ライフサイエンスコーパス: P2Y(4) receptor

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1 toma cells stably transfected with the human P2Y4 receptor.

2 receptor's being a species homologue of the P2Y4 receptor.

3 lecule that markedly activated the expressed P2Y4 receptor.

4 ponsive receptors, the P2Y6 receptor and the P2Y4 receptor.

5 nt coupling of this release to activation of P2Y4 receptors.

6 ons as an agonist or antagonist at mammalian P2Y(4) receptors.

7 minal nucleotides, mediated by P2X(2) and/or P2Y(4) receptors.

8 2Y6 receptor), selectively activated by UTP (P2Y4 receptor), and activated by UTP and ATP but not by

9 erythrocytes, at recombinant human P2Y2 and P2Y4 receptors, and at recombinant rat P2Y6 receptors.

10 No selective P2Y4 receptor antagonist has been described so far.

11 e-2-sulfonate) represents the most selective P2Y4 receptor antagonist known to date.

12 Therefore, we developed and optimized P2Y4 receptor antagonists based on an anthraquinone scaf

13 enopus oocytes expressing P2X(2), P2Y(2,) or P2Y(4) receptors, but not in oocytes expressing other P2

14 mologues, we expressed a series of human/rat P2Y(4) receptor chimeras in 1321N1 human astrocytoma cel

15 uman astrocytoma cells stably expressing the P2Y4 receptor, combined addition of these nucleotides re

16 Pharmacological studies of the P2Y4 receptor expressed in 1321N1 human astrocytoma cell

17 refore, we cloned and expressed the P2Y6 and P2Y4 receptors in 1321N1 human astrocytoma cells and com

18 UDP but weakly by UTP, ATP, and ADP; and the P2Y4 receptor is activated most potently by UTP, less po

19 the N terminus and 7TM, whereas that of the P2Y4 receptor is present in its C-terminal tail.

20 That is, whereas the P2Y4 receptor is selectively activated by UTP and is not

21 The P2Y4 receptor is selectively activated by UTP.

22 homology to the previously cloned mammalian P2Y4 receptor, its pharmacological selectivity was not c

23 ituted with the corresponding regions of the P2Y4 receptor lacking its targeting signal.

24 In the absence of dDAVP, P2Y(1) and P2Y(4) receptors localized to the apical membrane, where

25 ) receptor mRNA level was unchanged, and the P2Y(4) receptor mRNA was undetectable.

26 on of the uridine nucleotide-activated human P2Y4 receptor (P2Y4-R) and P2Y6 receptor (P2Y6-R) was st

27 Expression of the human P2Y(4) receptor, rat M(1)-muscarinic receptor, and human

28 Additional studies indicated that P2Y(4) receptors stimulate both TSP-1 expression and rel

29 l carcinomas for P2X5, P2X7, P2Y1, P2Y2, and P2Y4 receptors was performed, accompanied by detailed an

30 al tissues, while the expression of P2Y2 and P2Y4 receptors was up-regulated in GC cells.

31 P2Y4 receptors were found in basal cell carcinomas but n

32 in HUVEC was mediated by P2Y1, P2Y2, and/or P2Y4 receptors, whereas P2Y6, P2Y11, and P2X receptors w

33 5'-triphosphate, indicating the presence of P2Y4 receptors, whereas the P2Y1-specific agonist 2-meth

34 P2Y2 and P2Y4 receptors, which have 52% sequence identity, are bo

35 In contrast, stimulation of P2Y(4) receptors with UTP or P2Y(6) receptors with UDP p

36 t at human P2Y2 receptors and also activated P2Y4 receptors with an EC(50) of 85 nM.

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