ライフサイエンスコーパス: PGI

1 PGI has been used to map a total of 3858 BAC clones cove

2 PGI is a multifunctional dimeric protein that extracellu

3 PGI is a multifunctional dimeric protein that extracellu

4 PGI is a multifunctional dimeric protein that extracellu

5 PGI phosphorylation by CK2 also led to down-regulation o

6 PGI(2) (prostacyclin) is a lipid mediator with vasodilat

7 PGI(2) is also increasingly believed to have anti-inflam

8 PGI(2) plays a key role in limiting Th2-mediated airway

9 PGI-02776 was also readily hydrolyzed to both the mono-e

10 PGI-LysAP hydrolyzed bradykinin, Lys-bradykinin, Lys-(de

11 PGI-overexpressing cells also exhibited elevated express

12 PGI/AMF cellular expression in HT1080 human fibrosarcoma

13 PGI/AMF has been correlated significantly with breast ca

14 mbination of PGI/II-HpAb (0.786, P < 0.001), PGI/II-OPN (0.787, P < 0.001), and OPN-HpAb (0.801, P =

15 shold (P = 0.002), CGI-Severity (P = 0.048), PGI-Improvement (P = 0.033), and several quality-of-life

16 ese results suggest that activation of COX-1/PGI(2)/PPARdelta pathway is an important mechanism under

17 PARP-14-PGI/AMF interaction was confirmed by coimmunoprecipitati

18 -M), and PGI2, 2,3-dinor 6-keto PGF(1alpha) (PGI-M), only PGI-M was depressed by the COX-2 inhibitor.

19 B2 (Tx-M) and 2'3-donor-6-keto-PGF(1alpha) (PGI-M).

20 elease and production of prostaglandin I(2) (PGI(2)) and platelet-activating factor (PAF).

21 Prostaglandin I(2) (PGI(2)) stimulated VEGF-dependent angiogenesis to preven

22 such as nitric oxide and prostaglandin I(2) (PGI(2)), considerably less is known about intrinsic mech

23 increases production of prostaglandin I(2) (PGI(2)).

24 tabolism via stimulation of cyclooxygenase-2/PGI(2) synthase pathway.

25 muM) to the reference drug nitazoxanide (50% PGI release at c = 1.2 muM).

26 , Ph) with comparable in vitro toxicity (50% PGI release at c = 1.4 - 4.7 muM) to the reference drug

27 oprostol (a PGE(1/2) analog) or beraprost (a PGI(2) analog) significantly decreased ConA-induced live

28 gh-salt diet (HSD); this was attenuated by a PGI(2) receptor agonist.

29 t AAMvarphi-derived eicosanoid and propose a PGI(2)-PPARdelta axis maintains AAMvarphi during B malay

30 cident with TP-cAMP generation, promoting a "PGI(2)-like" cellular response to TP activation.

31 Furthermore, unlike the activators (PGI(2) and forskolin) of the cAMP pathway, 2MeSAMP and C

32 latory properties of clinically administered PGI(2) analogs.

33 AMF/PGI acts extracellularly as a potent mitogen/cytokine (C

34 Because little is known about AMF/PGI-dependent signaling in general and during tumorigene

35 Increased expression of AMF/PGI and its receptor/CXXC-R has been found in a wide spe

36 irectly elucidate the functional role of AMF/PGI on cell motility and neoplastic transformation, we s

37 Ectopic overexpression of AMF/PGI results in its secretion and activation via a consti

38 The transformed phenotype of AMF/PGI-transfected cells leads in part resistance to induct

39 ic transformation, we stably transfected AMF/PGI cDNA into NIH-3T3 cells.

40 ucose isomerase with a lysyl aminopeptidase (PGI-LysAP) activity was identified in Vibrio vulnificus.

41 d protein expression of cyclooxygenase-2 and PGI(2) in adventitia, media, and endothelium.

42 also caused increase in cyclooxygenase-2 and PGI(2) synthase protein expression associated with eleva

43 Ang2 and the hypoxic induction of PGE(2) and PGI(2) in a dose-dependent manner.

44 whereas it augmented excretion of PGD(2) and PGI(2) metabolites, reflecting rediversion of the accumu

45 S-stimulated COX-2 expression and PGE(2) and PGI(2) production.

46 I, whereas celecoxib blocked both PGE(2) and PGI(2) production.

47 eased expression of mRNA encoding PGE(2) and PGI(2) synthases.

48 Finally, exogenous PGE(2) and PGI(2) were able to stimulate Ang2 under normoxic condit

49 ed increases in the production of PGE(2) and PGI(2) were associated with increased expression of mRNA

50 Prostaglandin (PG) E(2) and PGI(2) were shown to be the major prostaglandin metaboli

51 Prostaglandins (PGs), PGE(2) and PGI(2), also accumulate in the interstitium during exerc

52 ediated through the production of PGE(2) and PGI(2), which exert anti-inflammatory functions.

53 Measured PLA(2) activity and PGI(2) production by iPLA(2)beta-KO cells were suppresse

54 high levels of COX-1 protein expression and PGI(2) biosynthesis in human EPCs outgrown from blood mo

55 that PGE(2) released from muscle fibres and PGI(2) released from capillaries and venular endothelium

56 otogenic, and differentiation functions, and PGI has been implicated in tumor progression and metasta

57 n both angiotensin II-induced relaxation and PGI(2) release but also abolished high-glucose-enhanced

58 Arachidonic acid release and PGI(2) production by stimulated iPLA(2)beta-KO endotheli

59 nt difference was found between sham-TBI and PGI-02776 treated groups in either analysis indicating a

60 As PGI(2) is unstable, we sought to define the effects of v

61 a), but not by other prostaglandins, such as PGI(2), TxB(2), or PGD(2).

62 GES-1 depressed PGE(2) expression, augmented PGI(2) expression, and had no effect on thromboxane bios

63 ic procedures, SIMCA achieved to be the best PGI-model with 93.3% of sensitivity and 100% of specific

64 Intron position is conserved between PGIs of Colias and the silkmoth, but no intron sequence

65 Augmented expressions of both PGI/AMF and AMFR have been implicated in tumor progressi

66 olytic cleavage of human-derived peptides by PGI-LysAP of V. vulnificus using three approaches: (i) a

67 gulates the expression level of tumor cells' PGI/AMF.

68 as associated with up-regulation of cellular PGI enzymatic activity.

69 and the Patient Global Impression of Change (PGI-C).

70 t are the hallmark of the well characterized PGI family.

71 Like Colias PGI's coding sequences, the introns evolve reticulately

72 on of the housekeeping gene product/cytokine PGI/AMF, and the results depicted here suggest a novel t

73 vestigated the impact of disrupted cytosolic PGI (cPGI) function on plant viability and metabolism.

74 2, arachidonic acid release, COX-2-dependent PGI(2) synthesis, and IP receptor-linked elevation of cA

75 regulated expression of the COX-2 dependent, PGI(2) biosynthesis/response pathway in the renal inner

76 NSAID-mediated suppression of COX-2-derived PGI(2) has negative cardiovascular consequences, yet lit

77 deletion of the receptor for PGHS-2-derived PGI(2), was shown to accelerate thrombogenesis and eleva

78 In contrast, the structurally distinct PGIs of eukaryotic or bacterial origin are thought to ca

79 The elevated PGI-M in smokers (189+/-25, median 174, range 85 to 390

80 human PGI/AMF down-regulated the endogenous PGI/AMF expression and completely extinguished the secre

81 PII inhibitor ZJ-43 and its prodrug di-ester PGI-02776 reduce the deleterious effects of excessive ex

82 n uninjured animals found that the di-ester (PGI-02776) crossed the blood-brain barrier.

83 ile the mono-ester (PGI-02749) and di-ester (PGI-02776) prodrug compounds exhibited moderate and weak

84 nt inhibitory activity while the mono-ester (PGI-02749) and di-ester (PGI-02776) prodrug compounds ex

85 o readily hydrolyzed to both the mono-ester (PGI-02749) and the parent compound (ZJ-43) in both blood

86 enzyme, compared to bacterial and eukaryotic PGIs.

87 se of equivalent complexes of the eukaryotic PGIs reveals similarities at the active site in the disp

88 ally high levels of endogenous and exogenous PGI/AMF, were stably transfected with PGI/AMF small inte

89 ect studies of the significance of exogenous PGI/AMF on tumor progression have been reported.

90 s in endothelial cells, and VSMCs expressing PGI synthase were enriched in mPGES-1(-/-) LDLR(-/-) les

91 glucose isomerase/autocrine motility factor (PGI/AMF) is a housekeeping gene product present in all c

92 glucose isomerase/autocrine motility factor (PGI/AMF) is a housekeeping gene product/cytokine that ca

93 glucose isomerase/autocrine motility factor (PGI/AMF) plays an important role in glycolysis and gluco

94 ntrast, the percentage of 18:0 was lower for PGI veal, and that of 18:1 c9 was higher in PDO veal, wh

95 terial content of cAMP, second messenger for PGI(2), were significantly augmented after transplantati

96 eural networks) to derive diverse models for PGI-honey class with the objective of detecting possible

97 nal medullary expression of the receptor for PGI(2), but not for other prostanoids, was depressed by

98 xamined the interaction of the receptors for PGI(2) (IP) and TxA(2) (TPalpha).

99 c inflammation, implying a critical role for PGI(2) in the programming of "natural" gammadelta-17 cel

100 od in order to differentiate between genuine PGI-Galician honey samples and other commercial honey sa

101 d as substrates for falsification of genuine PGI ones.

102 The siRNA targeting human PGI/AMF down-regulated the endogenous PGI/AMF expression

103 activities, although it is known that human PGI/AMF is phosphorylated at Ser(185) by protein kinase

104 Our results identify PGI(2)-IP as an important pathway for inhibiting allergi

105 Importantly, PGI(2) and its receptor IP, which downregulated airway e

106 e, Patient Global Impression of Improvement (PGI-Improvement) scale, Brief Pain Inventory (short form

107 these results suggest a role of miR-200s in PGI/AMF-induced EMT and thus approaches for upregulation

108 requires a rotation of its C2-C3 bond but in PGI this is sterically blocked by Gln511.

109 A proline residue (in place of a glycine in PGI) may also promote PMI activity by positioning the C1

110 Histamine-induced increases in PGI(2) and PGE(2) production were due to increased expre

111 reduced p27Kip1 protein expression level in PGI-overexpressing cells could be restored to control le

112 that the expression of miR-200s was lost in PGI/AMF overexpressing MCF-10A cells and in highly invas

113 increased superoxide and 3-nitrotyrosine in PGI(2) synthase (PGIS).

114 pendent kinase inhibitor was up-regulated in PGI/AMF knockdown cells and that superoxide dismutase is

115 In PGIs from bacterial and eukaryotic sources, which cannot

116 research supports a role for PGs, including PGI(2), in the regulation of both innate and acquired im

117 and macrophages with bacterial LPS increased PGI(2) and thromboxane A(2) to varied extents.

118 f EPCs promotes vasoprotection by increasing PGI(2) production and intracellular concentration of cAM

119 Pooled genomic indexing (PGI) is a method for mapping collections of bacterial ar

120 's Mountain Protected Geographic Indication (PGI).

121 neys with protected geographical indication (PGI) "Mel de Galicia" was processed by means of differen

122 (PDO) or Protected Geographical Indication (PGI) product has also been discussed.

123 re administered the NAAG peptidase inhibitor PGI-02776 (10mg/kg) 30 min following TBI combined with a

124 e experiments revealed that PARP-14 inhibits PGI/AMF ubiquitination, thus contributing to its stabili

125 1-selective inhibitor, dramatically inhibits PGI(2) production.

126 Over the two weeks following injury, PGI-02776-treated rats had significantly improved motor

127 Furthermore, two weeks post-injury, PGI-02776-treated animals had a significant decrease in

128 depletion of glucose-6-phosphate isomerase (PGI) in the glucose-depleted Deltamec/Deltamec null back

129 thway and the glucose-6-phosphate isomerase (PGI) reaction.

130 ococcus litoralis, phosphoglucose isomerase (PGI) activity is catalyzed by an enzyme unrelated to the

131 through action of phosphoglucose isomerase (PGI) and phosphoglucose mutase interconverting glucose 6

132 ility factor (AMF)/phosphoglucose isomerase (PGI) is a ubiquitous cytosolic enzyme and is produced as

133 Phosphoglucose isomerase (PGI) is an enzyme of glycolysis that interconverts gluco

134 Phosphoglucose isomerase (PGI) is one of the glycolytic enzymes and is a multifunc

135 To pursue this for phosphoglucose isomerase (PGI) of Colias butterflies, whose polymorphism is mainta

136 ) by baker's yeast phosphoglucose isomerase (PGI) with regard to k(cat) and K(m) were determined from

137 a dual specificity phosphoglucose isomerase (PGI)/phosphomannose isomerase from Pyrobaculum aerophilu

138 Phosphoglucose isomerase (PGI; EC 5.3.1.9) is a cytosolic housekeeping enzyme of t

139 Phosphoglucose isomerase (PGI; EC 5.3.1.9) is a housekeeping cytosolic enzyme of t

140 Phosphoglucose isomerase (PGI; EC 5.3.1.9) is a ubiquitous cytosolic enzyme essent

141 Phosphoglucose isomerase, PGI, of Colias butterflies offers such a case.

142 commonly seen in phosphoglucose isomerases (PGIs) that are found in bacteria, eukaryotes and some ar

143 s at 24 h post injury revealed that 10 mg/kg PGI-02776 significantly decreased the number of degenera

144 Along with elevated COX-2 levels, PGI(2) and PGE(2) levels were also increased.

145 We identified the PPARdelta ligand PGI(2) as the most abundant AAMvarphi-derived eicosanoid

146 Thus, PGD(2), like PGI(2), may function as a homeostatic response to thromb

147 e excretion, with the exception of the major PGI(2) metabolite that was suppressed on regular chow an

148 rotected by the European Union with the mark PGI (i.e., Protected Geographical Indication), and culti

149 consequences associated with PGHS-2-mediated PGI(2) suppression.

150 eats (n=68), "Vitela Tradicional do Montado"-PGI veal, Mertolenga-PDO veal and Mertolenga-PDO beef we

151 muscle cells generated less PGE(2) but more PGI(2) and expressed reduced tenascin-C compared with wi

152 Moreover, PGI(2) pretreatment of Th2 cells suppressed the ability

153 enzymatic activity, whereas the S185A mutant PGI protein retained full enzymatic activity.

154 /mg creatinine (P=0.002), and in nonsmokers, PGI-M at baseline (115+/-10, median 107, range 67 to 198

155 s2 and microsomal type PGE synthases but not PGI synthases are co-expressed.

156 nhibited prostaglandin E(2) (PGE(2)) but not PGI(2) production in response to Ang II, whereas celecox

157 GD(2), thromboxane, and PGF(2alpha), but not PGI(2).

158 wever, here we have shown that activation of PGI(2) receptor (IP) upregulated the expression of sever

159 rylation modulates the enzymatic activity of PGI thus has an important implication for the understand

160 The addition of PGI 2 alone also induced the expression of VEGF.

161 Administration of PGI-02776 immediately following the cessation of hypoxia

162 Conversely, iloprost, a stable analog of PGI(2), augmented IL-17 production by gammadelta T cells

163 madelta-17 cell responses, stable analogs of PGI(2) may be exploited in the development of new immuno

164 th suppression of PGE(2) and augmentation of PGI(2) attenuate tenascin-C expression and vascular smoo

165 801, P = 0.006), as well as one-biomarker of PGI/II (0.735, P < 0.001), HpAb (0.737, P < 0.001) and O

166 of a divergent impact on the biosynthesis of PGI(2).

167 ies are the first to explore the capacity of PGI(2) to regulate bacterial killing and phagocytosis in

168 y higher than two-dimensional combination of PGI/II-HpAb (0.786, P < 0.001), PGI/II-OPN (0.787, P < 0

169 er ROC from three-dimensional combination of PGI/II-HpAb-OPN (0.826) was significantly higher than tw

170 The combination of PGI/II-HpAb-OPN, yielded a sensitivity of 70.2% and spec

171 hanisms involved in the counterregulation of PGI(2)/TxA(2) signaling are unclear.

172 We show here that ectopic expression of PGI/AMF induced epithelial-to-mesenchymal transition (EM

173 t under hypoxic conditions the expression of PGI/AMF is regulated in part by the HIF pathway, which i

174 enzyme unrelated to the well known family of PGI enzymes found in prokaryotes, eukaryotes, and some a

175 e enzyme, resulting in a less active form of PGI, whereas non-phosphorylated protein species retain c

176 cells and again the increase in formation of PGI(2) observed in WTs was suppressed in cells derived f

177 f accumulated PGH(2) to augment formation of PGI(2).

178 at mediate the anti-inflammatory function of PGI(2.) In this study, we determined that PGI(2) analogs

179 lating platelets by maximizing the impact of PGI(2).

180 In addition, the hypoxia induction of PGI/AMF expression was suppressed by inhibitors of vascu

181 r benefit, despite concomitant inhibition of PGI(2).

182 robic energy generation; thus, inhibition of PGI/AMF expression and activities may provide a new ther

183 n breast epithelial cells, and inhibition of PGI/AMF expression triggered mesenchymal-to-epithelial t

184 e a new therapeutic target for inhibition of PGI/AMF inducing tumor cell migration and invasion durin

185 A specific inhibitor of PGI/AMF induced cellular senescence and p21 expression i

186 ogether, the results show the involvement of PGI/AMF in both EMT and MET: overexpression of PGI/AMF i

187 tumor cells, we examined the involvement of PGI/AMF in overcoming cellular senescence in cancer cell

188 Homology-based modeling of PGI's structure shows that these regions are related spa

189 Ectopic overexpression of PGI results in the acquisition of a transformed phenotyp

190 I/AMF in both EMT and MET: overexpression of PGI/AMF induces EMT in normal breast epithelial cells an

191 sis, and an intracellular binding partner of PGI/AMF is expected to regulate in part its diverse biol

192 mino acid variants occur in diverse parts of PGI's sequence.

193 The increased production of PGI(2) and arterial content of cAMP were inhibited only

194 Furthermore, production of PGI(2) and arterial content of cAMP, second messenger fo

195 d arachidonic acid release and production of PGI(2) and PAF.

196 in the expression of COX-2 and production of PGI(2) and PGE(2) with no significant change in the expr

197 The production of PGI(2) leads to an increase in the level of the pro-angi

198 vel mechanism by which stromal production of PGI(2) promotes survival of colonocytes through PPAR del

199 ible Ha-Ras(V12) increases the production of PGI(2) through the coordinate up-regulation of cPLA(2),

200 that the phosphorylation mutant proteins of PGI exhibited decreased enzymatic activity, whereas the

201 mal breast epithelial cells and reduction of PGI/AMF expression led to MET in aggressive breast cance

202 le is known of the biochemical regulation of PGI/AMF activities, although it is known that human PGI/

203 1, which in turn led to the up-regulation of PGI/AMF expression and was specifically inhibited by inh

204 ld assist in understanding the regulation of PGI/AMF intracellular function(s) and may provide a new

205 ormal fibroblasts whereas down-regulation of PGI/AMF leads to mesenchymal-to-epithelial transition in

206 To elucidate the functional role of PGI, we stably transfected its cDNA into NIH/3T3 and BAL

207 and completely extinguished the secretion of PGI/AMF in a human fibrosarcoma HT1080, whereas the cont

208 Silencing of PGI/AMF expression by RNA interference in MDA-MB-231 cel

209 Moreover, silencing of PGI/AMF expression in MDA-MB-231 cells led to overexpres

210 ther reexpression of miR-200 or silencing of PGI/AMF suppressed pulmonary metastases of MDA-MB-231 ce

211 re with G6P also explains the specificity of PGI for glucose 6-phosphate over mannose 6-isomerase (M6

212 Suppression of PGI/AMF led to a contact-dependent inhibition of cell gr

213 Furthermore, transfection of PGI(2) synthase siRNA, COX-1 siRNA, or PPARdelta siRNA i

214 f its fold, with the inner core structure of PGIs from eubacterial and eukaryotic sources, confirms t

215 hod to discriminate three "Tropea Red Onion" PGI ecotypes (TrT, TrMC and TrA) from each other and the

216 , 2,3-dinor 6-keto PGF(1alpha) (PGI-M), only PGI-M was depressed by the COX-2 inhibitor.

217 romboxane (TxA(2)) are biological opposites; PGI(2), a vasodilator and inhibitor of platelet aggregat

218 hacin or by genetic inactivation of COX-1 or PGI(2) synthase with small interfering (si)RNA.

219 threonine, in place of a glutamine in other PGI enzymes, which could permit rotation of the C-2-C-3

220 AMs to a much greater degree than the other PGI(2) analogs and more closely resembled the effects of

221 Mice that overexpress PGI(2) synthase selectively in bronchial epithelium are

222 post-injury treatment with the ZJ-43 prodrug PGI-02776 reduces both acute neuronal pathology and long

223 y important stable analogues of prostacyclin PGI(2), namely benzindene prostacyclins, has been achiev

224 Prostacyclin (PGI(2)) and thromboxane (TxA(2)) are biological opposite

225 Prostacyclin (PGI(2)) is a major PG with antiapoptotic activity and is

226 Prostacyclin (PGI(2)) is the major prostaglandin generated downstream

227 Prostacyclin (PGI(2)) is widely used to treat pulmonary arterial hyper

228 n to the production of PGE(2), prostacyclin (PGI(2)), and thromboxane A(2) in human coronary artery e

229 ular Cyclooxygenase-2 (COX-2), prostacyclin (PGI(2)), restrains atherogenesis, inhibition and deletio

230 s, (c) hypoxia and (d) altered prostacyclin (PGI(2)) and enhanced isoprostane formation.

231 ostanglandin E(2) (PGE(2)) and prostacyclin (PGI(2)) production.

232 othelial nitric oxide (NO) and prostacyclin (PGI(2)) production.

233 n augmented expression of both prostacyclin (PGI(2)) and thromboxane (Tx) synthases in endothelial ce

234 cyclooxygenase (COX)-2 depress prostacyclin (PGI(2)) without a concomitant inhibition of platelet COX

235 suppression of PGHS-2-derived prostacyclin (PGI(2)) and PGE(2).

236 clooxygenase 2 (COX-2)-derived prostacyclin (PGI(2)) is sufficient to explain most elements of the ca

237 normally caused by endothelial prostacyclin (PGI(2)).

238 roduced just prior to labor is prostacyclin (PGI(2)), a smooth muscle relaxant.

239 d the subsequent production of prostacyclin (PGI(2)) is an important mechanism responsible for the re

240 latory proteins, production of prostacyclin (PGI(2)), and cAMP were determined.

241 s, likely due to inhibition of prostacyclin (PGI(2)).

242 ched angiotensin II-stimulated prostacyclin (PGI(2))-dependent relaxation into a persistent vasoconst

243 lial cell COX-2 coupled to the prostacyclin (PGI(2)) synthase (PGIS) activates the nuclear receptor p

244 he sugar substrates suggests that pyrococcal PGI has a preference for straight chain substrates and t

245 roduction and is replenished by the reversed PGI reaction.

246 ess observed for the Deltamec/Deltamec/(RNAi)PGI double mutant when compared with the single mutants,

247 ta agonist GW501516 but not by the selective PGI(2) receptor agonist cicaprost.

248 At the time of H. pylori seroconversion, PGI peaked to levels significantly higher than in the ne

249 ation, short-tag pooled genomic indexing (ST-PGI), was also introduced to further improve the economy

250 In the present study PGI-02776, a newly designed di-ester prodrug of the urea

251 tecting against RSV-induced illness and that PGI(2) is a potential therapeutic target in the treatmen

252 We conclude that PGI(2) exerts anti-inflammatory action by inhibiting STA

253 al of bacterial enzymes, we demonstrate that PGI-LysAP has broad exopeptidase activity which may enha

254 of PGI(2.) In this study, we determined that PGI(2) analogs modulate dendritic cell (DC) cytokine pro

255 hough there are many studies indicating that PGI/AMF has been implicated in progression of metastasis

256 We therefore propose that PGI(2)-mediated upregulation of contractile proteins and

257 We report that PGI(2) analogs (iloprost, cicaprost, treprostinil) diffe

258 We now report that PGI-02776 (10mg/kg) is neuroprotective when administered

259 We also report that PGI/AMF degradation is mainly regulated by the ubiquitin

260 In vitro studies showed that PGI(2) did not affect IL-4 and IL-5 production or the le

261 Molecular analysis showed that PGI/AMF suppressed epithelial marker expressions and enh

262 Together, these findings suggest that PGI(2) plays a key immunoregulatory role by promoting th

263 These findings suggest that PGI(2) signaling through the IP may exert anti-inflammat

264 Collectively, these experiments suggest that PGI(2), which is generated by endothelial cells during l

265 her, the results presented here suggest that PGI/AMF is involved in oxidative stress-induced cellular

266 The data suggested that PGI veal has higher variability for most fatty acids tha

267 hese results suggest for the first time that PGI/AMF is a key gene to both EMT in the initiating step

268 Here we show, for the first time, that PGI/AMF overexpression led to an increase in the DNA-bin

269 The PGI(2) analogs decreased BMDC production of proinflammat

270 The PGI/AMF siRNA caused cells to change shape dramatically

271 hern Italy (Siracusa), have been awarded the PGI (Protected Geographical Indication) recognition as '

272 these effects were strongly inhibited by the PGI/AMF, VEGF, or VEGF receptor inhibitors.

273 In contrast, mice deficient in the PGI(2) receptor IP have exacerbated RSV-induced weight l

274 rved in the thymus of naive mice lacking the PGI(2) receptor IP, as well as in the lungs during aller

275 ces, confirms this enzyme as a member of the PGI superfamily.

276 h muscle cells, similar to the effect of the PGI(2) analog iloprost.

277 deleted mice have shown that ablation of the PGI(2) receptor (the IP) predisposes to an exaggerated r

278 Intramedullary infusion of the PGI(2) receptor agonist increased urine volume and sodiu

279 Although deletion of the PGI(2) receptor fosters atherogenesis, the importance of

280 f "much better" or "very much better" on the PGI-C.

281 ng that hypoxia-inducible VEGF regulates the PGI/AMF expression.

282 , with energies significantly lower than the PGI/PGII conformations characteristic of polyglycine str

283 nderlying such regulation, we found that the PGI(2) receptor, IP, is preferentially expressed by effe

284 Signaling through the PGI(2) receptor (IP) has been shown to inhibit inflammat

285 he concentration and time of exposure to the PGI(2) analog iloprost and was blocked by both RO3244794

286 Those PGI/AMF siRNA-transfected cells showed epithelial phenot

287 lori acquisition, accompanied by a transient PGI increase, was frequent in this population, especiall

288 n as the catalytic base in the eukaryal-type PGIs.

289 chanisms of these two structurally unrelated PGIs may be similar and based on an enediol intermediate

290 , we sought to define the effects of various PGI(2) analogs on resident alveolar macrophage (AM) and

291 The vasodilator PGI(2) analog, cicaprost, increased Rap1 activity and de

292 enge remains to identify a mechanism whereby PGI(2) and PGE(2) expression can be suppressed while avo

293 s; however, the molecular mechanism by which PGI/AMF regulates EMT is not known.

294 Furthermore, tumor cells with PGI/AMF deficiency lost their abilities to form tumor ma

295 ification system to authenticate honeys with PGI.

296 se-14 (PARP-14) to be a binding partner with PGI/AMF.

297 an improvement in cognitive performance with PGI-02776 treatment.

298 ransfer of DO11.10 Th2 cells pretreated with PGI(2) resulted in considerably attenuated pulmonary inf

299 genous PGI/AMF, were stably transfected with PGI/AMF small interfering RNA (siRNA).

300 as markedly reduced following treatment with PGI(2), whereas IP-deficient Th2 cells were unaffected a