ライフサイエンスコーパス: PACAP receptor

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1 sence of PACAP-6-38, an antagonist at type-I PACAP receptor.

2 g PACAPR TM4 and splice variant forms of the PACAP receptor.

3 sis contain cells that display authentic VIP/PACAP receptors.

4 PTSD and are known to have high densities of PACAP receptors.

5 ry adenylate cyclase-activating polypeptide (PACAP) receptor 1 (PAC1) signaling regulates neural prec

6 /PACAP are mediated through the specific VIP/PACAP receptor-1 and the cAMP/protein kinase A (PKA) tra

7 These data suggest that PACAP receptor activation in posterior BNST subregions c

8 administration elevated BNST PACAP, and BNST PACAP receptor activation was necessary and sufficient f

9 tivated cells express mRNA for all three VIP/PACAP receptors, agonist and antagonist studies indicate

10 he above data suggest that PACAP, the type-I PACAP receptors, and adenylyl cyclase play a role in the

11 modulator has ever been reported for the VIP/PACAP receptors, and there is a lack of specific VPAC(2)

12 ion stimulated MSK1 phosphorylation, whereas PACAP receptor antagonist infusion attenuated light-indu

13 Acute CeA infusions with the PACAP receptor antagonist PACAP(6-38) blocked chronic co

14 epolarization was insensitive to the type II PACAP receptor antagonist PACAP6-38.

15 nsmission, with either PACAP6-38, a specific PACAP receptor antagonist, or anti-PACAP antibodies, aug

16 PACAP and VIP was competitively inhibited by PACAP-receptor antagonist (IC50, 10(-)9 mol/L, 3 x 10(-)

17 Treatment with the PACAP receptor antagonists PACAP 6-38 (PACAP type I rece

18 Given our previous findings that PACAP receptors couple to AC, the present results demons

19 se enzymes or endocytosis to block endosomal PACAP receptor extracellular signal-regulated kinase sig

20 ore, a single nucleotide polymorphism in the PACAP receptor gene ADCYAP1R1, adenylate cyclase activat

21 Tumors from PACAP/ptc1 mutant mice retained PACAP receptor gene expression, and exhibited superinduc

22 hese findings in human physiology, the human PACAP receptor gene was cloned.

23 ry adenylate cyclase activating polypeptide (PACAP) receptor gene generates four major splice variant

24 Expression of PACAP receptors in neuroendocrine rather than nonneuroen

25 otype of PACAPR TM4 is characteristic of the PACAP receptor involved in regulation of insulin secreti

26 ry adenylate cyclase-activating polypeptide (PACAP) receptor is a class II G protein-coupled receptor

27 When Glu activates the system, PACAP receptor-mediated processes can provide gain contr

28 erior pituitary hormones by interacting with PACAP receptors on pituitary cells.

29 PACAP and PACAP receptor (PAC(1)) mRNA's were detected at embryoni

30 de (PACAP) is present in gastric nerves, and PACAP receptors (PAC1) are found on gastric enterochroma

31 from the previously cloned short form of the PACAP receptor (PACAPR) primarily by discrete sequences

32 interacting with both PACAP-selective type I PACAP receptors (PACAPRs) and type II PACAPRs that do no

33 PACAP receptor (PACR1) stimulation triggered both G(i)al

34 Molecular cloning of the PACAP receptor revealed the existence of five splice var

35 l line HP75, which expresses all three major PACAP receptors, showed that both PACAP-38 and PACAP-27

36 cts of PACAP are determined by expression of PACAP receptor splice isoforms and differential coupling

37 Here, we report cloning of a novel PACAP receptor variant, designated PACAPR TM4 (transmemb

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