ライフサイエンスコーパス: PGE synthase

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1 no effect on the expression of the cytosolic PGE synthase.

2 etermined using mice deficient in microsomal PGE synthase 1 (mPGES-1) and in the receptors for PGI2.

3 ination a mouse line deficient in microsomal PGE synthase 1 (mPGES1) on the inbred DBA/1lacJ backgrou

4 onses, we infected macrophages from membrane PGE synthase 1 knockout mice (mPGES1(-/-)) that cannot p

5 natants from F. tularensis-infected membrane PGE synthase 1(-/-) macrophages did not inhibit T cell p

6 ghts the role of cyclooxygenase-2/microsomal PGE synthase 1/PGE2 signaling in hypertension and diabet

7 a the sequential up-regulation of microsomal PGE synthase-1 (mPGES-1) and L-PGDS.

8 COX-2 and microsomal PGE synthase-1 (mPGES-1) and mPGES-2 are present in post

9 cence, we detected both COX-2 and microsomal PGE synthase-1 (mPGES-1) but not COX-1 in the Golgi appa

10 Microsomal PGE synthase-1 (mPGES-1) is an inducible enzyme that act

11 Microsomal PGE synthase-1 (mPGES-1) is an inducible enzyme that spe

12 PS exposure induced expression of microsomal PGE synthase-1 (mPGES-1), a key enzyme in PGE2 biosynthe

13 n primarily through inhibition of microsomal PGE synthase-1 (mPGES-1), not COX-2.

14 dinate actions of COX enzymes and microsomal PGE synthase-1 (mPGES-1).

15 ave increased levels of COX-2 and microsomal PGE synthase-1 (mPGES-1).

16 erved with PGHS-2, PGD synthases, microsomal PGE synthase-1 and EP1, EP2, EP3, and FP receptors.

17 IL-6 coinduced Cox-2 and microsomal PGE synthase-1, and inhibited the expression of 15-hydro

18 Microsomal prostaglandin E (PGE) synthase-1 (mPGES-1) is an inducible enzyme that co

19 -146a in BMSCs correlated with inhibition of PGE synthase-2 and inhibition of PGE2 release.

20 -HSL induction of Cox-2, membrane-associated PGE synthase, and PGE(2) likely contributes to the infla

21 Microglial cyclooxygenase-2, microsomal PGE synthase, and PGE2 expression were increased 2- to 2

22 wly discovered inducible membrane-associated PGE synthase but had no effect on the expression of the

23 tation sites where Ptgs2 and microsomal type PGE synthases but not PGI synthases are co-expressed.

24 To produce biologically active PGE2, PGE synthases catalyze the isomerization of PGH2 into PG

25 Recently, several PGE synthases have been identified and cloned, but their

26 2) synthesis in inflammation suggests that a PGE synthase may be linked to an inducible pathway for P

27 of the recently cloned inducible microsomal PGE synthase (mPGES) in synoviocytes from patients with

28 ssion of both COX-2 and microsome-associated PGE synthase (mPGES) in the MD.

29 G) E(2) is formed from PGH(2) by a series of PGE synthase (PGES) enzymes.

30 re synthesized by the prostanoid isomerases, PGE synthases (PGES) and PGD synthases (PGDS), respectiv

31 lism of prostanoid endoperoxides by specific PGE synthases (PGES).

32 uential actions of cyclooxygenases (COX) and PGE synthases (PTGES).

33 Inhibition of PGE synthase reduced TF in vivo and in vitro and prevent

34 Here, we identify mPGES1 as the PGE synthase that contributes to the pathogenesis of col

35 udy the physiological role of the individual PGE synthases, we have generated by targeted homologous

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