ライフサイエンスコーパス: PARylation

1 gative regulation by poly(ADP-ribosyl)ation (PARylation).

2 th or without PARP-1 poly(ADP-ribosyl)ation (PARylation).

3 te by posttranslationally modulating protein PARylation.

4 s, loss of HMGN1 protein reduces PARP-1 self-PARylation.

5 hways to block histone polyADP-ribosylation (PARylation), a known effect of chemotherapy.

6 Notably, the endogenous Parp1 and PARylation activity was enhanced by overexpression of c-

7 spectrometry and Western blotting, Parp1 and PARylation activity were intensively detected in induced

8 in to poly(ADP-ribose) and stimulates the de-PARylation activity.

9 alization of RECQL5 and WRN, suggesting that PARylation acts as a fine-tuning mechanism to coordinate

10 9 muM), as well as inhibiting PARP-modulated PARylation and cell proliferation in MDA-MB-436 cells (B

11 Thus, both substrate PARylation and PARdU are catalysed by enzymes within the

12 ith a strand break, and this results in self-PARylation and PARylation of other chromatin proteins.

13 1 (Parp1) catalyzes poly(ADP-ribosylation) (PARylation) and induces replication networks involved in

14 vented mitochondrial poly(ADP-ribosyl)ation (PARylation) and ROS formation.

15 increase in protein poly(ADP-ribosyl)ation (PARylation), and was blocked by pharmacological inhibiti

16 (e.g. PARG, ARH3) of poly-ADP-ribosylation (PARylation) are relatively well described, the enzymes i

17 e) (PAR) polymerase 1 (PARP1) activation and PARylation at DNA damage sites, PAR-dependent recruitmen

18 These data illustrate that PARylation at DSBs promotes NHEJ through recruitment or

19 ntrast, although Adprt1b was dispensable for PARylation at DSBs, Adprt1a and, to a lesser extent, Adp

20 er low energy laser-induced DNA damage, less PARylation at lesion sites was observed in Hmgn1(-/-) th

21 lation (PARylation) at genomic damage sites, PARylation at telomeres is mainly dependent on tankyrase

22 PARylation at these sites inhibits C/EBPbeta's DNA bindi

23 unlike PARP1-mediated Poly-ADP-Ribosylation (PARylation) at genomic damage sites, PARylation at telom

24 n of Parp1 and pharmacological inhibition of PARylation both reduced the efficiency of iPSC generatio

25 tic investigations indicated that inhibiting PARylation by either hyperthermia or PARPi induced letha

26 ly adenosine diphosphate (ADP)-ribosylation (PARylation) by poly ADP-ribose (PAR) polymerases (PARPs)

27 Our results provide direct evidence that PARylation can control processing of mRNA precursors, an

28 Recent studies have shown that PARylation can serve as a signal for the polyubiquitinat

29 146 (also known as Iduna) is responsible for PARylation-dependent ubiquitination (PARdU).

30 The efficiency of XPC-RAD23B PARylation depends on DNA structure and increases after

31 ates both Drosophila Axin and APC2, but that PARylation does not globally regulate APC2 protein level

32 plored the model that disruption in cellular PARylation, driven by LMP1 expression, subsequently prom

33 provide a clear example of how site-specific PARylation drives biological outcomes.

34 we detail the mechanisms that drive cellular PARylation during latent EBV infection and the effects o

35 TDP1 PARylation enhances its recruitment to DNA damage sites

36 iglio et al. (2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to atta

37 serine ADPr is strictly dependent on histone PARylation factor 1 (HPF1), a recently identified regula

38 We report the identification of histone PARylation factor 1 (HPF1; also known as C4orf27) as a r

39 biology, physiology, and pathophysiology of PARylation, focusing on the activity of PARP-1, the most

40 Although PARylation has been studied extensively, few examples of

41 Protein poly(ADP-ribosyl)ation (PARylation) has a role in diverse cellular processes suc

42 efinitive biological roles for site-specific PARylation have been reported.

43 It inhibits PARP-mediated PARylation in a whole-cell assay with an EC50 of 2.51 nM

44 ge response localized to telomeres, inhibits PARylation in cells, and has an antiproliferative effect

45 elium discoideum to uncover a novel role for PARylation in regulating nonhomologous end joining (NHEJ

46 ings establish the involvement of PARP-1 and PARylation in the long-term actions of cocaine.

47 PARylation in vitro inhibits ORC2 recruitment and remode

48 and modifies PAP by poly(ADP-ribosyl)ation (PARylation) in vitro, which inhibits PAP activity.

49 AF(V600E)-induced senescence phenotypes in a PARylation-independent manner.

50 venting demethylation of H3K4me3 through the PARylation, inhibition, and exclusion of the histone dem

51 These results suggest that PARylation is important for myofibroblast differentiatio

52 We show that PARylation is involved in the recruitment of RECQL5 and

53 Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of prot

54 Poly(ADP-ribosyl)ation (PARylation) is a post-translational protein modification

55 Poly(ADP-ribosyl)ation (PARylation) is a posttranslational modification catalyze

56 Poly(ADP-ribosyl)ation (PARylation) is mainly catalysed by poly-ADP-ribose polym

57 Tankyrase-mediated PARylation marks protein targets for proteasomal degrada

58 se and other recent findings suggesting that PARylation may be the critical event that mediates the f

59 he decrease in PARG levels enhances the auto-PARylation-mediated inhibition of PARP, thereby avoiding

60 corresponding to a release of C/EBPbeta from PARylation-mediated inhibition.

61 ARP1 enzyme activity, poly-ADP-ribosylation (PARylation), nor did inhibition of SUMOylation of PARP1

62 nhibition and the D226 mutation impair HuR's PARylation, nucleocytoplasmic shuttling and mRNA binding

63 PARylation occurred at single-strand breaks, and two PAR

64 PARylation occurs at or near the sites of DNA damage and

65 We propose that PARP1-dependent PARylation of EBNA1 and adjacently bound TRF2 induces st

66 PARylation of EZH2 by PARP1 then induces PRC2 complex di

67 eak, and this results in self-PARylation and PARylation of other chromatin proteins.

68 Moreover, auto-PARylation of PARP1 allowed the protein to switch its da

69 Purified HMGN1 was able to stimulate self-PARylation of purified PARP-1, and in experiments with c

70 ith TRF1, which subsequently facilitates the PARylation of TRF1 after damage.

71 cilitating SSBR at damaged telomeres through PARylation of TRF1, thereby protecting genome stability

72 fects the self-poly(ADP-ribosyl)ation (i.e., PARylation) of poly(ADP-ribose) polymerase-1 (PARP-1), a

73 PARP1) catalyzes the poly(ADP-ribosyl)ation (PARylation) of proteins, a posttranslational modificatio

74 ring latent EBV infection and the effects of PARylation on host gene expression and cellular function

75 oss of SUMOylation increased PARP1-dependent PARylation on isolated chromosomes, indicating SUMOylati

76 ast differentiation, we examined the role of PARylation on myofibroblast differentiation.

77 yers in the early DNA damage response, since PARylation orchestrates the recruitment of repair protei

78 PARP1-dependent poly-ADP-ribosylation (PARylation) participates in the repair of many forms of

79 Poly(ADP-ribosyl)ation (PARylation) plays diverse roles in many molecular and ce

80 vl1)/human antigen R (HuR), resulting in its PARylation, primarily at site D226.

81 difications, such as poly(ADP-ribosyl)ation (PARylation), regulate chromatin-modifying enzymes, ultim

82 e) (PAR) chain removal (de-MARylation and de-PARylation, respectively) from mono- and poly(ADP)-ribos

83 cal inhibition of PARP-1, or mutation of the PARylation sites on C/EBPbeta, enhances these early adip

84 PARylation stabilizes TDP1 together with SUMOylation of

85 and in experiments with cell extracts, self-PARylation was greater in Hmgn1(+/+) than in Hmgn1(-/-)

86 alyze massive protein poly ADP-ribosylation (PARylation) within seconds after the induction of DNA si