ライフサイエンスコーパス: PDF

1 PDF analysis reveals strong local structural distortion

2 PDF contributes to the amplitude, synchrony, as well as

3 PDF copy of the standard paper participant information s

4 PDF data for nanocrystalline platinum (n-Pt) were collec

5 PDF is known to increase cAMP levels in PDR receptor (PD

6 PDF neuron rescue induced high amplitude rhythms in the

7 PDF promotes roaming states through a Galphas-coupled PD

8 PDF receptors (PDFR-1) expressed in peripheral mechanose

9 PDF secreted by the ventral pacemaker subset of circadia

10 PDF-expressing neurons consist of two neuronal clusters:

11 PDFs of n-Pt and nano Au (n-Au) under quasi-hydrostatic

12 A PDF manual for R package "SampleSizeSNP" is given in Add

13 the individual ratios are characterized by a PDF with power-law tails X(i)(-1-alpha) with infinite va

14 the same rate and particles surviving the A-PDF had an even higher oxidative potential on a per PM m

15 Adding PDF to fly brains in vitro has a similar effect.

16 e Alzheimer's disease-associated APP affects PDF expression and causes retraction of the sLNv synapti

17 rprisingly, disruption of AC3 does not alter PDF responses in E cells--the PDF-R(+) LNd.

18 regulation via control of axonal growth and PDF levels within the sLNv-encompassing neural network a

19 blished and is appended to both the HTML and PDF versions of this paper.

20 No colocalization of MIP- and PDF immunostaining was detected in the anterior optic co

21 ar oscillations between disparate PDF(+) and PDF(-) circadian pacemaker neurons and controlling pacem

22 X-ray total scattering and PDF analysis indicate that the majority phase for both t

23 -ray scattering (SAXS) confirms the STEM and PDF analysis.

24 modes, and it outputs data files in text and PDF formats.

25 Analysis of XAFS, X-ray scattering, and PDFs confirm that the lattice parameter, a, of the fcc c

26 In wild-type animals, PDF-TRI neurons in the central brain undergo programmed

27 pacemaker neuron output, we focally applied PDF to DN1p neurons and found that it acutely depolarize

28 action intermediates from techniques such as PDF can be a valuable asset in the development of system

29 h the original data is part of the automated PDF output.

30 Additionally, cell-autonomous PDF signaling reversed the circadian behavioral effects

31 imicrobial agents, and that many of the best PDF inhibitors demonstrate slow, time-dependent binding.

32 ese findings extend the similarities between PDF and VIP beyond their shared central role as circadia

33 Both PDF and sNPF suppress basal Ca(2+) levels in target pace

34 R couples preferentially to a single AC, but PDF-R association with a different AC(s) is needed to ex

35 PDF) neuropeptide into the dorsal brain, but PDF expression persists in their cell bodies and remaini

36 ction eliminates sLNvdorsal projections, but PDF expression persists in sLNvand large ventral lateral

37 Yet, axonal defects by PDF knockdown are presynaptic and become apparent only a

38 e circuit also features negative feedback by PDF to truncate the s-LNv Ca(2+) wave and terminate PDF

39 h known roles of M pacemakers as mediated by PDF.

40 confirms an autocrine feedback signaling by PDF back to PDF-expressing cells.

41 function is analogous to that of chloroplast PDF.

42 tes roaming states through a Galphas-coupled PDF receptor; optogenetic activation of cAMP production

43 Both d-PDF and EXAFS results indicated that the bidentate binuc

44 s differential pair distribution function (d-PDF) analysis and extended X-ray absorption fine structu

45 Polypeptide deformylase (PDF) is a highly conserved bacterial enzyme, which is es

46 atalysis and inhibition by several different PDF inhibitors.

47 ing molecular oscillations between disparate PDF(+) and PDF(-) circadian pacemaker neurons and contro

48 etic disruptions of AC3 specifically disrupt PDF responses: they do not affect other Gs-coupled GPCR

49 y higher heat shock protein 72 levels during PDF treatment.

50 who were randomly assigned to receive either PDF or TF from term age until 6-mo CA.A total of 79 of 1

51 a I and Ga II, based on fitting experimental PDF to known crystal structure, with a controversy.

52 with a different AC(s) is needed to explain PDF signaling in the E pacemakers.

53 rt that Ap and Chi in the neurons expressing PDF, a neuropeptide, play important roles in proper slee

54 In Drosophila, PIGMENT-DISPERSING FACTOR (PDF) acts as a master network regulator with dual functi

55 the neuropeptide pigment-dispersing factor (PDF) amplifies the molecular rhythms via time-of-day- an

56 the neuropeptide PIGMENT-DISPERSING FACTOR (PDF) are especially important for morning anticipation a

57 levels within the pigment dispersing factor (PDF) cell-pacemaker neurons; only mir-92a peaks during t

58 Pigment-dispersing factor (PDF) denotes a conserved family of homologous neuropepti

59 and neuropeptide pigment dispersing factor (PDF) from morning cells (s-LNv) together delay the phase

60 tral neuropeptide pigment-dispersing factor (PDF) in circadian timekeeping in Drosophila is remarkabl

61 s the function of pigment-dispersing factor (PDF) in four s-LNv neurons and its receptor PDFR in two

62 The neuropeptide Pigment Dispersing Factor (PDF) is essential for normal circadian function in Droso

63 protein levels in pigment dispersing factor (PDF) neurons.

64 rons that release pigment-dispersing factor (PDF) neuropeptide into the dorsal brain, but PDF express

65 n Drosophila, the PIGMENT DISPERSING FACTOR (PDF) neuropeptide-expressing morning (M) and non-PDF eve

66 verelaboration in pigment dispersing factor (PDF) peptidergic neurons in the adult brain.

67 The neuropeptide pigment-dispersing factor (PDF) synchronizes molecular oscillations within circadia

68 the neuropeptide pigment-dispersing factor (PDF) that functions to stabilize Drosophila sleep-wake c

69 uropeptide called pigment-dispersing factor (PDF) whose signaling is often equated with M oscillator

70 the neuropeptide pigment dispersing factor (PDF), each initiate and extend one behavioral state.

71 the neuropeptide pigment-dispersing factor (PDF), however, revealed species-specific differences.

72 the neuropeptide pigment-dispersing factor (PDF), released by the well-characterized central pacemak

73 the neuropeptide pigment-dispersing factor (PDF), which mediates pacemaker neuron synchrony and outp

74 lation of NPF and pigment dispersing factor (PDF)-immunoreactive neurons has additive effects in LD,

75 dian neuropeptide pigment-dispersing factor (PDF).

76 coupling peptide pigment-dispersing factor (PDF).

77 The PIGMENT DISPERSING-FACTOR (PDF)-positive small ventral lateral neurons (sLN(v)s) pr

78 Pigment-dispersing factor- (PDF) and MIP immunostaining was colocalized in two neuro

79 trategies are based on probe design factors (PDFs), which include probe hybridization free energy (PH

80 health variables when comparing children fed PDF with those fed TF.

81 to glucose-based peritoneal dialysis fluid (PDF).

82 13.8% reduction in portable document format (PDF) article downloads from the journals' websites when

83 and mineral-enriched postdischarge formula (PDF) from term age to 6-mo corrected age (CA) gained mor

84 sed as the potentially disappeared fraction (PDF) of native freshwater fish species in the rivers Rhi

85 long records, probability density function (PDF) analyses of the 95% percentile exceedance of total

86 ters (GPFs), a probability density function (PDF) based heterogeneous multiscale filtration (HMF) mod

87 is based on a probability density function (PDF) description of the pore size distribution and class

88 In situ pair distribution function (PDF) analyses and density functional theory (DFT) comput

89 Operando pair distribution function (PDF) analysis and ex situ (23)Na magic-angle spinning so

90 ering and atomic pair distribution function (PDF) analysis are used to show that precursors that firs

91 Diffraction and Pair Distribution Function (PDF) analysis in amorphous solid dispersions of lapatini

92 Pair distribution function (PDF) analysis indicates that the local structure of the

93 , we used atomic pair distribution function (PDF) analysis of synchrotron X-ray powder diffraction da

94 diffraction, and pair distribution function (PDF) analysis of X-ray total scattering from standard an

95 Furthermore, pair distribution function (PDF) analysis suggests that the local structure of these

96 Pair distribution function (PDF) analysis was applied for structural characterizatio

97 y scattering and pair distribution function (PDF) analysis were used to determine the local structure

98 ffraction (XRD), pair distribution function (PDF) analysis, and magic-angle-spinning NMR spectroscopy

99 various uses of pair distribution function (PDF) analysis, dielectric spectroscopy, peak-shape analy

100 vestigated using pair distribution function (PDF) analysis.

101 diffraction, and pair distribution function (PDF) analysis.

102 ction as well as pair distribution function (PDF) analysis.

103 lly distorted by pair distribution function (PDF) analysis.

104 ved by combining pair distribution function (PDF) and small-angle X-ray scattering (SAXS) analysis fo

105 rotron radiation pair distribution function (PDF) and X-ray absorption spectroscopy (XAS) measurement

106 Atomic pair distribution function (PDF) data indicate that the local atomic structure is co

107 f operando X-ray pair distribution function (PDF) data is combined with Li NMR spectroscopy to gain c

108 The pair distribution function (PDF) from the sulfate-free sample reveals that the avera

109 eam suitable for pair distribution function (PDF) measurements at high pressure using a diamond anvil

110 igh energy X-ray pair distribution function (PDF) measurements, microtomography and reverse Monte Car

111 idated by atomic pair distribution function (PDF) methods using in situ neutron total scattering data

112 by Rietveld and pair distribution function (PDF) methods.

113 using the atomic pair-distribution function (PDF) obtained from electron diffraction.

114 The probability distribution function (PDF) of CTT for dust-mixed clouds shifted to the warmer

115 diffraction and pair distribution function (PDF) studies have been used to overcome the insensitivit

116 ork, we combined Pair Distribution Function (PDF) technique with Raman spectroscopy and electrical re

117 tric Levy probability distribution function (PDF) to describe the stochastic properties of commodity

118 attering (SAXS), pair distribution function (PDF), and X-ray powder diffraction (XRPD) techniques, is

119 Meanwhile, the pair-distribution-function (PDF) analysis of the as-cast and post-fatigue samples sh

120 around the dawn hours to promote functional PDF signaling.

121 ssed to yield probability density functions (PDFs) describing the circumferential location of maximum

122 ) MEMLET fits probability density functions (PDFs) for many common distributions (exponential, multie

123 nd fat-tailed probability density functions (PDFs).

124 employs atomic pair distribution functions (PDFs), determined from X-ray total scattering that depen

125 r-Planck equation with strongly non-Gaussian PDFs in much higher dimensions even with orders in the m

126 h the transient and equilibrium non-Gaussian PDFs requires only [Formula: see text] samples!

127 Thus, RalA activity confers high PDF responsiveness, providing a daily gate around the da

128 How PDF circuits develop the specific connectivity traits th

129 To address how PDF impacts pacemaker neuron output, we focally applied

130 evening (LNd) group by approximately 12 hr; PDF alone delays the phase of the DN3 group by approxima

131 st, in constant darkness, knockdown of Ap in PDF-expressing neurons did not promote arousal, indicati

132 are more strongly reset to timing changes in PDF clocks than other pacemaker neurons, suggesting that

133 n of dominant-negative forms of Ap or Chi in PDF-expressing neurons or l-LNvs promoted arousal.

134 al, indicating that a reduced Ap function in PDF-expressing neurons promotes light-driven arousal.

135 sample results and supporting information in PDF format.

136 core clock target of PDF, we rescued per in PDF neurons of arrhythmic per(0)(1) mutants.

137 etic inhibition of protein kinase A (PKA) in PDF(-) clock neurons can phenocopy PDF mutants while act

138 elimited files, publication quality plots in PDF format.

139 optogenetic activation of cAMP production in PDF receptor-expressing cells induces prolonged roaming

140 -LNvs, particularly the circadian rhythms in PDF accumulation and axonal arbor remodeling.

141 urther analyses, and visualizations saved in PDF and PNG formats.

142 utputs an overview of genome-wide synteny in PDF.

143 ophila genus, although there is variation in PDF and CRY expression.

144 be important for activity rhythms, including PDF accumulation and arborization rhythms in the small v

145 f the sLNv synaptic terminals and increasing PDF levels, supporting a neuroprotective role for dTip60

146 We find that intestinal PDF acts at a distance on the renal system, where it reg

147 contrast, we describe a approximately 70-kB PDF receptor (pdfr) transgene that does rescue the entir

148 In contrast to flies that lack PDF, flies that lackLaranticipate lights-on and lights-o

149 nticipatory activity seen in flies that lack PDF,LarRNAi knockdown flies anticipate the lights-on and

150 growth rates are distributed with a Laplace PDF.

151 circadian neurons: the 8 small and 10 large PDF-expressing ventral lateral neurons (s-LNvs and l-LNv

152 score, we find that P(DeltaZ) follows a Levy PDF with power-law exponent alpha approximately 1, consi

153 We find that an asymmetric Levy PDF, L, characterized by infinite variance, models sever

154 We thus find that Levy PDFs describe both the static and dynamics of credit rat

155 ness and does not require endogenous ligand (PDF) signaling or rhythmic receptor gene transcription.

156 PDFR-1 and its ligand, PDF-1, stimulated mate searching in the male, but not in

157 r sharing workshop content is through making PDF, PowerPoint and Word documents available online.

158 al mir-92a target and that mir-92a modulates PDF neuronal excitability via suppressing SIRT2 levels i

159 Neuropeptide PDF (pigment-dispersing factor)-secreting large ventrola

160 maker neurons of the larva, the neuropeptide PDF (pigment-dispersing factor)-expressing lateral neuro

161 The neuropeptide PDF is crucial for Drosophila circadian behavior: it kee

162 The neuropeptide PDF is important for Drosophila circadian rhythms: pdf(0

163 Loss of the receptor for the neuropeptide PDF promoted synchrony of Ca(2+) waves.

164 The neuropeptide PDF promotes the normal sequencing of circadian behavior

165 reased secretion of an arousal neuropeptide (PDF-1) from central neurons.

166 We developed a new PDF, pseudo probe binding energy (PPBE), by iteratively

167 neuropeptide-expressing morning (M) and non-PDF evening (E) cells are coupled cell groups important

168 nscripts are also under clock control in non-PDF DN1p neurons.

169 on also results in reduced TIM levels in non-PDF neurons of per(0)(1) flies.

170 we have developed Utopia Documents, a novel PDF reader that semantically integrates visualization an

171 h of the asynchrony caused by the absence of PDF.

172 Activation of PDF receptors in DH31-positive DN1 specifically affects

173 Activation of PDF-R stimulates cAMP increases in vitro and in M cells

174 Analysis of PDF, neutron prompt gamma, and thermogravimetric data, c

175 e, we identify a very different component of PDF neuron misregulation in dfmr1 mutants: the aberrant

176 However, there is no known connection of PDF or of cAMP with the Drosophila molecular clockworks.

177 In vivo calcium monitoring, dynamics of PDF projections, ArcLight, GCaMP6 imaging and sleep assa

178 The effect of PDF on clock gene transcription and the known role of PD

179 strates an acute direct excitatory effect of PDF on target neurons to control neuronal output.

180 ren, we showed that the favorable effects of PDF at 6-mo CA either were not maintained or could not b

181 increases underlie the myotropic effects of PDF.

182 Brief firing of PDF cells at different times of day generates a phase re

183 and cellular basis for the dual functions of PDF in clock resetting and pacemaker output.

184 Immunolocalization of PDF-like peptides in six onychophoran species, by using

185 ition, we examined in detail the kinetics of PDF catalysis and inhibition by several different PDF in

186 The lack of PDF-like-immunoreactive somata associated with the onych

187 Complete loss of PDF or PKA inhibition also results in reduced TIM levels

188 aCl, which binds to the active site metal of PDF.

189 nstrate that the DN1(p)s lie at the nexus of PDF and photic signaling to produce appropriate daily be

190 lator model, which emphasizes the primacy of PDF-containing neurons, and a cell-autonomous model for

191 ere, we identify GW182 as a key regulator of PDF signaling.

192 ic arbor required for presynaptic release of PDF.

193 the mechanistic understanding of the role of PDF in controlling the synchrony of the pacemaker neuron

194 ock gene transcription and the known role of PDF in enhancing PER/TIM stability occur via independent

195 Here we investigate the visceral roles of PDF by adapting cellular and physiological methods to th

196 Given the significance of PDF signaling to numerous aspects of behavioral and mole

197 he existence of two conformational states of PDF(Ec) is further supported by the observation of two d

198 ptimal hydrogen bonds within the subsites of PDF.

199 The identification of TIM as a target of PDF signaling suggests it is a multimodal integrator of

200 To address the core clock target of PDF, we rescued per in PDF neurons of arrhythmic per(0)(

201 nsiveness also cycles, in phase with that of PDF, in the same pacemakers, but does not cycle in large

202 er subset of circadian clock neurons acts on PDF receptors in the DH31-expressing dorsal clock neuron

203 The original PDF version of this Article inadvertently highlighted th

204 In the original PDF version of this Article, which was published on 16 O

205 In the original PDF version of this Article, which was published on 16 O

206 vity and a better specificity than all other PDFs, although training data are required to construct a

207 Within M pacemakers, PDF-R couples preferentially to a single AC, but PDF-R a

208 graphical output plus an in-depth multi-page PDF report including error profile, quality and yield da

209 We show that PdfR, PDF's established receptor, is expressed by the muscles

210 system, in contrast to the fully persistent PDF-TRI neurons.

211 (PKA) in PDF(-) clock neurons can phenocopy PDF mutants while activated PKA can partially rescue PDF

212 , colors or node sizes, and exported as PNG, PDF or GraphML files.

213 The PDF receptor (PDF-R) is present in both M and subsets of E cells.

214 a broadly reactive antibody that recognizes PDF/PDH peptides in numerous species, revealed an elabor

215 clock neurons (lLN(v) s) and showed reduced PDF immunostaining in the small ventrolateral clock neur

216 -like scaffolding protein Nervy also reduces PDF responses.

217 on, the effect of PubMed Central on reducing PDF article downloads is increasing over time, growing a

218 e activity of RalA GTPase in s-LNv regulates PDF responsiveness and behavioral locomotor rhythms.

219 normally, which suggests that the remaining PDF expression mediates activity during light/dark cycle

220 e, we show that mature sLNv circuits require PDF signaling during early development, acting through i

221 ich mimics a light-mediated PRC and requires PDF receptor expression in the five E neurons.

222 nts while activated PKA can partially rescue PDF receptor mutants.

223 by means of in situ X-ray total scattering (PDF) measurements.

224 In all our data sets, PDFs related to probe secondary structure (PMFE, hairpin

225 tandard paper participant information sheet (PDF-PIS) and an electronic Interactive Information Sheet

226 rdination number) extracted from the in situ PDF data, suggests that anion partitioning occurs during

227 the anterior optic commissure, but two small PDF-immunoreactive commissural fibers near the posterior

228 , Gaussian, etc.), as well as user-specified PDFs without the need for binning.

229 truncate the s-LNv Ca(2+) wave and terminate PDF release.

230 These findings support a hypothesis that PDF signaling components within target cells are sequest

231 The results indicate that PDF contributes to clock neuron synchrony by increasing

232 However, we show that PDF-expressing LNs are dispensable for light avoidance,

233 It has previously been shown that PDF inhibitors represent a promising new area for the de

234 rsal projection development and suggest that PDF expression in LNvcell bodies and their remaining pro

235 Our results suggest that PDF neurons integrate light information and then modulat

236 The PDF for relatively pristine cloud only show one peak at

237 The PDF indicates that the Zr-Zr distances in this glass are

238 The PDF is sensitive to local ionic displacements and their

239 The PDF receptor (PDF-R) is present in both M and subsets of

240 The PDF results show that the structure of SiOC alloys are n

241 This has now been corrected in both the PDF and HTML versions of the article.

242 This has now been corrected in both the PDF and HTML versions of the Article.

243 These errors have been corrected in both the PDF and HTML versions of the Article.

244 e errors have now been corrected in both the PDF and HTML versions of the Article.

245 his error has now been corrected in both the PDF and HTML versions of the Article.

246 e errors have all been corrected in both the PDF and HTML versions of the Article.

247 does not alter PDF responses in E cells--the PDF-R(+) LNd.

248 To view this SnapShot, open or download the PDF.

249 this Bench to Bedside, open or download the PDF.

250 To view this SnapShot, open or download the PDF.

251 To view this SnapShot, open or download the PDF.

252 To view this Timeline, open or download the PDF.

253 This has now been corrected in the PDF and HTML versions of the Article.

254 structures is the only motif apparent in the PDF of either precursor.

255 These have now been corrected in the PDF version of the Article.

256 In the PDF version of this article, Eq.

257 fat body clock require clock function in the PDF-positive cells of the fly brain.

258 This has now been corrected in the PDF; the HTML version of the paper was correct from the

259 Subtraction of the PDF of crystalline NaxSb phases from the total PDF, an a

260 r via independent pathways downstream of the PDF receptor, the former through a cAMP-independent mech

261 ynamic data reveal that the formation of the PDF(Ec)-actinonin complex results in the transfer of one

262 42 were randomised to receive the PDF-PIS and 44 to receive the IIS (with consent rates of

263 se projections in the heart suggest that the PDF neuropeptides functioned as both circulating hormone

264 Unexpectedly, we found that the PDF Receptor (PdfR) is required in both LNvs and DN1s to

265 The result therefore suggests that the PDF-mediated increase in cAMP might lengthen circadian p

266 ng precisely where and how signaling via the PDF receptor (PDFR) occurs is now a central question in

267 N(v)s) promote morning behavior, whereas the PDF-negative sLN(v) and the dorsal lateral neurons (LN(d

268 nanoscale structural changes observed in the PDFs are dominated by piezoelectric lattice strain and i

269 The proper modification of the PDFs occurs automatically in the program and greatly inc

270 The impact of these PDFs on probe performance was evaluated using four sets

271 A practical way to use these PDFs for probe design is to set cutoff thresholds to fil

272 but the function and mode of action of this PDF have not been characterized.

273 autocrine feedback signaling by PDF back to PDF-expressing cells.

274 that is even more advanced in comparison to PDF-ablated flies.

275 under normal conditions or after exposure to PDF.

276 ortant molecular mechanism after exposure to PDF.

277 ethods to the study of visceral responses to PDF signaling in wild-type and mutant genetic background

278 eport daily rhythmicity in responsiveness to PDF in critical pacemakers called small LNvs.

279 .e., instrument "dead time") when fitting to PDFs.

280 ermolecular drug interactions from the total PDF x-ray pattern was successfully applied allowing the

281 F of crystalline NaxSb phases from the total PDF, an approach constrained by chemical phase informati

282 ention of normally developmentally-transient PDF tritocerebral (PDF-TRI) neurons.

283 fects on a clock neuron peptide transmitter (PDF) and behavior demonstrate the capacity for glia-to-n

284 ce and time per amount of goods transported (PDF.m(3).yr.kg(-1)).

285 developmentally-transient PDF tritocerebral (PDF-TRI) neurons.

286 tion: The LS BAM is freely available as UML, PDF and HTML.

287 we show that adenylate cyclase AC3 underlies PDF signaling in M cells.

288 Finally, the results present an unexpected PDF receptor site: the large LNv cells appear to target

289 The original version (PDF) is appended to this article as a Supplement.

290 Like VIP, PDF is expressed outside the circadian network by neuron

291 ploading of processed information in visual, PDF, CSV, and Excel formats.

292 Yet the mechanisms by which PDF functions are not clear.

293 (PKA) and a molecular target (TIM) by which PDF resets and synchronizes clocks and demonstrates an a

294 ignaling components that are associated with PDF receptor in specific circadian pacemaker neurons?

295 NPF, we knocked it down in conjunction with PDF using RNA-interference (RNAi) and further suggest a

296 Consistent with PDF analysis, Raman spectroscopy data suggest that the l

297 to seamlessly integrate on-line content with PDF articles.

298 In addition, mir-92a levels within PDF cells respond to light pulses and also affect the ph

299 ions (RMC) guided by the experimental HE-XRD/PDF data.

300 to atomic pair distribution function (HE-XRD/PDF) analysis to probe the atomic structure of PdNi nano