ライフサイエンスコーパス: PGF2

1 prostaglandin D2 (PGD2) or 9 alpha, 11 beta PGF2 (11 beta PGF2) formation did not correlate with lys

2 e (NO), adenosine, or prostaglandins PGI2 or PGF2, all of which are putative KATP channel openers.

3 PGF2 alpha (1 microM) did not significantly potentiate [

4 ardiomyocyte cultures was increased by 10 nM PGF2 alpha and 11 beta-PGF2 alpha but was unchanged by 1

5 The balance between PGF2 alpha and PGJ2 signaling may thus be central to the

6 dro-TxB2 production and suppression of 8-epi-PGF2 alpha and TxB2 in serum.

7 ddition, myofibrillogenesis was increased by PGF2 alpha as assessed by immunocytochemical staining wi

8 We report here that PGF2 alpha blocks adipogenesis through activation of mit

9 as increased by 10 nM PGF2 alpha and 11 beta-PGF2 alpha but was unchanged by 10 nM PGD2, PGE2, PGF1 a

10 PGF2 alpha caused a dose-dependent increase in total ino

11 Production of 8-epi-PGF2 alpha coincided with that of thiobarbituric acid-re

12 enty-four hours after UVB exposure, PGE2 and PGF2 alpha concentrations in aqueous humor were increase

13 ests that caution be exercised in the use of PGF2 alpha derivatives in the therapy of glaucoma.

14 t failed to suppress urinary levels of 8-epi-PGF2 alpha despite a significant reduction in urinary 11

15 8-epi-PGF2 alpha excretion (in pmol/mmol, mean +/- SEM) was 17

16 rmation of PG G/H S-2 as the source of 8-epi-PGF2 alpha formation was obtained by down-regulating the

17 also exhibit the facility to generate 8-epi-PGF2 alpha in a free radical-dependent manner.

18 Elevated levels of 8-epi-PGF2 alpha in smokers may be modulated by quitting cigar

19 The evidence presented for a role of PGF2 alpha in the development of cataract suggests that

20 ediating some of the IOP-lowering effects of PGF2 alpha in the eye.

21 Lens PGE2 and PGF2 alpha increased by 6- and 4-fold, respectively, aft

22 In contrast, topical administration of PGF2 alpha increased cataract severity.

23 nted UVB-induced cataract formation, whereas PGF2 alpha increased the severity of the cataract.

24 the rise in lens and aqueous humor PGE2 and PGF2 alpha levels.

25 Urinary 8-epi-PGF2 alpha may represent a noninvasive, quantitative ind

26 cular myocytes in culture and speculate that PGF2 alpha plays a role in myocardial adaptation to chro

27 Both carbachol and PGF2 alpha potentiated phosphorylation of MLC20 in depol

28 intrarenal prostanoid receptors include the PGF2 alpha receptor (FP), the thromboxane A2 receptor (T

29 We hypothesized that PGF2 alpha stimulates hypertrophic growth of neonatal ra

30 imulation of myofibrillar gene expression by PGF2 alpha was demonstrated by Northern and Western blot

31 plementary studies, tracer isoprostane B-iso-PGF2 alpha was found to be transported at approximately

32 Urinary 8-epi PGF2 alpha was unchanged after circumflex artery occlusi

33 reventing synthesis of PGE2, TxB2, and 8-epi-PGF2 alpha with the specific PG G/H S-2 inhibitor, L 745

34 Prostaglandin F2 alpha (PGF2 alpha) and analogs, such as latanoprost, are though

35 Prostaglandin F2 alpha (PGF2 alpha) stimulates protein synthesis of skeletal and

36 ily prostaglandins E2 and F2 alpha (PGE2 and PGF2 alpha).

37 uence in monolayer cultures and treated with PGF2 alpha, 11-deoxy-PGE1, or PhXA85 (the nonesterified

38 Treatment with 200 nM PGF2 alpha, 11-deoxy-PGE1, or PhXA85 for 72 hours increa

39 In addition, exposure to PGF2 alpha, 11-deoxy-PGE1, or PhXA85 increases productio

40 Mass spectrometry was used to measure PGE2, PGF2 alpha, and 6-keto-PGF1 alpha content of the lens an

41 Other pharmacologic agents, such as PGE2, PGF2 alpha, and misoprostol, were applied topically to t

42 nity uptake of PGE2, PGF2 alpha, PGD2, 8-iso-PGF2 alpha, and thromboxane B2.

43 PGE2 and PGF2 alpha, both known to be transported, had similar af

44 E2 (PGE2), thromboxane B2 (TxB2), and 8-epi-PGF2 alpha, but not of other F2-isoprostanes.

45 specific, and high-affinity uptake of PGE2, PGF2 alpha, PGD2, 8-iso-PGF2 alpha, and thromboxane B2.

46 , in the presence or absence of carbachol or PGF2 alpha, resulted in significant attenuation of force

47 d 24-h urinary excretion rates of free 8-iso PGF2 alpha, two markers of oxidative stress, were measur

48 We have shown that 8-epi-PGF2 alpha, unlike other F2-isoprostanes, is a minor pro

49 133.5+/-29.6 P<.05) suppressed urinary 8-epi-PGF2 alpha, whereas vitamin E alone had no effect.

50 2-glycerol (15d-PGJ2-G), PGD2-G, PGE2-G, and PGF2 alpha-G.

51 hain reaction (RT-PCR), functional assays of PGF2 alpha-stimulated inositol phosphate hydrolysis, and

52 of mRNA, protein, and functional response to PGF2 alpha.

53 required for the anti-adipogenic effects of PGF2 alpha.

54 iac fibroblast-like cells were unaffected by PGF2 alpha.

55 steine increased the amplitude of the NPV to PGF2(alpha) by approximately 50%, and had a similar effe

56 eated with fluprostenol or prostaglandin F2 (PGF2), and MKP1 mRNA levels were determined.

57 IPF2alpha-I, IPF2alpha-III, and 9beta,11beta-PGF2, caused trivial, or no, activation of the FP.

58 D2 (PGD2) or 9 alpha, 11 beta PGF2 (11 beta PGF2) formation did not correlate with lyso-PL generatio

59 Serum 9alpha,11ss-PGF2 , recently identified as a suitable biomarker for a

60 suggest that ApoA1 combined with 9alpha,11ss-PGF2 represents a useful composite biomarker of anaphyla

61 o 1 microM fluprostenol and 0.01 to 1 microM PGF2 significantly induced MKP1 mRNA levels, which peake

62 Agonist activity for 8-iso-PGF2 was diminished and that for pinane thromboxane A no

63 ostaglandin (PG) D2 metabolite 9alpha,11beta-PGF2 were evaluated at baseline and after 1, 3, 5, and 6