ライフサイエンスコーパス: PDZ domain

1 protein, the NHERF family and SNX27 (related PDZ domains).

2 HE3 (C-terminus) primarily through the SNX27 PDZ domain.

3 ker TGN38 upon deletion of either the ACT or PDZ domain.

4 myotilin, and other Z-disc proteins via the PDZ domain.

5 interact with flexible loop residues of the PDZ domain.

6 pha isoform, additionally, has an N-terminal PDZ domain.

7 le holding the protease inactive through its PDZ domain.

8 an extended antiparallel beta-sheet with the PDZ domain.

9 e only sorting family member that contains a PDZ domain.

10 nd Golgin45 as novel partners for the MYO18A PDZ domain.

11 equires a conformational change in the IL-16 PDZ domain.

12 Secreted IL-16 contains a characteristic PDZ domain.

13 DegS trimer contains a protease domain and a PDZ domain.

14 ical and non-canonical Wnt signaling via its PDZ domain.

15 lexinB2 forms a secondary interface with the PDZ domain.

16 It encodes a protein with multiple PDZ domains.

17 f EBP50 is regulated by the occupancy of its PDZ domains.

18 ding specificity and promiscuity of the five PDZ domains.

19 ed experimental and computational studies of PDZ domains.

20 though full activity requires the Par-6 CRIB-PDZ domains.

21 basis for the binding selectivity of NHERF1 PDZ domains.

22 ith NHERF1 forming a complex with one of the PDZ domains.

23 ion mode both for MyTH4-FERM tandems and for PDZ domains.

24 MAML1, and p300/CBP and proteins containing PDZ domains.

25 and telethonin/T-Cap, which required intact PDZ domains.

26 ediction was experimentally validated for 26 PDZ domains.

27 fold, and can occupy as many as 15% of these PDZ domains.

28 rates or peptides that bind to either of its PDZ domains.

29 discussed in the context of previous work on PDZ domains.

30 nal peptides activate DegS by binding to its PDZ domains.

31 c density-95/discs large/zonula occludens-1 (PDZ) domain.

32 t N-cadherin binds to PSD-95/SAP90/DLG/ZO-1 (PDZ) domain 2 of the glutamate receptor interacting prot

33 It features a PDZ domain, a BAR domain, and an acidic C-terminal tail

34 e photoswitch across the binding groove of a PDZ domain, a conformational transition, similar to the

35 Our data suggest the concept that the multi-PDZ-domain adaptor protein GRIP1 can act as a scaffold a

36 and membrane-binding surfaces of the BAR and PDZ domains adjacent to each other on the concave side o

37 In this report, we demonstrate that the PDZ domain allows the recruitment of nNOS to nuclei, thu

38 dly describes a unique interaction between a PDZ domain and an arrestin-like fold.

39 tor 1 (Ppr1), which bridges between the Rip1 PDZ domain and anti-sigma factor M (Anti-SigM), a Rip1 s

40 of nNOS can behave as a bona fide class III PDZ domain and bind to C-terminal sequences with acidic

41 ins insert within the binding groove of this PDZ domain and determine the subcellular distribution of

42 that places the receptor-binding site of the PDZ domain and membrane-binding surfaces of the BAR and

43 he PDLIM family of proteins, which contain a PDZ domain and one or more LIM domains, protein interact

44 SNX27 contains a PDZ domain and serves as a cargo selector for the retrom

45 peptides initiate a steric clash between the PDZ domain and the L3 loop that results in a structural

46 artner for AE1 in human kidney, via PDLIM5's PDZ domain and the PDZ binding motif in AE1C.

47 al plasticity of the native ensemble of this PDZ domain and the regulation of insulin secretion.

48 ilt a protein domain microarray that harbors PDZ domains and 14-3-3 proteins.

49 caffolding protein that possesses two tandem PDZ domains and a carboxy-terminal ezrin-binding domain

50 protein E3KARP/NHERF2, which consists of two PDZ domains and a tail containing an ezrin-binding domai

51 nguishing functional properties of different PDZ domains and allow us to make predictions that can be

52 phosphoprotein of 50 kD), consisting of two PDZ domains and an ezrin-binding site, retains specific

53 interactions between the individual Scribble PDZ domains and beta-PIX.

54 r the specificity between the vast number of PDZ domains and ligands in the cell.

55 ckbone hydrogen bonds between four different PDZ domains and peptides corresponding to natural protei

56 lity to specifically engage beta-PIX via its PDZ domains and provide a mechanistic platform for under

57 ral beta HPV E6s bind to proteins containing PDZ domains and that at least two beta HPV E6s bind to p

58 The affinities of recombinant Scribble PDZ domains and the synthetic peptides representing the

59 nd Npt2a involves competition between NHERF1 PDZ domains and the target proteins.

60 was reduced by mutations that inactivate its PDZ domains and was enhanced by protein kinase C phospho

61 tains an N-terminal PSD-95/Discs large/ZO-1 (PDZ) domain and a central lipid-binding Bin/amphiphysin/

62 hat contains the N-terminal PDZ (myosin-18 M-PDZ) domain and one that does not (myosin-18 M-DeltaPDZ)

63 tic density 95/disks large/zona occludens-1 (PDZ) domains and a tail ending in an ezrin-binding domai

64 The interaction requires multiple PDZ domains, and conserved patches of positively charged

65 ssion of two phenotypic programs through its PDZ domains, and these programs form the mechanistic bas

66 PDZ domains are abundant protein interaction modules and

67 PDZ domains are classic examples of dynamic allostery wi

68 PDZ domains are common domains that serve to provide spe

69 red constructs finding that both the DEP and PDZ domains are dispensable for canonical signaling only

70 PDZ domains are the most prominent biological structural

71 PDZ domains are typically characterized by a defined glo

72 ength protein, the dynamics is lost when the PDZ domains are unable to bind ligand.

73 PDZ domains are widely conserved protein interaction mod

74 ut other parts of the protein, including the PDZ domain, are apparently required for stabilizing the

75 hibitor for the CFTR-associated ligand (CAL) PDZ domain as a potential treatment for cystic fibrosis.

76 a protein of 1,517 amino acids, containing a PDZ domain at the N-terminus and sharing similar regulat

77 It contains a PDZ domain (beta2S-PDZ) that, in complex with protein-ty

78 Our results indicate that, unlike other PDZ domains, beta2S-PDZ is marginally stable.

79 Most PDZ domains bind peptides in a canonical conformation in

80 However, a subset of PDZ domains bind peptides with a bent main-chain conform

81 For example, several PDZ domains bind the cystic fibrosis (CF) transmembrane

82 or light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by

83 ustering and reducing the recycling rates of PDZ domain binding partners sorted to the Rab11-dependen

84 hich binds to neurexins, and mutation of the PDZ-domain binding sequence of neurexin-3beta blocked it

85 terminal neurexin sequence with an unrelated PDZ-domain binding sequence that does not bind to CASK f

86 ous proteins is the presence of a C-terminal PDZ domain-binding motif (PBM) in Tax1, previously repor

87 istic mutations in NS1: the avian virus-type PDZ domain-binding motif ESEV (which affects virulence)

88 demonstrate the in vivo significance of the PDZ domain-binding motif in the correct expression of Na

89 Similarly, the mutation in the PDZ domain-binding motif of NS1 altered its binding to c

90 esidues of NaV1.5 (Ser-Ile-Val) constitute a PDZ domain-binding motif that interacts with PDZ protein

91 for its specific interaction with the PICK1 PDZ domain, but a functional consequence of this interac

92 have captured the binding of a peptide to a PDZ domain by unbiased molecular dynamics simulations.

93 nase-2 (PLK2) decreases its affinity for the PDZ domains by several fold, which would free PDZ domain

94 w that the peptide-binding pocket of the Dvl PDZ domain can be occupied by Dvl's own highly conserved

95 It remains unknown why individual PDZ domains can bind the extreme C terminus of very dive

96 Yet, Scribble PDZ domains can still exhibit unique binding profiles to

97 analysis showed that PDZ4, but not the other PDZ domains, can bind vesicles that mimic the plasma mem

98 of the BAR domain (2K-E mutation) or of the PDZ domain (CC-GG mutation) was sufficient to reproduce

99 de recognition specificity in the Syntrophin PDZ domain, confirming the designed interaction biochemi

100 omeric bowl-shaped structure with a lid-like PDZ domain connected by a substrate-sensing hinge that r

101 membrane associated guanylate kinase, WW and PDZ domain containing 2 and protein tyrosine phosphatase

102 nofluorescence imaging shows NaPi-2b and two PDZ domain containing proteins, NHERF1 and PDZK1, are ex

103 profile analysis and functional clustering, PDZ domain-containing 1 (PDZK1) was revealed to be downr

104 embrane-associated guanylate kinase, WW, and PDZ domain-containing 2 (MAGI2) through whole-exome sequ

105 and BIRC4 (XIAP) as well as FRMPD2 (FERM and PDZ domain-containing 2).

106 PDZ domain-containing 7 protein (PDZD7) is a paralog of

107 w that not all of the PDZ domains of a multi-PDZ domain-containing adaptor protein are required for i

108 ein, C-terminus and CFTR-associated ligand), PDZ domain-containing guanine nucleotide exchange factor

109 ry factor proteins (NHERFs) (NHERF1, NHERF2, PDZ domain-containing kidney protein 1, and PDZ domain-c

110 PDZ domain-containing kidney protein 1, and PDZ domain-containing kidney protein 2), Golgi-associate

111 Here, we report the identification of PDZ domain-containing protein 11 (PDZD11) as a new inter

112 We identified the PDZ domain-containing protein 8 (PDZD8) as a critical co

113 further show that this complex contains the PDZ domain-containing protein connector enhancer of kina

114 hRNA-mediated knockdown of the GluA2 binding PDZ domain-containing protein interacting with C kinase

115 cal CAR(Ex8) are negatively regulated by the PDZ domain-containing protein MAGI-1 (membrane-associate

116 In contrast, the multiple PDZ domain-containing protein Pals1-associated tight jun

117 We discovered that the PDZ domain-containing protein Sipa1l1 (signal-induced pr

118 Several PDZ domain-containing proteins (PDZ proteins for short)

119 with the PDZ-binding motif of EphB2 through PDZ domain-containing proteins and can promote the reten

120 ew the known functional interactions between PDZ domain-containing proteins and GPCRs and provide ins

121 s tax interacting protein 1, is unique among PDZ domain-containing proteins because it is composed al

122 These PDZ domain-containing proteins include the membrane-asso

123 PTHR contains a type I PDZ ligand that binds PDZ domain-containing proteins.

124 on its ability to interact with cadherin and PDZ domain-containing proteins.

125 ), which encodes an evolutionarily conserved PDZ domain-containing putative tumor suppressor, is requ

126 G protein signaling (RGS)-homology-RhoGEFs (PDZ domain-containing RhoGEF and leukemia-associated Rho

127 rge/ZO-1 (PDZ) domains; via interaction with PDZ domain-containing scaffold proteins, this allows for

128 pe CFTR because of reduced interactions with PDZ domain-containing scaffold proteins.

129 MDA-9/Syntenin, a highly conserved double-PDZ domain-containing scaffolding protein, is robustly e

130 tween the C-terminus of the Dscams and multi-PDZ domain-containing scaffolding proteins in mouse.

131 5 kilodaltons, disc large, zona occludens-1 (PDZ) domain-containing proteins appear most abundant and

132 pes target a select group of PSD95/DLG1/ZO1 (PDZ) domain-containing proteins by using a C-terminal PD

133 tions with PSD-95/disc large/zona occludens (PDZ) domain-containing proteins.

134 tion of PSD-95/Discs Large/Zona Occludens 1 (PDZ) domain-containing proteins.

135 found that one candidate, the tail-anchored, PDZ-domain-containing OMM protein SYNJ2BP, dramatically

136 Harmonin is a PDZ-domain-containing protein that interacts with the C-

137 Here we show that expression of MPP1, a PDZ-domain-containing protein, highly correlated with AB

138 However, PDZ-domain-containing proteins have diverse functions an

139 engage the transport mechanism, but with the PDZ domains deleted, basolateral displacement still occu

140 A PDZ domain-deleted nNOS gene (DeltaPDZ nNOS) was package

141 f these peptides to ordered target proteins, PDZ domains, demonstrate that native side-chain interact

142 gand severely affected the affinity with the PDZ domain, demonstrating that hydrogen bonds contribute

143 t specificities and that they have disparate PDZ domain-dependent biological functions.

144 Taken together, these results suggest that PDZ domain-dependent ephrinB2 reverse signaling protects

145 erful tools for acute perturbation of native PDZ domain-dependent interactions in live cells.

146 iated recycling of the receptor in a BAR and PDZ domain-dependent manner.

147 regulates trafficking of cargo proteins in a PDZ domain-dependent manner.

148 mong them; and stimulates ENaC function in a PDZ domain-dependent, aldosterone-induced manner.

149 To better understand how Scribble PDZ domains direct cell polarity signaling, we investiga

150 ses the fundamental question as to how these PDZ domains discriminate ligands and exert specificities

151 al that an exposed beta-hairpin in the SNX27 PDZ domain engages a groove in the arrestin-like structu

152 iva phototropin 1 (AsLOV2) and an engineered PDZ domain (ePDZ).

153 r protein-protein interactions, those of the PDZ domain family involve formation of intermolecular hy

154 earch and is perhaps best exemplified by the PDZ domain family of proteins.

155 alysis provides a structural portrait of the PDZ domain family, which serves as a guide in understand

156 ble for the diverse specificities across the PDZ domain family.

157 cluding at conserved functional sites in the PDZ domain family.

158 binding increases the affinity of the SNX27 PDZ domain for PDZ- binding motifs by an order of magnit

159 DZ domains by several fold, which would free PDZ domains for occupancy by other proteins.

160 ferentiate the binding affinities of the two PDZ domains, for the type 1 PDZ-binding motif (QDTRL) in

161 how that cholesterol specifically binds many PDZ domains found in scaffold proteins, including the N-

162 ted the membrane-binding properties of 2,000 PDZ domains from 20 species.

163 At least seven more PDZ domains from other scaffold proteins also bind chole

164 BAI1 C terminus interacts with a variety of PDZ domains from synaptic proteins, including MAGI-3.

165 We have identified 16 structures of PDZ domains in complex with high-affinity ligands and ha

166 Comparison of the structures of these two PDZ domains in complex with ligands containing P(0) Leu

167 ssociates with the N-terminal tandem pair of PDZ domains in PSD-95, suggesting that PSD-95 may be inv

168 nteracting with scaffold proteins containing PDZ domains, in the subcellular localization of CaV1.2 i

169 Here we show that the Bazooka PDZ domains interact with the negatively charged phospho

170 (PKC) and requires localization of PKC via a PDZ domain interaction with Aplysia PICK1.

171 oP-PD libraries are useful tools for probing PDZ domain interactions.

172 complex with nectin-1 and nectin-3, and its PDZ domain interacts directly with the PDZ-binding motif

173 We also subdivided lipid-binding PDZ domains into three classes based on the interplay be

174 ne depletion also reduced the affinity for a PDZ domain involved in synaptic trafficking and affected

175 c density 95/discs large/zonula occludens 1 (PDZ) domain, involved in scaffolding and signaling and e

176 he margin of thermodynamic stability for the PDZ domain is modest ( approximately 3 kcal/mol) and fur

177 unconventional myosin MYO18A that contains a PDZ domain is required for muscle integrity during zebra

178 at distinguishes CAL from other CFTR-binding PDZ domains is the accommodation of an isoleucine residu

179 these proteins, which consists of two tandem PDZ domains, is required to tether the Golgi membranes.

180 nds to the PDZ3 domain of PSD-95 through the PDZ domain ligand at its C terminus.

181 phosphorylation-dependent modulation of the PDZ domain-ligand interaction involving the water channe

182 phosphorylation-dependent alteration in the PDZ domain-ligand interaction was explained by 3D struct

183 hat Tiam family proteins have highly evolved PDZ domain-ligand interfaces with distinct specificities

184 For different classes of PDZ domains, lipid binding regulates their protein inter

185 Using a human PDZ domain (LNX2(PDZ2)) as a model system, we show that

186 (E6peptide) immobilized on the sensor and a PDZ domain (MAGI-1 PDZ1) in the mobile phase.

187 PDZ domains make up an important class of protein-protei

188 (peptide binding-independent) capacities of PDZ domains may be employed by a single such adaptor for

189 e ephrin-B2 tyrosine phosphorylation- and/or PDZ domain-mediated signaling indicates there are at lea

190 els to presynaptic active zones via a direct PDZ-domain-mediated interaction, thereby enabling fast,

191 We use PDZ domain microarrays to identify candidate interaction

192 onstitution experiments with wild type and a PDZ domain mutant (GYGF --> GAGA) of SNX27 demonstrate t

193 an oncogenic signaling pathway, in which two PDZ domains (NHERF-2 PDZ2-N2P2 and MAGI-3 PDZ6-M3P6) com

194 Importantly, full active nNOS lacking PDZ domain (nNOSbeta) does not localize in nuclei and fa

195 ependent on its tail region but modulated by PDZ domain occupancy, which is not the case for E3KARP.

196 he PDZ motif, suggesting that binding to the PDZ domain of CAL is required for MARCH2-mediated degrad

197 terminal cytoplasmic region of RNF43 and the PDZ domain of dishevelled is essential for this suppress

198 facilitating the membrane recruitment of the PDZ domain of Dvl and its interaction with other protein

199 scaffold proteins, including the N-terminal PDZ domain of NHERF1/EBP50.

200 ion, it has been recently suggested that the PDZ domain of nNOS binds with very low affinity to the C

201 teractions are poorly understood because the PDZ domain of nNOS can apparently exhibit class I, class

202 We describe herein that the PDZ domain of nNOS can behave as a bona fide class III P

203 rmeable peptide that competes for the unique PDZ domain of nNOS that interacts with NOS1AP.

204 nalyzed the high affinity association of the PDZ domain of nNOS to claudin-3 and claudin-14, two tigh

205 asmic region of PlexinB2 in complex with the PDZ domain of PDZ-RhoGEF.

206 ree structural mechanisms explaining why the PDZ domain of PICK1 selectively binds >30 receptors, tra

207 We solved the crystal structure of the PDZ domain of PTPN4 bound to the p38gamma C terminus.

208 n between the C terminus of p38gamma and the PDZ domain of PTPN4.

209 e that the kinesin KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediat

210 d in part by a novel interaction between the PDZ domain of SNX27 and sequences in a central portion o

211 GYGF --> GAGA) of SNX27 demonstrate that the PDZ domain of SNX27 is required to maintain basal NHE3 a

212 on the PDZ recognition motif in PTHR and the PDZ domain of SNX27.

213 identify a direct interaction of the central PDZ domain of the active-zone protein RIM with the C ter

214 The second PDZ domain of the protein tyrosine phosphatase BL (PDZ2)

215 nduced misfolding pathway of PDZ3, the third PDZ domain of the PSD95 neuronal protein, is populated b

216 terminus of claudins binds to the N-terminal PDZ domain of zonula occludens proteins (PDZ1).

217 The His-ZO-1-PDZ1 (first PDZ domain of zonula occludens) domain that binds Neph1-

218 Our results show that not all of the PDZ domains of a multi-PDZ domain-containing adaptor pro

219 nvolved protein trafficking through specific PDZ domains of GIRK2c and GIRK3 subunit isoforms.

220 1) endocytosis requires interaction with the PDZ domains of Mint1 and that this interaction facilitat

221 selectivity and binding affinity of the two PDZ domains of NHERF1.

222 RF2/NHERF3 heterodimerization is mediated by PDZ domains of NHERF2 and the C-terminal PDZ domain reco

223 In addition, both PDZ domains of NHERF2 could be simultaneously occupied b

224 , ZL006 and IC87201 do not interact with the PDZ domains of nNOS or PSD-95, nor inhibit the nNOS-PDZ/

225 Our data further indicate that the four PDZ domains of PATJ function, to a large extent, in redu

226 synaptic signaling proteins that bind to the PDZ domains of PSD-95 are present in higher concentratio

227 ion of the PSD by restricting binding to the PDZ domains of PSD-95.

228 known putative viral protein ligands for the PDZ domains of Scribble and Erbin were also identified.

229 ein-protein interactions, and confirmed that PDZ domains of Scribble interact with the C terminus of

230 We find that NC mimics the PDZ domains of syntenin, a membrane-binding adaptor invo

231 main that is phylogenetically related to the PDZ domains of the NHERF proteins.

232 raries we screened the nine PSD-95/Dlg/ZO-1 (PDZ) domains of human Densin-180, Erbin, Scribble, and D

233 his study, we have found that the C-terminal PDZ-domain of both A2BR and CFTR were crucial for this i

234 Notably, GluA2 and N-cadherin use different PDZ domains on GRIP1 to simultaneously bind the transpor

235 bined to study peptide binding by the second PDZ domain (PDZ1) of MAGI1, which has been identified as

236 d orientation protein-1) and that two MAGI-1 PDZ domains, PDZ1 and PDZ3, regulate CAR(Ex8) levels in

237 ms of the two alternative spliced forms of a PDZ domain (PDZ2 and PDZ2as) that share a nearly identic

238 In this study, allostery in the second PDZ domain (PDZ2) in the human PTP1E protein is examined

239 pectroscopy experiments on a photoswitchable PDZ domain (PDZ2S) have indicated that the allosteric tr

240 e mutations into the context of five related PDZ domain-peptide complexes.

241 first time specifically addresses these for PDZ domain-peptide interactions.

242 f ligand specificity in a PSD95, DLG1, ZO-1 (PDZ) domain preferentially occurs through class-bridging

243 HHC5 and DHHC8 as specific regulators of the PDZ domain protein GRIP1b.

244 BX-Cter expression caused depletion of PIST (PDZ domain protein interacting specifically with TC10),

245 Periaxin (Prx), a PDZ domain protein involved in myelin sheath stabilizati

246 the Drosophila homolog of whirlin/DFNB31, a PDZ domain protein linked to Usher syndrome, the most co

247 The absence of the PDZ domain protein Na(+)/H(+) exchange regulatory factor

248 CFTR abundance by phosphorylating Shank2E, a PDZ domain protein that contains two SGK1 phosphorylatio

249 Sorting nexin 27 (SNX27), a brain-enriched PDZ domain protein, regulates endocytic sorting and traf

250 Functional studies of a PDZ domain protein, rhophilin 2, suggest that all classe

251 ensity, discs large, and zonula occludens-1 (PDZ) domain protein SAP97 is a component of this macromo

252 ns exhibited a decrease in the levels of the PDZ-domain protein CASK (a calcium/calmodulin-activated

253 cient neurons, suggesting that no particular PDZ-domain protein is essential for neurexin surface tra

254 -associated tight-junction protein), a multi-PDZ-domain protein that associates with many tight junct

255 r (NHERF1) is a molecular pathway organizer, PDZ-domain protein that recruits membrane, cytoplasmic,

256 motif of NS1 altered its binding to cellular PDZ domain proteins and affected Akt phosphorylation.

257 However, the presence of PDZ domain proteins attached to intracellular membranes

258 PDZ domain proteins control multiple cellular functions

259 Z domain that distinguishes TIP-1 from other PDZ domain proteins that more often contain multiple pro

260 ut also the interaction of NS1 with cellular PDZ domain proteins.

261 r (Dlg1), zonula occludens-1 protein (zo-1) (PDZ) domain proteins.

262 Using a PDZ domain (PSD95(pdz3)) model system, we show that sect

263 t is composed almost exclusively of a single PDZ domain rather than one of many domains as part of a

264 by PDZ domains of NHERF2 and the C-terminal PDZ domain recognition motif of NHERF3.

265 7 interacts with these receptors through its PDZ domain, regulating their recycling to the plasma mem

266 PDZ domains represent one group of the major structural

267 structure of iCAL36 in complex with the CAL PDZ domain reveals stereochemical interactions distribut

268 Mutations within PDZ domain (S280A and S311A) reduced the ability of Dvl3

269 We now report that NHERF1, a modular PDZ domain scaffolding protein, coordinates the assembly

270 horylation) of EphA2, and recruitment of the PDZ domain scaffolding protein, PATJ, to the cell periph

271 Given the similarities of the Scribble PDZ domain sequences in their binding grooves, it is com

272 2, suggest that all classes of lipid-binding PDZ domains serve as genuine dual-specificity modules re

273 Characterization of 70 PDZ domains showed that ~40% had submicromolar membrane

274 The structure establishes how the SNX27 PDZ domain simultaneously binds PDZ-binding motifs and r

275 The AHNAK2 PDZ domain structure contains a bound class III ligand p

276 We have analyzed the existing database of PDZ domain structures in the context of a specificity tr

277 ther, these findings suggest that binding to PDZ domains, such as those from USH1C, PDZD7, and Whirli

278 The presence of a PDZ domain suggests that MYO18A may interact with other

279 tein (TIP)-1 protein is composed of a single PDZ domain that distinguishes TIP-1 from other PDZ domai

280 jor features of this myosin is an N-terminal PDZ domain that is included in some of the predicted alt

281 Sorting nexin 27 (SNX27) contains a PDZ domain that is phylogenetically related to the PDZ d

282 Many S2Ps also contain a PDZ domain, the function of which is poorly understood.

283 PDZ domains: the human Dvl2 (Dishevelled-2) PDZ domain, the human Erbin PDZ domain, the PDZ1 domain

284 (Dishevelled-2) PDZ domain, the human Erbin PDZ domain, the PDZ1 domain of InaD (inactivation no aft

285 ry to the C terminus of proteins that engage PDZ domains, the C-terminal three residues of beta1, per

286 In contrast to other reported PDZ domains, the solution structure previously reported

287 between flexibility and promiscuity in five PDZ domains: the human Dvl2 (Dishevelled-2) PDZ domain,

288 leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical ro

289 erminus of BAI1 against a proteomic array of PDZ domains to identify novel interacting partners.

290 density 95, discs large, zonula occludens-1 (PDZ) domains to engage the transport mechanism, but with

291 l ligand motifs for PSD-95/discs large/ZO-1 (PDZ) domains; via interaction with PDZ domain-containing

292 scovered that its free C-terminal tail binds PDZ domains (when unphosphorylated) and 14-3-3 proteins

293 Ca(2+)-channel localization required the RIM PDZ domain, whereas rescue of vesicle priming required t

294 er is surprising considering Nas2 contains a PDZ domain, which is often involved in binding to C term

295 ubiquitous recognition modules--for example, PDZ domains, which bind C-terminal sequences of partner

296 ed protein that interacts through its single PDZ domain with a variety of cell surface receptors.

297 the sarcolemma through an interaction of its PDZ domain with dystrophin spectrin-like repeats R16 and

298 nteraction profiles of all isolated Scribble PDZ domains with a beta-PIX peptide.

299 NHERF1 interacts via its PDZ domains with PHLPP1/PHLPP2 and scaffolds heterotrime

300 sts of a leucine-rich repeat domain and four PDZ domains, with the latter being responsible for most

301 ucture capable of tolerating insertions of a PDZ domain without disruption of the enzyme's binding an