ライフサイエンスコーパス: PADI4

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1 ated with the RA susceptibility haplotype of PADI4.

2 PADI4 (also called PAD4 or PADV), the only PADI with a n

3 We further demonstrate how eQTL in PADI4 and NOD2 delineate risk variant function in rheuma

4 hat the expression and enzymatic activity of Padi4 are also induced under conditions of ground-state

5 sults provide support for PTPN22, CTLA4, and PADI4 as RA susceptibility genes and demonstrate novel a

6 Peptidylarginine deiminase 4 (PAD4/PADI4) counteracts the functions of protein Arg methyltr

7 for intraductal aggregate formation and that PADI4-deficiency abrogates disease progression.

8 4_92*G/C, and padi4_104*T/C), mapping to the PADI4 gene and defining a haplotype previously reported

9 Polymorphisms in the PADI4 gene influence the immune response to the PAD-4 pr

10 ingle-nucleotide polymorphisms (SNPs) in the PADI4 gene with RA in a UK population.

11 stocompatibility complex region and from the PADI4 gene.

12 pe of the peptidylarginine deiminase 4 gene (PADI4) has recently been identified as a gene conferring

13 driver analysis identifies six genes (LTB4R, PADI4, IL1R2, PPP1R3D, KLHL2, and ECHDC3) predicted to c

14 ptidylarginine deiminase 4 (PAD4, encoded by Padi4 in mice), an enzyme important in chromatin deconde

15 ullination by peptidyl arginine deiminase-4 (PADI4) in contact to particulate agents to extrude decon

16 Experimental models indicate that PADI4 is critical for intraductal aggregate formation an

17 Padi4 is part of the pluripotency transcriptional networ

18 ne deiminase family member PAD4 (also called PADI4) is markedly overexpressed in a majority of human

19 Wound healing was accelerated in Padi4(-/-) mice as compared to WT mice, and it was not c

20 NETs in wounds, but this was not observed in Padi4(-/-) mice.

21 of CTLA4 (CT60 allele, OR 1.23; P=.001) and PADI4 (PADI4_94, OR 1.24; P=.001) with the development o

22 rotein modification; suggestively, Padi2 and Padi4 RNA expression was correlated with arthritis sever

23 he generation of compact chromatin, as novel PADI4 substrates.

24 A PADI4 susceptibility haplotype associated with RA in a J

25 nes include LTF, LCN2, MMP9, S100A8, S100A9, PADI4, TGFBI, and CYBB.

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