ライフサイエンスコーパス: PABP

1 PABP also interacts genetically and biochemically with E

2 PABP and eIF4B compete with eIF4A for binding eIFiso4G i

3 PABP binds several translation factors but is primarily

4 PABP cleavage did not affect eIF4GI-PABP interactions, a

5 PABP cleavage may be a common mechanism among certain vi

6 PABP did not significantly increase the rate of the conf

7 PABP has been found to stimulate translation initiation

8 PABP increases the efficiency of translation termination

9 PABP is a modular protein, with four N-terminal RNA-bind

10 PABP is able to bind the poly(A) tail of mRNA, as well a

11 PABP's function in translation termination depends on it

12 PABPs accelerate miRNA-mediated deadenylation, but this

13 ith the SG marker poly(A)-binding protein 1 (PABP-1), whereas inclusions in spinal cord, which contai

14 tein 3, and polyadenylate-binding protein 1 (PABP-1).

15 by the eukaryotic initiation factor (eIF) 4G/PABP/poly(A) tail interaction is achieved instead throug

16 und to be an mCRD-binding protein and also a PABP-interacting protein.

17 y and sufficient to regulate expression of a PABP TOP-containing reporter.

18 ure that may be responsible for binding to a PABP interacting protein, Paip1, and other shared intera

19 l elements of mRNA circularization, poly(A), PABP, and eIF4G.

20 iation time of a cooperatively bound poly(A)/PABP complex as compared with a noncooperatively bound o

21 However, approximately 50% of the poly(A)/PABP complexes exhibit a noncooperative binding conforma

22 t translational initiation, shifted mRNA-A3G-PABP from polysomes into stress granules in a manner tha

23 ntrol animals receiving MCT injection alone (PABP 49.67+/-3.22 mmHg; RV/WH ratio 0.290+/-0.0265; wall

24 genome and by interactions with 2C, 3A, and PABP.

25 -related protein-4 (LARP4) binds poly(A) and PABP.

26 s assessed mechanisms whereby aldolase C and PABP control NF-L expression.

27 of mRNAs by simultaneously binding CAF1 and PABP.

28 there are interaction domains for eIF4A and PABP and we identify, for the first time, the interactio

29 Moreover, the eIF4B and PABP binding domains overlap.

30 A binding domain overlaps with the eIF4B and PABP binding domains.

31 c promoted the interaction between eIF4B and PABP but not the interaction between eIF4B and eIF4A or

32 These studies show that eIF4B and PABP enhance the interaction with the cap and probably a

33 However, when both eIF4B and PABP were present, not only was the energy barrier reduc

34 eIFiso4G was also observed between eIF4B and PABP.

35 promoting the interaction between eIF4B and PABP.

36 , respectively, in the presence of eIF4B and PABP.

37 osition, marked by dissociation of eIF4G and PABP, and by recruitment of DDX6.

38 f the core mRNP components eIF4E, eIF4G, and PABP and of the decay factor DDX6 in human cells.

39 In contrast, eIF3, G3BP, eIF4G, and PABP-1 are restricted to SGs, whereas DCP1a and 2 are co

40 ever, the relative importance of eIF4GII and PABP cleavage has not been determined.

41 onal repression of unlocalized grk mRNA, and PABP and Enc facilitate translational activation of the

42 nd disrupted the association between TYF and PABP.

43 Interaction between UNR and PABP is necessary for the full destabilization function

44 tly measure interactions between poly(A) and PABPs.

45 Wheat PABP differs from animal PABP in that its RRM1 does not bind RNA as an individual

46 Although animal PABPs are well-studied proteins, the biological role, th

47 of cross-regulation between the Arabidopsis PABPs that belong to different classes but are simultane

48 urodegenerative disease-related proteins are PABPs.

49 with 2-[N-(alpha-picolyl)amino]benzophenone (PABP)] 2 via alkyl halide alkylations and Michael additi

50 The interaction between PABP and eIFiso4G was also stimulated by zinc but requir

51 ults demonstrate a novel interaction between PABP and several plant proteins sharing a SxLnpxApxFxP m

52 Lsm/LsmAD domain and indirectly via binding PABP that is itself directly bound to mRNA.

53 ression, which interferes with poly(A)-bound PABP, precluding PABP-enhanced microRNA-mediated inhibit

54 grated with other PAM2 protein activities by PABP as part of mRNA homeostasis.

55 viral replication compartments surrounded by PABP.

56 ection, only 25 to 35% of the total cellular PABP is cleaved; therefore, we hypothesized that the poo

57 ble database of experimentally characterized PABPs.

58 Also, 3C(pro) is more efficient in cleaving PABP in ribosome-enriched fractions than 2A(pro) in vitr

59 ble to immunoprecipitate BC1 RNA, confirming PABP's presence in the BC1 RNP.

60 C domain interaction between two consecutive PABPs promotes cooperative binding.

61 m cells/neurons) and/or limiting cytoplasmic PABP (e.g., viral infection, cell stress).

62 ePAB is the predominant cytoplasmic PABP in Xenopus oocytes and early embryos and prevents d

63 Thus, cytoplasmic PABP accumulation is translationally controlled in HCMV-

64 The DB-PABP is a comprehensive, manually curated and searchable

65 The DB-PABP is maintained at the University of Kansas.

66 The DB-PABP was implemented as a MySQL relational database.

67 Assaying RNA-dependent PABP-eIF4G association in cell extracts suggests that RN

68 validating that this is the sole detectable PABP cleavage site.

69 The kinetic effects of eIF4B, PABP, and wheat germ eIFiso4F with two mRNA cap analogue

70 l as other initiation factors (eIF4A, eIF4G, PABP, and eIF3).

71 PABP cleavage did not affect eIF4GI-PABP interactions, and the results of kinetics experimen

72 th explain little of the variation in either PABP association or mRNP organization more generally.

73 We find that C. elegans PABPs are required for miRNA-mediated silencing in embry

74 we implicate the two Caenorhabditis elegans PABPs (PAB-1 and PAB-2) in miRNA-mediated silencing, and

75 The 5' UTR within the mRNA encoding PABP contains a terminal oligopyrimidine (TOP) element f

76 ical and biochemical depletion of endogenous PABP increases the instability of the transcript suggest

77 In contrast, eight expressed PABP genes are present in Arabidopsis thaliana.

78 t eukaryotes examined have only one or a few PABPs.

79 the nature of the essential requirement for PABP in yeast.

80 onic mRNAs and resulted in a requirement for PABP.

81 c reporter, thus showing the requirement for PABP.

82 ive mode is the most stable conformation for PABPs binding onto the poly(A).

83 t ICP27 and UL47 jointly displace Paip2 from PABP.

84 for a particular modulator of PABP function, PABP-interacting protein 2a (PAIP2A), in the normal term

85 f the nucleophilic glycine equivalent Ni-Gly-PABP [Ni(II) complex of glycine Schiff base with 2-[N-(a

86 rget mRNA deadenylation, and identify GW182, PABP, and deadenylase subunits CAF1 and CCR4 as factors

87 As little is known about how PABP can interact with RNA and three distinct translatio

88 from the reticulocyte lysate with anti-human PABP antibody, the cytosolic factor did not inhibit tran

89 s reveal a novel direct involvement of human PABP in the stabilization of mRNA by protecting the 5' e

90 , therefore, is reminiscent of that of human PABP-interacting protein 2 (Paip2).

91 d domain (SxLnpnApxFxP) in common with human PABP-CT interactors, and with Arabidopsis ERD15 (early-r

92 Surprisingly, ICP27-PABP-eIF4G complexes act independently of the effects of

93 Importantly, we find that ICP27-PABP forms a complex with, and requires the activity of,

94 on structural information concerning type II PABPs and an example of a single RRM domain protein that

95 nd are relevant to understanding how type II PABPs function in mRNA processing and human disease.

96 Remarkably, preventing the rise in PABP abundance by RNAi impaired eIF4E binding to eIF4G,

97 inding to their overlapping binding sites in PABP by preferentially promoting the interaction between

98 ing protein (PABP), significantly increasing PABP abundance.

99 Instead, HCMV-induced PABP accumulation resulted from new protein synthesis an

100 While virus-induced PABP accumulation did not require p70 S6K, it was inhibi

101 e, zebrafish and Drosophila further involved PABPs in microRNA (miRNA)-mediated silencing, but throug

102 This LARP4 activity requires its PABP-interaction domain and the RNA-binding module which

103 nical translation factor, eIF4G, which lacks PABP- and cap binding complex-interacting domains, is re

104 hat includes the RNA-binding proteins Larp1, PABP, and Ago2.

105 a commonality matrix, a function of listing PABPs by the number of interacting polyanions and a stri

106 Here we demonstrate that the minor PABP isoform PABPC4 is expressed in erythroid cells and

107 tally determined (HYD) and homology modeled (PABP) protein surfaces revealed a conserved feature that

108 nts include the RNA binding proteins Modulo, PABP, and Smooth, the known localization factor Swallow,

109 to enhance formation of activated eIF4F*mRNA*PABP complexes competent to recruit 43S pre-initiation c

110 pping functions in forming native eIF4G*mRNA*PABP complexes.

111 e extracts was almost completely in A3G-mRNA-PABP complexes that shifted reversibly between polysomes

112 mmunofluorescence microscopy showed A3G-mRNA-PABP stress granules only partially overlapping with Sta

113 In human ALS spinal cord neurons, PABP accumulates abnormally, suggesting that prolonged s

114 Here, we establish that new PABP synthesis is translationally controlled by the HCMV

115 sPABPN1 has a domain architecture of nuclear PABPs (PABPNs) with a single RNA recognition motif (RRM)

116 ells, where PABP is redistributed to nuclei, PABP accumulated in the cytoplasm of HCMV-infected cells

117 F4G protein levels, the overall abundance of PABP mRNA, together with the half-life of the polypeptid

118 ition was poly(A) dependent, and addition of PABP to extracts restored translation.

119 2 decapping activity reduced the affinity of PABP for cap association and consequently its ability to

120 The specific association of PABP with the cap occurred only within the context of th

121 ng, suggestive of a regulated association of PABP with the cap.

122 as microRNAs, influence the associations of PABP and other core factors, and do so without substanti

123 In addition, binding of PABP to poly(A) RNA stimulates 3C(pro)-mediated cleavage

124 Binding of PABP to the RNA 5' end required the presence of the cap

125 g poly(A) tails, suggesting that cleavage of PABP and IRES trans-activating factors polypyrimidine tr

126 ), like PV 3C(pro), mediates the cleavage of PABP as part of its strategy to inhibit cellular transla

127 d the substrate determinants for cleavage of PABP by 2A protease (2A(pro)) or 3C protease (3C(pro)).

128 t translation shutoff, requiring cleavage of PABP by 3Cpro and of eIF4G by 2Apro.

129 bit cap-poly(A) synergy, partial cleavage of PABP by 3Cpro inhibited translation of endogenous mRNAs

130 These results suggest that cleavage of PABP contributes to viral translation shutoff that is re

131 ecific proteins accumulated, and cleavage of PABP occurred in virus-infected cells.

132 efines a unique mechanism whereby control of PABP abundance regulates eIF4F assembly.

133 o interact with the carboxy terminus (CT) of PABP in yeast two-hybrid and in vitro binding assays.

134 data illustrate the importance of the CTD of PABP in poly(A)-dependent translation in mammalian cells

135 f these polypeptides modulates the degree of PABP-mediated enhancement of mRNA expression.

136 proteases separated the C-terminal domain of PABP that binds translation factors eIF4B and eRF3 from

137 make direct contact with the MLLE domain of PABP, and their competition for the MLLE is thought to r

138 F3 from the N-terminal RNA-binding domain of PABP.

139 The effect of PABP cleavage by the norovirus r3CL(pro) was analyzed in

140 omplexes act independently of the effects of PABP-eIF4G on cap binding to promote small ribosomal sub

141 s its levels of expression when an excess of PABP is transiently provided in trans.

142 These results show that the function of PABP in mRNA biogenesis alone could be sufficient to sup

143 nhibited, as shown by immunoprecipitation of PABP followed by quantitation of the poly(A) tail by rev

144 Immunoprecipitation of PABP-associated ribonucleoprotein complexes of human spi

145 tosolic inhibitor blocked the interaction of PABP with the poly(A) tail or with eIF4G.

146 virus infection and that the interaction of PABP with translation initiation factors, ribosomes, or

147 nting LARP4 PAM2w interacts with the MLLE of PABP within the affinity range measured for other PAM2 m

148 unctional role for a particular modulator of PABP function, PABP-interacting protein 2a (PAIP2A), in

149 nd eIF4B interact with distinct molecules of PABP to increase the stability of the interaction betwee

150 RNA-binding protein, as a binding partner of PABP that interacts with PABP in an RNA-independent mann

151 therefore, we hypothesized that the pool of PABP associated with polysomes may be preferentially tar

152 tion was markedly reduced in the presence of PABP.

153 s more than 5-fold slower in the presence of PABP.

154 have investigated what cleavage products of PABP are produced in vivo and the substrate determinants

155 n representing the C-terminal end of RRM1 of PABP that overlaps with the N-proximal eIFiso4G interact

156 n domain for eIF4G is present in the RRM1 of PABP, whereas eIFiso4G interacts at two sites, i.e. one

157 nc controls the partner protein selection of PABP such that the interaction with eIF4B is preferred o

158 An antibody against the C terminus of PABP is able to immunoprecipitate BC1 RNA, confirming PA

159 The N-terminus of PABP is responsible for the high binding specificity and

160 r a comprehensive and searchable database of PABPs.

161 evelopment through the direct recruitment of PABPs.

162 Our results refine the roles of PABPs in miRNA-mediated silencing and support a model wh

163 th the poly(A) tail exacerbate dependency on PABP for deadenylation, more potent miRNA-binding sites

164 icantly, Paip2 accumulation was dependent on PABP accrual, as preventing PABP1 accumulation suppresse

165 agment identified a 3C(pro) cleavage site on PABP between amino acids Q437 and G438, severing the C-t

166 Mutagenesis of the RNA binding or PABP interaction motifs decrease LARP4 association with

167 4A with eIFiso4G in the presence of eIF4B or PABP.

168 y reduced in the presence of either eIF4B or PABP.

169 Thus, a better understanding of PA/PABP interactions may not only enhance our understanding

170 n of 3Cpro in HeLa cells resulted in partial PABP cleavage and similar inhibition of translation.

171 PC1, but not its physiologic binding partner PABP-interacting protein 2 (Paip2), in the nucleus.

172 cumber ( Cucumis sativus L.) proteins, PCI6 (PABP-CT-interacting) and PCI243 were identified based on

173 esting that the diversification of the plant PABP genes has occurred prior to the split of monocots a

174 onal structure and RNA-binding mode of plant PABPs remain largely uncharacterized.

175 Such a high complexity of the plant PABPs might enable a very fine regulation of organismal

176 which enhanced binding of eIF4G and possibly PABP with 100k protein, and simultaneous interaction wit

177 terferes with poly(A)-bound PABP, precluding PABP-enhanced microRNA-mediated inhibition and canonical

178 nt reduction in pulmonary arterial pressure (PABP, 31.67+/-6.03 mmHg, P<0.01), an attenuation of righ

179 The norovirus r3CL(pro) PABP cleavage products were indistinguishable from those

180 hat 3C(pro) plays a major role in processing PABP during virus infection and that the interaction of

181 further indicate that RNA1 and Box1 promote PABP binding, in addition to RNA binding, by the eIF4G1

182 tion with PABP that is sufficient to promote PABP recruitment and necessary for ICP27-mediated activa

183 o by the cytoplasmic poly(A)-binding protein PABP through a direct and specific binding to the 5' end

184 ase (3Cpro) cleaves poly(A)-binding protein (PABP) and removes the C-terminal domain (CTD) that inter

185 f stress granules, poly (A) binding protein (PABP) and TIA-1, appear to be present in the oocyte RNP

186 mains for eIF4E and poly(A)-binding protein (PABP) are thought to enhance formation of activated eIF4

187 decided to examine poly(A) binding protein (PABP) as a candidate member of the RNP.

188 hown here that the poly (A)-binding protein (PABP) binds the body of the NF-L transcript and increase

189 Cleavage of poly(A)-binding protein (PABP) by 3C(pro) has been shown to be a necessary compon

190 studies showed that poly(A)-binding protein (PABP) enhanced the cap binding of eIFiso4F about 40-fold

191 script excludes the poly(A)-binding protein (PABP) from the complex.

192 vage of eIF4GII and poly(A)-binding protein (PABP) has been recently proposed to contribute to comple

193 ere found to cleave poly(A)-binding protein (PABP) in the absence of other viral proteins.

194 We show that Cup and polyA-binding protein (PABP) interact physically with Sqd and with each other i

195 bundant cytoplasmic poly(A) binding protein (PABP) is a highly conserved multifunctional protein, man

196 Poly(A)-binding protein (PABP) is a major component of the messenger RNA-protein

197 Eukaryotic poly(A)-binding protein (PABP) is a ubiquitous, essential factor involved in mRNA

198 Poly(A) binding protein (PABP) is an essential, well-conserved, multifunctional p

199 A FLAG-tagged poly(A)-binding protein (PABP) is expressed in a specific tissue and mRNA from th

200 nctional homolog of poly(A) binding protein (PABP) known as nonstructural protein 3 (NSP3) for transl

201 The poly(A)-binding protein (PABP) recognizes the 3' mRNA poly(A) tail and plays an e

202 fection on the host poly(A)-binding protein (PABP) remains unknown.

203 ssociate with polyadenylate-binding protein (PABP) suppressed behavioral rhythms and decreased abunda

204 E), eIF4G, and poly(A) tail-binding protein (PABP) that circularizes mRNAs, promoting translation and

205 oly(A) tail and the poly(A)-binding protein (PABP) to achieve maximal IRES-mediated translational eff

206 ins aldolase C and poly (A)-binding protein (PABP) undergo competitive interactions in cells coexpres

207 by interactions of poly(A)-binding protein (PABP) with both the poly(A) tail and initiation factor e

208 iation of the polyadenylate-binding protein (PABP) with the cap-binding complex.

209 The poly(A)-binding protein (PABP), a key component of different ribonucleoprotein co

210 h polyribosomes and poly(A)-binding protein (PABP), a key regulator of mRNA translation.

211 The poly(A)-binding protein (PABP), a protein that contains four conserved RNA recogn

212 ncoding eIF4E, Larp1, polyA binding protein (PABP), and Ago2.

213 A, eIF4G, eIF3, the poly(A)-binding protein (PABP), and RNA.

214 on factor eIF4G and poly(A)-binding protein (PABP), and strongly and selectively enhances the level o

215 ap-binding complex, poly(A)-binding protein (PABP), as well as per and tim transcripts.

216 sis of the cellular poly(A) binding protein (PABP), significantly increasing PABP abundance.

217 il becomes bound by poly(A) binding protein (PABP), which in turn binds eIF4G and helps it displace M

218 y(A) tail (PAT) and poly(A)-binding protein (PABP).

219 F-associated factor poly(A) binding protein (PABP).

220 A and interact with poly(A) binding protein (PABP).

221 nteracting with the poly(A) binding protein (PABP).

222 anslation regulator poly(A)-binding protein (PABP).

223 as well as cellular poly(A) binding protein (PABP).

224 rs, mRNA, rRNA, and poly(A) binding protein (PABP).

225 the cellular polyadenylate-binding protein (PABP).

226 ss granule component, polyA-binding protein (PABP).

227 eraction with polyadenylate-binding protein (PABP).

228 eIF4GI, poly(A)-binding protein (PABP)1, eIF3, eIF4AI, and eIF2alpha coimmunopurify with

229 Poly(A)-binding proteins (PABPs) are multifunctional proteins that play important

230 otides (poly A) and poly A binding proteins (PABPs) for optimal expression, we complexed synthetic mR

231 anions (PAs) and polyanion-binding proteins (PABPs) have been found to play significant roles in many

232 Cytoplasmic poly(A)-binding proteins (PABPs) link mRNA 3' termini to translation initiation fa

233 Poly(A)-binding proteins (PABPs) play crucial roles in mRNA biogenesis, stability,

234 Poly(A) binding proteins (PABPs) specifically bind the polyadenosine tail of mRNA

235 eins interact with poly(A)-binding proteins (PABPs), which are critical for the initiation of transla

236 and A3F, including poly(A)-binding proteins (PABPs), YB-1, Ro-La, RNA helicases, ribosomal proteins,

237 ons of the cognate poly(A)-binding proteins (PABPs).

238 ail and associated poly(A)-binding proteins (PABPs).

239 bacterially expressed 3C cleaved recombinant PABP in vitro in the absence of any virus-encoded or euk

240 partially rescued by addition of recombinant PABP in vitro.

241 hat tissue is thus tagged by the recombinant PABP and separated from mRNA in other tissues by co-immu

242 iverse RNA-binding proteins directly recruit PABP, in a non-poly(A) tail-dependent manner, to stimula

243 a structurally similar but distantly related PABP/HYD domain.

244 Expression of 3C(pro) cleavage-resistant PABP in cells increased translation of nonreplicating vi

245 Further, expression of cleavage-resistant PABP in cells reduced the accumulation of viral RNA and

246 fected cells expressing a cleavage-resistant PABP variant, viral RNA synthesis and infectious virus p

247 ction of this activity, the levels of RPS17, PABP, eEF1A, and eEF2 proteins are also diminished in DM

248 es and RNA-binding mode of a Citrus sinensis PABP (CsPABPN1).

249 Vertebrates encode six PABP isoforms that vary in abundance, distribution, deve

250 he EMCV 3C proteinase mediates site-specific PABP cleavage and demonstrate that PABP cleavage by 3C r

251 that EMCV infection stimulates site-specific PABP proteolysis, resulting in accumulation of a 45-kDa

252 se was necessary and sufficient to stimulate PABP cleavage in uninfected cells, and bacterially expre

253 whereas the C-terminus is known to stimulate PABP multimerization on poly(A).

254 s poly(A) nuclease(s) to the 3' poly(A) tail-PABP complex.

255 minal sequencing of the resulting C-terminal PABP fragment identified a 3C(pro) cleavage site on PABP

256 thermore, we have identified four N-terminal PABP cleavage products produced during PV infection and

257 lting in accumulation of a 45-kDa N-terminal PABP fragment in virus-infected cells.

258 -specific PABP cleavage and demonstrate that PABP cleavage by 3C regulates EMCV replication.

259 Our findings indicate that PABP-eIF4G association is only one of several interactio

260 an in vitro translation system, we show that PABP directly stimulates translation termination.

261 Our results show that PABP in ribosome-enriched fractions is preferentially cl

262 Based on our findings, we suggest that PABP enhances the productive binding of the eRF1-eRF3 co

263 ansposition process, these data suggest that PABP may contribute to the SINE retrotransposition proce

264 nstability of the transcript suggesting that PABP shields the NF-L mRNA from aldolase attack.

265 The PABP interaction domains for eIF4G and eIFiso4G were dis

266 in Azoospermia-like (Dazl), also employs the PABP-eIF4G interaction in a similar manner.

267 t eIF4G1 can functionally substitute for the PABP-binding segment to rescue the function of an eIF4G1

268 slational activation and the function of the PABP-eIF4G complex in translation initiation.

269 tivate translation initiation as part of the PABP-eIF4G-eIF4E complex that stimulates the initial cap

270 conserved region, an x-ray structure of the PABP-like segment of the human HYD protein has been dete

271 Fluorescence stopped-flow studies of the PABP.eIFiso4F protein complex with cap show a concentrat

272 ion in cell extracts suggests that RNA1, the PABP-binding domain, and two conserved elements (Box1 an

273 line with previous studies showing that the PABP C-terminal domain also interacts with additional pr

274 leavage and a competing interaction with the PABP.

275 nd eIFiso4G exhibited competitive binding to PABP, supporting the overlapping nature of their interac

276 lly cleaved in vitro and in vivo compared to PABP in other fractions.

277 Although total PABP levels were unchanged, HSV-1 infection prompted acc

278 Using glutathione S-transferase-PABP pull-down and proteomic analyses, we identified sev

279 F2alpha in the pioneer round of translation, PABP-interacting protein 2, which is known to destabiliz

280 transposon and a nonfunctional transposase (PABP 44.33+/-4.04 mmHg; RV/WH ratio 0.280+/-0.01; wall t

281 ition vector, we examined the effects of two PABPs (encoded by PABPN1 and PABPC1) on the retrotranspo

282 ation (i.e., the internal arrangement of two PABPs on a poly(A) streak in which the C-termini face to

283 ooperative binding conformation of wild-type PABPs indicates that the C-C domain interaction doubles

284 mphasize that closed-loop mRNP formation via PABP-eIF4G interaction is non-essential in vivo.

285 Wheat PABP differs from animal PABP in that its RRM1 does not

286 of the protein interaction domains in wheat PABP was investigated.

287 When PABP was depleted from the reticulocyte lysate with anti

288 a- or gammaherpesvirus-infected cells, where PABP is redistributed to nuclei, PABP accumulated in the

289 Paradoxically, while PABP accumulation promotes human cytomegalovirus (HCMV)

290 mediates a physical interaction of ATX2 with PABP in addition to promoting ATX2 assembly with polyrib

291 sults suggest that ORF transit combined with PABP function contribute to interactions between ribosom

292 dent, and replenishment of the extracts with PABP restored translation.

293 FUS to stress granules and interaction with PABP are RNA dependent.

294 We reveal a direct interaction with PABP that is sufficient to promote PABP recruitment and

295 binding partner of PABP that interacts with PABP in an RNA-independent manner.

296 mammalian neurons MKRN1-short interacts with PABP to locally control the translation of dendritic mRN

297 nal dendrites, MKRN1-short co-localizes with PABP in granule-like structures, which are morphological

298 nd in proteins that interact physically with PABP.

299 he post-transcriptional level, compared with PABPs of other eukaryotes.

300 synthetic mRNA containing a poly A tail with PABPs in a stoichiometric manner and stabilized the ribo