ライフサイエンスコーパス: PDGFR-alpha

1 PDGFR alpha hyperphosphorylation and enhanced proliferat

2 PDGFR alpha-positive cells in optic nerve and spinal cor

3 PDGFR-alpha activation led to BBB impairment and this wa

4 PDGFR-alpha and -beta immunoreactivity was observed in r

5 PDGFR-alpha and -beta proteins are expressed in native a

6 PDGFR-alpha and -beta were expressed on all melanoma cel

7 PDGFR-alpha signaling may contribute to BBB impairment v

8 PDGFR-alpha suppression prevented neurological deficits,

9 PDGFR-alpha(+)Sca-1(+) (PalphaS) MSCs have augmented gro

10 Ab-PDGFR-alpha decreased significantly the overall smooth m

11 eived a blocking antibody to PDGFR-alpha (Ab-PDGFR-alpha; 10 mg/kg; n=5) or PDGFR-beta (Ab-PDGFR-beta

12 PDGFR-beta (1.2+/-0.2, P<0.01) but not in Ab-PDGFR-alpha (2.2+/-0.4).

13 Serum Ab-PDGFR-alpha concentrations fell rapidly after day 7 to 0

14 In addition, PDGFR-alpha and -beta protein expression was observed in

15 These data demonstrate that all PDGFR alpha-positive cells in the embryonic rat spinal c

16 lial cells that express PDGF receptor alpha (PDGFR alpha) [1] and divide in response to PDGF [2-5], s

17 atelet-derived growth factor receptor alpha (PDGFR alpha) as one target of mutant Cbl-induced deregul

18 atelet-derived growth factor receptor alpha (PDGFR alpha)-positive.

19 atelet-derived growth factor receptor-alpha (PDGFR alpha) expression in vivo and in isolated mammary

20 atelet-derived growth factor receptor-alpha (PDGFR alpha), suggesting that negative selection using c

21 atelet-derived growth factor receptor alpha (PDGFR-alpha) and stem cell antigen 1 (Sca-1) have recent

22 atelet-derived growth factor receptor alpha (PDGFR-alpha) signaling, resulting in increased apoptosis

23 atelet-derived growth factor receptor alpha (PDGFR-alpha), a tyrosine kinase receptor, was found in p

24 atelet-derived growth factor receptor-alpha (PDGFR-alpha) activation caused an increase of IKDR in NG

25 atelet-derived growth factor receptor-alpha (PDGFR-alpha)(+)Sca-1(+)CD45(-)Ter119(-) (PalphaS) cells.

26 growth factor receptor beta (PDGFR beta) and PDGFR alpha, but not insulin-like growth factor-1R and e

27 from fusion of the Fip1-like 1 (FIP1L1) and PDGFR alpha (PDGFRA) genes has been identified as a ther

28 Both PDGFR-beta- and PDGFR-alpha-mediated pathways promote collagen depositio

29 Because KIT and PDGFR-alpha remain drivers of GIST after resistance to i

30 and indicate an oncogenic role for c-Kit and PDGFR-alpha tyrosine kinases in the context of Int3 sign

31 ing anti-PDGFR-beta antibody (APB5), an anti-PDGFR-alpha antibody (APA5), or control immunoglobulin G

32 The PDGF-B, PDGFR-alpha, and PDGFR-beta mRNA expression was induced

33 ived growth factor receptor-alpha and -beta (PDGFR-alpha and -beta), we designed this study to test t

34 nstrated that imatinib mesylate blocked both PDGFR-alpha and PDGFR-beta in vivo.

35 antibodies: allophycocyanin (APC)-conjugated PDGFR-alpha, FITC-conjugated Sca-1, phycoerythrin (PE)-c

36 In contrast, PDGFR-alpha inhibition did not affect vascular maturatio

37 oligodendrocytes develops from a different, PDGFR alpha-negative lineage(s).

38 o test the hypothesis that inhibiting either PDGFR-alpha or PDGFR-beta with a specific mouse/human ch

39 Viral entry in cells harbouring endogenous PDGFR-alpha was competitively inhibited by pretreatment

40 R-1, -3, c-Kit and RET, most cells expressed PDGFR-alpha and -beta.

41 PDGF-A null mice had many fewer PDGFR alpha-progenitors than either wild-type or PDGF-B

42 Consistent with this finding, PDGFR-alpha immunoreactivity was confined to NG2+ cells

43 mouse, a deletion that includes the gene for PDGFR alpha, is a recessive lethal that exhibits a domin

44 like Nanog(low)Sox2(low)Lin28(high)CD24(high)PDGFR-alpha(high) population.

45 Targeted human PDGFR-alpha activation in mouse beta-cells stimulated Er

46 ockade of receptor function with a humanized PDGFR-alpha blocking antibody (IMC-3G3) or targeted inhi

47 otype in Pdgfr-alpha(-/-) embryos identified PDGFR-alpha as a critical mediator of signaling in the e

48 a activation and exogenous PDGF-AA increased PDGFR-alpha activation, regardless of thrombin inhibitio

49 neutralizing antibodies inhibit HCMV-induced PDGFR-alpha phosphorylation.

50 At least one target of imatinib (KIT, PDGFR-alpha, or PDGFR-beta) was expressed in all tumors,

51 pathway with lithium treatment rescued NG2(+)PDGFR-alpha(+) progenitor cell proliferation in BBS muta

52 so known as neuron-glial antigen 2 or NG2)(+)PDGFR-alpha(+) neural progenitors.

53 responds to activation of PDGFR-beta but not PDGFR-alpha, was not phosphorylated on tyrosine in mutan

54 after E16, coinciding with the appearance of PDGFR alpha-immunoreactive cells in the starting populat

55 Our findings highlight a novel aspect of PDGFR alpha signaling in tumorigenesis.

56 spinal cord cells that had been depleted of PDGFR alpha-expressing cells by antibody-mediated comple

57 lso failed to induce hyperphosphorylation of PDGFR alpha.

58 othesis that TGF-beta mediates the levels of PDGFR alpha protein via regulation of c-Cbl was tested.

59 e were profound reductions in the numbers of PDGFR alpha-progenitors and oligodendrocytes in the spin

60 > G mutation in exon 12 (amino acid 567) of PDGFR-alpha.

61 e Pdgf-c gene or pharmacological blockade of PDGFR-alpha impair the WAT-beige transition.

62 IFN-gamma treatment led to downregulation of PDGFR-alpha (platelet-derived growth factor receptor-alp

63 Both RA and D3 decreased the expression of PDGFR-alpha and PDGFR-beta throughout differentiation.

64 are downregulated by increased expression of PDGFR-alpha or PDGFR-beta in NSCLC cells.

65 king a functional Shp-2, while the levels of PDGFR-alpha EGFR and IGFIR were not changed.

66 tial of the melanoma cells: higher levels of PDGFR-alpha were expressed on cells with higher metastat

67 in expression, activity, and localization of PDGFR-alpha and -beta were analyzed by Western blot and

68 so correlated with the expression pattern of PDGFR-alpha.

69 Subsequent experiments confirmed the role of PDGFR-alpha and PDGFR-beta as receptors for AAV-5.

70 e present study, we investigated the role of PDGFR-alpha following ICH-induced brain injury in mice,

71 ker profile of infected cells, NG2+, olig2+, PDGFR-alpha+, nestin+, GFAP-, and CC1-, indicated a clos

72 We found that FAP was robustly expressed on PDGFR-alpha(+), Sca-1(+) multipotent bone marrow stromal

73 Only siRNA constructs for c-Kit and/or PDGFR-alpha were able to inhibit HC11-Int3 colony format

74 d demonstrated that disrupting the paracrine PDGFR alpha signaling between tumor cells and stromal fi

75 stimulation by HCMV, tyrosine-phosphorylated PDGFR-alpha associated with the p85 regulatory subunit o

76 vimentin+), and oligodendrocyte progenitors (PDGFR-alpha+) were proliferating.

77 atelet-derived growth factor-alpha receptor (PDGFR-alpha) is specifically phosphorylated by both labo

78 the platelet-derived growth factor receptor (PDGFR-alpha-polypeptide) and AAV-5 transduction.

79 telet-derived growth factor alpha-receptors (PDGFR alpha) are expressed by a subset of neuroepithelia

80 through activation of PDGF-alpha receptors (PDGFR-alpha) on perivascular astrocytes, and treatment o

81 We conclude that TGF-beta regulates PDGFR alpha in the mammary stroma via a c-Cbl-independen

82 Furthermore, RGC-5 cells showed PDGFR-alpha/beta tyrosine phosphorylation that induced t

83 mor cells and stromal fibroblasts by soluble PDGFR alpha-IgG significantly reduced tumor growth.

84 Thrombin inhibition suppressed PDGFR-alpha activation and exogenous PDGF-AA increased P

85 Together, these data indicate that PDGFR-alpha and tyrosine kinase activity act via a commo

86 Taken together, these data indicate that PDGFR-alpha is a critical receptor required for HCMV inf

87 ectable levels in O4+ cells, suggesting that PDGFR-alpha signaling is absent in pre-OLs in situ.

88 The therapeutic interventions targeting the PDGFR-alpha signaling may be a novel strategy to prevent

89 r astrocytes, and treatment of mice with the PDGFR-alpha antagonist imatinib after ischemic stroke re

90 Thus, PDGFR alpha signaling is required for the recruitment of

91 In vitro, Cbl-N directly bound to PDGFR alpha derived from PDGF-AA-stimulated cells but no

92 ental groups received a blocking antibody to PDGFR-alpha (Ab-PDGFR-alpha; 10 mg/kg; n=5) or PDGFR-bet

93 -mediated induction was primarily limited to PDGFR-alpha.

94 In mutant Cbl transfectants, PDGFR alpha was hyperphosphorylated and constitutively c

95 +) progenitor cells, as well as in human WAT-PDGFR-alpha(+) adipocytes, supporting the physiological

96 beige phenotype in differentiated mouse WAT-PDGFR-alpha(+) progenitor cells, as well as in human WAT

97 When PDGFR alpha-positive cells were purified from embryonic

98 Cells in which PDGFR-alpha was genetically deleted or functionally bloc

99 association of transfected Cbl proteins with PDGFR alpha.

100 HCMV glycoprotein B directly interacts with PDGFR-alpha, resulting in receptor tyrosine phosphorylat