ライフサイエンスコーパス: P2X7 receptor

1 h-promoting agent (acting at P2Y1, P2Y2, and P2X7 receptors).

2 al role in the transcriptional regulation of P2X7 receptor.

3 hought to be characteristic hallmarks of the P2X7 receptor.

4 o cellular responses typically attributed to P2X7 receptor.

5 S) stimulation and ATP signaling through the P2X7 receptor.

6 to be driven by unimpeded activation of the P2X7 receptor.

7 K(+) caused by stimulation of the purinergic P2X7 receptor.

8 a was unimpaired in macrophages deficient in P2X7 receptor.

9 of the extracellular loop of the full-length P2X7 receptor.

10 hly sensitive to that stimulated through the P2X7 receptor.

11 ing of a large pore at the recombinant human P2X7 receptor.

12 ess marked than for cells expressing the rat P2X7 receptor.

13 reatment for epilepsy based on targeting the P2X7 receptor.

14 ophages but not from macrophages lacking the P2X7 receptor.

15 esponse to SCI by activation of low-affinity P2X7 receptors.

16 l lines expressing recombinant human and rat P2X7 receptors.

17 ue-G, and KN-62, demonstrating activation of P2X7 receptors.

18 iate between the two widely used agonists at P2X7 receptors.

19 inhibitor Z-VADfmk, and requires functional P2X7 receptors.

20 with DNA fragmentation, and does not require P2X7 receptors.

21 ifferentially regulated by the activation of P2X7 receptors.

22 stably express the human or rat recombinant P2X7 receptors.

23 a(2+) permeability are difficult to apply to P2X7 receptors.

24 asses that selectively target P2X1, P2X3, or P2X7 receptors.

25 human embryonic kidney cells expressing rat P2X7 receptors.

26 nergistically up-regulated mRNA encoding the P2X7 receptor, a recently cloned ATP-gated channel that

27 mma disrupts the functionality of purinergic P2X7 receptors, a key step controlling eCB production by

28 Moreover, in vitro blockade of the P2X7 receptor abrogates the levels of these cytokines.

29 e investigated whether LTB4 is produced upon P2X7 receptor activation and examined whether LTB4 modul

30 Evidence also shows that P2X7 receptor activation is linked to elevated expressio

31 These results indicate that P2X7 receptor activation leads to LTB4 formation, which

32 TLR2 agonists required pannexin-1 and P2X7 receptor activation to stimulate IL-1beta release.

33 investigated for dependence upon caspase-1, P2X7 receptor activation, and loss of membrane asymmetry

34 specific TLR agonists and was accelerated by P2X7 receptor activation.

35 reliant on active caspase-1, pannexin-1, and P2X7 receptor activation.

36 response to ATP concentrations that exclude P2X7 receptor activation.

37 astrocytes with properties characteristic of P2X7 receptor activation: the current was amplified in l

38 Likewise, the purinergic P2X7 receptor acts as a direct conduit for Ca(2+)-influx

39 ll patch clamp studies, exposure to the P2X4/P2X7 receptor agonist 2'3'-O-(4-benzoyl-benzoyl)-adenosi

40 apoptosis in response to treatment with the P2X7 receptor agonist benzoyl-ATP.

41 The P2X7 receptor agonist benzoylbenzoyl-adenosine 5'-tripho

42 receptor agonist ATPgammaS (p<0.001) and the P2X7 receptor agonist BzATP (p<0.001).

43 Acini were stimulated with the P2X7 receptor agonist, (benzoylbenzoyl)adenosine 5' trip

44 ed treatment with lipopolysaccharide and the P2X7 receptor agonist, benzylated ATP, suggesting that n

45 ess functional purinergic receptors and that P2X7 receptor agonists significantly reduce cell numbers

46 ly, o-ATP prevents cell death induced by P2Z/P2X7 receptor agonists.

47 n the plasma membrane, but activation of the P2X7 receptor also leads to rapid cytoskeletal re-arrang

48 to be partially mediated by activation of a P2X7 receptor, although hybrid channels cannot be ruled

49 P2Y2, P2Y4, P2Y6, and P2Y12, and at P2X4 and P2X7 receptors), an immunosuppressant (acting at P2Y11),

50 ng mechanisms were prevented by knocking out P2X7 receptor and by the use of specific antagonists.

51 iprotein inflammasome complex, including the P2X7 receptor and caspase-1.

52 However, the roles of P2X7 receptor and intracellular K(+) in IL-1beta secreti

53 Furthermore, we demonstrated that P2X7 receptor and NLRP3 transcription were modulated in

54 -induced cell death in oocytes co-expressing P2X7 receptor and pannexin 1.

55 n experiments with HEK cells, which lack the P2X7 receptor and showed strikingly increased response t

56 S. aureus supernatant was independent of the P2X7 receptor and the essential TLR adaptors MyD88 and T

57 ess a low activation threshold allele of the P2X7 receptor and the P2X7 gene maps to a locus associat

58 derived macrophage cells natively expressing P2X7 receptors and cells transfected with human P2X7 but

59 ry cytokines through mechanisms depending on P2X7 receptors and Px1 HCs.

60 P2X7 receptors and UTP-activated receptors mediated thes

61 g lipin-2 decreases ion currents through the P2X7 receptor, and downstream events that drive IL-1beta

62 anism that involves ATP release, P2 (perhaps P2X7) receptors, and p38 MAPK activation.

63 he centrally available, potent, and specific P2X7 receptor antagonist JNJ-47965567 (30 mg/kg) signifi

64 The selective P2X7 receptor antagonist JNJ-47965567 partly replicated

65 f both cytokines was blocked completely by a P2X7 receptor antagonist, oxidized ATP, and partially by

66 reatment of RAW 264.7 macrophages with a P2Z/P2X7 receptor antagonist, periodate oxidized adenosine 5

67 ion in oxidized ATP (200 microM); a putative P2X7 receptor antagonist.

68 To ascertain how P2Z/P2X7 receptor antagonists influence LPS signaling, we ev

69 Other P2X7 receptor antagonists, however, had no effect on LT

70 N'-aryl acyl hydrazides were identified as P2X7 receptor antagonists.

71 ed ATP and the isoquinoline KN-62, two known P2X7 receptor antagonists.

72 y revealed positive immunoreactivity of anti-P2X7 receptor antibodies on non-neuronal cells.

73 ular constituent immunoreactive for specific P2X7 receptor antiserum in the kainate-induced seizure a

74 P2X7 receptors are ATP-gated ion channels that contribut

75 P2X7 receptors are involved not only in physiological fu

76 P2X7 receptors are nonselective cation channels gated by

77 pressing a rat P2X7 receptor indicating that P2X7 receptors are not involved in stimulation of ATP re

78 TP injection or conditioning lesion, whereas P2X7 receptors are not.

79 ATP-gated P2X7 receptors are prominently expressed in inflammatory

80 pore-forming properties of human and rodent P2X7 receptors are sensitive to perturbations of cholest

81 ive stress in ALS microglia and identify the P2X7 receptor as a promising target for the development

82 P2X7 receptors associate with cholesterol-rich lipid raf

83 The P2X7 receptor binds extracellular ATP to mediate numerou

84 nistration of an inhibitor of the purinergic P2X7 receptor blocks the anxiety caused by HFD.

85 f pannexin-1-hemichannel (PNX1) coupled with P2X7-receptor blocks the infection-induced eATP release

86 of fluorescent dyes in many cells expressing P2X7 receptors, but controversy persists as to whether s

87 , in SOD1-G93A microglia, the stimulation of P2X7 receptor by 2'-3'-O-(benzoyl-benzoyl) ATP enhanced

88 onic kidney cells that interact with the rat P2X7 receptor, by affinity purification followed by mass

89 lts demonstrate that the open channel of the P2X7 receptor can allow passage of molecules with sizes

90 itionally, it has been demonstrated that the P2X7 receptor can induce PLA2 activation and arachidonic

91 , we evaluated whether antagonism of the P2Z/P2X7 receptor can influence LPS signaling and expression

92 We further show that activation of P2X7 receptors can lead to the release of tumor necrosis

93 The ATP-gated P2X7 receptor channel (P2X7R) operates as a cytolytic an

94 de during activation by endogenous ATP-gated P2X7 receptor channels, the exogenous bacterial ionophor

95 P2X7 receptors colocalized with anti-caspase-3 antibody

96 we present crystal structures of a mammalian P2X7 receptor complexed with five structurally-unrelated

97 Considering that extracellular ATP through P2X7 receptor constitutes a neuron-to-microglia alarm si

98 rs controlling proliferation, while P2X5 and P2X7 receptors control early differentiation, terminal d

99 cing T-cell activation through the ATP-gated P2x7 receptor controlling Ca2(+) influx.

100 Patch clamp analysis of P2X7 receptor currents carried by Na(+) and N-methyl-D-g

101 eptic mice displayed enhanced agonist-evoked P2X7 receptor currents, and synaptosomes from these anim

102 In P2X7 receptor deficient mice (P2rx7-/-), the social inte

103 fficient to induce motor neuron death by the P2X7 receptor-dependent activation of the Fas pathway.

104 TLR agonists induced P2X7 receptor-dependent IL-1beta release in both monocyt

105 ion by means of its fimbriae in a purinergic P2X7 receptor-dependent manner.

106 The generation of prothrombotic MPs required P2X7 receptor-dependent production of ROS leading to inc

107 e data suggest that PDI regulates a critical P2X7 receptor-dependent signaling pathway that generates

108 c receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P2rx7) induced activation (dec

109 These results were relevant in vivo since P2X7 receptor expression was upregulated in a P. gingiva

110 tative measures of the Ca(2+) current of the P2X7 receptor for the first time, and suggest that the c

111 P2X7 receptors form large ion channels when activated by

112 study, we investigate the effect of loss of P2X7 receptor function on retinal structure and function

113 Lack of P2X7 receptor function reduced phagocytosis at all ages

114 nalgesic tolerance, without affecting normal P2X7 receptor function.

115 no and carboxyl termini in the regulation of P2X7 receptor gating.

116 Our in vitro findings revealed that P2X7 receptor has a dual role, being critical not only f

117 Overall, we conclude that the P2X7 receptor has a role in periodontal immunopathogenes

118 he present study suggests that targeting the P2X7 receptor has anticonvulsant and possibly disease-mo

119 The P2X7 receptor has since been shown to play a leading rol

120 lly relevant strategy by which to antagonize P2X7 receptors has yet, to the best of our knowledge, be

121 ular ATP signaling, particularly through the P2X7 receptor, has considerable translational potential,

122 sue, followed by activation of high-affinity P2X7 receptors, has previously been implicated in second

123 idely distributed in the nervous system, and P2X7 receptors have roles in neuropathic pain and in the

124 normal mice or those in which genes for the P2X7 receptor, IL-1beta, IL-1alpha, IL-18, or caspase-1

125 pothesized that the ATP-activated macrophage P2X7 receptors implicated in nucleotide-mediated macroph

126 Our data confirm the importance of the P2X7 receptor in ATP-stimulated cell death and IL-1beta

127 We expressed the rat P2X7 receptor in human embryonic kidney cells and measur

128 ent study shows that loss of function of the P2X7 receptor in mice induces retinal changes representi

129 This report implicates the P2Z/P2X7 receptor in the control of protein kinase cascades

130 element in the transcriptional regulation of P2X7 receptor in the nervous system.

131 The importance in vivo of P2X7 receptors in control of virulent Mycobacterium tube

132 study demonstrated functional expression of P2X7 receptors in non-neuronal but not in small diameter

133 In the present study, the expression of P2X7 receptors in non-neuronal cells and neurons isolate

134 showed that prolonged agonist activation of P2X7 receptors in non-neuronal cells did not lead to cyt

135 Modulation of P2X7 receptors in non-neuronal cells might have impact o

136 In addition, the released ATP activates P2X7 receptors in satellite cells that enwrap each DRG n

137 lso acted as a selective antagonist of human P2X7 receptors in several functional studies.

138 le for P2X2 and P2Y1, but not P2X1, P2X3, or P2X7, receptors in injury-induced ERK activation.

139 ophages; however, only monocytes also showed P2X7 receptor-independent release of mature IL-1beta.

140 K293 cells and HEK293 cells expressing a rat P2X7 receptor indicating that P2X7 receptors are not inv

141 In addition, the sustained activation of P2X7 receptors inhibited cell-to-cell electrotonic trans

142 le translational potential, given that novel P2X7-receptor inhibitors are already available for clini

143 es through mediation of integrin beta(3) and P2X7 receptor interactions in primed cells.

144 The P2X7 receptor is a non-selective cation channel activate

145 The P2X7 receptor is a trimeric channel with three binding s

146 The P2X7 receptor is an ATP-gated ion channel known for its

147 The P2X7 receptor is an ATP-sensitive ligand-gated cation ch

148 The P2X7 receptor is an ionotropic receptor predominantly ex

149 well as wild-type mice, suggesting that the P2X7 receptor is not required for control of pulmonary M

150 The P2X7 receptor is unique in having an intracellular carbo

151 In our study, we show that the ATP-gated P2X7 receptor is upregulated in experimental epilepsy an

152 unctional studies, our data suggest that the P2X7 receptor itself constitutes a lipid-composition dep

153 xogenous LTB4, and macrophages obtained from P2X7 receptor knockout mice eliminated L. amazonensis wh

154 tochemical studies on human lymphoid tissue, P2X7 receptor labeling was observed within discrete area

155 at hyperoxia induces K(+) efflux through the P2X7 receptor, leading to inflammasome activation and se

156 indings suggest a noxious mechanism by which P2X7 receptor leads to enhanced oxidative stress in ALS

157 Activation of the P2X7 receptor leads to opening of the characteristic dye

158 ptosomes from these animals showed increased P2X7 receptor levels and altered calcium responses.

159 tivation by mithramycin A reduced endogenous P2X7 receptor levels in primary cultures of cortical neu

160 P2X7 receptor levels were increased in hippocampal subfi

161 Gln have >85% loss of 'pore' function of the P2X7 receptor measured by ATP-induced ethidium uptake.

162 Several observations indicated that the P2X7 receptor mediated this effect.

163 infection inhibits extracellular-ATP (eATP)/P2X7-receptor mediated cell death in gingival epithelial

164 lagellin proceeds normally in the absence of P2X7 receptor-mediated cytoplasmic K(+) perturbations.

165 ctivation of the NLRP3 inflammasome utilizes P2X7 receptor-mediated potassium efflux.

166 The P2X7 receptor mediates extracellular ATP signaling impli

167 In summary, these data suggest that the P2Z/P2X7 receptor modulates LPS-induced macrophage activatio

168 one (compound 35), were found to have robust P2X7 receptor occupancy at low doses in rat with ED50 va

169 Stimulation of the P2X7 receptor of NOD mice resulted in more pronounced sh

170 the agonist-gated Ca(2+) flux of recombinant P2X7 receptors of dog, guinea pig, human, monkey, mouse,

171 3cr1-deficient MPs express increased surface P2X7 receptor (P2RX7), which stimulates IL-1beta maturat

172 Increased P2X7 receptor (P2X7R) activity is a cardinal feature of

173 The P2X7 receptor (P2X7R) belongs to the P2X family of ATP-g

174 n1 (Panx1) channel and purinergic ionotropic P2X7 receptor (P2X7R) blockers.

175 Agonist properties of the P2X7 receptor (P2X7R) differ strikingly from other P2X r

176 the pore of the monovalent cation-selective P2X7 receptor (P2X7R) expands to accommodate large molec

177 Here, we demonstrate that stimulation of the P2X7 receptor (P2X7R) for ATP alkalinizes lysosomes in c

178 The P2X7 receptor (P2X7R) for ATP is a therapeutic target fo

179 nine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated wit

180 The proposed presence of P2X7 receptor (P2X7R) in neurons has been the source of

181 Among all P2X receptors, the P2X7 receptor (P2X7R) is a well-defined therapeutic targ

182 The P2X7 receptor (P2X7R) is an ATP-gated cation channel tha

183 The P2X7 receptor (P2X7R) is an ATP-gated nonselective catio

184 The ATP-gated ionotropic P2X7 receptor (P2X7R) modulates glial activation, cytoki

185 The P2X7 receptor (P2X7R) orchestrates neuroinflammation, an

186 We find that the P2X7 receptor (P2X7R) plays an important role in LL-37 i

187 The P2X7 receptor (P2X7R) regulates many cellular functions.

188 previously that activation of the purinergic P2X7 receptor (P2X7R) triggers sAPPalpha shedding from n

189 ctive pores similar to those elicited by the P2X7 receptor (P2X7R), an ATP-gated cation channel expre

190 Stimulation of the P2X7 receptor (P2X7R), an ATP-gated ion channel, trigger

191 ling purinergic receptors, predominantly the P2X7 receptor (P2X7R), via an ATP analog initiate innate

192 We recently reported that P2X7 receptor (P2X7R)-induced activation of caspase-1 in

193 was inhibited by a specific inhibitor of the P2X7 receptor (P2X7R).

194 enin release (>/=2-fold), whereas purinergic P2X7 receptors (P2X7R) blockade with A740003 (3 microM)

195 involving autocrine activation of ionotropic P2X7 receptors (P2X7R) by ATP.

196 tes/macrophages in response to activation of P2X7 receptors (P2X7R) by extracellular ATP.

197 gh the inhibition of the P2X purinoceptor 7 (P2X7) receptor (P2X7R), an ATP-gated ion channel, and a

198 Blockading P2X7 receptor(P2X7R) provides neuroprotection toward var

199 P2X7 receptors (P2X7Rs) affect many epithelial cell func

200 Purinergic ionotropic P2X7 receptors (P2X7Rs) are closely associated with exci

201 P2X7 receptors (P2X7Rs) are ligand-gated ion channels se

202 o ethidium (Etd(+)) and Ca(2+) by activating P2X7 receptors (P2X7Rs) that open pannexin hemichannels

203 tracellular ATP binds to and signals through P2X7 receptors (P2X7Rs) to modulate immune function in b

204 we found that infection with H37Ra inhibits P2X7 receptor (P2XR) signals and that CsA restores P2XR

205 Antagonizing the ATP-dependent P2X7 receptor pathway of inflammasome activation signifi

206 We demonstrate that ATP acting via the P2X7 receptor pathway promotes a Th17 polarizing microen

207 sion of the death signal requires functional P2X7 receptors, pointing to a role for these receptors i

208 eveal cholesterol as a negative regulator of P2X7 receptor pore formation, protecting cells from P2X7

209 MoAb was used to immunoprecipitate the human P2X7 receptor protein, and in immunohistochemical studie

210 BM chimeras revealed that P2X7 receptor prothrombotic function was present in both

211 Here we show that P2X7 receptors provide a route for excitatory amino acid

212 The P2X7 receptor regulates cell growth through mediation of

213 -1 hemichannels to the immune synapse, while P2X7 receptors remain uniformly distributed on the cell

214 Activation of the P2X7 receptor resulted in its dephosphorylation.

215 ATP stimulation of cell surface P2X7 receptors results in cytolysis and cell death of ma

216 P2X7 receptors (Rs) constitute a subclass of ATP-sensiti

217 tly, we identified a novel pathway involving P2X7 receptor scavenger function expressed on ocular imm

218 Whole-cell recordings from cells expressing P2X7 receptors showed that this markedly reduced subsequ

219 ith cellular activation typically induced by P2X7 receptor signaling.

220 Thus, we have identified a P2X7 receptor signalling complex, some members of which

221 Dissipation of ATP by CD39 reduced P2X7 receptor stimulation and thereby suppressed baselin

222 Because P2X7 receptor stimulation can rapidly activate caspase f

223 We also found that, following P2X7 receptor stimulation, the phosphorylation of ERK1/2

224 ere shed preferentially from NOD cells after P2X7 receptor stimulation.

225 Here we show P2X7 receptor subunits on presynaptic motor nerve termin

226 However, whether and how P2X7 receptor suppression protects blood-brain barrier(B

227 lar amounts of ATP, activation of purinergic P2X7 receptors, sustained rise in intracellular calcium,

228 uncovered a novel site (Y382-384) within the P2X7 receptor that can be targeted to blunt the developm

229 drial ATP production, and stimulate P2X4 and P2X7 receptors that elicit interleukin 2 production and

230 nt set of mechanisms, not requiring ART-2 or P2X7 receptors that more slowly induce cell death.

231 ce, and that these groups act as ligands for P2X7 receptors that then induce rapid cell death.

232 iggers, through activation of the purinergic P2X7 receptor, the formation of the inflammasome, a mult

233 om a human monocyte library that encodes the P2X7 receptor; the predicted protein is 80% identical to

234 m channels is less potent than inhibition of P2X7 receptors, there may be significant inhibition of s

235 When compared with the rat P2X7 receptor, these effects required higher concentrati

236 ctivates the inflammasome via the purinergic P2X7 receptor to cause inflammation and hyperoxic acute

237 agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.

238 ns circumvent the requirement of ATP and the P2X7 receptor to induce caspase-1 activation via Nlrp3.

239 OD1-G93A mice and SOD1-G93A mice lacking the P2X7 receptor to investigate the effects of both pharmac

240 ease, which in turn activated the purinergic P2X7 receptor to mediate cytotoxicity.

241 cells, the activation of M3AChRs stimulates P2X7 receptors to increase [Ca2+]i and protein secretion

242 ing pathways that overlap with those used by P2X7 receptors to increase [Ca2+]i, but they also use si

243 to become self sustaining through action of P2X7 receptors to open pannexin hemichannels and then co

244 they also use signaling pathways not used by P2X7 receptors to stimulate protein secretion.

245 ed SAPK activation could be recapitulated in P2X7 receptor-transfected HEK293 cells, but not in wild-

246 strate that ATP signaling through macrophage P2X7 receptors uncouples the thioredoxin (TRX)/TRX reduc

247 Finally, we found that Sp1 mediates P2X7 receptor up-regulation in neuroblastoma cells cultu

248 lonal antibody (MoAb) specific for the human P2X7 receptor was generated in mice.

249 P2X7 receptor was higher expressed in murine atheroscler

250 Interestingly, we found that the P2X7 receptor was upregulated in the chronic phase of EA

251 blue G (BBG), best known as an antagonist of P2X7 receptors, was found to inhibit voltage-gated sodiu

252 Using macrophages lacking the P2X7 receptor, we observed that ATP was not able to redu

253 P2X7 receptors were expressed in the necrotic center of

254 l and intermediate layers, and both P2Y2 and P2X7 receptors were in the periderm.

255 ly as the channel opened, in contrast to the P2X7 receptor where the NMDG permeability develops over

256 vation of macrophage surface-associated P2Z (P2X7) receptors, which are one of the purinergic recepto