ライフサイエンスコーパス: PAK kinase

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1 self, as well interacting with its effector, Pak kinase.

2 robe derived from the kinase domain of a rat PAK kinase.

3 k3, a member of the serine/threonine group I PAK kinases.

4 PF kinases, whose closest relatives are the PAK kinases.

5 mologous to mammalian p21-activated kinases (PAKs) (kinases activated by the rho-class GTPase Rac or

6 We investigated Pak kinase activation in more detail to gain insight int

7 PAK kinase activity and subcellular distribution are tig

8 This effect on PAK kinase activity closely parallels Nischarin's abilit

9 Inhibition of Pak kinase activity dramatically decreased phosphorylati

10 Pak substrate and further suggest a role for Pak kinase activity in atypical MAPK signaling.

11 showed that selective inhibition of class I Pak kinase activity in cells promoted increased nuclear

12 These results show that PAK kinase activity is required for bacteria-induced nuc

13 sion of this domain did not, indicating that PAK kinase activity is required for normal growth factor

14 n of PAK1 activity was dependent upon intact PAK kinase activity, as indicated by studies with a kina

15 l adhesions in these cells is independent of PAK kinase activity, NCK binding, or GTPase binding, but

16 w that the closely related Cool-2 stimulates Pak kinase activity.

17 , these results elucidate the specificity of Pak kinases and illustrate a general method for the iden

18 Pak kinases are a family of serine/threonine protein kin

19 Because the Rho family of GTPases and the Pak kinases are implicated in actin polymerization, the

20 In conclusion, our studies demonstrate that PAK kinases are necessary for polar growth during mating

21 Pak kinases are thought to play critical roles in cell m

22 hosphorylation of the activation loop of one PAK kinase domain by another, but little is known about

23 nd that the Cdc42 GTPase and a member of the PAK kinase family called Cla4 both function in the pathw

24 ious studies demonstrating the role of Ste20/PAK kinases in heterotrimeric G protein signaling, sugge

25 ther investigated the involvement of group I PAK kinases in HIV using siRNA.

26 ak) function; however, the specific role for Pak kinases in megakaryocyte biology remains elusive.

27 ther investigate the possible involvement of PAK kinases in tumorigenesis, we analyzed the expression

28 ion of this individual Nck SH3 domain, or of Pak kinase itself, to the membrane results in activation

29 actor Nef has been shown to associate with a PAK kinase, leading to enhanced viral production; howeve

30 As, designated PAK-1 and PAK-3, encode mouse PAK kinases of 545 and 544 amino acids, respectively.

31 otentiating adhesion-dependent activation of PAK kinase (p < 0.001), a Rac effector that associates w

32 Two p21-activated kinase (PAK) kinases, Pak1 and Ste20, are required for both mati

33 between cardiomyocytes through the Arhgef7b/Pak kinase pathway in order to guide atrioventricular ca

34 Comparison of the two mouse PAK kinases revealed that the proteins show 87% amino ac

35 A second genetically separable function of Pak kinase signaling controls muscle membrane specializa

36 These subunits signal through the PAK kinase Ste20 to activate a mitogen-activated protein

37 hose components include Ras proteins and the PAK kinase Ste20, allows the human fungal pathogen Crypt

38 SH2/SH3-containing adaptor protein Nck binds Pak kinase through its second SH3 domain.

39 which is responsible for the localization of PAK kinases to focal complexes in the cell, is mediated

40 defects and conversely, overexpression of a PAK kinase was able to rescue the loss of RhoU cardiac d

41 Two cDNAs encoding PAK kinases were isolated from a mouse embryo library by

42 PAK kinases were unique in having exceptionally strong A

43 ct of Rac or Cdc42 can be substituted by the Pak kinase, which is a direct downstream target of Rac/C

44 is a brain-specific isoform of the group II Pak kinases whose substrates and roles within the centra

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