ライフサイエンスコーパス: PDIM

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1 PDIMs and PGLs are important effectors of virulence.

2 We performed whole-genome resequencing of a PDIM-deficient clone and identified a spontaneous point

3 Although PDIM has been implicated in NO defense, this result indi

4 could be transferred between the FAS-II and PDIM biosynthetic pathways.

5 ds, and suggest that drugs aimed at blocking PDIM and/or PGL production might synergize with antibiot

6 led to increased abundance and mass of both PDIM and SL-1.

7 rulence factors, phthiocerol dimycocerosate (PDIM) and sulfolipid-1 (SL-1), are controlled by the ava

8 he surface lipid phthiocerol dimycocerosate (PDIM) exhibited significant death rates, and consequentl

9 ted lipid called phthiocerol dimycocerosate (PDIM) which is found only in pathogenic mycobacteria.

10 biosynthesis of phthiocerol dimycocerosate (PDIM), a cell wall lipid that is required for full virul

11 in synthesis of phthiocerol dimycocerosate (PDIM), a surface lipid critical for virulence during acu

12 rface glycolipid phthiocerol dimycocerosate (PDIM).

13 orting the lipid phthiocerol dimycocerosate (PDIM).

14 virulence lipid phthiocerol dimycocerosate (PDIM).

15 Phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs) are structurally

16 ace-associated phthiocerol dimycoceroserate (PDIM) lipids to mask underlying pathogen-associated mole

17 rol and phthiodiolone dimycocerosate esters (PDIMs).

18 n Mt demonstrated that papA5 is required for PDIM synthesis.

19 ppsD(G44C) point mutation is responsible for PDIM deficiency, virulence attenuation in NOS2(-/-) and

20 us, we have identified coordinated roles for PDIM, known to be essential for mycobacterial virulence,

21 son insertions affecting genes implicated in PDIM synthesis; the third has a disruption in a gene enc

22 Importantly, we detected increased PDIM synthesis in bacteria growing within host tissues a

23 The mean probable daily intake (PDIM) of FB1 was 63.3 ng kg(-1)body weight day(-1), whic

24 In the absence of PDIM, these PAMPs signal a Toll-like receptor (TLR)-depe

25 uired for proper subcellular localization of PDIM.

26 Host restriction of PDIM-deficient M. tuberculosis was not alleviated by the

27 ding complemented strain control in terms of PDIM and PGL production.

28 ads to a mutant that produces only traces of PDIMs and PGLs, has a slight growth yield increase and d

29 e data suggest that in addition to producing PDIMs, the growing phthiocerol product can also be shutt

30 We conclude that PDIM biosynthesis is required for M. tuberculosis resist

31 We additionally found that PDIM transport is required for virulence in mice lacking

32 Taken together, these data indicate that PDIM protects M. tuberculosis from an early innate host

33 ed in NO defense, this result indicates that PDIM has other roles during infection.

34 Analysis of surface lipids showed that PDIM synthesis is increased in a sigM-disrupted strain a

35 tide-associated protein (Pap) encoded in the PDIM synthesis gene cluster, as well as PapA5 homologs f

36 Thus, PDIM is important for resisting an interferon-gamma-inde

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