ライフサイエンスコーパス: PEDF

1 PEDF blocked VEGF-induced phosphorylation of extracellul

2 PEDF bound the PEDF-R ectodomain L4 (Leu(159)-Met(325))

3 PEDF bound to LRP6, a Wnt coreceptor, with high affinity

4 PEDF distribution was evaluated by immunofluorescence of

5 PEDF expression and/or regulation during melanoma develo

6 PEDF expression was consistently decreased in invasive a

7 PEDF expression was reduced in 12-HETE-treated rMCs, ast

8 PEDF immunostaining around CNV lesions diminished after

9 PEDF inhibited adipogenesis and promoted osteoblast diff

10 PEDF or DHA alone did not produce a significant increase

11 PEDF overexpression suppressed thrombospondin-1 levels i

12 PEDF up-regulates expression of tight junction-associate

13 PEDF up-regulation of full-length presenilin 1 (Fl.PS1)

14 PEDF was lost in thicker melanomas (P = 0.003), and corr

15 PEDF+DHA promotes the regeneration of corneal nerves.

16 PEDF, VEGFR3, beta-3 tubulin, CD45, CD11b, and F4/80 exp

17 PEDF-dependent SOD2 expression in PanIN lesions was reca

18 PEDF-null mice, however, demonstrated enhanced early fib

19 inear trends of greater reductions in PAI-1, PEDF, and VEGF.

20 oduction of BrM components, including TSP-1, PEDF, and tropoelastin in vitro and increased the antian

21 The factor involved is likely PEDF, as a PEDF-antiserum blocked the repulsing action.

22 in turn is critical for NFkappaB activation, PEDF-dependent apoptosis, and anti-angiogenesis.

23 Thus, adding PEDF enhanced Wnt-beta-catenin signal transduction in hu

24 In addition, PEDF+DHA accelerated corneal wound healing, selectively

25 In addition, PEDF-Tg mice with OIR had significantly lower vascular l

26 1 associated with VEGFR1 within 15 min after PEDF treatment.

27 e in VEGFR3 (57.5% reduction, P = 0.001) and PEDF protein expression (64% reduction, P < 0.001).

28 MMP-2, MMP-9, and PEDF protein levels were determined by ELISA.

29 alculations, these data implicate VEGF-A and PEDF as key RPE-derived factors promoting preservation o

30 rm homooligomers under basal conditions, and PEDF dissociates the homooligomer to activate the recept

31 of its accumulation upon addition of DHA and PEDF at earlier time points.

32 lculations, these data may implicate HGF and PEDF as key factors promoting the preservation of retina

33 In the in vitro cultures, NPD1 and PEDF+DHA induced a 3-fold increase in neurite outgrowth

34 s demonstrated to bind immobilized PEDF, and PEDF was shown to bind to immobilized C1q, in particular

35 ntravitreal injections of these peptides and PEDF in the rd1 mouse model of retinal degeneration decr

36 GF-E rapidly increased RPE permeability, and PEDF inhibited the VEGF-E response dose-dependently.

37 eu(232)) and internally truncated PEDF-R and PEDF-R4 (DeltaHis(203)-Leu(232)) retained phospholipase

38 ockdown by small interfering RNA (siRNA) and PEDF knockout in PEDF(-/-) mice induced activation of Wn

39 y i.p. injections) protocol in wild-type and PEDF-null mice.

40 of retinal NV through modulation of VEGF and PEDF expression and could provide a new therapeutic targ

41 ne the effects of NT on RPE-derived VEGF and PEDF expression in the context of passive smoking.

42 VEGF and PEDF expression was assessed by ELISA, Western blot and

43 VEGF and PEDF expression was assessed by ELISA, Western blot, and

44 The effects of 12-HETE on VEGF and PEDF expression were evaluated in Muller cells (rMCs), p

45 and nAChR-mediated upregulation of VEGF and PEDF were observed in RPE from rats exposed to NT.

46 and nAChR-mediated upregulation of VEGF and PEDF were observed in RPE from rats exposed to NT.

47 ent by altering the balance between VEGF and PEDF.

48 hMSCs, whereas the combination of Wnt3a and PEDF potentiated mineralization.

49 In wild-type animals, PEDF expression increased with pancreatitis and was more

50 l, which was ablated by the presence of anti-PEDF antibody.

51 treatment of the conditioned media with anti-PEDF antibodies allowed fhRPE cells to fully respond to

52 ch's membrane and promote the antiangiogenic PEDF to inhibit neovascularization.

53 ence of various amounts of complexes between PEDF and C4d in the SF from 30 RA patients, whereas none

54 produced PDGF-BB and TGFbeta, which blocked PEDF production in fibroblasts.

55 increase in permeability was blocked by both PEDF and the same kinase inhibitors.

56 Blockade of adipogenesis by PEDF suppressed peroxisome proliferator-activated recept

57 -catenin and uPAR expression were blocked by PEDF and by inhibitors of p38 and MEK.

58 red here an active cornea-TG axis, driven by PEDF-R activation, that fosters axon outgrowth in the co

59 l control of Sod2 expression was mediated by PEDF-induced NFkappaB nuclear translocation.

60 Differentiation to osteoblasts by PEDF resulted in a common pathway that involved PPARgamm

61 4T1-BR breast cancer cells was suppressed by PEDF expression, as supported by in vitro analyses as we

62 s suggested that, in arthritis patients, C4d-PEDF complexes found in sera arise from the joints, as w

63 ts cytotoxic effects on breast cancer cells, PEDF also exerted a prosurvival effect on neurons that s

64 sum, demonstrate induction of endogenous CNS PEDF production following demyelination, and make PEDF a

65 l-time PCR and microarray analyses confirmed PEDF down-regulation at the mRNA level in several melano

66 Purified HC.HA did not contain PEDF and TSP-1 but did contain IGFBP-1 and platelet fact

67 Similarly, continuous PEDF administration into the lateral ventricles of adult

68 In contrast, PEDF-Tg animals with oxygen-induced retinopathy (OIR) de

69 Ethanol-exposed hepatic lysates degraded PEDF in a MMP-2/9-dependent manner, and liver sections d

70 investigated the role of fibroblast-derived PEDF in melanoma progression.

71 f adult New Zealand rabbits treated with DHA+PEDF, PEDF, or DHA for 6 weeks.

72 gative MEK5 mutant and Erk5 shRNA diminished PEDF-dependent apoptosis, inhibition of the endothelial

73 Using siRNA to selectively knock down PEDF-R in retina cells, we demonstrated that PEDF-R is e

74 1 nAchR, upregulated VEGF, and downregulated PEDF expression through nAChR in ARPE-19 cells.

75 a1 nAchR, upregulated VEGF and downregulated PEDF expression through nAChR in ARPE-19 cells.

76 Doxycycline elevated PEDF levels in plasma and did not affect the active and

77 idase Inhibitor, Clade F) gene which encodes PEDF (pigment epithelium-derived factor), a potent inhib

78 al-time RT-PCR was used to detect endogenous PEDF expression in human uveal melanoma cell lines and m

79 s showed a robust upregulation of endogenous PEDF in the corpus callosum upon lysolecithin-induced de

80 Our findings establish PEDF as both a metastatic suppressor and a neuroprotecta

81 ta-treated normal fibroblasts with exogenous PEDF decreased the expression of CAF markers and restore

82 se melanoma cell lines were found to express PEDF mRNA.

83 dying neurons adjacent to tumors expressing PEDF.

84 encoding pigment epithelium-derived factor (PEDF) (SERPINF1) was performed.

85 DNF), and pigment epithelium-derived factor (PEDF) and significantly lower concentrations of leukemia

86 usly that pigment epithelium-derived factor (PEDF) can, via gamma-secretase-mediated events, inhibit

87 BRIL) and pigment epithelium-derived factor (PEDF) defects cause types V and VI osteogenesis imperfec

88 acellular pigment epithelium-derived factor (PEDF) displays retina survival activity by interacting w

89 ment with pigment epithelium-derived factor (PEDF) in combination with docosahexaenoic acid (DHA) on

90 ith NPD1, pigment epithelial-derived factor (PEDF) in combination with docosahexaenoic acid (DHA) or

91 Pigment epithelium-derived factor (PEDF) is a multifunctional secreted glycoprotein that is

92 Pigment epithelium-derived factor (PEDF) is a potent inhibitor of vascular endothelial grow

93 Pigment Epithelium Derived Factor (PEDF) is a secreted factor that has broad biological act

94 Pigment epithelium-derived factor (PEDF) is a serine protease inhibitor (serpin) protein wi

95 Pigment epithelium-derived factor (PEDF) is a serine proteinase inhibitor with antiangiogen

96 Pigment epithelium-derived factor (PEDF) is a serpin with antiangiogenic properties.

97 cytokine pigment epithelium-derived factor (PEDF) is downregulated in resected human brain metastase

98 Pigment epithelium-derived factor (PEDF) is important for maintaining the normal extracellu

99 Pigment epithelium-derived factor (PEDF) is known to be an angiogenesis suppressor and to h

100 o measure pigment epithelium-derived factor (PEDF) levels from conditioned media.

101 ngiogenic pigment epithelium derived factor (PEDF) may cause choroidal neovascularization (CNV), a ke

102 ngiogenic pigment epithelium derived factor (PEDF) may cause choroidal neovascularization (CNV), key

103 endent on pigment epithelium-derived factor (PEDF) on the outer surface of exosomes.

104 to either pigment epithelial derived factor (PEDF) or an AAV2 vector containing a PS1 gene driven by

105 molecule, pigment epithelium-derived factor (PEDF) plus docosahexaenoic acid (DHA), has been shown to

106 VEGF) and pigment epithelium-derived factor (PEDF) protein, and mRNA levels were analyzed by Western

107 ffects of pigment epithelium-derived factor (PEDF) require interactions between an as of a yet undefi

108 retion of pigment epithelium-derived factor (PEDF) via activation of signal transducer and activator

109 retion of pigment-epithelium-derived factor (PEDF) was directed apically in both cultures, but fhRPE

110 I-1), and pigment epithelium-derived factor (PEDF) were measured by immunoassay at baseline and 12 mo

111 pathway, pigment epithelium-derived factor (PEDF), a multifunctional serine proteinase inhibitor.

112 thermore, pigment epithelium-derived factor (PEDF), a secreted glycoprotein known for its anti-tumor

113 acts via pigment epithelium-derived factor (PEDF), an antiangiogenic protein, to regulate retinal pi

114 P-1), and pigment epithelium-derived factor (PEDF), as well as by degeneration of the elastic layer.

115 olecules, pigment epithelium-derived factor (PEDF), is a broadly expressed multifunctional member of

116 ns in for pigment epithelium-derived factor (PEDF), the protein product of the SERPINF1 gene, are the

117 Pigment epithelium-derived factor (PEDF), the protein product of the SERPINF1 gene, has bee

118 EGF), and pigment epithelium-derived factor (PEDF).

119 (HGF) and pigment epithelium-derived factor (PEDF).

120 nhibitor, pigment epithelial-derived factor (PEDF).

121 nd -9 and pigment epithelium-derived factor (PEDF).

122 onized by pigment epithelium-derived factor (PEDF).

123 Loss of pigment epithelium-derived factor (PEDF, SERPINF1) in cancer cells is associated with poor

124 er pigment epithelial-derived growth factor (PEDF), together with docosahexaenoic acid (DHA), enhance

125 molecule, pigment epithelium growth factor (PEDF).

126 EGFR3 and pigment epithelium-derived factor [PEDF]) and for quantitative RT-PCR (VEGFR3, PEDF, and CD

127 y secrete pigment epithelium-derived factor, PEDF, which is known to exert anti-angiogenic actions.

128 blasts can be regulated by specific factors, PEDF-directed dependency of murine and human MSCs was as

129 EDF on retina cells and has determinants for PEDF binding within its L4 ectodomain that are critical

130 we demonstrated that PEDF-R is essential for PEDF-mediated cell survival and antiapoptotic activities

131 DC1 and PLXDC2 as cell-surface receptors for PEDF.

132 8-114 of PEDF contains critical residues for PEDF-R interaction that mediates survival effects, the f

133 Searching for PEDF regulatory mechanisms revealed two occupied conserv

134 Furthermore, PEDF intracerebral infusion enhanced survival and matura

135 Furthermore, PEDF knockdown by small interfering RNA (siRNA) and PEDF

136 lar neovascularization in vivo, we generated PEDF transgenic (PEDF-Tg) mice that ubiquitously express

137 Accordingly, mice with global PEDF knockout were more susceptible to melanoma metastas

138 at normal dermal fibroblasts expressing high PEDF levels attenuated melanoma growth and angiogenesis

139 A long-standing challenge is to reveal how PEDF acts on its target cells and the identities of the

140 DHT) increased PEDF (qPCR) in HTPCs, however PEDF expression in the testis of a non-human primate occ

141 However, PEDF-R polypeptides without the His(203)-Leu(232) region

142 EDF-Tg) mice that ubiquitously express human PEDF driven by the beta-actin promoter.

143 Recombinant human PEDF (rhuPEDF) was cleaved at its serpin-exposed loop by

144 protein was demonstrated to bind immobilized PEDF, and PEDF was shown to bind to immobilized C1q, in

145 Immunoreactive PEDF receptor was detectable in multiple cell types in b

146 In PEDF knockout (KO) mice, total body adiposity was increa

147 Here we characterized the area in PEDF that interacts with PEDF-R to promote photoreceptor

148 a 2.5-fold increase in corneal nerve area in PEDF+DHA-treated animals compared with control animals.

149 irius red staining revealed more fibrosis in PEDF-null versus wild-type pancreas 1 week after pancrea

150 agen I, and thrombospondin-1) were higher in PEDF-null mice at baseline.

151 interfering RNA (siRNA) and PEDF knockout in PEDF(-/-) mice induced activation of Wnt signaling.

152 ammatory factors were significantly lower in PEDF-Tg mice with OIR than in the Wt mice with OIR.

153 nal pigment epithelium of Wt mice but not in PEDF-Tg mice.

154 stically significantly greater reductions in PEDF (-9.20%, -9.90%, respectively, both P < 0.0001) and

155 Inhibition of MMP-2/9 activity increased PEDF and decreased VEGF levels in the apical and basal s

156 Dihydrotestosterone (DHT) increased PEDF (qPCR) in HTPCs, however PEDF expression in the tes

157 ding and experimental pancreatitis increased PEDF expression in wild-type mice.

158 5)) with affinity similar to the full-length PEDF-R (Met(1)-Leu(504)).

159 ed phospholipase activity of the full-length PEDF-R.

160 The factor involved is likely PEDF, as a PEDF-antiserum blocked the repulsing action.

161 e contact with PEDF-null melanoma cells lost PEDF expression and tumor-suppressive properties.

162 production following demyelination, and make PEDF a strong candidate for pharmacological intervention

163 Mechanistically, PEDF sustained GSC self-renewal by Notch1 cleavage, and

164 Mutation of a single amino acid on a 34-mer PEDF peptide increased mineralization of hMSC cultures c

165 In young (19-d-old) PEDF-KO mice, PEDF restoration increased bone volume fraction by 35% a

166 e mice is down-regulation of PVM/M modulated PEDF production.

167 A lentiviral vector containing a mouse PEDF expression sequence was constructed and transduced

168 ) in the first intron of the human and mouse PEDF promoter regions, confirmed by binding assays.

169 Notably, PEDF infusion also resulted in an induction of doublecor

170 from 5-day-old mice were treated with NPD1, PEDF+DHA, lipoxin A4 (LXA4), 12- or 15-hydroxyeicosatetr

171 Additional rabbits were treated with NPD1, PEDF+DHA, or vehicle, and corneal sections were stained

172 t the region composed of positions 98-114 of PEDF contains critical residues for PEDF-R interaction t

173 of bone development; however, the ability of PEDF to restore bone mass in a mouse model of OI type VI

174 Dual antitumor/antiangiogenic activities of PEDF suggest that PEDF gene therapy may be considered an

175 The co-administration of PEDF and VEGF-E depleted the amount of VEGF-R2 in the me

176 EDF in transgenic mice and administration of PEDF protein attenuated Wnt signaling induced by retinal

177 tance were evaluated after administration of PEDF, placenta growth factor (VEGF-R1 agonist), and VEGF

178 In addition, binding of PEDF to LRP6 blocked Wnt ligand-induced LRP6-Frizzled re

179 We demonstrate that delivery of PEDF to the damaged ear ameliorates hearing loss by rest

180 Therefore, the inhibitory effect of PEDF appears to be mediated via the processing of VEGF-R

181 or the survival and antiapoptotic effects of PEDF on retina cells and has determinants for PEDF bindi

182 Here, they examined the effects of PEDF polypeptide fragments on vessel sprouting and on ch

183 nction by blocking the protective effects of PEDF to prevent VEGF from driving the dry to wet AMD tra

184 Notably, the suppressive effects of PEDF were not only rapid but independent of the effects

185 agonists prevented the inhibitory effects of PEDF.

186 In human PanIN lesions, co-expression of PEDF and SOD2 was observed in the majority of early PanI

187 rized hES-RPE showed prominent expression of PEDF in apical cytoplasm and a marked increase in secret

188 ohistochemistry, we determined expression of PEDF in common and dysplastic melanocytic nevi, melanoma

189 Inhibition of PEDF diminished GSC self-renewal and increased survival

190 es either received intravitreal injection of PEDF, DAPT (a gamma-secretase inhibitor) or PEDF + DAPT

191 The physical interaction of PEDF with LRP6 was confirmed by a coprecipitation assay,

192 zation, hES-RPE cells secrete high levels of PEDF that can support RPC survival.

193 hermore, a subpopulation with high levels of PEDF was capable of infiltration along corpus callosum.

194 ived tumors expressed markedly low levels of PEDF.

195 These findings suggest that loss of PEDF expression promotes early invasive melanoma growth.

196 creatic fibrosis is dependent on the loss of PEDF.

197 Both overexpression of PEDF in transgenic mice and administration of PEDF prote

198 these results suggest that overexpression of PEDF inhibits retinal inflammation and neovascularizatio

199 gates whether constitutive overexpression of PEDF inhibits the growth and hepatic micrometastasis of

200 Furthermore, preincubation of PEDF with P1 and E5b peptides blocked the PEDF.PEDF-R-me

201 Finally, expression profiling of PEDF-depleted fibroblasts revealed induction of IL8, SER

202 -R interacts with the neurotrophic region of PEDF (44-mer, positions 78-121).

203 and CNV resides within the 34-mer region of PEDF.

204 decreased VEGF expression and restoration of PEDF levels.

205 ether, these data indicate the novel role of PEDF as a key regulator of GSC and suggest clinical impl

206 l for further investigation into the role of PEDF in inflammatory processes in the joint, which, in c

207 oplasm and a marked increase in secretion of PEDF into the medium compared with nonpolarized culture.

208 However, the PEDF binding site of PEDF-R and its involvement in survival activity have not

209 es suggested that the ligand binding site of PEDF-R interacts with the neurotrophic region of PEDF (4

210 Lentivirus-mediated gene transfer of PEDF decreased the growth of ocular melanoma and its hep

211 bone volume/total volume by 52% in 6-mo-old PEDF-KO mice but not in wild-type mice.

212 In young (19-d-old) PEDF-KO mice, PEDF restoration increased bone volume fra

213 direct transcriptional influence of MITF on PEDF, establishing the PEDF gene (SERPINF1) as a MITF ta

214 biologically relevant ligand-binding site on PEDF-R.

215 PEDF, DAPT (a gamma-secretase inhibitor) or PEDF + DAPT at the time of laser injury, or AAV2 infecti

216 noculated with constitutively overexpressing PEDF melanoma cells.

217 Endogenous overexpressing PEDF melanoma cells lost the ability to migrate and form

218 Pancreatic PEDF expression was assessed in wild-type mice fed eithe

219 t New Zealand rabbits treated with DHA+PEDF, PEDF, or DHA for 6 weeks.

220 hat PEDF binds and stimulates PEDF receptor (PEDF-R), a transmembrane phospholipase.

221 a distinct ectodomain on the PEDF receptor (PEDF-R).

222 spholipase A2 activity of the PEDF-receptor (PEDF-R) leading to the release of DHA; this free DHA led

223 When immobilized, recombinant PEDF expressed in eukaryotic cells activated the classic

224 ed oligodendrotrophic effects of recombinant PEDF on the adult SVZ and corpus callosum, demonstrate i

225 Addition of recombinant PEDF to PEDF-null hepatocytes, reduced their triglycerid

226 mice, we found that addition of recombinant PEDF to the medium enhanced expressions of oligodendrogl

227 d the expression of CAF markers and restored PEDF expression.

228 effects, the findings reveal distinct small PEDF fragments with neurotrophic effects on photorecepto

229 says were performed in constitutively stable PEDF-overexpressing cells and transduced lentiviral vect

230 usly reported that PEDF binds and stimulates PEDF receptor (PEDF-R), a transmembrane phospholipase.

231 metastasis, but the contribution of stromal PEDF to cancer evolution is poorly understood.

232 isms by which melanoma cells silence stromal PEDF to promote malignancy.

233 In this study, PEDF delivery increased trabecular bone volume/total vol

234 Synthetic PEDF peptides 34-mer (Asp(44)-Asn(77)) and 44-mer (Val(7

235 d activation of the uPA/uPAR system and that PEDF-mediated inhibition of the VEGF-induced increase in

236 We first confirmed that PEDF + DHA increased nerve regeneration in the mouse cor

237 Collectively, our results demonstrate that PEDF maintains tumor-suppressive functions in fibroblast

238 Our group and others have demonstrated that PEDF directs human mesenchymal stem cell (hMSC) commitme

239 Binding assays demonstrated that PEDF-R bound the 44-mer peptide.

240 PEDF-R in retina cells, we demonstrated that PEDF-R is essential for PEDF-mediated cell survival and

241 Our findings establish that PEDF-R is required for the survival and antiapoptotic ef

242 These findings indicate that PEDF acts as a compensatory antifibrotic cytokine in pan

243 These results indicate that PEDF counters Wnt signaling to allow for osteoblast diff

244 These results indicate that PEDF regulates autophagy through coordinate Wnt signalin

245 We have previously reported that PEDF binds and stimulates PEDF receptor (PEDF-R), a tran

246 y a coprecipitation assay, which showed that PEDF bound to LRP6 at the E1E2 domain.

247 Previously, the authors showed that PEDF injected into the subconjunctiva reaches the choroi

248 g synthetic peptides spanning L4 showed that PEDF selectively bound E5b (Ile(193)-Leu(232)) and P1 (T

249 Cell surface labeling showed that PEDF-R is present in the plasma membranes of retina cell

250 Recent studies have also shown that PEDF enhances renewal of adult subventricular zone (SVZ)

251 tiangiogenic activities of PEDF suggest that PEDF gene therapy may be considered an approach for the

252 These results suggest that PEDF is an endogenous antagonist of LRP6, and blocking W

253 Our experiments suggest that PEDF receptors form homooligomers under basal conditions

254 The PEDF-knockout (KO) mouse captures crucial elements of th

255 The PEDF-R inhibitor, atglistatin, blocked all of these chan

256 The PEDF-Tg mice provide a useful model for studying the rol

257 The PEDF-Tg mice under normal conditions did not show any ab

258 of PEDF with P1 and E5b peptides blocked the PEDF.PEDF-R-mediated retina cell survival activity, impl

259 PEDF bound the PEDF-R ectodomain L4 (Leu(159)-Met(325)) with affinity s

260 In conclusion, we determined the PEDF-mediated events responsible for VEGFR1 signaling an

261 influence of MITF on PEDF, establishing the PEDF gene (SERPINF1) as a MITF target in melanocytes and

262 Moreover, peptide P1 from the PEDF-R ectodomain had affinity for the 44-mer and a shor

263 provides a mechanistic insight into how the PEDF null state results in OI type VI.

264 However, the PEDF binding site of PEDF-R and its involvement in survi

265 d at 1 week and was four times higher in the PEDF+DHA-treated group than in the controls.

266 he CNV area was significantly smaller in the PEDF-Tg mice than in the Wt mice.

267 ithout the His(203)-Leu(232) region lost the PEDF affinity that stimulated their enzymatic activity.

268 Interrogation of the PEDF sequence identified a conserved motif found in othe

269 tivates the phospholipase A2 activity of the PEDF-receptor (PEDF-R) leading to the release of DHA; th

270 ned region with a distinct ectodomain on the PEDF receptor (PEDF-R).

271 Thus PEDF could be involved in the establishment of the avasc

272 l activity, implying that peptide binding to PEDF excluded ligand-receptor interactions on the cell s

273 cells were infected with AAV2 or exposed to PEDF in the presence or absence of VEGF and in vitro ang

274 Addition of recombinant PEDF to PEDF-null hepatocytes, reduced their triglyceride conten

275 The effect was similar to PEDF+DHA-treated animals.

276 NT increased VEGF-to-PEDF ratio in RPE through nAchR in vitro and in vivo whi

277 NT increased the VEGF-to-PEDF ratio in the RPE through nAchR in vitro and in vivo

278 ation in vivo, we generated PEDF transgenic (PEDF-Tg) mice that ubiquitously express human PEDF drive

279 4 (Met(1)-Leu(232)) and internally truncated PEDF-R and PEDF-R4 (DeltaHis(203)-Leu(232)) retained pho

280 Recombinant C-terminal truncated PEDF-R4 (Met(1)-Leu(232)) and internally truncated PEDF-

281 ly associated with reduced circulating VEGF, PEDF, and PAI-1, and could provide incentive for reducin

282 xidative stress; complement activation; VEGF/PEDF ratio; and MMP activity.

283 [PEDF]) and for quantitative RT-PCR (VEGFR3, PEDF, and CD45).

284 Thus testicular peritubular cells, via PEDF, may prevent vascularization of human seminiferous

285 d in a murine model of PanIN formation where PEDF was deleted.

286 of early PanIN lesions (47/50, 94%), whereas PEDF and SOD2 immunolocalization in high-grade human Pan

287 oma growth and angiogenesis in vivo, whereas PEDF-depleted fibroblasts exerted tumor-promoting effect

288 To investigate whether PEDF overexpression has an impact on ocular neovasculari

289 udy was to understand the mechanism by which PEDF blocks VEGF-induced increases in vascular permeabil

290 rate that the human diseases associated with PEDF reflect its ability to modulate MSC differentiation

291 hat normal fibroblasts in close contact with PEDF-null melanoma cells lost PEDF expression and tumor-

292 MITF positively correlated with PEDF expression in invasive melanomas (P = 0.0003).

293 the right eye and treated in both eyes with PEDF+DHA for 2 weeks, there was a significant increase i

294 re compared between the mice inoculated with PEDF-overexpressing tumor cells and those mice with the

295 terized the area in PEDF that interacts with PEDF-R to promote photoreceptor survival.

296 ntiation pattern analogous to that seen with PEDF.

297 prisingly, corneal injury and treatment with PEDF + DHA induced transcription of neuropeptide y (npy)

298 Treatment with PEDF activates the phospholipase A2 activity of the PEDF

299 results suggest that topical treatment with PEDF+DHA promotes corneal nerve regeneration and wound h

300 observed in rabbits treated for 8 weeks with PEDF+DHA.