ライフサイエンスコーパス: PAG

1 PAG at 1 mm had no effect on HPV recorded in control PSS

2 PAG MBE thus demonstrates electrophoretic assays with mi

3 PAG was characterized to be meso- and macroporous, with

4 comparable after enoxaparin initiation (14% PAG v 10% AG).

5 cted a survey of members of Beyond Celiac (a PAG), collecting responses from 1832 U.S. adults ages 19

6 uals diagnosed with CeD who participate in a PAG.

7 HPV in rat IPA by generating sulphide via a PAG-sensitive pathway, presumably CSE.

8 o support an appropriate response, activated PAG LepRb neurons, which project to and activate parabra

9 Furthermore, activating PAG LepRb neurons increased SNS activity and blood gluco

10 activation during rejection in the amygdala, PAG and subgenual anterior cingulate cortex (sgACC), sug

11 Using phosphoproteomic analysis, PAG showed low levels of tyrosine phosphorylation in res

12 ogenous opioid release in the dorsal ACC and PAG was positively correlated with placebo-induced reduc

13 ioid system activation in the dorsal ACC and PAG, and as a trend, negatively with NEO Angry Hostility

14 s a dual role in modulating the amygdala and PAG in juveniles, we pharmacologically disinhibited each

15 UCS-evoked responses in both amygdala and PAG were inhibited by expectation.

16 These increases in the ARC and PAG were abolished by systemic pretreatment with L-N(G)-

17 u-opioid receptor activity in POM, BSTm, and PAG may underlie previous links identified between undir

18 ved mast cells (BMMCs) with PAG knockout and PAG knockdown and the corresponding controls.

19 cular plating additives (SPS, Imep, PEI, and PAG) used in the semiconductor industry for the on-chip

20 f the mu-opioid receptor in the thalamus and PAG and could have implications for treatment of neuropa

21 [(35)S]GTPgammaS binding in the thalamus and PAG of CCI mice, with no change in the rACC.

22 2 phosphorylation in cells treated with anti-PAG siRNA or in PAG/Cbp-knockout (KO) cells.

23 s with significant differences between arms (PAG v AG) included muscle spasms (13% v 1%), neutropenia

24 multiprotein complexes that are found around PAG over 5 min of activation.

25 we compared functional connectivity between PAG and a subset of brain areas involved in nociceptive/

26 t significantly reduced connectivity between PAG, prefrontal regions, and anterior cingulate compared

27 The CSE blocker PAG (dl-propargylglycine) significantly reduced the ampl

28 r potential vanilloid (TRPV1) receptors, but PAG microinjection of a TRPV1 receptor antagonist (capsa

29 CAT antagonist aspartate (1 mm) and also by PAG.

30 hat this release was strongly antagonized by PAG, indicating that at this concentration PAG could ent

31 at the adjustment to temperature extremes by PAG corals was facilitated by the positive selection of

32 he functional integrity of the dorsal caudal PAG is not essential for reflex micturition.

33 on when microinjected into the dorsal caudal PAG, microinjection of BIC at these sites evoked pronoun

34 In caudal PAG, activity was localized to the ventrolateral region.

35 G and the ventrolateral column of the caudal PAG.

36 PTP1B regulated the interaction between CBP/PAG and CSK.

37 hosphorylated, the transmembrane protein CBP/PAG at Tyr-317, resulting in CSK recruitment.

38 In these cells, PAG/Cbp dephosphorylation is promoted by the PS1/gamma-s

39 y PAG, indicating that at this concentration PAG could enter cells intact and antagonize CSE.

40 Moreover, LPI depolarizes PAG neurons and upon intra-PAG microinjection, reduces n

41 chers from localizing responses to different PAG subregions.

42 he following: main effects of task in dorsal PAG and right LC; and main effect of temperature in RVM

43 ts either received stimulation of the dorsal PAG (dPAG) or stimulation of closely adjacent structures

44 ioning, electrical stimulation of the dorsal PAG (dPAG) produced unconditional responses (URs) compos

45 ors generated by the PAG, such as the dorsal PAG generating avoidance behavior, the lateral PAG gener

46 Stimulation in the dorsal PAG increased the firing of pre-I neurons, resulting in

47 increase in c-Fos expression in dorsolateral PAG (dlPAG) following the SR test in the brains of rats

48 ve reported previously that the dorsolateral PAG (dlPAG) exhibits a small but reliable increase in ne

49 To examine PAG function in humans, researchers have relied primaril

50 ting with the Zn finger transcription factor PAG-3/Gfi to induce peptidergic neuron identity and dire

51 ronectin (FN)-coated polyacrylamide gels (FN-PAG) and on FN-coated pillars used as a micro-force sens

52 ted adhesion stimulated cell spreading on FN-PAG, and this was modulated by the substrate stiffness.

53 ification was knocked in the gene coding for PAG to determine the composition and dynamics of the mul

54 Our findings provide a model of the role for PAG in mouse primary CD4(+) T cells that is consistent w

55 y CeD care, and highlight an opportunity for PAGs to bring together patients and HCPs to improve mana

56 When BMMCs from PAG-knockout mice were activated via the KIT receptor, e

57 and cervical levels that were labelled from PAG and LPb, and to investigate morphological difference

58 opatterned free-solution-polyacrylamide gel (PAG) stacking interface at the head of the MBE microchan

59 ded in a thin layer of a polyacrylamide gel (PAG).

60 ith PEGPH20 plus nab-paclitaxel/gemcitabine (PAG) or nab-paclitaxel/gemcitabine (AG).

61 ated precatalyst with a photoacid generator (PAG) in the presence of ultraviolet light resulted in a

62 d a series of nonionic photoacid generators (PAGs) for carboxylic and sulfonic acids based on N-hydro

63 PA) of the endocytosed photoacid generators (PAGs).

64 accumulation of procyclin-associated genes (PAGs), these being co-transcribed by RNA polymerase I wi

65 SIV) virions with protein A-conjugated gold (PAG) nanoparticles using negative-stain electron microsc

66 ere evaluated using polyaluminum granulates (PAG) with high content of aluminum nanoclusters.

67 strate in rats that the periaqueductal gray (PAG) affects motor systems at the following multiple lev

68 The periaqueductal gray (PAG) and amygdala are known to be important for defensiv

69 project to the midbrain periaqueductal gray (PAG) and the paraventricular nucleus of the thalamus, tw

70 el caudally through the periaqueductal gray (PAG) and then ventrally through the lateral lemniscus to

71 visions of the midbrain periaqueductal gray (PAG) are intricately (and differentially) involved in in

72 ncy have identified the periaqueductal gray (PAG) as a key brainstem structure implicated in endogeno

73 The periaqueductal gray (PAG) coordinates behaviors essential to survival, includ

74 euroinflammation in the periaqueductal gray (PAG) drives tolerance.

75 ons between the DMN and periaqueductal gray (PAG) dynamically tracked spontaneous attention away from

76 t parts of the midbrain periaqueductal gray (PAG) in the cat generates four different types of vocali

77 The periaqueductal gray (PAG) is a brain region involved in nociception modulatio

78 The periaqueductal gray (PAG) is an important center that controls spinal nocicep

79 The ventrolateral periaqueductal gray (PAG) is an important neuronal network site for mediating

80 The midbrain periaqueductal gray (PAG) is involved in many basic survival behaviors that a

81 ENT We demonstrate that periaqueductal gray (PAG) microglia contribute to the sexually dimorphic effe

82 vels in dissociated rat periaqueductal gray (PAG) neurons, which express GPR55 mRNA.

83 ons in the amygdala and periaqueductal gray (PAG) of rats during fear conditioning.

84 he hypothalamus and the periaqueductal gray (PAG) of the midbrain.

85 co-injections into the periaqueductal gray (PAG) or into the spinal subarachnoid space.

86 The periaqueductal gray (PAG) orchestrates survival behaviors, with the dorsal (d

87 The midbrain periaqueductal gray (PAG) plays a central role in the descending control of v

88 which the mesencephalic periaqueductal gray (PAG) plays a central role, as demonstrated by the fact t

89 The midbrain periaqueductal gray (PAG) region is organized into distinct subregions that c

90 cts to the amygdala and periaqueductal gray (PAG) to modulate emotional responses.

91 oglia activation in the periaqueductal gray (PAG), a central locus mediating the antinociceptive effe

92 ectivity (rs-fc) of the periaqueductal gray (PAG), a key region in the descending pain modulatory sys

93 PEs were encoded in the periaqueductal gray (PAG), a structure important for pain control and learnin

94 (LepRb neurons) in the periaqueductal gray (PAG), the largest population of LepRb neurons in the bra

95 lateral portion of the periaqueductal gray (PAG), the Su3 and PV2 nuclei of the ventrolateral PAG, t

96 divisions, amygdala and periaqueductal gray (PAG).

97 ain structures plus the periaqueductal gray (PAG).

98 accumbens, amygdala and periaqueductal gray (PAG).

99 terminalis (BSTm), and periaqueductal gray (PAG).

100 a, midline thalamus and periaqueductal gray (PAG).

101 c-Fos expression in the periaqueductal gray (PAG).

102 dividual columns of the periaqueductal grey (PAG) during breathlessness and its conditioned anticipat

103 The midbrain periaqueductal grey (PAG) lies at the heart of the defence-arousal system and

104 CC (rACC), thalamus and periaqueductal grey (PAG) of CCI and sham-operated mice.

105 he caudal ventrolateral periaqueductal grey (PAG), but not at other sites in the PAG, either depresse

106 c nucleus, STN) and the periaqueductal grey (PAG), which have now been recorded from in humans during

107 al frontal pole (mFP) and periaquiduct grey (PAG) are significantly greater in the verum acupuncture

108 also participate in patient advocacy groups (PAGs) for education and support.

109 ral communities in the Persian/Arabian Gulf (PAG) withstand unusually high salinity levels and regula

110 transmembrane adaptor protein PAG/CBP (here, PAG) is expressed in multiple cell types.

111 E10 epitope also showed significantly higher PAG association after CD4 ligation and incubation with 4

112 We identified PAG as a substrate of PTP1B, and dephosphorylation aboli

113 In PAG, however, DAMGO E(max) values did not significantly

114 nalgesia involves endocannabinoid actions in PAG.

115 cose concentrations, while ablating LepRb in PAG neurons augmented glucose mobilization in response t

116 ng to the short separation lengths needed in PAG MBE, we reduced the separation channel length to dem

117 n in cells treated with anti-PAG siRNA or in PAG/Cbp-knockout (KO) cells.

118 The lack of a blatant phenotype in PAG-deficient mice has impeded our understanding of the

119 e results also suggest that CB1 receptors in PAG are critical for mediating post-ictal analgesia in G

120 Here we investigate how these individual PAG columns are differently involved with respiratory th

121 (SOM(+)) neurons, which can directly inhibit PAG neurons, and some of which innervate both the PAG an

122 ed in the lateral column of the intermediate PAG and howls and hisses in the ventrolateral column of

123 the ventrolateral column of the intermediate PAG.

124 inoid (CB1) receptor antagonist (AM251) into PAG.

125 in, whereas As(V) diffused up to 81 mum into PAG.

126 251 (100 and 200, but not 50 pmol/side) into PAG significantly decreased post-ictal analgesia in GEPR

127 The descending facilitatory actions of intra-PAG PGs play a direct and central role in the maintenanc

128 , LPI depolarizes PAG neurons and upon intra-PAG microinjection, reduces nociceptive threshold in the

129 ved in ventrolateral PAG (vlPAG) and lateral PAG (lPAG), where activity scaled with breathlessness in

130 teral PAG, and aspects of the dorsal lateral PAG, appear to be key communicating circuitry for 'centr

131 istive loading, with activity in the lateral PAG (lPAG) during resistive loading, revealing spatially

132 timulation in the medial part of the lateral PAG converted the pre-I neurons into inspiratory phase-s

133 imulation in the lateral part of the lateral PAG generated an early onset of the pre-I neuronal disch

134 G generating avoidance behavior, the lateral PAG generating fight and flight, and the ventrolateral P

135 imulation in the ventral part of the lateral PAG induced tachypnea but inhibited pre-I cell firing, w

136 uclei, whereas those confined to the lateral PAG preferentially labeled hypothalamic and midbrain aud

137 e manner, the PAG, in particular the lateral PAG, and aspects of the dorsal lateral PAG, appear to be

138 tified in a crescentic column of the lateral PAG, as well as in the Edinger-Westphal, the lateral hab

139 halamus, and the periaqueductal gray matter (PAG) are involved in these circuits; so, too, are the br

140 ions such as the periaqueductal gray matter (PAG) plays a critical role in acute and chronic pain.

141 The periaqueductal gray matter (PAG), a known modulator of somatic pain transmission, sh

142 ct mainly to the periaqueductal grey matter (PAG), predominantly ipsilaterally.

143 Injections in the medial PAG produced dense label within hindbrain auditory nucle

144 ith glycosphingolipid-enriched microdomains (PAG).

145 ysis of a model protein sample, microfluidic PAG MBE baseline-resolved species in 5 s and in a separa

146 l neurobiotin injections into the midshipman PAG to both map its auditory-vocal circuitry and allow e

147 eine was abolished by pretreatment with 1 mm PAG.

148 The nanoporous PAG molecular sieve physically induces a mobility shift

149 t MAb or CD4-only (no MAb) showed negligible PAG association, as did a vesicle-rich fraction devoid o

150 tracing studies revealed that nearly 50% of PAG-projecting VMHdm/c neurons send collateral projectio

151 However a detailed analysis of PAG c-Fos expression provided hints about some of the ph

152 on the sensory and autonomic consequences of PAG activation.

153 both the EphB2-induced dephosphorylation of PAG/Cbp and the phosphorylation of ephrinB2.

154 EphB2 induces tyrosine dephosphorylation of PAG/Cbp in a gamma-secretase-dependent manner.

155 dence from our own and other laboratories of PAG control of motor outflow is also discussed.

156 We found moderate levels of PAG associated with unliganded HIV-1 and SIV virions inc

157 Significantly higher levels of PAG were associated with CD4-liganded HIV-1 (epitope-pos

158 The role of PAG as a negative regulator of immunoreceptor signaling

159 These findings suggest an important role of PAG in post-ictal analgesia.

160 Irradiation of PAGs in acetonitrile (ACN) using UV light above 410 nm r

161 Thus, decreased leptin action on PAG LepRb neurons augments the autonomic response to nox

162 osine phosphorylation of ephrinB2 depends on PAG/Cbp because EphB2 cannot increase ephrinB2 phosphory

163 pitulates the effects of TbNMD3 depletion on PAG mRNAs and mRNAs accumulated in the nucleus of TbNMD3

164 nted with microdialysis probes in the ARC or PAG.

165 kidney (HEK293) cell extracts overexpressing PAG/Cbp, we show that EphB2 induces tyrosine dephosphory

166 the MSCs of human major SGs, namely parotid (PAG), sublingual (SLG) and submandibular (SMG) glands.

167 Tyrosine-phosphorylated PAG serves as an anchor for C-terminal SRC kinase, an in

168 Looking forward, we see the low-power PAG MBE as a basis for highly multiplexed protein separa

169 te vocalization by activating the prefrontal-PAG-NRA-motoneuronal pathway, and, at the same time, the

170 nd in nNOS-knockout (KO) mouse preparations, PAG shifted the transwall gradient in the depolarizing d

171 asing H2S donor GYY4137 and propargylglycin (PAG), an inhibitor of cystathionine-gamma-lyase (CSE), a

172 that the CSE inhibitor dl-propargylglycine (PAG, 500 mum) had no effect on the transwall gradient.

173 ulature, demonstrated that propargylglycine (PAG, 1 mm) had little or no effect on the NPV caused by

174 The transmembrane adaptor protein PAG/CBP (here, PAG) is expressed in multiple cell types.

175 d-enriched microdomains/Csk binding protein (PAG/Cbp), an adaptor protein that controls the activity

176 ptide via lentiviral vector injection in rat PAG to sequester soluble TNF (solTNF), we demonstrate th

177 in patients with HA-high tumors who received PAG.

178 o regions, the lateral column of the rostral PAG and the ventrolateral column of the caudal PAG.

179 In the rostral PAG, activity was localized to lateral and dorsomedial s

180 antly, the individual strength of the spinal-PAG coupling predicted individual pain ratings highlight

181 connectivity and more dynamic resting state PAG-DMN functional connectivity were associated with the

182 pain; and (iii) across individuals, stronger PAG-DMN structural connectivity and more dynamic resting

183 The newly synthesized PAGs exhibited positive solvachromatic emission (lambda(

184 support for the hypothesis that the teleost PAG is centrally involved in auditory-vocal integration.

185 Thus, the teleost PAG may have functional subdivisions playing different r

186 entral striatum, amygdala, midline thalamus, PAG, anterior insula and ACC are rich in MORs and compri

187 These results demonstrate that PAG microglia are sexually dimorphic in both basal and L

188 However, animal studies indicate that PAG analgesia is mediated largely via caudal brainstem s

189 The combined data indicate that PAG can function as both a positive and a negative regul

190 h former biochemical studies indicating that PAG is constitutively phosphorylated in resting T cells

191 sition of fear conditioning, indicating that PAG may be an important part of the pathway that relays

192 These findings show that PAG stimulation changes the activity of the pre-Botzinge

193 Our data show that PAG-deficient BMMCs exhibit impaired antigen-induced deg

194 In vivo experiments showed that PAG is a positive regulator of passive systemic anaphyla

195 The data suggest that PAGs may be an attractive alternative PDT modality to se

196 The PAG has also been implicated in auditory-vocal integrati

197 The PAG receives strong projections from higher limbic regio

198 The PAG, LC, and RVM were anatomically discriminated using a

199 ch fear conditioning naturally activated the PAG.

200 The changes of rs-fc among the PAG, rACC and ventral striatum were significantly associ

201 fish depend on vocal communication, and the PAG is a central component of the midshipman vocal-motor

202 escending pain-modulatory system such as the PAG, the hypothalamus, and the amygdala.

203 ated the functional relationship between the PAG and amygdala in two different settings, fear conditi

204 ional resting-state connectivity between the PAG and brain regions with a predominant role in pain mo

205 ectional pattern of connectivity between the PAG and known sites in both the descending vocal-motor a

206 The reduced rs-fc between the PAG and rACC/mPFC was associated with increased migraine

207 oA patients showed reduced rs-fc between the PAG and rostral anterior cingulate cortex/medial prefron

208 dings show stronger connectivity between the PAG and several brain areas within nociceptive and somat

209 After treatments, rs-fc between the PAG and the rACC in MwoA patients significantly increase

210 eurons, and some of which innervate both the PAG and paraventricular nucleus of the thalamus.

211 hough morphine is thought to act in both the PAG and RVM by pre-synaptic inhibition of inhibitory GAB

212 However, the information encoded by the PAG during these survival behaviors is poorly understood

213 integration of sensorimotor functions by the PAG is considered, as part of coordinated defence behavi

214 ith the different behaviors generated by the PAG, such as the dorsal PAG generating avoidance behavio

215 ic), which was critical for dissociating the PAG from the greater signal variability in the aqueduct.

216 rwhelming evidence of a pivotal role for the PAG in coordinating motor responses essential to surviva

217 eus failed to reduce changes evoked from the PAG and actually enhanced the increase in T(co).

218 p down control of sensory functions from the PAG, including selective control of different modalities

219 esults move us towards understanding how the PAG might be intricately involved in human responses to

220 strength (7-T) fMRI techniques to image the PAG at high resolution (0.75 mm isotropic), which was cr

221 onal vocal expressions are segregated in the PAG and that the PAG uses the NRA as a tool to gain acce

222 An early imbalance in TE events in the PAG arm led to a clinical hold; thereafter, patients wit

223 maximal, a field potential was evoked in the PAG by the auditory fear conditioned stimulus (CS).

224 hat increased activation of microglia in the PAG contributes to the attenuated response to morphine o

225 demonstrated by the fact that lesions in the PAG lead to complete mutism in cats, monkeys, as well as

226 that interfering with GPR55 signaling in the PAG may promote analgesia.

227 In the PAG of arthritic, but not naive, rats, there is enhanced

228 induced greater microglia activation in the PAG of females compared with males and was accompanied b

229 ts and establish that TLR4 inhibition in the PAG of females reverses the sex differences in morphine

230 The number of c-Fos-labeled cells in the PAG was generally low but there was a reliable increase

231 al grey (PAG), but not at other sites in the PAG, either depressed reflex voiding frequency (-60%, n

232 enerated by neurochemical stimulation in the PAG.

233 lgesia in several brain sites, including the PAG, and generalized seizures result in endocannabinoid

234 how an effective treatment can influence the PAG rs-fc in MwoA patients.

235 entifies novel neural pathways that link the PAG to fear-evoked motor responses.

236 ata are viewed in an integrative manner, the PAG, in particular the lateral PAG, and aspects of the d

237 Moreover, the PAG also fulfils many requirements of a command centre.

238 ive images segregated into subregions of the PAG along both dorsal/ventral and rostral/caudal axes.

239 Due to the recent formation of the PAG and its subsequent shift to a hot climate, these cor

240 Pharmacological inactivation of the PAG attenuated UCS-evoked responses in the amygdala and

241 as to examine functional connectivity of the PAG in migraine.

242 etermining how the individual columns of the PAG interact with higher cortical centres, both at rest

243 leted cells we confirm the regulation of the PAG transcripts by TbNMD3 and using reporter constructs

244 tudinally oriented functional modules of the PAG, but overlaps none of them.

245 y of symbiotic algae across >5,000 km of the PAG, the Gulf of Oman, and the Red Sea coastline, we sho

246 rolateral to the aqueduct on the edge of the PAG.

247 revealing the functional architecture of the PAG.

248 during stimulation in different parts of the PAG.

249 neurons in all 4 longitudinal columns of the PAG.

250 the insula and attentional activation of the PAG.

251 ymbionts cryptically distributed outside the PAG.

252 mporary fear-conditioning models present the PAG as downstream of the amygdala, directing the appropr

253 Animal data indicate that the PAG acts via caudal brainstem structures to control noci

254 ction-resistant cells also suggests that the PAG plays a role in encoding fear memories.

255 We hypothesized that the PAG promotes these behaviors by changing the firing of p

256 sions are segregated in the PAG and that the PAG uses the NRA as a tool to gain access to the motoneu

257 prefrontal cortex and the projections to the PAG and brainstem can be studied with precision.

258 vides an expected value-related input to the PAG, which then conveys PE signals to prefrontal regions

259 In turn, the PAG has strong access to the caudal medullary nucleus re

260 More importantly, using the PAG monomer N-(p-vinylbenzenesulfonyloxy)anthracene-1,9-

261 al responses to threat in animals, while the PAG has previously only been considered as a single enti

262 iumvirate in attentional analgesia: with the PAG activated by attentional load; specific RVM regions

263 e density of microglia were noted within the PAG of male or female rats, microglia exhibited a more "

264 aracterization of MD-2 expression within the PAG revealed dense MD-2 expression throughout the vlPAG.

265 ation with pronociceptive actions within the PAG under normal conditions.

266 One of these PAGs, which had a significantly lower dark cytotoxicity

267 This PAG-EMG coupling was only present for the onset of freez

268 in anxiety and pain in which the amygdala to PAG pathway is also implicated.

269 Blockade of morphine binding to PAG TLR4 with (+)-naloxone potentiated morphine antinoci

270 ify projections from cervical enlargement to PAG and LPb, to determine the proportion of spinothalami

271 In patients with HA-high tumors (PAG v AG), the objective response rate was 45% versus 31

272 Various PAG configurations are characterized, with injection dis

273 imbic mPFC, the medial amygdala, and ventral PAG.

274 context conditional stimuli, neither ventral PAG nor BLA stimulation supported fear conditioning.

275 In contrast, stimulation of ventral PAG and the basolateral amygdalar complex (BLA) evoked f

276 haracterized dopamine neurons in the ventral PAG (vPAG)/dorsal raphe (DR) region are a potentially cr

277 and decreased FOS expression in the ventral PAG.

278 g pattern of activity from dorsal to ventral PAG along the rostrocaudal axis mirrors structural and f

279 rity of synapses in the caudal ventrolateral PAG is essential to permit micturition.

280 via projections to the caudal ventrolateral PAG, as part of the behavioural response to psychologica

281 Activation was observed in ventrolateral PAG (vlPAG) and lateral PAG (lPAG), where activity scale

282 in rats that activation of the ventrolateral PAG (vlPAG) affects motor systems at multiple levels of

283 We showed activity in the ventrolateral PAG (vlPAG) during anticipation of resistive loading, wi

284 ting fight and flight, and the ventrolateral PAG generating freezing and immobility.

285 ng, whereas stimulation in the ventrolateral PAG inhibited not only pre-I cells but also the diaphrag

286 the Su3 and PV2 nuclei of the ventrolateral PAG, the cuneiform nucleus, the mesencephalic reticular

287 ode A-nociceptive information, even after VL-PAG COX-1 inhibition, whereas the encoding of C-nocicept

288 instem ventrolateral periaqueductal grey (VL-PAG), which control the spinal processing of nociceptive

289 Inhibition of VL-PAG COX-1 in anaesthetised rats increased firing thresho

290 we determined the effect of inhibition of VL-PAG COX-1 on dorsal horn wide dynamic-range neurons evok

291 1 (COX-1)-prostaglandin system within the VL-PAG alters spinal nociceptive reflexes evoked by C-nocic

292 rgic descending control mechanisms in the VL-PAG.

293 s, with the dorsal (dPAG) and ventral (vPAG) PAG concerned respectively with innate and learnt fear r

294 nderstanding of the mechanisms through which PAG exerts its negative-regulatory role in TCR signaling

295 ase PTPN22 and lipid phosphatase SHIP-1 with PAG following T cell activation suggests that both coope

296 bone marrow-derived mast cells (BMMCs) with PAG knockout and PAG knockdown and the corresponding con

297 (ephrinB2/CTF2), which forms complexes with PAG/Cbp when introduced exogenously.

298 Inhibition of CSE with PAG resulted in increased viral replication and chemokin

299 PFS was significantly improved with PAG treatment overall (hazard ratio [HR], 0.73; 95% CI,

300 intrinsic resting-state correlations within PAG networks and the average monthly frequency of migrai