysosomes in c

216 The P2X7 receptor (P2X7R) for ATP is a therapeutic target fo

217 nine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated wit

218 The proposed presence of P2X7 receptor (P2X7R) in neurons has been the source of

219 Among all P2X receptors, the P2X7 receptor (P2X7R) is a well-defined therapeutic targ

220 The P2X7 receptor (P2X7R) is an ATP-gated cation channel tha

221 The P2X7 receptor (P2X7R) is an ATP-gated nonselective catio

222 The ATP-gated ionotropic P2X7 receptor (P2X7R) modulates glial activation, cytoki

223 The P2X7 receptor (P2X7R) orchestrates neuroinflammation, an

224 We find that the P2X7 receptor (P2X7R) plays an important role in LL-37 i

225 The P2X7 receptor (P2X7R) regulates many cellular functions.

226 previously that activation of the purinergic P2X7 receptor (P2X7R) triggers sAPPalpha shedding from n

227 ctive pores similar to those elicited by the P2X7 receptor (P2X7R), an ATP-gated cation channel expre

228 Stimulation of the P2X7 receptor (P2X7R), an ATP-gated ion channel, trigger

229 ling purinergic receptors, predominantly the P2X7 receptor (P2X7R), via an ATP analog initiate innate

230 We recently reported that P2X7 receptor (P2X7R)-induced activation of caspase-1 in

231 was inhibited by a specific inhibitor of the P2X7 receptor (P2X7R).

232 enin release (>/=2-fold), whereas purinergic P2X7 receptors (P2X7R) blockade with A740003 (3 microM)

233 involving autocrine activation of ionotropic P2X7 receptors (P2X7R) by ATP.

234 tes/macrophages in response to activation of P2X7 receptors (P2X7R) by extracellular ATP.

235 gh the inhibition of the P2X purinoceptor 7 (P2X7) receptor (P2X7R), an ATP-gated ion channel, and a

236 Blockading P2X7 receptor(P2X7R) provides neuroprotection toward var

237 P2X7 receptors (P2X7Rs) affect many epithelial cell func

238 Purinergic ionotropic P2X7 receptors (P2X7Rs) are closely associated with exci

239 P2X7 receptors (P2X7Rs) are ligand-gated ion channels se

240 o ethidium (Etd(+)) and Ca(2+) by activating P2X7 receptors (P2X7Rs) that open pannexin hemichannels

241 tracellular ATP binds to and signals through P2X7 receptors (P2X7Rs) to modulate immune function in b

242 we found that infection with H37Ra inhibits P2X7 receptor (P2XR) signals and that CsA restores P2XR

243 Antagonizing the ATP-dependent P2X7 receptor pathway of inflammasome activation signifi

244 We demonstrate that ATP acting via the P2X7 receptor pathway promotes a Th17 polarizing microen

245 Here, we show that P2X(7) receptors play a key role in calcium influx and d

246 sion of the death signal requires functional P2X7 receptors, pointing to a role for these receptors i

247 eveal cholesterol as a negative regulator of P2X7 receptor pore formation, protecting cells from P2X7

248 lent cations with ectodomain residues of the P2X(7) receptor, primarily involving combined interactio

249 P2X(7) receptor protein and BzATP-activated inward catio

250 BM chimeras revealed that P2X7 receptor prothrombotic function was present in both

251 Here we show that P2X7 receptors provide a route for excitatory amino acid

252 e results demonstrate that the ATP-sensitive P2X(7) receptor regulates fluid secretion in the mouse s

253 The P2X7 receptor regulates cell growth through mediation of

254 -1 hemichannels to the immune synapse, while P2X7 receptors remain uniformly distributed on the cell

255 P2X7 receptors (Rs) constitute a subclass of ATP-sensiti

256 tly, we identified a novel pathway involving P2X7 receptor scavenger function expressed on ocular imm

257 ith cellular activation typically induced by P2X7 receptor signaling.

258 As BzATP binds to the P2X(7) receptor, specific characteristics of this recept

259 This study asked whether P2X(7) receptor stimulation alters the Ca(2+) levels and

260 The effect of P2X(7) receptor stimulation on cell viability was examin

261 Dissipation of ATP by CD39 reduced P2X7 receptor stimulation and thereby suppressed baselin

262 We also found that, following P2X7 receptor stimulation, the phosphorylation of ERK1/2

263 ere shed preferentially from NOD cells after P2X7 receptor stimulation.

264 bution of P2X(1), P2X(2), P2X(3), P2X(4) and P2X(7) receptor subunit immunoreactivity (R-IR) in the d

265 Here we show P2X7 receptor subunits on presynaptic motor nerve termin

266 However, whether and how P2X7 receptor suppression protects blood-brain barrier(B

267 lar amounts of ATP, activation of purinergic P2X7 receptors, sustained rise in intracellular calcium,

268 uncovered a novel site (Y382-384) within the P2X7 receptor that can be targeted to blunt the developm

269 drial ATP production, and stimulate P2X4 and P2X7 receptors that elicit interleukin 2 production and

270 nt set of mechanisms, not requiring ART-2 or P2X7 receptors that more slowly induce cell death.

271 ce, and that these groups act as ligands for P2X7 receptors that then induce rapid cell death.

272 In the absence of the P2X(7) receptor, the expression of proteins in the corne

273 iggers, through activation of the purinergic P2X7 receptor, the formation of the inflammasome, a mult

274 m channels is less potent than inhibition of P2X7 receptors, there may be significant inhibition of s

275 ATP appeared to also act through the P2X(7) receptor to inhibit muscarinic-induced fluid secr

276 of alpha(1D)-AR releases ATP, which induces P2X(7) receptors to increase [Ca(2+)](i) but not to stim

277 ATP uses P2X(3) and P2X(7) receptors to stimulate an increase in [Ca(2+)](i)

278 ctivates the inflammasome via the purinergic P2X7 receptor to cause inflammation and hyperoxic acute

279 agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.

280 ns circumvent the requirement of ATP and the P2X7 receptor to induce caspase-1 activation via Nlrp3.

281 OD1-G93A mice and SOD1-G93A mice lacking the P2X7 receptor to investigate the effects of both pharmac

282 ease, which in turn activated the purinergic P2X7 receptor to mediate cytotoxicity.

283 cells, the activation of M3AChRs stimulates P2X7 receptors to increase [Ca2+]i and protein secretion

284 ing pathways that overlap with those used by P2X7 receptors to increase [Ca2+]i, but they also use si

285 to become self sustaining through action of P2X7 receptors to open pannexin hemichannels and then co

286 they also use signaling pathways not used by P2X7 receptors to stimulate protein secretion.

287 strate that ATP signaling through macrophage P2X7 receptors uncouples the thioredoxin (TRX)/TRX reduc

288 Finally, we found that Sp1 mediates P2X7 receptor up-regulation in neuroblastoma cells cultu

289 Furthermore, alpha(1D)-AR compared with P2X(7) receptors use different cellular mechanisms to in

290 Consistent with this hypothesis, P2X(7) receptor was specifically up-regulated around bet

291 P2X7 receptor was higher expressed in murine atheroscler

292 Interestingly, we found that the P2X7 receptor was upregulated in the chronic phase of EA

293 blue G (BBG), best known as an antagonist of P2X7 receptors, was found to inhibit voltage-gated sodiu

294 Using macrophages lacking the P2X7 receptor, we observed that ATP was not able to redu

295 P2X(7) receptors were present in the lacrimal gland by R

296 The authors previously showed that P2X(7)receptors were functional in the lacrimal gland.

297 l and intermediate layers, and both P2Y2 and P2X7 receptors were in the periderm.

298 ly as the channel opened, in contrast to the P2X7 receptor where the NMDG permeability develops over

299 lular ATP with apyrase, by inhibition of the P2X(7) receptor with A438079, zinc, or AZ 10606120, and

300 Activation of P2X(7) receptors with (benzoylbenzoyl)adenosine 5'-triph