ライフサイエンスコーパス: P2X2 receptor

1 ionally interacting purinergic receptor: the P2X2 receptor.

2 s little to the permeation properties of the P2X2 receptor.

3 sstalk occurs between alpha6beta4 nAChRs and P2X2 receptors.

4 l openings that were never seen in wild-type P2X2 receptors.

5 e key components of the zinc binding site in P2X2 receptors.

6 els incorporating the properties of P2X1 and P2X2 receptors.

7 -1.5) but was significantly higher (2.5) for P2X2 receptors.

8 epend on the intracellular C terminus of the P2X2 receptors.

9 neurons are likely to express predominantly P2X2 receptors.

10 h half-maximal concentrations of 5 mM at the P2X2 receptor, 89 mM at the P2X3 receptor and 15 mM at b

11 ion, calcium permeability, and dye uptake as P2X2 receptors activated by ATP.

12 h frequent mating over days, suggesting that P2X2 receptor adds a selection advantage under these con

13 P2X2 receptors also functionally interact with alpha6bet

14 Zinc binds to rat P2X2 receptors and acts as an allosteric modulator, pote

15 cells stably transfected with either P2X1 or P2X2 receptors and by absorption controls with the cogna

16 he cranial neural crest and does not express P2X2 receptors and fails to respond to alpha,beta-methyl

17 a6beta4-containing (alpha6beta4*) nAChRs and P2X2 receptors and/or P2X3 receptors have not been fully

18 P2X2 receptors are ATP-gated ion channels widely express

19 sures of P2X receptor mobility and show that P2X2 receptors are mobile ATP sensors, sampling more of

20 el, since ATP currents evoked at recombinant P2X2 receptors are potentiated by lowering extracellular

21 surface, indicating that the nonglycosylated P2X2 receptors are retained inside the cell.

22 ATP-gated ionotropic P2X2 receptors are widely expressed in neurons.

23 robe the location of this zinc binding site, P2X2 receptors bearing mutations of the histidines at po

24 of removing N-linked glycosylation from the P2X2 receptor by using two different approaches, tunicam

25 The slowly desensitizing P2X2 receptor can be activated by free ATP, but MgATP(2-

26 essing either wild-type or functional mutant P2X2 receptors containing a cysteine substitution in or

27 at a significant component of TTS represents P2X2 receptor-dependent purinergic hearing adaptation th

28 ing commonly described as non-desensitizing, P2X2 receptors do desensitize or inactivate.

29 distances in the transmembrane domain of the P2X2 receptor during activation.

30 sequential expression of the P2X5, P2Y1, and P2X2 receptors during the process of muscle regeneration

31 Similar results were obtained at P2X2 receptors even without previous agonist tethering:

32 Subsequent P2X2 receptor expression on newly formed myotubes showed

33 These data indicate that modulation of P2X2 receptor function, such as that evoked by acidifica

34 current is not detected in mice lacking the P2X2 receptor gene (P2rx2(-/-)).

35 is a noncompetitive antagonist at wild-type P2X2 receptors, had a pronounced agonist action at both

36 hough the electrophysiological properties of P2X2 receptors have been extensively studied, little is

37 Human P2X2 receptors (hP2X2) are strongly inhibited by zinc ov

38 of the first transmembrane domain of the rat P2X2 receptor in cation permeability and flux.

39 In the present study, the distribution of P2X2 receptor in the rat hypothalamus was studied with i

40 spontaneous gating, and rectification of rat P2X2 receptor in which polar and charged residues of the

41 lamp recordings to track quantum dot-labeled P2X2 receptors in the dendrites of rat hippocampal neuro

42 to Cd(2+) at substituted cysteines in TM2 of P2X2 receptors in the open and closed states.

43 The propyl-MTS did not open P2X2 receptors in which the Val(48) side chain was remov

44 the unspliced, 472 amino acid isoform of the P2X2 receptor, inactivation required membrane disruption

45 clude that the C-terminal splice site of the P2X2 receptor is located within a region that is critica

46 We find that plasma membrane P2X2 receptor lateral mobility in dendrites is heterogen

47 drites of rat hippocampal neurons to explore P2X2 receptor mobility and its regulation.

48 dge, a comparison of the closed and open rat P2X2 receptor models revealed a significant rearrangemen

49 els likely activates the broadly distributed P2X2 receptors on epithelial cells lining the endolympha

50 bout the plasma membrane lateral mobility of P2X2 receptors or whether receptor mobility is regulated

51 The P2X2 receptor (P2X2R) is a member of the ATP-gated ion c

52 f ionic modulation that is characteristic of P2X2 receptors: potentiation by acidification and extrac

53 of the two transmembrane domains of the rat P2X2 receptor protein, and is likely to be close to the

54 direct evidence that calcium influx through P2X2 receptors results in the activation of the MAP kina

55 inc over the range of 2-100 muM, whereas rat P2X2 receptors (rP2X2) are strongly potentiated over the

56 amino-terminal region with the corresponding P2X2 receptor section (P2X7-2Nbeta) gave responses that

57 Interpreted with a P2X2 receptor structural model of the closed state, our

58 ere we describe null mutant mice lacking the P2X2 receptor subunit (P2X2-/-) and double mutant mice l

59 asparagine residues 182, 239, and 298 of the P2X2 receptor subunit by showing that the protein is gly

60 P2X2 receptor subunit immunoreactivity was detected in a

61 HEK-293 cells stably transfected with the P2X2 receptor subunit showed little or no response to AT

62 n mice null for the P2RX2 gene (encoding the P2X2 receptor subunit), sustained 85-dB noise failed to

63 of the VLM respiratory neurones express the P2X2 receptor subunit.

64 w that ATP-gated ion channels assembled from P2X2 receptor subunits in the cochlea are necessary for

65 rostral ventrolateral medulla (VLM) express P2X2 receptor subunits of the ATP-gated ion channel, sin

66 P2X2 receptor subunits of the ATP-gated ion channels are

67 introducing pairs of cysteines into the rat P2X2 receptor that might form disulfide bonds within or

68 We have engineered a P2X2 receptor that opens within milliseconds by irradiat

69 In rat P2X2 receptors, these intersect at Thr(339).

70 We have used chimeras between human P2X1 and P2X2 receptors to address the contribution of the extrac

71 nnels that physically couple with purinergic P2X2 receptors to trigger a functional cross-inhibition

72 ment for P2X1 receptors but had no effect on P2X2 receptor trafficking.

73 Rat wild-type and mutant P2X2 receptors were expressed in Xenopus oocytes and cur

74 P2X2 receptors were forced into a prolonged desensitized

75 study, we used homology modeling of the rat P2X2 receptor with the zebrafish P2X4 X-ray template to