ライフサイエンスコーパス: P2X4 receptor

1 lar dynamics study of the closed form of the P2X4 receptor.

2 ding of these antagonists are present in the P2X4 receptor.

3 toma cells stably transfected with the human P2X4 receptor.

4 EK293 cells transfected to express the human P2X4 receptor.

5 ated current in WT cells, implying that both P2X4 receptor and another yet-to-be-identified P2X recep

6 ion results in the translocation of P2X1 and P2X4 receptors and pannexin-1 hemichannels to the immune

7 P2X4 receptor antagonists have potential as drugs for th

8 P2X4 receptors are ATP-gated cation channels that are wi

9 Thus, our data indicate that P2X4 receptors are dynamically regulated mobile ATP sens

10 These studies provide evidence that P2X4 receptors are functionally important in hepatocyte

11 P2X4 receptors are likely involved because the calcium r

12 However, the nature of how plasma membrane P2X4 receptors are regulated in microglia is not fully u

13 ATP-gated ionotropic P2X4 receptors are up-regulated in activated microglia a

14 r at other sites in the nervous system where P2x4 receptors are widely expressed.

15 mpletely abolished the pH sensitivity of the P2X4 receptor at all agonist concentrations.

16 purification and pulldown assays reveal that P2X4 receptors complex with aminobutyric acid, type A (G

17 The chick P2X4 receptor (cP2X(4)R) mRNA was expressed in the heart

18 2X receptors, ion currents through homomeric P2X4 receptors exhibit intermediate desensitization when

19 To identify P2X4 receptor-expressing cells, we generated BAC transge

20 well-characterized tool with which to study P2X4 receptor-expressing cells.

21 P2X4 receptor expression in the liver, liver histology,

22 Furthermore, increased surface P2X4 receptor expression significantly decreases the fre

23 de that pannexin-1 hemichannels and P2X1 and P2X4 receptors facilitate ATP release and autocrine feed

24 ever, it was not clear whether the lysosomal P2X4 receptors function as channels and how they are act

25 expressing tdTomato under the control of the P2X4 receptor gene (P2rx4).

26 Cells expressing ATP-gated P2X4 receptors have proven problematic to identify and s

27 eport the crystal structure of the zebrafish P2X4 receptor in complex with ATP and a new structure of

28 aracterize the electrophysiologic actions of P2X4 receptors in cardiac myocytes and to determine whet

29 cells, consistent with an important role of P2X4 receptors in mediating the ATP current not only in

30 t previously unanticipated roles for ATP and P2X4 receptors in the neural circuitry controlling feedi

31 The crystal structure of a P2X4 receptor, in combination with mutagenesis studies,

32 l and functional data regarding the P2X2 and P2X4 receptors indicate that the central trihelical TM2

33 hibition, mutation, or silencing of P2X1 and P2X4 receptors inhibits Ca(2+) entry, nuclear factors of

34 The P2X4 receptor is a newly identified receptor expressed i

35 e and have shown further that ATP-responsive P2X4 receptor is required for Tbeta4-induced HUVEC migra

36 The P2X4 receptor is unique among family members in its sens

37 Ca(2+) entry through P2X4 receptors is known to trigger downstream signaling

38 We find that plasma membrane P2X4 receptor lateral mobility in resting microglial pro

39 GABA(A) receptors in recombinant system and P2X4 receptor-mediated GABAergic depression in SF-1 GFP-

40 nd clear evidence for functional presynaptic P2X4 receptor-mediated responses in terminals of AgRP-NP

41 ATP decreased cellular glycogen content; and P2X4 receptor messenger RNA increased in glycogen-rich l

42 uantum dot-labeled P2X4 receptors to explore P2X4 receptor mobility in the processes of resting and a

43 1 microM), while at recombinant rat P2X2 and P2X4 receptors no enhancing or antagonistic properties w

44 Genetic deletion of the PSD-95 or P2X4 receptors obliterated ATP-mediated down-regulation

45 ogical evidence for functional expression of P2X4 receptors on AgRP-NPY neuron somata, but instead, w

46 ned in myocytes from both wild-type (WT) and P2X4 receptor-overexpressing transgenic (TG) mice.

47 The P2X4 receptor (P2X4R) is a member of a family of puriner

48 P2X4 receptors (P2X4R) have emerged as potentially impor

49 Of the seven P2X subtypes, P2X4 receptors (P2X4Rs) are richly expressed in the brai

50 Activation of a cardiac myocyte P2X4 receptor protects against heart failure.

51 tures of the detergent-solubilized zebrafish P2X4 receptor provide a blueprint for receptor mechanism

52 The recent crystal structure of a P2X4 receptor provides a 3D view of their topology and a

53 on feeding-related regulation of presynaptic P2X4 receptor responses, and the rationale to explore ex

54 In the presence of the P2X4 receptor-selective allosteric enhancer ivermectin (

55 In intact heart study, the P2X4 receptor TG mouse exhibited significantly elevated

56 on with no associated heart pathology in the P2X4 receptor TG mouse suggests a novel physiologic role

57 use suggests a novel physiologic role of the P2X4 receptor, that of stimulating the cardiac contracti

58 Furthermore, in P2X4 receptors, this ability to alter ion selectivity ca

59 ncreased responsiveness of the overexpressed P2X4 receptor to endogenous ATP is responsible for the e

60 olecule imaging to track quantum dot-labeled P2X4 receptors to explore P2X4 receptor mobility in the

61 P2X4 receptors were expressed in hepatocytes and Kupffer

62 -2,4-disulfonate, with residues from the rat P2X4 receptor, which is insensitive to these antagonists

63 nsistent with overexpression of a functional P2X4 receptor with consequent increase in the receptor-m