ライフサイエンスコーパス: PCN

1 PCN also demonstrated the poorest functional properties

2 PCN and IMF had the highest and lowest extent of surface

3 PCN has been shown to interfere with a variety of cellul

4 PCN incidence increased with age, but due to the rarity

5 PCN risk was 1.8-fold increased relative to the general

6 PCN risk was especially high in recipients who were Epst

7 PCN-128W exhibits interesting piezofluorochromic behavio

8 PCN-134 demonstrates high porosity (N2 uptake of 717 cm(

9 PCN-521 has the largest BET surface area (3411 m(2) g(-1

10 PCN-600 exhibits a one-dimensional channel as large as 3

11 PCN-600(Fe) has been demonstrated as an effective peroxi

12 PCN-700, a Zr-MOF with eight-connected Zr6O4(OH)8(H2O)4

13 PCN-777 exhibits the largest cage size of 3.8 nm and the

14 PCN-dependent loss of mineral density is observed in the

15 PCN-mediated goblet cell hyperplasia and metaplasia requ

16 egional cancer registries, we identified 140 PCNs in 202 600 recipients (1987-2009).

17 5% of cell migration into Gtn-HPA/SDF-1alpha-PCN hydrogels involved MMP-2, 3, and 9, respectively, de

18 d their neuronal progeny, Gtn-HPA/SDF-1alpha-PCN hydrogels promoted chemotactic recruitment to enhanc

19 Overall, Gtn-HPA/SDF-1alpha-PCN hydrogels prove to be promising biomaterials for inj

20 ked with 0.85-0.95 mM HO, Gtn-HPA/SDF-1alpha-PCN hydrogels provided optimally permissive structural s

21 ic metal-organic frameworks (MOFs), PCN-228, PCN-229, and PCN-230, with ftw-a topology were synthesiz

22 A series of flexible MOFs (PCN-605, PCN-606, and PCN-700) are synthesized and applied to rev

23 tions of the expression plasmid pA-EGFP_B, a PCN from 1 to 64 could be accurately detected.

24 ontinuously treated with mouse PXR activator PCN to evaluate the hypothesis that induction of the Cyp

25 expression of Oatp2, rats were administered PCN, livers were extracted at various times, and Oatp2 e

26 with increased Mrp2 protein synthesis after PCN treatment.

27 ic frameworks (Zr-MOFs), namely, PCN-133 and PCN-134.

28 nic frameworks (MOFs), PCN-228, PCN-229, and PCN-230, with ftw-a topology were synthesized using the

29 table, non-interpenetrated MOFs, PCN-521 and PCN-523, were synthesized by a symmetry-guided strategy.

30 for the catenation isomer pairs of PCN-6 and PCN-6' (both have the formula of Cu(3)(TATB)(2), where T

31 ries of flexible MOFs (PCN-605, PCN-606, and PCN-700) are synthesized and applied to reversible bromi

32 DP and PCN form a bilateral column of cells extending ventrolat

33 yrido-[3,2-d:2',3'-f]-quinoxaline (dpq), and PCN = tris-(2-cyanoethyl)phosphine, have been synthetize

34 TrfA1 enhanced transformation efficiency and PCN.

35 ganic frameworks (MOFs), PCN-426-Fe(III) and PCN-426-Cr(III), have been synthesized through a strateg

36 the structures range from 2.5 to 3.8 nm, and PCN-229 demonstrates the highest porosity and BET surfac

37 stent with our previous findings that PB and PCN enhance hepatic uptake of cardiac glycosides.

38 2 expression increases in response to PB and PCN is consistent with our previous findings that PB and

39 rved from livers of rats treated with PB and PCN, in which PCN caused a robust elevation of Oatp2 mRN

40 Oatp2, but not Oatp1, is inducible by PB and PCN, which imparts the increased capacity of the liver t

41 f 14C-labeled Mrp2 in control, pregnant, and PCN-treated rats were 27, 36, and 22 h, respectively, an

42 regulation of Mrp2 in control, pregnant, and PCN-treated rats.

43 allergy evaluation with history-appropriate PCN skin testing: if skin test negative, give cefazolin

44 The MOFs studied are PCN-222, MOF-525, and NU-902, which are based on the csq

45 ructed a metal-organic framework, denoted as PCN-128W, starting from chromophoric linker and zirconiu

46 The correlation between PCN times and ADHD symptom ratings suggests that this br

47 urface modification, the interaction between PCN-777 and different guests can be varied to realize ef

48 PXR activation by PCN in high-fat diet fed mice also increases expression

49 ral pH value, singlet oxygen is generated by PCN-222/MOF-545 using an inexpensive and commercially av

50 he molecular mechanism of oatp2 induction by PCN, rat oatp2 gene was cloned.

51 quired for maximal induction of rat oatp2 by PCN.

52 I) in aqueous solution was also performed by PCN-134-22%TCPP which exhibits excellent catalytic activ

53 The singlet oxygen produced by PCN-222/MOF-545 selectively oxidizes CEES to the compara

54 CLE1, a multidomain CLE effector secreted by PCN during infection, is a 12-amino acid arabinosylated

55 Induction of UGT1A1 by PCN and TCDD is believed to be highly dependent upon glu

56 R agonist pregnenolone-16alpha-carbonitrile (PCN) activated Akr1b7 gene expression, whereas the effec

57 R ligands pregnenolone-16alpha-carbonitrile (PCN) and dexamethasone increased p-glycoprotein expressi

58 activator pregnenolone 16alpha-carbonitrile (PCN) down-regulated the mRNA levels of carnitine palmito

59 of PXR by pregnenolone 16alpha-carbonitrile (PCN) in AKR/J mice can prevent the development of high-f

60 (PB) and pregnenolone-16alpha-carbonitrile (PCN) occurs via increased hepatic expression of Oatp1 an

61 activator pregnenolone-16alpha-carbonitrile (PCN) or the Ah receptor ligand 2,3,7,8-tetrachlorodibenz

62 rats with pregnenolone-16alpha-carbonitrile (PCN), a ligand for the rodent pregnane X receptor (PXR),

63 regnen-3beta-ol-20-one-16alpha-carbonitrile (PCN), followed by an increase in Cyp3a11 mRNA.

64 s such as pregnenolone 16alpha-carbonitrile (PCN), which induce cytochrome P450 3A (CYP3A) expression

65 nant, and pregnenolone-16alpha-carbonitrile (PCN)-treated rats using in vivo metabolic-labeling studi

66 nd to be substantially stronger in catenated PCN-6 than in noncatenated PCN-6', leading to much highe

67 Cationic PCN-223(Fe) formed by postsynthetic treatment is an exce

68 uch lower PCN (</=1) than fluorescent cells (PCN of up to 5) under standard conditions.

69 With its extremely high connectivity, PCN-223 shows high stability in aqueous solutions with a

70 The two most effective complexes [HB(pz)3]Cu(PCN), 1, and [HB(pz)3]Cu(PTA), 2, showed selectivity tow

71 DP-PCN neurons show an oscillatory pattern of activity, fir

72 ons only fire during the silent period of DP-PCN neurons, suggesting that they provide recurrent inhi

73 During "scallops", only DP-PCN neurons with high baseline firing rates increase the

74 ventroposterior nucleus (VPd) projects to DP-PCN and receives input from the electric organ corollary

75 that they provide recurrent inhibition to DP-PCN.

76 extracellularly from single units within DP-PCN and VPd and correlated their activity patterns with

77 cells along the ventral edge projects to DP/PCN and to CN, whereas a dorsal group of small, ovoid ce

78 l group of small, ovoid cells projects to DP/PCN but not to CN.

79 The primary input to DP/PCN is from VP, which is identified as having two distin

80 taxa, suggest that modifiable feedback to DP/PCN plays a critical role in electromotor control and th

81 [CuCl(phen)(PCN)].DMF (5.DMF) and [CuBr(dpq)(PCN)].2DMF (10.2DMF).

82 The most effective complex, [CuCl(dpq)(PCN)] (9), exhibited nanomolar cytotoxicity toward both

83 ycholic acid, and lithocholic acid by either PCN or TCDD in small intestine from Tg-UGT1 mice corresp

84 As a representative example, PCN-230, constructed with the most extended porphyrinic

85 f-PCN(DXR) can readily discriminate FR-positive tumor cell

86 ulting folate-conjugated, DXR-loaded PCNs (f-PCN(DXR)) demonstrated enhanced potency to folate recept

87 and pH-sensitive drug-releasing triggers, f-PCN(DXR) was fifty-times more potent than the untargeted

88 These two subpopulations were sorted for PCN determination with ddPCR.

89 at 298 K/50 bar, respectively, and that for PCN-6' is 42 mg/g (4.0 wt %) at 77 K/50 bar or 4.0 mg/g

90 much higher than the corresponding value for PCN-14 (157 cm(3) (STP) cm(-3) ).

91 the highest amounts were stored in soil for PCNs, PBDEs, and PCBs while highest PAH amounts were sto

92 of the water-stable metal-organic framework PCN-200 provides a new route to low-energy selective CO(

93 A microporous metal-organic framework, PCN-14, based on an anthracene derivative, 5,5'-(9,10-an

94 ation of 4-OH-tam with liver microsomes from PCN-treated rat yielded three detectable metabolites.

95 n of the exchange system, the functionalized PCN-333(Cr), N3-PCN-333(Cr) shows well maintained crysta

96 A1 alone, again, generally elicited a higher PCN of an IncP1-beta replicon than strains expressing Tr

97 ells, TrfA1 maintained a 3- to 4-fold higher PCN than TrfA2 at the same TrfA concentrations, indicati

98 lasma cells generates a mouse model of human PCN that recapitulates some features of human multiple m

99 lls might lead to an improved model of human PCN, we generated Myc transgenics by inserting a single-

100 Importantly, PCN-6 exhibits a total hydrogen uptake of 95 mg/g (8.7 w

101 More importantly, PCN-134 tolerates the partial absence of auxiliary linke

102 robic alcohol oxidation reaction is built in PCN-700 through linker installation, which shows high ac

103 hermodynamic work of cohesion was highest in PCN and may have contributed to inadequate rehydration b

104 ncorporation of 35S into Mrp2 was highest in PCN-treated rats.

105 nally large pores ( approximately 5.5 nm) in PCN-333(Cr), a secondary functional moiety, Zn-TEPP with

106 oughly analyzed ligand exchange phenomena in PCN-333 and demonstrate that the extent of exchange can

107 amide effectively inhibits ROS production in PCNs induced by blood exposure or hemoglobin insult.

108 ransplantation is supported by the increased PCN risk in young EBV seronegative recipients and the pr

109 beta and dephosphorylated APC in the injured PCNs.

110 Interestingly, PCNs utilized FGF-2 found in situ to induce chemokinesis

111 y of functional groups are incorporated into PCN-333.

112 onalities can be sequentially installed into PCN-700.

113 the left anteromedial IPL (a-mIPL) and left PCN did signal strength decrease parametrically from non

114 We suggest that the left PCN may contribute a supporting visuospatial representat

115 the resulting folate-conjugated, DXR-loaded PCNs (f-PCN(DXR)) demonstrated enhanced potency to folat

116 th nonfluorescent cells showing a much lower PCN (</=1) than fluorescent cells (PCN of up to 5) under

117 ing metal organic framework (MOF) materials: PCN-14, UTSA-20, HKUST-1, Ni-MOF-74 (Ni-CPO-27), NU-111,

118 he porphyrinic metal-organic framework (MOF) PCN-224 is metalated with Fe(II) to yield a 4-coordinate

119 A facile preparation of a mesoporous Cr-MOF, PCN-333(Cr) with functional group, has been demonstrated

120 A series of flexible MOFs (PCN-605, PCN-606, and PCN-700) are synthesized and appli

121 porphyrinic metal-organic frameworks (MOFs), PCN-228, PCN-229, and PCN-230, with ftw-a topology were

122 two robust metal-organic frameworks (MOFs), PCN-426-Fe(III) and PCN-426-Cr(III), have been synthesiz

123 Two stable, non-interpenetrated MOFs, PCN-521 and PCN-523, were synthesized by a symmetry-guid

124 Moreover, PCN-777 shows excellent stability in aqueous environment

125 plexes of the type [Cu(X)(N( intersection)N)(PCN)], 3-10, where X = Cl or Br, N( intersection)N = 2,2

126 e system, the functionalized PCN-333(Cr), N3-PCN-333(Cr) shows well maintained crystallinity, porosit

127 aining metal-organic framework (MOF), namely PCN-777, has been designed and synthesized.

128 mesoporous metalloporphyrin Fe-MOFs, namely PCN-600(M) (M = Mn, Fe, Co, Ni, Cu), have been synthesiz

129 ly stable MOFs with 3-D nanochannels, namely PCN-224 (no metal, Ni, Co, Fe), have been assembled with

130 we designed a flexible Zr-MOF system, namely PCN-700 series, for the realization of switchable cataly

131 metal-organic frameworks (Zr-MOFs), namely, PCN-133 and PCN-134.

132 with inherent missing linker sites, namely, PCN-700, was initially constructed under kinetic control

133 Modularly clickable polymer-caged nanobins (PCNs) were prepared from liposome templates using a drop

134 tosan polyelectrolyte complex nanoparticles (PCNs) that delivered stromal cell-derived factor-1alpha

135 biphenyl (PCB), polychlorinated naphthalene (PCN), and polybrominated diphenyl ether (PBDE) congeners

136 few studies of polychlorinated naphthalenes (PCNs) for biota in polar regions and even fewer reports

137 henyls (PCBs), polychlorinated naphthalenes (PCNs), and polybrominated diphenyl ethers (PBDEs) were m

138 s and included polychlorinated naphthalenes (PCNs), polychlorinated dibenzofurans (PCDFs), chlorinate

139 ing: the posterior contralateral negativity (PCN) was used to index focal-attentional selection times

140 arasitic nematode, the potato cyst nematode (PCN) Globodera rostochiensis.

141 matodes, including the potato cyst nematode (PCN); however, the mechanistic details of this cross-kin

142 Potato cyst nematodes (PCNs), Globodera rostochiensis and G. pallida, cause imp

143 ent features of human plasma cell neoplasms (PCNs).

144 ave elevated risk for plasma cell neoplasms (PCNs, comprising multiple myeloma and plasmacytoma), but

145 emerging approach (Protein Contact network, PCN) based on the formalization of 3D structures as cont

146 nd in blood-induced primary cortical neuron (PCNs) cellular model of SAH in vitro.

147 al target, NQO1, in primary cortical neuron (PCNs).

148 rall spike rates of piriform cortex neurons (PCNs) were sensitive to the relative timing of activatio

149 Primary cortical neurons (PCNs) were subjected to oxygen glucose deprivation (OGD)

150 nger in catenated PCN-6 than in noncatenated PCN-6', leading to much higher H(2) uptake in the isomer

151 ) pneumococci, or penicillin-nonsusceptible (PCN-NS) pneumococci.

152 Carriage of COT-NS, but not PCN-NS, pneumococci also decreased (38%; P=.02), not onl

153 s from the mesencephalic precommand nucleus (PCN) and the adjacent thalamic dorsal posterior nucleus

154 receives inputs from the precommand nucleus (PCN) at the mesencephalic-diencephalic border and the ve

155 or the determination of plasmid copy number (PCN) are available, and most of them average the PCN of

156 ency of transformation, plasmid copy number (PCN), and plasmid stability were first compared between

157 ion assisted by the structural attributes of PCN-333 has been studied while maintaining the integrity

158 gnificantly, the expected usable capacity of PCN-6 is as high as 75 mg/g (or 41.9 g/L) at 77 K, if a

159 erall carriage of pneumococci or carriage of PCN-NS pneumococci.

160 However, the contributions of PCN during infection of bronchiectatic airways are not a

161 00 sorted cells for precise determination of PCN.

162 The beneficial effects of PCN treatment are seen with reduced lipogenesis and gluc

163 To determine the temporal effects of PCN treatment on the expression of Oatp2, rats were admi

164 rried out for the catenation isomer pairs of PCN-6 and PCN-6' (both have the formula of Cu(3)(TATB)(2

165 Here, we have studied the progression of PCN transcriptomes from dry cysts to hatched juveniles u

166 N2-adsorption studies of PCN-14 at 77 K reveal a Langmuir surface area of 2176 m2

167 Treatment of PCN induced the expression of the reporter gene in a dos

168 For instance, the dichromate uptake of PCN-134 is tuned by adjusting the BTB/TCPP ratios, which

169 For example, the excess hydrogen uptake of PCN-6 is 72 mg/g (6.7 wt %) at 77 K/50 bar or 9.3 mg/g (

170 We determined concentrations of PCNs in eggs of thick-billed murres (Uria lomvia) collec

171 reatment stimulated the neurite outgrowth of PCNs after OGD, which was attenuated by LY294002 and enh

172 increased with age, but due to the rarity of PCNs in younger people in the general population, SIRs w

173 first published study of temporal trends of PCNs in Canadian Arctic biota.

174 eptor) and PXR in mice injected with D(3) or PCN.

175 fferent lengths were installed into a parent PCN-700, giving rise to 11 new MOFs and each bearing up

176 e Sprague-Dawley rats were injected with PB, PCN, 3-methylcholanthrene (3-MC), or vehicle for 4 days.

177 wo photochromic metal-organic frameworks, PC-PCN and SO-PCN, have been developed.

178 eaction has been successfully realized in PC-PCN while maintaining its single crystallinity.

179 ns of total suspended particles, PAHs, PCBs, PCNs, and PBDEs, were typically observed in the flaming

180 in the 10% of patients reporting penicillin (PCN) allergy, but most of these patients are not truly a

181 on two representative examples, [CuCl(phen)(PCN)].DMF (5.DMF) and [CuBr(dpq)(PCN)].2DMF (10.2DMF).

182 ey (DMW), skimmed milk (SMP), phosphocasein (PCN) and infant milk formula (IMF) powders were determin

183 Posterior PCNs showed higher sensitivity to relative input times t

184 tic (PPa, PPp, and PM), pretectal (PPd, PPv, PCN, PSp, and PSm), ventral (= pre-) thalamic (I, VM, an

185 parietal lobule (IPL), bilateral precuneus (PCN), bilateral premotor cortex, and left inferior front

186 cipants, which were accompanied by prolonged PCN and lateralized readiness potentials synchronized to

187 entrations of dexamethasone actively promote PCN and TCDD induction of UGT1A1 in Tg-UGT1 primary hepa

188 these, the redox active exotoxin pyocyanin (PCN) is produced in concentrations up to 100 mumol/L dur

189 ts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection.

190 Remarkably, PCN-224(Co) exhibits high catalytic activity for the CO2

191 Patients with MSSA bacteremia and a reported PCN allergy should have the allergy addressed for optima

192 r patients with MSSA bacteremia and reported PCN allergy.

193 n via its functional connection to the right PCN.

194 On average, Sigma67TEQ-PCN in the murre eggs accounted for only 1.9% of the tot

195 accounted for the majority of the Sigma67TEQ-PCN, concentrations of which also decreased significantl

196 Similarly, PCN treatment of animals on high-fat diet increases expr

197 h concentration of mesoporous cages as SMTs, PCN-333(Al) encapsulates three enzymes with record-high

198 Additionally, SO-PCN shows catalytic activity towards photooxidation of 1

199 omic metal-organic frameworks, PC-PCN and SO-PCN, have been developed.

200 photochromic switch and photosensitizer, SO-PCN has demonstrated reversible control of (1)O2 generat

201 pore size and excellent chemical stability, PCN-333 may be of interest not only for enzyme encapsula

202 min D(3) and the catatoxic synthetic steroid PCN (pregnenolone-16alpha-carbonitrile).

203 controlled synthetic process, we synthesized PCN-223, a new porphyrinic Zr-MOF constructed from the n

204 As such, the TEQ-PCN concentrations calculated for the murre eggs in this

205 ults are consistent with the conclusion that PCN-activated PXR represses FoxA2-mediated transcription

206 In this study, we demonstrate that PCN is critical for chronic infection in mouse airways a

207 act models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infe

208 In summary, this study establishes that PCN is an important P. aeruginosa virulence factor capab

209 etabolism and energy homeostasis reveal that PCN treatment on high-fat diet-fed mice reduces expressi

210 X-ray single crystal analysis revealed that PCN-14 consists of nanoscopic cages suitable for gas sto

211 metabolism in white adipose tissue show that PCN treatment reduces expression of Ppargamma2, Acc1, Cd

212 rption studies at 290 K and 35 bar show that PCN-14 exhibits an absolute methane-adsorption capacity

213 Moreover, ChIP assays showed that PCN treatment attenuated the binding of FoxA2 to these p

214 The PCN approach proved successful in both reconstructing th

215 The PCN-224 series not only exhibits the highest BET surface

216 We anticipate the PCN-333 with functional anchor can serve as a stable pla

217 are available, and most of them average the PCN of total populations disregarding heterogeneous dist

218 dominantly CN-52/60 and CN-42) dominated the PCN profile, the hexa-CNs (mainly CN-66/67) accounted fo

219 empts to interpret the exchange event in the PCN-333.

220 ncreased and decreased, respectively, in the PCN-treated Pxr(+/+) mice.

221 in lipogenesis) mRNA was up-regulated in the PCN-treated Pxr(+/+) mice.

222 Moreover, the PCN timing was positively correlated with ADHD symptom r

223 confirm that the catalytic activities of the PCN-700 series can be switched on and off upon reversibl

224 The breathing amplitudes of the PCN-700 series were modulated through pre-functionalizat

225 Among them, PCN-250(Fe2Co) exhibits high volumetric uptake of hydrog

226 These PCNs possess pH-responsive characteristics that can be u

227 Wild-type FVBN mice chronically exposed to PCN developed goblet cell hyperplasia and metaplasia, ai

228 analyses indicated that chronic exposure to PCN profoundly increased the lung population of recruite

229 Furthermore, after 12 weeks of exposure to PCN, mouse lungs down-regulated the expression of T help

230 dulates the activation of PXR in response to PCN treatment.

231 ed StCLV2 expression are less susceptible to PCN infection, indicating that interference of the CLV2-

232 Following liver transplantation, PCN risk was higher in recipients with cholestatic liver

233 roprotection in blood- or hemoglobin-treated PCNs and partially restores normal neuronal morphology.

234 ce of a family of isomorphic MOFs based upon PCN-14.

235 Utilizing PCN-426-Mg as a template, two robust metal-organic frame

236 PXR was retained in the cytoplasm from where PCN treatment translocated PXR into the nucleus.

237 a elucidate the molecular mechanism by which PCN treatment induces rat oatp2 gene expression.

238 rs of rats treated with PB and PCN, in which PCN caused a robust elevation of Oatp2 mRNA and protein.

239 Dosing rats with PCN and dexamethasone increased p-glycoprotein expressio

240 significantly increased in rats treated with PCN for 2 days but significantly decreased in 19-day pre

241 At the functional level, treatment with PCN in wild-type mice, but not PXR(-/-) mice, led to a d