ライフサイエンスコーパス: PAF acetylhydrolase

1 lost after pretreatment of the extract with PAF acetylhydrolase.

2 e rate of degradation, which is catalyzed by PAF acetylhydrolase.

3 are hydrolyzed and inactivated by the enzyme PAF acetylhydrolase.

4 positive cells now contained an abundance of PAF acetylhydrolase.

5 line-treated animals contained no detectable PAF acetylhydrolase.

6 s proinflammatory actions are antagonized by PAF acetylhydrolase.

7 activating factor (PAF) and is also known as PAF acetylhydrolase.

8 thological actions, and it is inactivated by PAF acetylhydrolase.

9 is hydrolyzed and inactivated by the enzyme PAF-acetylhydrolase.

10 PAF acetylhydrolase 1b (PAFAH1B) hydrolyzes PAF and is c

11 bunits of type I platelet-activating factor (PAF) acetylhydrolase, a phospholipase A(2) with selectiv

12 Miwa et al. reported that PAF acetylhydrolase activity is absent in 4% of the Japa

13 clonal antibody (MAb), 2B11, neutralized the PAF acetylhydrolase activity of SsE.

14 erum PAF levels and a concurrent decrease in PAF acetylhydrolase activity.

15 Plasma PAF-acetylhydrolase activity increased 2-fold by 24 h fo

16 Plasma PAF acetylhydrolase, an enzyme that hydrolyzes PAF and s

17 PAF acetylhydrolase, an oxidized phospholipid phospholip

18 bunit of a brain platelet-activating factor (PAF) acetylhydrolase, an enzyme that inactivates PAF by

19 Enzymes associated with HDL such as PAF acetylhydrolase and paraoxonase can participate in t

20 ms at determining whether SsE(M28) is also a PAF acetylhydrolase and participates in innate immune ev

21 es not associate with LDL), the mutant mouse PAF acetylhydrolase associated with lipoproteins.

22 PAF acetylhydrolase catalyzes the degradation of PAF and

23 is association defines the physical state of PAF acetylhydrolase, confers a long half-life, and is a

24 We asked if PAF acetylhydrolase deficiency correlates with the incid

25 We found that the prevalence of PAF acetylhydrolase deficiency is higher in Japanese ast

26 Recombinant PAF-acetylhydrolase degrades PAF generated by NMDA-recep

27 Plasma samples from subjects deficient in PAF acetylhydrolase do not release F2-isoprostanes from

28 In human plasma, PAF acetylhydrolase (EC 3.1.1.47) circulates in a comple

29 ccumulated in oxLDL with a recombinant human PAF acetylhydrolase eliminated the inhibitory effects of

30 We examined the regulation of PAF acetylhydrolase expression and demonstrated the admi

31 The up-regulation of the plasma-type PAF acetylhydrolase expression constitutes an important

32 d WEB 2170, inhibited by 50% the increase in PAF acetylhydrolase expression in response to LPS.

33 e tissues examined, the greatest increase in PAF acetylhydrolase expression was observed in lung foll

34 n Kupffer cells were established in culture, PAF-acetylhydrolase expression became constitutively act

35 Alterations in plasma-type PAF-acetylhydrolase expression may constitute an importa

36 Human plasma platelet-activating factor (PAF) acetylhydrolase functions by reducing PAF levels as

37 aining the 5' genomic sequence of the plasma PAF acetylhydrolase gene and further characterized the p

38 a donor with an inactivating mutation in the PAF acetylhydrolase gene did not hydrolyze oxidized phos

39 We conclude that the PAF acetylhydrolase gene is a modulating locus for the s

40 A missense mutation (V279F) in the PAF acetylhydrolase gene results in the complete loss of

41 examined the regulation of expression of the PAF acetylhydrolase gene.

42 found that both the intracellular and plasma PAF acetylhydrolases have high affinity for esterified F

43 t PAFAH1B2, but not its family member plasma PAF acetylhydrolase, hydrolyzed aspirin, and PAF competi

44 The intracellular PAF acetylhydrolase II, which shares homology to the pla

45 lotting did not reveal detectable amounts of PAF acetylhydrolase in PON1 preparations, although very

46 n of LPS resulted in increased expression of PAF acetylhydrolase in several tissues.

47 In addition, this enzyme acted as a PAF-acetylhydrolase in the absence of lipid acceptor mol

48 H1B2 or PAFAH1B3, and the competitive type I PAF acetylhydrolase inhibitor NaF reduced erythrocyte hy

49 We conclude that intracellular type I PAF acetylhydrolase is the major aspirin hydrolase of hu

50 We show that inherited deficiency of PAF acetylhydrolase is the result of a point mutation in

51 We conclude that PAF acetylhydrolase is the sole phospholipase A(2) of HD

52 ciency of plasma platelet-activating factor (PAF) acetylhydrolase is an autosomal recessive syndrome

53 These data on the molecular basis of the PAF acetylhydrolase-LDL association provide a new level

54 poprotein (apo) B100 in the formation of the PAF acetylhydrolase-LDL complex, we tested the ability o

55 an important mechanism for elevating plasma PAF-acetylhydrolase levels and an important component in

56 ospholipids turnover in vivo and the role of PAF acetylhydrolase/Lp-PLA(2) in this process.

57 1 preparations, although very low amounts of PAF acetylhydrolase might still account for PON1 phospho

58 exposure with the production of plasma-type PAF acetylhydrolase mRNA and protein expression specific

59 alyzed the tissue distribution of the plasma PAF acetylhydrolase mRNA in humans.

60 Additionally, the expression of PAF acetylhydrolase mRNA increased in circulating leukoc

61 ial cells were responsible for the increased PAF-acetylhydrolase mRNA levels.

62 inistration had no effect on the increase in PAF-acetylhydrolase mRNA seen at 24 h.

63 demonstrated very low levels of plasma-type PAF-acetylhydrolase mRNA transcripts in the livers of sa

64 llowing LPS exposure, a 20-fold induction of PAF-acetylhydrolase mRNA was detected.

65 In Kupffer cells, plasma-type PAF-acetylhydrolase mRNA was induced by 12 h, peaked at

66 tain barely detectable levels of plasma-type PAF-acetylhydrolase mRNA, when Kupffer cells were establ

67 comigrates with platelet-activating factor (PAF) acetylhydrolase on KBr density gradients.

68 is can also be blocked by co-incubation with PAF acetylhydrolase, or a PAF receptor antagonist.

69 evolved to target PAF by characterizing the PAF acetylhydrolase (PAF-AH) activity and substrate spec

70 PAF acetylhydrolase (PAF-AH) degrades PAF and regulates

71 PAF acetylhydrolase (PAF-AH) is a recently isolated natu

72 PAF acetylhydrolase (PAF-AH), which is known to hydrolyz

73 e inactive metabolite lyso-PAF by the enzyme PAF acetylhydrolase (PAF-AH).

74 e plasma form of platelet-activating factor (PAF) acetylhydrolase (PAF-AH), also known as lipoprotein

75 These lipid mediators are inactivated by PAF-acetylhydrolase (PAF-AH).

76 y inactive lyso-PAF by cellular and secreted PAF-acetylhydrolase (PAF-AH).

77 A single enzyme (plasma PAF acetylhydrolase [PAF-AH] or lipoprotein-associated p

78 se (PAF-CPT), and its main catabolic enzyme (PAF acetylhydrolase; PAF-AH), on U937 cells, in cell fre

79 from reduced turnover due to lower levels of PAF acetylhydrolase (PAFAH), the enzyme that catabolizes

80 riming was restored by HDL or HDL-associated PAF acetylhydrolase (PAFAH), which mediates inactivation

81 Our results suggested that PAF acetylhydrolases play key roles in the hydrolysis of

82 tor (PAF)-like lipids in L5 by a recombinant PAF acetylhydrolase prevented both FGF-2 downregulation

83 The abundance of PAF acetylhydrolase production in the liver lobule likel

84 There are multiple regions in the PAF acetylhydrolase promoter that contain responsive ele

85 A crystal structure is also presented of PAF acetylhydrolase reacted with the organophosphate com

86 -BB rats were treated with human recombinant PAF acetylhydrolase (rPAF-AH), which efficiently inactiv

87 of termination of PAF action by recombinant PAF-acetylhydrolase (rPAF-AH) were investigated.

88 inflammatory activities of recombinant human PAF-acetylhydrolase (rPAF-AH), which converts PAF to bio

89 The platelet-activating factor (PAF) acetylhydrolase SsE produced by GAS is required for

90 internalized, and overexpression of PLA2g7 (PAF acetylhydrolase) that specifically hydrolyzes such o

91 inactive metabolite, lysoPAF, by the enzyme PAF acetylhydrolase, the activity of which has shown to

92 which can be prevented by co-incubation with PAF acetylhydrolase, the enzyme that catabolizes PAF in

93 rolase-LDL complex, we tested the ability of PAF acetylhydrolase to bind to lipoproteins containing t

94 PON1 purification by first depleting HDL of PAF acetylhydrolase to find PON1 purified in this way no

95 Studies using PAF acetylhydrolase transgenic mice indicated that these

96 domains within the primary sequence of human PAF acetylhydrolase, tyrosine 205 and residues 115 and 1

97 When residues 115 and 116 from human PAF acetylhydrolase were introduced into mouse PAF acety

98 e (LPS) significantly inhibited synthesis of PAF acetylhydrolase, whereas other cytokines, including

99 F acetylhydrolase were introduced into mouse PAF acetylhydrolase (which normally does not associate w

100 PAF is effectively and tightly regulated by PAF acetylhydrolases, which convert PAF back to lysoPAF.

101 apoB plays a key role in the association of PAF acetylhydrolase with LDL.