ライフサイエンスコーパス: P2Y1 receptor

1 ted to act as competitive antagonists at the P2Y1 receptor.

2 ect on the capacity of MRS 2179 to block the P2Y1 receptor.

3 receptors supplements signaling through the P2Y1 receptor.

4 kidney 293 cells, which natively express the P2Y1 receptor.

5 and triphosphates are agonists at the human P2Y1 receptor.

6 3 and TM7 on the exofacial side of the human P2Y1 receptor.

7 enine nucleotide binding pocket of the human P2Y1 receptor.

8 ant modulatory role in ligand binding to the P2Y1 receptor.

9 urkey P2Y1 receptor and -36 mV for the human P2Y1 receptor.

10 were devoid of agonist activity at the human P2Y1 receptor.

11 cells stably expressing the human or turkey P2Y1 receptor.

12 response, continue to express the purinergic P2Y1 receptor.

13 ion of the genes encoding E-NTPDase2 and the P2Y1 receptor.

14 se agonists in platelets from mice that lack P2Y1 receptor.

15 created based on the X-ray structures of the P2Y1 receptor.

16 d P2Y12 receptor and the G(alpha)(q)-coupled P2Y1 receptor.

17 reatly reduced the antagonist potency at the P2Y1 receptor.

18 e, and that this response is mediated by the P2Y1 receptor.

19 greatly reduced the ability to interact with P2Y1 receptors.

20 rved in muscles with genetic deactivation of P2Y1 receptors.

21 purinergic neurotransmission is mediated via P2Y1 receptors.

22 in ventilation is mediated by ATP acting at P2Y1 receptors.

23 ediated responses in HEK293 cells expressing P2Y1 receptors.

24 at alpha,beta-methylene-ADP is an agonist at p2y1 receptors.

25 rough the cooperation of H1 and P2 (probably P2Y1) receptors.

26 s, NHERF binds to the tail of the purinergic P2Y1 receptor, a seven-transmembrane receptor with an in

27 P2Y1 receptor activation appears to be necessary and suf

28 PKC inhibitors prevented P2Y1 receptor activation of TRPV4.

29 The potent P2Y1 receptor agonist 2-methylthio-ATP (2-MeSATP) had no

30 P2Y2 receptor agonist UTP (p<0.001), and the P2Y1 receptor agonist 2MeSADP (p<0.05).

31 knockdown is refractory to activation by the P2Y1 receptor agonist ATP and shows aberrant purinergic

32 ration-dependent manner, indicating that the P2Y1 receptor alone mediates ADP-induced generation of t

33 reversal potential of -38 mV for the turkey P2Y1 receptor and -36 mV for the human P2Y1 receptor.

34 n identified as selective antagonists at the P2Y1 receptor and have been modified structurally to inc

35 , we conclude that ADP activates nPKCeta via P2Y1 receptor and is subsequently dephosphorylated by PP

36 adenosine 5'-triphosphate (ATP), binding to P2Y1 receptors and activating small conductance K(+) cha

37 dy provides a link between purine binding to P2Y1 receptors and activation of SK3 channels in PDGFRal

38 onto receptor (type II) cells by activating P2Y1 receptors and enhancing ATP secretion.

39 owed high levels of expression of purinergic P2Y1 receptors and SK3 K(+) channels in PDGFRalpha(+) ce

40 to ADPR, but not ADP, were inhibited by the P2Y1 receptor antagonist (1R,2S,4S,5S)-4-[2-iodo-6-(meth

41 The present study used the selective P2Y1 receptor antagonist MRS2500 (1 mum) and the nitric

42 completely absent in P2ry1(-/-) mice and the P2Y1 receptor antagonist MRS2500 had no effect on electr

43 l firing, an effect blocked by the selective P2Y1 receptor antagonist MRS2500.

44 didate from our in vitro screen (MRS 2179, a P2Y1 receptor antagonist) also improves histological and

45 ut not by AMP, and was inhibited by MRS2179 (P2Y1 receptor antagonist) but not by AR-C69931MX (P2Y12/

46 d its metabolite, ADP, whereas the selective P2Y1 receptor antagonist, MRS2179, partially attenuated

47 Pretreatment of platelets with MRS-2179, a P2Y1 receptor antagonist, or YM-254890, a G(q) blocker,

48 cture-activity of adenosine bisphosphates as P2Y1 receptor antagonists and have led to the identifica

49 osition of the adenine ring were more potent P2Y1 receptor antagonists than analogues containing vari

50 9-position of adenine, are moderately potent P2Y1 receptor antagonists.

51 lular space and the activation of peripheral P2Y1 receptors appear to participate in the generation o

52 ly, the results have indicated that although P2Y1 receptors are involved in the initiation of platele

53 beta-NAD is an agonist for P2Y1 receptors, as demonstrated by receptor-mediated res

54 Tail current analysis of the novel P2Y1 receptor-associated cation conductance revealed tha

55 ere specific for the phospholipase C-coupled P2Y1 receptor, because no agonistic or antagonistic effe

56 ding to at least two distinct domains of the P2Y1 receptor, both outside and within the TM core.

57 cribe specific competitive antagonism of the P2Y1 receptor by an adenine nucleotide derivative and pr

58 In addition, genetic knockdown of the P2Y1 receptor by in vivo application of short hairpin RN

59 drolysable ADP analogue, ADPbetaS, acting at P2Y1 receptors, caused robust local and spreading dilata

60 The P2Y1 receptor couples to Gq and mobilizes intracellular

61 versible and associated with purinergic type P2Y1 receptor desensitization.

62 ctivation of the novel cation current by the P2Y1 receptor does not involve a G protein.

63 These results indicate that the P2Y1 receptor exhibits both metabotropic properties and

64 ere weak antagonists in studies of the human P2Y1 receptor expressed in human Jurkat cells.

65 We also examine the possible contribution of P2Y1 receptors expressed in the RTN to the purinergic dr

66 e might explain this discrepancy of results, P2Y1 receptor-expressing 1321N1 cells were incubated for

67 e in Cl- current similar to that observed in P2Y1 receptor-expressing oocytes but had no effect on ca

68 d both the cation current and Cl- current in P2Y1 receptor-expressing oocytes with EC50 values and an

69 responses activated by the G protein-coupled P2Y1 receptor for ADP.

70 ort the cloning of a cDNA clone encoding the P2Y1 receptor from a human platelet cDNA library by homo

71 Costimulation of P2X1 and P2Y1 receptors generated a superadditive Ca(2+) increase

72 in the extracellular loops (EL) of the human P2Y1 receptor has been investigated.

73 nosine 5'-diphosphate (2-MeSADP) was lost in P2Y1 receptors having F226A, K280A, or Q307A mutations,

74 These results demonstrate the role of the P2Y1 receptor in ADP-induced platelet shape change and c

75 specific upregulation of the ADP-responsive P2Y1 receptor in the DRGs.

76 Inhibition of the P2Y1 receptor in the RTN had no effect on CO2 responsivn

77 Conversely, exogenous expression of P2Y1 receptors in Cx43-null cells restored their migrati

78 munication attributable to reduced levels of P2Y1 receptors in neural progenitor cells lacking Cx43 a

79 ATP in turn stimulates P2Y1 receptors in neurons.

80 that purines activate SK currents via mainly P2Y1 receptors in PDGFRalpha(+) cells.

81 The activation of P2Y1 receptors in platelets contributes to platelet aggr

82 Unilateral blockade of P2Y1 receptors in the preBotC via local antagonist injec

83 A new rhodopsin-based molecular model of the P2Y1 receptor indicated that the optimal docked orientat

84 three extracellular loops (ELs) of the human P2Y1 receptor indicates the existence of two essential d

85 We now report that activation of endogenous P2Y1 receptors induces inhibition of the M-current in ra

86 important than the alpha-phosphate in ligand/P2Y1 receptor interactions.

87 ADP-induced P2Y1 receptor internalization is attenuated by PKC inhib

88 The P2Y1 receptor is a G protein-coupled receptor (GPCR) and

89 The P2Y1 receptor is a membrane-bound G protein-coupled rece

90 The P2Y1 receptor is present in the heart, in skeletal and v

91 racellular signaling from both the P2TAC and P2Y1 receptors is essential for ADP-induced platelet agg

92 ndicating that coactivation of the P2Y12 and P2Y1 receptors is essential for this event.

93 a to purinergic agents demonstrated that the P2Y1 receptor-mediated increase in fictive inspiratory f

94 of excitability are caused, respectively, by P2Y1 receptor-mediated inhibition of a two-pore domain p

95 man endothelial cell migration by activating P2Y1 receptor-mediated MAPK pathways, possibly contribut

96 We performed a screen for P2Y1 receptor-mediated receptor tyrosine kinase transact

97 that ATP excitation of the preBotC involves P2Y1 receptor-mediated release of Ca(2+) from intracellu

98 Our observation that P2Y1 receptor-mediated responses involve Flt3 transactiv

99 P2Y1 receptor-mediated responses were enhanced in TRPV4-

100 Platelet P2X1 receptor-, but not P2Y1 receptor-, mediated increases in intracellular calc

101 Stimulation of P2Y1 receptors modulates the amplitudes of STHs.

102 kedly decreased expression of the purinergic P2Y1 receptor mRNA.

103 r antagonists at the phospholipase C-coupled P2Y1 receptor of turkey erythrocytes, at recombinant hum

104 The molecular basis for recognition by human P2Y1 receptors of the novel, competitive antagonist 2'-d

105 Expression of pannexin-1 and ADP-sensitive P2Y1 receptor on human subcutaneous fibroblasts was conf

106 The P2Y1 receptor on the neurones was identified as a metabo

107 presence of functional M-current-inhibitory P2Y1 receptors on hippocampal pyramidal neurons, as pred

108 eBotC astrocytes during hypoxia and acts via P2Y1 receptors on inspiratory neurons (and/or glia) to e

109 mediated by release of ATP and its action at P2Y1 receptors on morphologically identified neurones in

110 receptor whereas there is no synergy via the P2Y1 receptor or with thromboxanes.

111 The human P2Y1 receptor (P2Y1-R) was purified after high-level exp

112 In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation,

113 P2Y1 receptor (P2Y1R) structures showed two antagonists

114 rgic motor neurotransmission, acting through P2Y1 receptors (P2Y1R), mediates inhibitory neural contr

115 1 glutamate mGluR5 receptors and nucleotide P2Y1 receptors (P2Y1Rs) show promiscuous ion channel cou

116 flux stimulation) and at turkey erythrocyte P2Y1 receptors (phospholipase C activation).

117 e two disulfide bridges present in the human P2Y1 receptor play a major role in the structure and sta

118 ions (M-SMP) of rat colon was reduced by the P2Y1 receptor (R) antagonist 2'deoxy-N6-methyl adenosine

119 ate > or = 5'uridine-diphosphate, supports a P2Y1 receptor (R).

120 receptor apparently depends on the degree of P2Y1 receptor reserve.

121 On the other hand, the P2Y1 receptor selective antagonist, adenosine-2'-phospha

122 might act to trigger eye development through P2Y1 receptors, selective in Xenopus for ADP, we simulta

123 alcium flux that was completely blocked by a P2Y1 receptor-selective antagonist and was not cross-des

124 and shape change were unaffected by A3P5P, a P2Y1 receptor-selective antagonist, and/or cyproheptadin

125 enosine-2'-phosphate-5'-phosphate (A2P5P), a P2Y1 receptor-selective antagonist, inhibited ADP-induce

126 tive P2 receptor antagonist, and MRS-2179, a P2Y1 receptor-selective antagonist, reduced the prolifer

127 cells revealed that both isoforms regulated P2Y1 receptor signaling and trafficking, although only P

128 L 66096, but not by alpha, beta-MeATP or the P2Y1 receptor-specific antagonists, A3P5PS, A3P5P, or A2

129 ular calcium increases were inhibited by the P2Y1 receptor-specific antagonists, adenosine 3'-phospha

130 antagonists in studies with the cloned human P2Y1 receptor stably expressed in 1321N1 human astrocyto

131 d triphosphates was determined for the human P2Y1 receptor stably expressed in human 1321N1 astrocyto

132 f the analogues were more potent at P2X7 and P2Y1 receptors than 2, which acted in the micromolar ran

133 ically through interaction with the RAGE and P2Y1 receptors, thereby eliciting intracellular Ca(2+) r

134 s, is required for proper trafficking of the P2Y1 receptor to the cell surface.

135 e determine coupling of mGluR5 receptors and P2Y1 receptors to calcium channels.

136 spiratory rhythm-generating network acts via P2Y1 receptors to mediate this effect.

137 ion, release a gliotransmitter that acts via P2Y1 receptors to stimulate ventilation and reduce the s

138 first on activated satellite cells, and the P2Y1 receptor was also expressed on infiltrating immune

139 A computer-generated model of the human P2Y1 receptor was built and analyzed to help interpret t

140 The activity of each analogue at P2Y1 receptors was determined by measuring its capacity

141 The activity of each analogue at P2Y1 receptors was determined by measuring its capacity

142 The potency of nucleotide antagonists at P2Y1 receptors was enhanced by replacing the ribose moie

143 Strong immunostaining for P2Y1 receptors was shown in most cells in these cultures

144 nctional properties of the G protein-coupled P2Y1 receptor were investigated in Xenopus oocytes.

145 The P2X5 and P2Y1 receptors were expressed first on activated satelli

146 P2Y1 receptors were found in fetal keratinocytes positiv

147 distinct zones of the developing epidermis: P2Y1 receptors were found in the basal layer, P2X5 recep

148 P2Y1 receptors were only expressed in the stroma surroun

149 ocytes expressing either the human or turkey P2Y1 receptor with adenine nucleotide agonists resulted

150 phosphate) (7), was a full antagonist at the P2Y1 receptor with an IC(50) value of 0.48 microM.