ライフサイエンスコーパス: PAS

1 PAS accounted for 18% of strokes in women younger than 3

2 PAS and CNBh domains participate in channel gating, but

3 PAS and euthanasia present potential risks for vulnerabl

4 PAS distribution analysis indicated that the PAS positio

5 PAS domain containing protein kinase (Pask) is an evolut

6 PAS of 10 healthy donors provided [Ca(t)]i data for trai

7 Six of 33 (18.2%) PAS and 20 of 171 (11.7%) manufacturer/investigator-init

8 could form a ternary complex with HIF-2alpha PAS-B and ARNT PAS-B via beta-sheet/coiled-coil interact

9 We found that the HIF-2alpha PAS-B domain also directly interacts with TACC3, motivat

10 cooperatively mediate between the HIF-2alpha PAS-B.ARNT PAS-B complex, thereby participating more dir

11 In this study, we discovered 28,363 PASs using pig RNAseq data, with 13,033 located in 7,403

12 cells containing hyperactive Snf1 display a PAS kinase-dependent decrease in TORC1 activity.

13 cloche gene and discovered that it encodes a PAS-domain-containing bHLH transcription factor, and tha

14 longation complexes undergo termination in a PAS-dependent manner when incubated in buffer, in the ab

15 ral relaxation in other regions, including a PAS dimerization interface and a segment in the H-NOX do

16 ocation and surrounding sequence motifs of a PAS appear to differentiate its regulation by the PAPs.

17 Together, our results reveal a PAS-guided and PAP-mediated paradigm for gene expression

18 As continuous variables, a PAS or Alvarado score of 5 or lower could be used to exc

19 Strikingly, the AAUAAA PAS assumes an unusual conformation that allows this sho

20 h as sulfonamides and p-aminosalicylic acid (PAS), we hypothesized that bacterial PABA biosynthesis c

21 A refined Aer PAS-HAMP interaction model is presented.

22 e mapped the interaction surfaces of the Aer PAS, HAMP and proximal signalling domains in the kinase-

23 g static-dynamic model in which oxidized Aer-PAS interacts directly with HAMP AS-2, enforcing a stati

24 Here, we show that Aer-PAS controls aerotaxis through direct, lateral interacti

25 ith the global higher flexibility of the AHR PAS-A and its loosely packed structural elements, sugges

26 lymers gives water-soluble altrose PASs (alt-PASs) in high yields without degradation of the polymer

27 Circular dichroism analysis shows the alt-PASs adopt a right-handed helical conformation in aqueou

28 Cytotoxicity studies reveal that the alt-PASs are nontoxic to HEK, HeLa, and NIH3T3 cells.

29 Although PAS domains were described as intracellular sensors, rec

30 zylated polymers gives water-soluble altrose PASs (alt-PASs) in high yields without degradation of th

31 models were developed for both the PAS-A and PAS-B dimers and they were characterized by combining a

32 We showed that adding CAS and PAS substantially improve the accuracy of identifying mi

33 ere hyperconcentrated during collection, and PAS was added, whereas the Haemonetics platelets were el

34 en legalized in three European countries and PAS has been legalized in Washington, Oregon, and Montan

35 y the strongest TSS for 5207 (90%) genes and PAS for 5277 (91%) genes.

36 nti-tubercular action of DHPS inhibitors and PAS by up to 1000 fold.

37 At a prevalence of 75%, KOH screening and PAS testing before treatment with efinaconazole, 10%, sa

38 PE analyses to date (microarray, RNA-Seq and PAS-Seq) are NRIP1 (RIP140), a transcriptional co-regula

39 For excitability-diminishing tDCS and PAS, aftereffects were abolished or converted trendwise

40 hundreds of previously unidentified TSS and PAS which revealed two interesting phenomena: first, gen

41 curately annotate cell type-specific TSS and PAS.

42 ata were captured as Pediatric Appendicitis (PAS) or Alvarado scores and considered as categoric (hig

43 esent homology models of the murine AhR:ARNT PAS domain dimer developed using recently available X-ra

44 rnary complex with HIF-2alpha PAS-B and ARNT PAS-B via beta-sheet/coiled-coil interactions.

45 cond PER-ARNT-SIM (PAS) domain of ARNT (ARNT PAS-B).

46 ly mediate between the HIF-2alpha PAS-B.ARNT PAS-B complex, thereby participating more directly in HI

47 ods to investigate the structure of the ARNT PAS-B domain in complex with the C-terminal fragment of

48 creasingly discussed in end-of-life care, as PAS and euthanasia have now been legalized in three Euro

49 favored the HIF2alpha:ARNT heterodimer-based PAS-B model, most mutants derived from the CLOCK:BMAL1-b

50 The basic helix-loop-helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (brain and muscle

51 Acting through intestinal bHLH-PAS domain proteins Methoprene-tolerant (Met) and Germ c

52 LOCK-BMAL1, we show the wider mammalian bHLH-PAS family is capable of multi-ligand-binding and presen

53 tly available X-ray structures of other bHLH-PAS protein dimers.

54 Pathways driven by other bHLH-PAS transcription factors have a homologous repressor th

55 he basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked t

56 nal regulation on a daily basis via the bHLH-PAS transcription factor CLOCK:BMAL1.

57 ting distance between the two flavin-binding PAS (Per-Arnt-Sim) domains implies that they tightly san

58 ha subunit reveals that it is a haem-binding PAS domain, similar in structure to PAS gas sensors.

59 udied 191 patients with severe bioprosthetic PAS (63+/-16 years, 58% men) who underwent redo AVR betw

60 udied 276 patients with severe bioprosthetic PAS (64+/-16 years, 58% men) who underwent redo-AVR betw

61 istics of patients with severe bioprosthetic PAS undergoing redo AVR, and (2) assess the outcomes of

62 mptomatic patients with severe bioprosthetic PAS undergoing redo AVR, baseline LV-GLS provides increm

63 enter, in patients with severe bioprosthetic PAS undergoing redo AVR, the majority undergo combinatio

64 ctions of lung were stained with Alcian Blue/PAS and examined microscopically.

65 Cys residues able to bind BV either in both PAS (Cys15) and GAF (Cys256) domains, in one of these do

66 RFP670 and iRFP682 have Cys residues in both PAS and GAF domains, rather than in the PAS domain alone

67 ants with Cys in the GAF or with Cys in both PAS and GAF show blue-shifted emission with long fluores

68 herefore increases the effectiveness of both PAS protocols.

69 least as reliable as those brought about by PAS or transcranial direct current stimulation.

70 Goblet cell hyperplasia, as indicated by PAS staining, was not different in ROCK1(+/-) vs. WT mic

71 conclude that cortical plasticity induced by PAS and cTBS interacts in a heterosynaptic and bidirecti

72 esis analogous to the functions performed by PAS-domain-containing regulatory proteins found in compl

73 ating defects identified by PL with those by PAS and DLTS methods.

74 Often called PAS-dependent termination, or PADT, it is widely assumed

75 or functional interactions between the N-Cap/PAS domains and the cNBH domain.

76 Categoric PAS and Alvarado scores were equivocal for 59.5% (53 of

77 es among APA isoforms than did S. cerevisiae PASs in different locations of gene are surrounded with

78 susceptibility in a previously characterized PAS resistant strain of M. tuberculosis.

79 gulation on the BMAL1 C terminus and the CLK PAS-B domain and demonstrate the importance of a BMAL1 T

80 ambiguously position a key loop of the CLOCK PAS-B domain in the secondary pocket of CRY1, analogous

81 iven primarily by interaction with the CLOCK PAS-B domain.

82 te capillary plexus with an empty, collapsed PAS-positive lens capsule in the pupillary region.

83 averaging times as compared to conventional PAS and QEPAS techniques and determines the electrical Q

84 irst viral protein shown to activate cryptic PASs in introns, we suspect that other viruses and cellu

85 oly(A) tracts, a common problem with current PAS annotation methods.

86 r any sample and enable the deployment of CV-PAS SECM as an analytical tool for traditionally challen

87 stripping charge extracted from a shared CV-PAS give three distinct probe approach curves (CV-PACs),

88 clic voltammetry probe approach surfaces (CV-PASs), consisting of CVs performed between incremental m

89 redox potential via FAD bound to a cytosolic PAS domain.

90 S-like domains do not match sequence-derived PAS domain models, and thus their distribution across th

91 Importantly, different PASs of a gene are distinctly regulated by different PAP

92 on inhibitory tDCS, excitability-diminishing PAS, and to a minor degree on excitability-enhancing PAS

93 otates, extends and cooperates with a distal PAS domain to bind hypoxia response elements.

94 nd others using both the proximal and distal PAS to differing degrees.

95 roximal PAS is conserved, whereas the distal PAS is disrupted within certain alleles by sequence vari

96 on use of either the proximal or the distal PAS, which differ in length by 100 bp.

97 d in the usage of the proximal versus distal PAS, with some alleles using only the proximal PAS, and

98 n S. pombe, strong motifs surrounding distal PASs lead to higher abundances of long 3' UTR isoforms t

99 investigation of the role of the endothelial PAS domain-containing protein 1 (EPAS1), a regulatory al

100 to a minor degree on excitability-enhancing PAS.

101 ytic activity, to our knowledge no enzymatic PAS domain has been found.

102 EU PAS registration number: EUPAS5269.

103 The highly evolvable PAS scaffold can bind a broad range of ligands, includin

104 show that structurally defined extracellular PAS-like domains belong to the Cache superfamily, which

105 er, these structurally defined extracellular PAS-like domains do not match sequence-derived PAS domai

106 Putting the extracytoplasmic PAS domain into context of the membrane-embedded CitA co

107 h reliably discerns bona fide PAS from false PAS that arise due to internal poly(A) tracts, a common

108 Our approach reliably discerns bona fide PAS from false PAS that arise due to internal poly(A) tr

109 Here we report characterization of the first PAS enzyme: a haem-dependent oxidative N-demethylase.

110 between $37.6 million and $90.2 million for PAS testing.

111 pecially well-suited and straightforward for PASs as the helical conformations formed result from con

112 how distinct differences in the glc- and gal-PAS systems that correlate well with observed difference

113 liable representations of novel glc- and gal-PASs.

114 served differences in solubility between gal-PASs and glc-PASs.

115 Glucose- (glc-) and galactose- (gal-) PAS 10-mer structures are synthesized and investigated w

116 ences in solubility between gal-PASs and glc-PASs.

117 The basic helix-loop-helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (

118 ide an elegant molecular explanation for how PAS sequences are recognized for mRNA 3'-end formation.

119 is opposite in S. cerevisiae Differences in PAS placement between convergent genes lead to starkly d

120 and subsequent rescue of TORC1 inhibition in PAS kinase-deficient yeast.

121 onical (Star-PAP) PAPs play diverse roles in PAS selection and gene expression.

122 monstrate HLA-A allele-specific variation in PAS usage, which modulates their cell surface expression

123 Inaccessible PAS-HAMP surfaces overlapped with a cluster of PAS kinas

124 hat permit small-molecule binding, including PAS domain encapsulated sites and an interfacial cavity

125 Removing an intronic PAS results in ectopic expression of the neuronal ankyri

126 Deleting the intronic PAS of unc-44 results in increased pre-mRNA processing o

127 ously reported that the use of this intronic PAS depends on the nuclear polyadenylation factor SYDN-1

128 et promotes termination at the weak intronic PAS of the MAP kinase dlk-1.

129 Categoric low- and high-likelihood PAS and Alvarado scores correctly predicted the presence

130 between 2000 and 2012 (excluding mechanical PAS, severe other valve disease transcatheter AVR, and L

131 between 2000 and 2012 (excluding mechanical PAS, severe other valve disease, and transcatheter AVR).

132 d light on the function of CPSF in mediating PAS-dependent RNA cleavage and polyadenylation.

133 The data indicate the modified PAS assay is a simple method for quantifying alginate re

134 esting phenomena: first, genes with multiple PASs tend to harbor a motif near the most proximal PAS,

135 Neuronal PAS domain protein 4 (Npas4), a recently discovered IEG,

136 -gamma, coactivator 1 (Pgc-1alpha), neuronal PAS domain-containing protein 2 (Npas2), and retinoic ac

137 he transcription factor (TF) NPAS4 (neuronal PAS domain protein 4) has been found to provide activity

138 s recapitulated with a knockdown of neuronal PAS domain protein 2 (NPAS2) specifically in the NAc, de

139 In mice, loss of neuronal PAS domain protein 3 (NPAS3) impairs postnatal hippocamp

140 The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the b

141 cerebral venous thrombosis, and nonspecified PAS.

142 This review focuses on some aspects of PAS and euthanasia and discusses deep terminal sedation

143 S-HAMP surfaces overlapped with a cluster of PAS kinase-on lesions and with cysteine substitutions th

144 ht-sensing photosensory module consisting of PAS, GAF, and PHY domains and a signaling output module,

145 t the photosensory core region consisting of PAS-GAF-PHY domains in the N-terminal is required for th

146 The number of eyes with 360 degrees of PAS increased from 6 of 20 before surgery to 9 of 20 aft

147 The incidence of PAS in women aged 12 to 24 years was 14 events per 10000

148 The cumulative incidence of PAS per 100000 pregnant/postpartum women vs nonpregnancy

149 his strategy restores the wild type level of PAS susceptibility in a previously characterized PAS res

150 s underpinning its assembly and mechanism of PAS recognition are not understood.

151 We also observed lower numbers of PAS-stained goblet cells and less Muc2 in germfree mice.

152 agonists simultaneously increased numbers of PAS-stained goblet cells and Muc2-expressing cells, wher

153 and Nod2 agonists enhanced the production of PAS-stained goblet cells and Muc2 in germfree mice.

154 limited on age-specific incidence ratios of PAS compared with stroke risk in nonpregnant women.

155 d facilitates further functional research of PAS.

156 t establish DNA binding and the stability of PAS domains and pockets.

157 ation indicated that the functional usage of PAS might participate in the immune response and may be

158 Sometimes, one gene can have more than one PAS, which can produce the alternative polyadenylation (

159 s, 41% were identified to have more than one PAS.

160 reconstituted on liposomes, we show that one PAS domain modulates kinase activity in a CckA density-d

161 between the molecular structure of the PER2 PAS core and the pace of SCN circadian timekeeping.

162 hly conserved interdomain linker of the PER2 PAS core such that, although PER2(Edo) complexes with cl

163 This study provides new insights into pig PAS and facilitates further functional research of PAS.

164 In other proteins, PAS domains bind ligands and modulate effector domains.

165 end to harbor a motif near the most proximal PAS, which likely represents a new cleavage and polyaden

166 The proximal PAS is conserved, whereas the distal PAS is disrupted wi

167 S, with some alleles using only the proximal PAS, and others using both the proximal and distal PAS t

168 polyurethane foam passive air samplers (PUF-PAS) from January 2012 to November 2015.

169 polyurethane foam passive air samplers (PUF-PAS).

170 We applied the model to PUF-PAS samples collected in Chicago and show that previous

171 s from TFEB-treated mice we observed reduced PAS staining and improved ultrastructure, with reduced n

172 When PAS-FAD is reduced, PAS interaction with HAMP is relaxed and a dynamic HAMP

173 How poly(A) polymerases may regulate PAS usage and hence gene expression is poorly understood

174 bility of HAMP residues (apparently relaxing PAS-HAMP interactions), but decreased the accessibility

175 l premarket studies, 33 (11.5%) FDA-required PAS, and 171 (59.8%) manufacturer/investigator-initiated

176 nonpivotal premarket, pivotal, FDA-required PAS, and manufacturer/investigator-initiated postmarket

177 sensors, recent structural studies revealed PAS-like domains in extracytoplasmic regions in several

178 Poly-amido-saccharides (PAS) are carbohydrate-based, enantiopure synthetic polym

179 right-handed helical poly amido-saccharides (PASs) with beta-N-(1-->2)-d-amide linkages are synthesiz

180 associated with Panic and Agoraphobia scale (PAS) scores (beta=0.005, SE=0.002, p=0.021, n=131) among

181 Pairwise Agonist Scanning (PAS) deployed all single and pairwise combinations of si

182 KOH) stain followed by periodic acid-Schiff (PAS) evaluation if KOH testing is negative, and (3) pret

183 a samples stained with Periodic Acid-Schiff (PAS) highlighted the presence of starch and cellulose.

184 ith hematoxylin-eosin, periodic acid-Schiff (PAS) reaction, and Masson trichrome method.

185 ens were reexamined by periodic acid-Schiff (PAS) staining and PCR to identify undiagnosed amoebic ap

186 r CK7, CEA, as well as periodic acid-Schiff (PAS), whereas negative for CK5/6, CK34betaE12, CK20, and

187 ed significantly fewer periodic acid-Schiff (PAS)-stained intestinal goblet cells and less mucin (Muc

188 on Score (CAS) and PubMed Association Score (PAS), which are designed for capturing functional cohere

189 The second PAS domain interacts with the asymmetrically partitioned

190 ere we used polyadenylation site sequencing (PAS-Seq) of RNA from normal and PE human placentae to in

191 hnology and polyadenylation site sequencing (PAS-seq) to re-annotate the bamboo genome, and identify

192 Severe PAS was defined as aortic valve area <0.8 cm(2), mean ao

193 Severe PAS was defined as AV area <0.8 cm(2), mean AV gradient

194 c/minimally symptomatic patients with severe PAS undergoing redo AVR, we sought to determine whether

195 rongly protected two regions of the sGCbeta1 PAS domain and caused local structural relaxation in oth

196 mRNAs requires a functional poly(A) signal (PAS) in the nascent pre-mRNA.

197 (A) tails, modest changes in poly(A) signal (PAS) usage, and evidence of mitochondrial damage in thes

198 y divergence in core polyadenylation signal (PAS) and downstream sequence element (DSE) motifs drive

199 nition of the AAUAAA polyadenylation signal (PAS), and the molecular mechanism of this recognition ha

200 ylated from cryptic polyadenylation signals (PAS) located in intron 1 or 2 of approximately 1% of cel

201 the presence of two polyadenylation signals (PAS).

202 human mRNAs by juxtaposing poly(A) signals (PASs) and cleavage sites that are otherwise too far apar

203 ydrocarbon receptor (AHR), a PER, ARNT, SIM (PAS) family transcription factor that responds to divers

204 nvironmental ligand-dependent, per ARNT-sim (PAS) domain containing bHLH transcription factor that me

205 ion, early doors (Edo), in the PER-ARNT-SIM (PAS) domain dimerization region of period 2 (PER2) (I324

206 of erWalK revealed a canonical Per-Arnt-Sim (PAS) domain for signal sensing.

207 The universal Per-ARNT-Sim (PAS) domain functions as a signal transduction module in

208 and its M domain bound to the Per-Arnt-Sim (PAS) domain of apo-sGC-beta1(1-359), which lies adjacent

209 eract directly with the second PER-ARNT-SIM (PAS) domain of ARNT (ARNT PAS-B).

210 racytoplasmic, citrate-sensing Per-Arnt-Sim (PAS) domain of HK CitA are identical for the isolated do

211 basic helix-loop-helix (bHLH), Per-Arnt-Sim (PAS) domain protein, a novel type of hormone receptor.

212 domain (eagD) that contains a Per-Arnt-Sim (PAS) domain that is preceded by a conserved sequence of

213 l aromatic hydrocarbon-sensing Per-Arnt-Sim (PAS) domain, followed by an autokinase domain, a respons

214 the presence of an N-terminal Per-Arnt-Sim (PAS) domain.

215 RmcA contains four Per-Arnt-Sim (PAS) domains and domains with the potential to catalyze

216 the Helix-Loop-Helix (HLH) and PER-ARNT-SIM (PAS) domains, is needed to convert the AhR into its tran

217 Per-Arnt-Sim (PAS) kinase is a sensory protein kinase required for glu

218 basic helix-loop-helix (bHLH)-Per-ARNT-SIM (PAS) protein, the repressor of AhR function (AhRR).

219 t upstream of an N-terminal Period/Arnt/Sim (PAS) domain, which upon removal dramatically accelerates

220 Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of spec

221 The average difference between the SIP-PAS derived concentrations in air for the individual VMS

222 rocessing by blocking the Fip1-poly(A) site (PAS) interaction.

223 ranslocates to the phagophore assembly site (PAS), where an autophagosome forms, at a very early stag

224 y role for an intronic polyadenylation site (PAS) in temporal- and tissue-specific regulation of UNC-

225 n at a strong intronic polyadenylation site (PAS) in unc-44/ankyrin yet promotes termination at the w

226 3' end of mRNAs at the polyadenylation site (PAS).

227 start sites (TSS) and polyadenylation sites (PAS).

228 (TSS) or cleavage and polyadenylation sites (PAS).

229 ctivating enhancer-containing poly(A) sites (PASs).

230 compared cleavage and polyadenylation sites (PASs) in two yeast species, S. cerevisiae and S. pombe A

231 genes harbor multiple polyadenylation sites (PASs), leading to expression of alternative polyadenylat

232 e (PAM) and periarbuscular apoplastic space (PAS) and expressed them from the constitutive AtUBQ10 pr

233 We show Star-PAP-specific PAS usage regulates the expression of the eukaryotic tra

234 A novel photoacoustic spectrophotometer (PAS) for the measurement of gas-phase and aerosol absorp

235 ata from positron annihilation spectroscopy (PAS), secondary ion mass spectrometry (SIMS), and deep l

236 o relieve severe prosthetic aortic stenosis (PAS) is increasing.

237 o relieve severe prosthetic aortic stenosis (PAS) is increasing.

238 Paired associative stimulation (PAS) has attracted particular attention as its effects o

239 nduced using paired associative stimulation (PAS), which involves repeated pairing of peripheral nerv

240 creased risk of pregnancy-associated stroke (PAS).

241 ocalized at the preautophagosomal structure (PAS).

242 approval; FDA-required postapproval studies [PAS]; or manufacturer/investigator-initiated); premarket

243 Physician-assisted suicide (PAS) and euthanasia have been increasingly discussed in

244 ne kinase upstream of CtrA, employs a tandem-PAS domain sensor to integrate two distinct spatiotempor

245 ind an internal cavity within the C-terminal PAS domain of the HIF-2alpha subunit.

246 stinguished by the presence of an N-terminal PAS (Per-Arnt-Sim) domain and a C-terminal domain with h

247 ed that DSF bound to the isolated N-terminal PAS domain with a Kd of 1.4 muM.

248 primary structure within the two N-terminal PAS domains of LovhK have distinct sensory roles under s

249 A deletion of the N-terminus PAS domain, mutation R4AR5A or the LQT2-causing mutation

250 The PAS assay quantified alginate with excellent linearity (

251 lizes an N-terminal latch region against the PAS core.

252 onto the transcription factor alongside the PAS domains, extending above the DNA-binding bHLH domain

253 :ARNT dimer models of both the PAS-A and the PAS-B dramatically decreased the levels of DNA binding,

254 d sequence of 25-27 amino acids known as the PAS-cap.

255 is critical for phagophore nucleation at the PAS.

256 an important hinge-bbeta region between the PAS beta-sheet and the N-terminal cap helix that in turn

257 We show that upon citrate binding, the PAS domain contracts, resulting in a shortening of the C

258 ternative models were developed for both the PAS-A and PAS-B dimers and they were characterized by co

259 MAL1-based AhR:ARNT dimer models of both the PAS-A and the PAS-B dramatically decreased the levels of

260 cysteine substitutions that crosslinked the PAS beta-scaffold to the HAMP AS-2 helix.

261 hich is homologous to, but distinct from the PAS superfamily.

262 at least twice in evolutionary history, the PAS domain has been lost and it is omitted by alternate

263 However, the PAS domains of KCNH channels are orphan receptors.

264 both PAS and GAF domains, rather than in the PAS domain alone as in wild-type BphPs.

265 In contrast, mutants with Cys in the PAS only or no Cys residues at all exhibit red-shifted e

266 on by Ca(2+) i However, deletion of just the PAS-cap resulted in a >15-fold potentiation in response

267 ge-charge interaction between Arg(56) of the PAS domain and Asp(803) of the cNBH domain, as well an a

268 We demonstrate that this contraction of the PAS domain, which is well characterized for the isolated

269 Drosophila eye, stochastic expression of the PAS-bHLH transcription factor Spineless (Ss) determines

270 gating and indicate that the binding of the PAS-cap with the cNBHD is required for the closure of th

271 vs) that recognize different epitopes on the PAS domain.

272 antitative Western blotting to show that the PAS domain is not required for normal channel traffickin

273 PAS distribution analysis indicated that the PAS position was highly variable in genes.

274 tion, or PADT, it is widely assumed that the PAS requirement reflects an obligatory poly(A) site clea

275 n from sensor to enzyme, suggesting that the PAS scaffold can support the development of artificial e

276 yl hydrocarbon receptor (AHR) belongs to the PAS (PER-ARNT-SIM) family transcription factors and medi

277 annel function through ligand binding to the PAS domain can be attained.

278 Here we show that CRY1 binds directly to the PAS domain core of CLOCK:BMAL1, driven primarily by inte

279 show that both antibodies, on binding to the PAS domain, increase the total amount of current that pe

280 lators of hERG that specifically bind to the PAS domain.

281 Women in the NPAS group vs the PAS group had more vascular risk factors, including chro

282 However, when the PAS domain is present, the N-Cap amphipathic helix must

283 abilization of full-length proteins when the PAS domain is present.

284 iver and testis showed a difference in their PAS number and usage.

285 which also interact with hsp90 through their PAS domains to control protein partner and small ligand

286 Outcomes for 2191 TL-PAS patients enrolled into DAPT were assessed.

287 The TAXUS Liberte Post Approval Study (TL-PAS) contributed patients treated with TAXUS Liberte pac

288 -binding PAS domain, similar in structure to PAS gas sensors.

289 The TlpC dCACHE LBD has two PAS-like subdomains, as predicted.

290 ) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other

291 Our data reveal that the ubiquitous PAS domain can make the transition from sensor to enzyme

292 Retrospective analyses using PAS staining and PCR identified 3 and 3 more cases, resp

293 When PAS-FAD is reduced, PAS interaction with HAMP is relaxed

294 e KOH screening model and $135 compared with PAS testing.

295 e Haemonetics platelets were elutriated with PAS, which may have resulted in less collection injury.

296 negative, and (3) pretreatment testing with PAS.

297 the women was 31 (25-35) years in those with PAS and 48 (41-52) years in those with NPAS.

298 in these extended 3'-end regions than within PAS-upstream regions and indeed are substantially more f

299 recruitment of Atg17 complexes to the yeast PAS, and their unusual shape.

300 P-regulated kinase (AMPK, or SNF1 in yeast), PAS kinase 1 (Psk1 in yeast), and the target of rapamyci