ライフサイエンスコーパス: P2Y2 receptor

1 and ATP but not by diphosphate nucleotides (P2Y2 receptor).

2 play a major role in apical targeting of the P2Y2 receptor.

3 released ATP, which activates the purinergic P2Y2 receptor.

4 ctivated Cl- conductance is regulated by the P2Y2 receptor.

5 that is pharmacologically distinct from the P2Y2 receptor.

6 uding UTP, decrease ENaC activity via apical P2Y2 receptors.

7 shape, confirming the presence of functional P2Y2 receptors.

8 ere similar for the wild-type and all mutant P2Y2 receptors.

9 P2Y2 receptor activation by nucleotides thus provides ph

10 irway epithelial surface reach the range for P2Y2 receptor activation by physiological stimuli and id

11 criptase polymerase chain reaction) and that P2Y2 receptor activation is the principal means by which

12 n in A431 cell number (p<0.001), whereas the P2Y2 receptor agonist uridine 5'-triphosphate caused a s

13 the nonspecific P2 receptor agonist ATP, the P2Y2 receptor agonist UTP (p<0.001), and the P2Y1 recept

14 on of P2Y2-HA receptor-expressing cells with P2Y2 receptor agonists also resulted in receptor-specifi

15 ay goblet cells secrete mucin in response to P2Y2 receptor agonists and to secretagogues, phorbol 12-

16 Incubation of cells with P2Y2 receptor agonists resulted in a concentration of ag

17 Results indicated that the equipotent P2Y2 receptor agonists UTP or ATP (1-100 microm) stimula

18 ne further the signaling cascade between the P2Y2 receptor and MAP kinase.

19 tor subtypes, the Gq-coupled ATP/UTP-sensing P2Y2 receptor and the Gs-coupled A2b adenosine receptor.

20 Wild-type P2Y2 receptors and a series of five C-terminal truncatio

21 was equipotent to UTP as an agonist at human P2Y2 receptors and also activated P2Y4 receptors with an

22 teracting systems--extracellular nucleotides/P2Y2 receptors and neurotrophin/TrkA--to sustain neurona

23 UTP activates P2Y2 receptors and signals only through Gq/11.

24 protein kinase responses through endogenous P2Y2 receptors, and these responses were not blocked by

25 2, and P2Y13 receptors; the ATP/UTP-specific P2Y2 receptor; and the ATP-selective P2Y11 receptor.

26 cade immediately upstream of MAP kinase, the P2Y2 receptor appears to uniquely utilize [Ca2+]i, PKC,

27 lease and autocrine purinergic signaling via P2Y2 receptors are essential for PMN activation.

28 2X7 or P2Y2 receptor knock-out mice indicate P2Y2 receptors are involved in the activation of STAT3 a

29 , UTP, and ATPgammaS, an effect mediated via P2Y2 receptors, as demonstrated by small interfering RNA

30 lease and autocrine purinergic signaling via P2Y2 receptors at the front and A2a receptors at the bac

31 , which indicates upregulation of functional P2Y2 receptors at which UTP and ATP are equipotent agoni

32 ted that the activation of G-protein-coupled P2Y2 receptors by extracellular ATP and UTP stimulated M

33 addressed the hypothesis that activation of P2Y2 receptors by extracellular nucleotides modulates th

34 PANX1) channels and autocrine stimulation of P2Y2 receptors contribute to the excitatory signals at t

35 l roles in the human epidermis with P2Y1 and P2Y2 receptors controlling proliferation, while P2X5 and

36 , whereas inhibition by UTP, which activates P2Y2 receptors coupled to Gq/11 and Gi3, was not affecte

37 edullary thick ascending limbs isolated from P2Y2 receptor-deficient mice compared with wild type.

38 wing HlyA-induced IL-6 release was absent in P2Y2 receptor-deficient mice.

39 Molecular determinants of P2Y2 receptor desensitization and sequestration have bee

40 9-null endothelial cells was associated with P2Y2 receptor desensitization.

41 ine and adenine nucleotides with that of the P2Y2 receptor expressed in the same cells.

42 knockout mice, we propose that a blunting in P2Y2 receptor expression or activity is a new mechanism

43 kinase C activation, which desensitizes the P2Y2 receptor, had no effect on sequestration, consisten

44 uent activation of Gq/G11-coupled purinergic P2Y2 receptors have been shown to mediate fluid shear st

45 that gene-targeted (knockout) mice that lack P2Y2 receptors have salt-resistant arterial hypertension

46 ndicating the far-reaching importance of the P2Y2 receptor in mediating migration.

47 of mRNA expression for the G protein-coupled P2Y2 receptor in mouse thymocytes after the addition of

48 pes indicates the predominant involvement of P2Y2 receptor in P2X3 inhibition, and immunolocalization

49 These findings suggest a novel role for the P2Y2 receptor in the p38- and Rho kinase-dependent expre

50 tracellular nucleotide signaling through the P2Y2 receptor in the survival of neurons: PC12 (pheochro

51 identify a previously unrecognized role for P2Y2 receptors in blood pressure regulation that is link

52 ar ATP is mediated through the activation of P2Y2 receptors in hepatocytes.

53 ular injury, suggesting a potential role for P2Y2 receptors in monocyte recruitment by vascular endot

54 hat mitochondria deliver ATP that stimulates P2Y2 receptors in response to chemotactic cues, and that

55 Loss of collecting duct P2Y2 receptors in the knock-out mouse is the primary def

56 The pattern of responses implied that P2Y2 receptors in visceral, and probably vascular, smoot

57 logy model of the nucleotide-activated human P2Y2 receptor, including loops, termini, and phospholipi

58 ype is not yet known, but stimulation of the P2Y2 receptor increases IL-1-mediated PGE2 release.

59 These results suggest that the P2Y2 receptor-initiated activation of MAP kinase was dep

60 The data indicate that the P2Y2 receptor is activated with similar potencies by ATP

61 The targeting signal of the P2Y2 receptor is located between the N terminus and 7TM,

62 ATP release from renal epithelia, which via P2Y2 receptors is the main mediator of HlyA-induced [Ca(

63 ion that the G protein-coupled P2U receptor (P2Y2 receptor) is activated by UTP as well as ATP provid

64 oupled P2Y receptor that, like the mammalian P2Y2 receptor, is activated by both adenine and uridine

65 Similar studies performed on P2X7 or P2Y2 receptor knock-out mice indicate P2Y2 receptors are

66 prepared cardiomyocytes from B2 receptor or P2Y2 receptor knock-out mice, respectively.

67 These results suggest that P2Y2 receptors mediate the effects of purinoceptor agoni

68 dicate that the EGF receptor is required for P2Y2 receptor-mediated MAP kinase activation.

69 These results demonstrate that the P2Y2 receptor-mediated transactivation of the EGF recept

70 d contributes to hypertension that occurs in P2Y2 receptor-/- mice.

71 It is proposed that the rapid increase of P2Y2 receptor mRNA expression could be a common early ev

72 After wounding, the P2Y2 receptor mRNA expression increased, and after knock

73 mocytes, the observed rapid up-regulation of P2Y2 receptor mRNA expression may reflect an immediate e

74 e possibility that the observed increases in P2Y2 receptor mRNA expression were due to the enrichment

75 ollar placement caused rapid upregulation of P2Y2 receptor mRNA in medial SMCs before appearance of n

76 P2Y2 receptor mRNA is upregulated in intimal lesions of

77 Although UDP does not activate the human P2Y2 receptor, mucosal addition of UDP promoted [3H]inos

78 P2Y2 receptor mutants were localized in a similar manner

79 At recombinant human P2Y1 and P2Y2 receptors, (N)-methanocarba-ATP was 138- and 41-fol

80 The G-protein-coupled P2Y2 receptor (P2Y2-R) is abundantly expressed on the ai

81 We recently reported that the P2Y2 receptor (P2Y2R) is the predominant nucleotide rece

82 ted that activation of the G protein-coupled P2Y2 receptor (P2Y2R) subtype expressed in human 1321N1

83 rs in response to chemotactic cues, and that P2Y2 receptors promote mTOR signaling, which augments mi

84 s a reporter system for detection of ATP via P2Y2 receptor-promoted formation of [3H]inositol phospha

85 Agonist occupation of the P2Y2 receptor promotes inhibition of Na+ absorption as w

86 This detailed view of P2Y2 receptor recognition suggests mutations for model v

87 In addition, silencing P2Y2 receptors reduced the level of P2Y2 mRNA by 75% and

88 identify the apical targeting signal in the P2Y2 receptor, regions of the P2Y2 receptor were progres

89 S-2 and primary osteoblasts express P2Y1 and P2Y2 receptors, respectively.

90 ect on the capacity of nucleotides to induce P2Y2 receptor-specific desensitization.

91 ated the expression of P2X5, P2X7, P2Y1, and P2Y2 receptor subtypes in 8- to 11-wk-old human fetal ep

92 gated the expression of P2X5, P2X7, P2Y1 and P2Y2 receptor subtypes in normal human epidermis and in

93 Mutation of RGD to RGE had no effect on P2Y2 receptor targeting, indicating that receptor-integr

94 tion to confirming the presence of classical P2Y2 receptors, these results also provide functional ev

95 For one class of P2Y receptors, P2Y2 receptors, this stimulation of adenylyl cyclase and

96 These results illustrate that the P2Y2 receptor undergoes agonist-promoted movement to an

97 P2Y2 receptor up-regulation and activation induces intim

98 The Gq/phospholipase C-linked human P2Y2 receptor was tagged at its amino terminus with the

99 Agonist-induced internalization of P2Y2 receptors was demonstrated directly by prelabeling

100 ibition by ATP, which activates both P2X and P2Y2 receptors, was not affected by zero Ca2+ alone; but

101 signal in the P2Y2 receptor, regions of the P2Y2 receptor were progressively substituted with the co

102 th, 1321N1 cells stably expressing the human P2Y2 receptor were used as a reporter system for detecti

103 P2Y2 receptors were found only in periderm cells and may

104 P2X5 and P2Y2 receptors were heavily expressed in basal cell carc

105 ell transfectants expressing the recombinant P2Y2 receptor, whereas vector-transfected control cells