ライフサイエンスコーパス: PGC

1 PGC and CVM cell types interact while PGCs are en route

2 PGC LC-MS of complex mixtures demonstrated that compound

3 PGC-1-related coactivator (PRC) has a dual function in g

4 PGC-1alpha enhances Mfn2 transcription, but also leads t

5 PGC-1alpha is a master regulator of mitochondrial biogen

6 PGC-1alpha is enhanced in NAc D1-MSNs, specifically afte

7 PGC-1alpha messenger RNA and protein were examined in NA

8 PGC-1alpha pathway activation has been shown to decrease

9 PGC-1alpha ribosome-associated messenger RNA in MSN subt

10 PGC-1alpha supports neurulation by stimulating autophagy

11 PGCs are specified during embryogenesis either by an anc

12 PGCs form in embryogenesis, typically by one of two mode

13 ator activated receptor gamma coactivator-1 (PGC-1)).

14 ing AMP-activated protein kinase, sirtuin 1, PGC-1alpha, sirtuin 3, estrogen-related receptor-alpha,

15 hrough a novel pathway, EGFR/ERK1/2/FOXO3a/1/PGC-1alpha, under physiological and pathological conditi

16 proteins, antioxidant enzymes and sirtuin-1/PGC-1 signalling) are central to the protective effects

17 activated receptor gamma coactivator 1alpha (PGC-1alpha) expression were decreased in ADPKD model ani

18 ctivated receptor gamma, coactivator 1alpha (PGC-1alpha) is a unique stress sensor that largely acts

19 activated receptor gamma coactivator 1alpha (PGC-1alpha) together with estrogen-related receptor alph

20 activated receptor gamma coactivator 1alpha (PGC-1alpha), and fewer mitochondria than controls from u

21 activated receptor gamma coactivator 1alpha (PGC-1alpha).

22 ription factor PPARgamma coactivator 1alpha (PGC-1alpha, encoded by Ppargc1a).

23 activated receptor-gamma coactivator-1alpha (PGC-1a) expression that is crucial to skeletal muscle mi

24 activated receptor-gamma coactivator-1alpha (PGC-1a), which mediates mitochondrial biogenesis and oxi

25 activated receptor gamma coactivator-1alpha (PGC-1alpha) expression.

26 activated receptor gamma coactivator-1alpha (PGC-1alpha) gene, a master regulator of mitochondrial fu

27 activated receptor gamma coactivator-1alpha (PGC-1alpha).

28 -activated receptor gamma coactivator 1beta (PGC-1beta) and PGC-1alpha-related coactivator (PRC).

29 nos-1nos-2 PGCs fail to silence hundreds of transcripts normally ex

30 Cs lacking PRC2 resembles that of nos-1nos-2 PGCs.

31 sum, TGCTs share collective entrapment in a PGC-like state of genomic-imprint and DPPA3 erasure, rec

32 tochondrial activity, possibly by activating PGC-1alpha and SIRT1, to improve physical endurance, str

33 uconeogenic enzyme G6Pase and a co-activator PGC-1alpha were all markedly decreased.

34 ators-activated receptor-gamma co-activator (PGC)-1alpha, a critical master of ROS metabolism, which

35 tion, and minimizes run times, thus allowing PGC columns to be used to their full potential.

36 some proliferator gamma coactivator 1 alpha (PGC-1alpha).

37 ctivated receptor gamma coactivator 1-alpha (PGC-1alpha), a critical transcriptional co-activator of

38 ctivated receptor gamma coactivator 1-alpha (PGC-1alpha).

39 These results show that alternative PGC-1alpha variants can affect target gene expression bo

40 These three alternative PGC-1alpha isoforms lack the arginine/serine-rich (RS) a

41 Selective expression of NT-PGC-1alpha and PGC-1alpha in PGC-1alpha(-/-) brown adipocytes similarly

42 biogenesis activators (TFAM, PGC-1alpha and PGC-1beta).

43 ptor gamma coactivator 1beta (PGC-1beta) and PGC-1alpha-related coactivator (PRC).

44 matic rearrangements underlying ES-cell- and PGC-specific transcriptional programs remains poorly und

45 partially by increasing glycolytic flux and PGC-1alpha mRNA in cultured podocytes.

46 munication between methionine metabolism and PGC-1alpha-mediated hepatic gluconeogenesis, suggesting

47 erexpression reduced palmitate oxidation and PGC-1alpha mRNA.

48 highlight the combined effects of Parkin and PGC-1alpha in the maintenance of mitochondrial homeostas

49 reases in uncoupled cellular respiration and PGC-1alpha and NDUFS1 mRNA expression and was blocked by

50 t inhibit the transcription of both TFAM and PGC-1alpha in BSM cells from asthmatic patients.

51 found that the interaction between Tug1 and PGC-1alpha promotes the binding of PGC-1alpha to its own

52 action of ATRA on the induction of UCP1 and PGC-1alpha expression in brown adipocytes and the restor

53 The genomes of both PGCLCs and PGCs selectively retained both 5meCs and 5hmeCs at a sma

54 Here we leveraged PPARGC1a (also known as PGC-1alpha; encoded by Ppargc1a), a transcriptional coac

55 ssion/activity (1.5- to 2.7-fold) as well as PGC-1a mRNA levels (1.5- to 5-fold) in rat soleus muscle

56 Data on clinical ASD (PGC-ASD: 5305 cases, 5305 pseudo-controls; iPSYCH-ASD: 7

57 TALEN-mediated gene targeting in avian PGCs is therefore an efficient process.

58 s indicate that a direct interaction between PGC-1alpha and Tug1 modulates mitochondrial bioenergetic

59 his review, we discuss the interplay between PGC-1 coactivators and cancer pathogenesis, including tu

60 gest that VEGF-B is the missing link between PGC-1alpha overexpression and the development of the dia

61 scle protein synthesis, ribosome biogenesis, PGC-1alpha expression and hypertrophy.

62 perates to induce its own inhibitor SIRT3 by PGC-1beta.

63 port the use of a porous graphitized carbon (PGC) LC-MS method with effective separation and sensitiv

64 ric separation on porous graphitized carbon (PGC) packed in long capillaries.

65 and important role in primordial germ cell (PGC) development and that ephrinB1 (efnb1) is required f

66 Primordial germ cell (PGC) development is characterized by global epigenetic r

67 is a key regulator of primordial germ cell (PGC) formation in Drosophila embryos.

68 sterior at the site of primordial germ cell (PGC) formation through an actin-dependent mechanism.

69 t for both somatic and primordial germ cell (PGC) specification.

70 correlates with higher primordial germ cell (PGC) survival probability.

71 The migration of primordial germ cells (PGCs) from their place of origin to the embryonic gonad

72 In animals, primordial germ cells (PGCs) give rise to the germ lines, the cell lineages tha

73 xpressed in unipotent primordial germ cells (PGCs) in mice, where its precise role is yet unclear.

74 of a small number of primordial germ cells (PGCs) in the early embryo.

75 ng pathway in chicken primordial germ cells (PGCs) in vitro.

76 The migration of primordial germ cells (PGCs) is a useful model for studying this process in the

77 the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs nos-1 and nos-2 in C. e

78 During development, primordial germ cells (PGCs) navigate a complex journey to generate the germlin

79 ications occur in the primordial germ cells (PGCs) of emergent starved L1 larvae that correlate with

80 ional activity in the primordial germ cells (PGCs) of the sea urchin embryo (Strongylocentrotus purpu

81 he developing embryo, primordial germ cells (PGCs) represent the exclusive progenitors of the gametes

82 directed migration of primordial germ cells (PGCs) towards somatic gonadal precursor cells (SGPs).

83 d for the survival of primordial germ cells (PGCs), as well as the suppression of germ cell tumours i

84 lantation embryos and primordial germ cells (PGCs), or locus specific, which can regulate neighboring

85 he differentiation of primordial germ cells (PGCs), precursors of sex-specific gametes that produce a

86 by transplantation of primordial germ cells (PGCs).

87 pportunities to study primordial germ cells (PGCs).

88 ectional migration of primordial germ cells (PGCs).

89 ines is a hallmark of primordial germ cells (PGCs).

90 strikingly, to early primordial germ cells (PGCs).

91 asa) locus in chicken primordial germ cells (PGCs).

92 nd BIO promoted the proliferation of chicken PGCs similarly to bFGF, whereas JW74 inhibited this prol

93 naling enhances the proliferation of chicken PGCs via the stabilization of beta-catenin and activatio

94 In DDX4 knockout chickens, PGCs are initially formed but are lost during meiosis in

95 on depended on the transcription coactivator PGC-1beta (peroxisome proliferator-activated receptor-ga

96 ipocytes are the transcriptional coactivator PGC-1alpha and its splicing isoform NT-PGC-1alpha, which

97 etylation of the transcriptional coactivator PGC-1alpha to control hepatic gluconeogenesis.

98 erator-activated receptor gamma coactivator (PGC)-1alpha as well as attenuated forskolin-stimulated u

99 Supporting this conclusion, PGC migration defects in Mdr49 embryos are substantially

100 Most generally, TGCTs conserve PGC-lineage erasure of maternal and paternal genomic imp

101 cs from the Psychiatric Genetics Consortium (PGC) Schizophrenia working group to build a drug reposit

102 The Psychiatric Genomics Consortium (PGC) aims for mega-analyses with sample sizes that will

103 The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychia

104 through the Psychiatric Genomics Consortium (PGC) or the Danish iPSYCH project.

105 ease of the Psychiatric Genomics Consortium (PGC), the PGC2-MDD (Major Depression Dataset).

106 cted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analys

107 = 6455) and Psychiatric Genomics Consortium (PGC:MDD) (N = 18,759)].

108 tantly, myricetin treatment led to decreased PGC-1alpha acetylation through SIRT1 activation.

109 ch are aberrantly elevated in DND1-deficient PGCs.

110 During early development, PGCs are exposed to numerous signals that specify somati

111 Here we show that different PGC-1alpha variants can affect target gene splicing thro

112 To prevent somatic differentiation, PGCs must transiently silence their genome, an early dev

113 stain elevated SIRT1 activity and downstream PGC-1alpha signalling.

114 grams and splicing options modulated by each PGC-1alpha isoform.

115 f genome-wide DNA demethylation in embryonic PGCs, including significant demethylation of imprint con

116 he transcription of Ucp1, Ppargc1a (encoding PGC-1alpha), and oxidative phosphorylation genes.

117 In conclusion, endothelial PGC-1alpha expression protects from vascular dysfunction

118 we sought to define the role of endothelial PGC-1alpha in vascular function using mice with endothel

119 Deletion of endothelial PGC-1alpha sensitized mice to endothelial dysfunction an

120 longer responsive to transgenic endothelial PGC-1alpha expression.

121 For example, PGCs express a number of transcription factors in common

122 , we show that both endogenous and exogenous PGC-1alpha down-regulate the expression of numerous gene

123 nced respiration in NT-PGC-1alpha-expressing PGC-1alpha(-/-) brown adipocytes.

124 PGC-1alpha(-/-) brown adipocytes expressing PGC-1alpha, suggesting a direct effect of NT-PGC-1alpha

125 In cortical neurons, co-expressing PGC-1alpha and Parkin increases the number of mitochondr

126 having comparable levels of TFAM expression, PGC-1alpha(-/-) brown adipocytes expressing NT-PGC-1alph

127 evels of the mitochondrial biogenesis factor PGC-1alpha falling, and shows similarities to adapted Ti

128 Finally, PGC-1alpha was expressed in NAc D1-MSNs versus D2-MSNs u

129 tory network in germline-competent cells for PGC specification.

130 We also reveal a function for PGC-1alpha in embryonic development through promoting au

131 Discrete functions for PGC-1alpha1 and -alpha4 have been described, but the bio

132 The causes of the shift to germ plasm for PGC specification in some animal clades remain largely u

133 lly, we demonstrate a bidirectional role for PGC-1alpha in mediating behavioral plasticity to cocaine

134 We demonstrate a novel role for PGC-1alpha in NAc in cocaine action.

135 here that CVM cells exhibit an affinity for PGCs, localizing to the position of PGCs whether misloca

136 with endothelial specific loss of function (PGC-1alpha EC KO) and endothelial specific gain of funct

137 ) and endothelial specific gain of function (PGC-1alpha EC TG).

138 Furthermore, PGC-1alpha expression was suppressed by decreased intrac

139 sortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular ge

140 inistration in mice likewise induced hepatic PGC-1alpha acetylation, suppressed the gluconeogenic gen

141 Here, we review the latest advances in human PGC specification and epigenetic reprogramming.

142 previous studies have shown that CVM impacts PGC migration.

143 to NF-kappaB over-activation which impaired PGC-1alpha-mediated anti-oxidant capacity resulting in t

144 In PGC:MDD, one pathway was significantly associated with M

145 xpression of NT-PGC-1alpha and PGC-1alpha in PGC-1alpha(-/-) brown adipocytes similarly induced expre

146 was accompanied by predicted alterations in PGC-1alpha-mediated gluconeogenic gene expression and gl

147 Cbfa2t2(-/-) mice display severe defects in PGC maturation and epigenetic reprogramming.

148 there are crucial mechanistic differences in PGC specification, reflecting divergence in the regulati

149 ike cells, methylation is globally erased in PGC-like cells.

150 acute and chronic RE promoted an increase in PGC-1alpha expression and these alterations were not aff

151 In PGCs, global and locus-specific DNA demethylation occur

152 e validate by overactivating beta-catenin in PGCs.

153 ression of Tet1s failed to erase imprints in PGCs and displayed developmental defects in progeny.

154 ress beta-catenin-dependent Wnt signaling in PGCs and limit their proliferation in specific locations

155 and identified small molecules that increase PGC-1alpha acetylation, suppress gluconeogenic gene expr

156 Increased PGC-1alpha occurred in D1-MSNs, while D2-MSNs showed red

157 lear FOXO3a/1 phosphorylation, and increased PGC-1alpha gene expression and its downstream mitochondr

158 Repeated cocaine increased PGC-1alpha levels and increased Egr3 binding and H3K4me3

159 These results were associated with increased PGC-1alpha, UCP2 and UCP3 mRNA and decreased reactive ox

160 ross age, as observed within two independent PGC-SCZ2 subsamples, and showed an increase in magnitude

161 rs Prdm1, Prdm14 and Tfap2c, directly induce PGC-like cells (PGCLCs) in EpiLCs, but not in ES cells.

162 enerated T3 plays a role in exercise-induced PGC-1a expression, male rats and mice with SKM-specific

163 uscle fibres impaired acute exercise-induced PGC-1a expression.

164 pathways, contributed to methionine-induced PGC-1alpha acetylation.

165 gh endurance training preferentially induces PGC-1alpha1 expression, resistance exercise activates th

166 ication of regulatory targets that influence PGC-1 expression and activity may reveal novel strategie

167 Interestingly, PGC-1alpha requires the central heat shock response regu

168 e bisulfite sequencing data for intragonadal PGCs.

169 greater amounts of 5hmeCs than intragonadal PGCs.

170 Proliferation of mammalian PGCs is concurrent with their movement through changing

171 f improved respiratory function, we measured PGC-1alpha pathway activity, which is suggested to be up

172 Mechanistically, PGC-1alpha promotes eNOS expression and activity, which

173 Ror2 and Wnt5a mutants with mislocalized PGCs corroborate the microenvironmental regulation of th

174 nces in the specification of human and mouse PGCs.

175 zation is required for the survival of mouse PGCs and spermatogonial stem cells by suppressing apopto

176 e training (6 weeks) increased soleus muscle PGC-1a mRNA levels ( approximately 25%) and the mitochon

177 NT-PGC-1alpha was specifically enriched at the D-loop regio

178 C-1alpha(-/-) brown adipocytes expressing NT-PGC-1alpha had higher expression of mtDNA-encoded ETC ge

179 appreciated and isoform-specific role for NT-PGC-1alpha in the regulation of mitochondrial transcript

180 s associated with enhanced respiration in NT-PGC-1alpha-expressing PGC-1alpha(-/-) brown adipocytes.

181 vator PGC-1alpha and its splicing isoform NT-PGC-1alpha, which control mitochondrial gene expression

182 Selective expression of NT-PGC-1alpha and PGC-1alpha in PGC-1alpha(-/-) brown adipo

183 Here we sought to investigate the role of NT-PGC-1alpha in brown adipocyte mitochondria.

184 PGC-1alpha, suggesting a direct effect of NT-PGC-1alpha on mtDNA transcription.

185 we found that, in brown adipocytes, some NT-PGC-1alpha localizes to mitochondria, whereas PGC-1alpha

186 , and biochemical analyses indicated that NT-PGC-1alpha was located in the mitochondrial matrix in br

187 Tug1 and PGC-1alpha promotes the binding of PGC-1alpha to its own promoter.

188 and RNA recognition motifs characteristic of PGC-1alpha1.

189 of ERRalpha is mediated by deacetylation of PGC-1alpha and is required for the transcription of Ucp1

190 Accordingly, depletion of PGC-1alpha in chemoAML cells abolished such induction of

191 consistent with a transcriptional effect of PGC-1alpha on the expression of genes encoding secreted

192 an-PPAR agonist, increases the expression of PGC-1alpha and mitochondrial biogenesis, and improves ph

193 Viral-mediated expression of PGC-1alpha in D1-MSNs enhanced behavioral responses to c

194 c neurons in which the chronic expression of PGC-1alpha is induced.

195 istance exercise activates the expression of PGC-1alpha2, -alpha3, and -alpha4.

196 Conversely, inducible expression of PGC-1beta in white adipose tissue is sufficient to induc

197 se inhibitor exhibited reduced expression of PGC-1beta, PRC, and mitochondrial biogenesis.

198 rfering with the RANKL-induced expression of PGC-1beta.

199 ults suggest that the selective induction of PGC-1alpha gene in specific areas of the brain is effect

200 Improving bioenergetics by overexpression of PGC-1alpha enhanced function in developing Tex cells.

201 techolamine-triggered interaction partner of PGC-1alpha.

202 gnificantly suppressed the rapid recovery of PGC-1alpha expression response to DOCA-salt challenge in

203 injury and attenuated the down-regulation of PGC-1alpha and downstream target genes.

204 rate that Wun2 and p53, another regulator of PGC survival, have opposite yet independent effects on P

205 by phosphorylation of upstream regulators of PGC-1alpha and subsequently decreasing MB.

206 terfere with PRC2-dependent reprogramming of PGC chromatin.

207 urthermore, the study highlights the role of PGC-1alpha as a master metabolic sensor that by regulati

208 However, the role of PGC-1alpha in NAc in cocaine action is unknown.

209 e been described, but the biological role of PGC-1alpha2 and -alpha3 remains elusive.

210 significant in this pathway in one subset of PGC:MDD.

211 Suppression of PGC-1beta and PRC with siRNA reverses the effects of IGF

212 -onset PD, and controls the transcription of PGC-1alpha, a master regulator of mitochondrial biogenes

213 igration and directs subsequent migration of PGCs through the midgut primordium.

214 nity for PGCs, localizing to the position of PGCs whether mislocalized or trapped in the endoderm.

215 ng in the germline, and the transcriptome of PGCs lacking PRC2 resembles that of nos-1nos-2 PGCs.

216 pared various methods for transplantation of PGCs aggregated with gonadal somatic cells and showed th

217 Together, transplantation of PGCs can effectively reconstitute ovarian functions but

218 ed folliculogenesis after transplantation of PGCs-aggregates into either kidney capsule or ovarian bu

219 aining self-renewal and expansion in vivo of PGCs and controlling follicle activation will be essenti

220 n FGF and Wnt, and that beta-catenin acts on PGC proliferation downstream of bFGF.

221 al, have opposite yet independent effects on PGC survival.

222 f the observed retention loss/variability on PGC.

223 overall germ plasm quantity, such that only PGCs with the highest germ plasm quantity survive.

224 tent in vivo, by either mTORC1 inhibition or PGC-1beta deletion, prevents senescence in the ageing mo

225 ates expression of Vegfb Mice overexpressing PGC-1alpha under the muscle creatine kinase promoter (MP

226 In particular, PGC-1alpha2 seems to mediate a decrease in the levels of

227 zation state of analytes and the polarizable PGC surface that influences the strength of dispersive f

228 Here we show that porcine PGCs originate from the posterior pre-primitive-streak c

229 Here we identify necdin as a potent PGC-1alpha stabilizer that promotes mitochondrial biogen

230 restored the impaired PPARgamma, PPARdelta, PGC-1alpha signaling pathway, enhanced mitochondrial bio

231 Perilipin 5 promotes PGC-1alpha co-activator function by disinhibiting SIRT1

232 We show that CRL3(GCL) promotes PGC fate by mediating degradation of Torso, a receptor t

233 that ephrinB1 (efnb1) is required for proper PGC migration.

234 vation of relevant genes required for proper PGC specification.

235 oughput chemical screen platform to quantify PGC-1alpha acetylation in cells and identified small mol

236 Here we recapitulate PGC specification in vitro from naive embryonic stem cel

237 osphate phosphatase Wunen-2 (Wun2) regulates PGC survival in a dose-dependent manner.

238 The metabolic regulators PGC-1alpha and ERRgamma increase significantly upon neur

239 Meanwhile, no replicative PGCs or prophase I meiocytes could be found.

240 bFGF treatment could not rescue PGC proliferation in the presence of JW74.

241 ylalanine chloromethyl ketone) that restored PGC-1alpha recovery and prevented blood pressure elevati

242 pothesized that failure to maintain the same PGC surface before and after running a gradient is a cau

243 3 cases, 11 359 controls) and schizophrenia (PGC-SCZ2: 34 241 cases, 45 604 controls, 1235 trios) wer

244 ed in the meta-analysis with the current SCZ PGC data (OR = 0.8853).

245 to kidney injury, mice with muscle-specific PGC-1alpha overexpression (mPGC-1alpha) exhibit reduced

246 Necdin strongly stabilizes PGC-1alpha by inhibiting its ubiquitin-dependent degrada

247 ds and that hPGCLCs resemble the early-stage PGCs randomly migrating in the midline region of human e

248 exit from naive pluripotency and subsequent PGC specification.

249 ase inhibitor, was able to potently suppress PGC-1alpha acetylation stimulated by methionine, which w

250 The targeted PGCs were germline competent and were used to produce DD

251 -2 represses autophagy by directly targeting PGC-1alpha, a positive regulator for mitochondrial funct

252 We hypothesized that targeting PGC-1alpha acetylation in the liver, a chemical modifica

253 d mitochondrial biogenesis activators (TFAM, PGC-1alpha and PGC-1beta).

254 hese data thus unveil a novel FLCN-mTOR-TFE3-PGC-1beta pathway-separate from the canonical TSC-mTOR-S

255 r expression of mtDNA-encoded ETC genes than PGC-1alpha(-/-) brown adipocytes expressing PGC-1alpha,

256 These data demonstrate that PGC and CVM cell migrations are interdependent and sugge

257 is of secreted proteins, we demonstrate that PGC-1alpha modulates the secretome of mouse embryonic fi

258 Collectively this work demonstrates that PGC column-based methods are powerful tools for enhanced

259 Here, we find that PGC proliferation varies by location rather than embryon

260 We found that PGC's resolving capabilities for the dp4 and dp6 isomeri

261 ell physiology, recent studies indicate that PGC-1 coactivators also serve important functions in can

262 We previously reported that PGC-1alpha also regulates the transcription of beta-APP

263 These data suggest that PGCs do not undergo self-renewal but rapidly enter meios

264 The PGC has recently commenced a program of research designe

265 In addition, the PGC-1alpha promoter has binding sites for early growth r

266 nd increased Egr3 binding and H3K4me3 at the PGC-1alpha promoter in NAc.

267 ng of Egr3 to and histone methylation at the PGC-1alpha promoter was examined in NAc using chromatin

268 d active methylation and Egr3 binding at the PGC-1alpha promoter.

269 ntify Vegfb as a novel gene regulated by the PGC-1alpha/ERR-alpha signaling pathway.

270 ss nine psychiatric disorders studied by the PGC.

271 pha (ERRalpha) is required to coordinate the PGC-1alpha -induced eNOS expression.

272 continued supplementation fails to drive the PGC-1alpha pathway.

273 development decreased with age, both in the PGC-ASD and the iPSYCH-ASD sample.

274 soderm to facilitate the transmission of the PGC attractant from the SGPs; however, the precise molec

275 The central idea of the PGC is to convert the family history risk factor into bi

276 This approach simplifies use of the PGC to the same level as that of a C-18 column, removes

277 of TFE3, leading to direct induction of the PGC-1 transcriptional coactivators, drivers of mitochond

278 4 to T3 within myocytes mediates part of the PGC-1a induction by treadmill exercise and its downstrea

279 mitochondrial function and expression of the PGC-1alpha protein are reduced.

280 ey aim of the recently funded phase 3 of the PGC.

281 energy demands and nutritional supplies, the PGC-1 family of transcriptional coactivators regulates m

282 ranslation factor eEF1A is excluded from the PGCs in a Nanos2-dependent manner, a consequence of a Na

283 ) in general translation specifically in the PGCs.

284 ntly restores translation selectively in the PGCs.

285 addition to eEF1A, the cytoplasmic pH of the PGCs appears to repress translation and simply increasin

286 e that together they ensure selection of the PGCs with highest germ plasm quantity and least cellular

287 We conclude that the PGCs of this sea urchin institute parallel pathways to q

288 -containing lineages (denoted herein as the "PGC-specification hypothesis").

289 nstrate reproducible chromatography on three PGC columns of different ages.

290 s from the DNA damage response (DDR) towards PGC-1beta-dependent mitochondrial biogenesis, contributi

291 ytical issues, and the plans for translating PGC phase 3 findings into new therapeutics.

292 (v) energy and mitochondrial biogenesis (via PGC, UCP3, NRF2, AMPK, MAPK1, and CAMK4).

293 r that promotes mitochondrial biogenesis via PGC-1alpha in mammalian neurons.

294 discovered an unexpected step along the way: PGCs get cut in half by endodermal cells.

295 nd hypertension in response to ATII, whereas PGC-1alpha EC TG mice were protected.

296 GC-1alpha localizes to mitochondria, whereas PGC-1alpha resides in the nucleus.

297 PGC and CVM cell types interact while PGCs are en route to the somatic gonadal mesoderm, and p

298 e A and forms transcriptional complexes with PGC-1alpha and SIRT1 in the nucleus.

299 ecreased in ADPKD model animal kidneys, with PGC-1alpha expression inversely correlated with oxidativ

300 Zebrafish PGC migration depends on the formation of cellular protr