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1                   Even though there are four PDHK genes, PDHK1 is essential for inhibitory PDH phosph
2 e cavity, however, appears more open than in PDHK, suggesting that its closure may be required to ach
3 -hydroxy-2-methylpropionamide (10a) inhibits PDHK in the primary enzymatic assay with an IC(50) of 13
4 2-hydroxy-2-methylpropanamide (14e) inhibits PDHK in the primary enzymatic assay with an IC(50) of 16
5 inding to the pyruvate dehydrogenase kinase (PDHK) enzyme.
6  homodimer of pyruvate dehydrogenase kinase (PDHK) is an integral part of pyruvate dehydrogenase comp
7 inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that started from N-phenyl-3,3,3-trif
8 80 microM) of pyruvate dehydrogenase kinase (PDHK).
9                       The catalytic cycle of PDHK and its translocation over the PDC surface is thoug
10 ors but also modulate the catalytic cycle of PDHK.
11 fy pan-isoform ATP-competitive inhibitors of PDHK.
12 xy-2-methylpropionic acid, are inhibitors of PDHK.
13       Whereas the structure of the symmetric PDHK/L2 complex was reported, the structural organizatio
14 g of a single L2-domain activates one of the PDHK protomers while inactivating another.
15  the target peptide might gain access to the PDHK active center through the open but not through the
16 metric" and "asymmetric" modes, in which the PDHK dimer binds to two and one L2-domain(s), respective
17                                        These PDHK inhibitors, however, do not lower glucose in diabet
18 trast to sodium dichloroacetate (DCA), these PDHK inhibitors did not lower blood glucose levels.

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